{"id":"https://openalex.org/W2124993365","doi":"https://doi.org/10.1128/jb.179.18.5947-5950.1997","title":"Acquisition of resistance genes by the IncQ plasmid R1162 is limited by its high copy number and lack of a partitioning mechanism","display_name":"Acquisition of resistance genes by the IncQ plasmid R1162 is limited by its high copy number and lack of a partitioning mechanism","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W2124993365","doi":"https://doi.org/10.1128/jb.179.18.5947-5950.1997","mag":"2124993365","pmid":"https://pubmed.ncbi.nlm.nih.gov/9294457","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/179489"},"language":"en","primary_location":{"id":"doi:10.1128/jb.179.18.5947-5950.1997","doi":"https://doi.org/10.1128/jb.179.18.5947-5950.1997","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.179.18.5947-5950.1997","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/179489","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107429633","display_name":"Eric C. Becker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E C Becker","raw_affiliation_strings":["Department of Microbiology, University of Texas, Austin 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Texas, Austin 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078395710","display_name":"R J Meyer","orcid":"https://orcid.org/0009-0009-3595-1248","observed_orcids":["https://orcid.org/0009-0009-3595-1248"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R J Meyer","raw_affiliation_strings":["Department of Microbiology, University of Texas, Austin 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Texas, Austin 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.18264822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"179","issue":"18","first_page":"5947","last_page":"5950"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.13279999792575836,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/incq-plasmids","display_name":"IncQ plasmids","score":0.9279999732971191},{"id":"https://openalex.org/keywords/plasmid-copy-number","display_name":"plasmid copy number","score":0.8650000095367432},{"id":"https://openalex.org/keywords/plasmid-partitioning","display_name":"plasmid partitioning","score":0.9610000252723694},{"id":"https://openalex.org/keywords/plasmid-maintenance","display_name":"plasmid maintenance","score":0.6470000147819519},{"id":"https://openalex.org/keywords/antibiotic-resistance-genes","display_name":"antibiotic resistance genes","score":0.8259999752044678},{"id":"https://openalex.org/keywords/plasmid-instability","display_name":"plasmid instability","score":0.7089999914169312},{"id":"https://openalex.org/keywords/plasmid-loss","display_name":"plasmid loss","score":0.7319999933242798},{"id":"https://openalex.org/keywords/broad-host-range-plasmids","display_name":"broad-host-range plasmids","score":0.8130000233650208},{"id":"https://openalex.org/keywords/multicopy-plasmid","display_name":"multicopy plasmid","score":0.8019999861717224},{"id":"https://openalex.org/keywords/plasmid-encoded-genes","display_name":"plasmid genes","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9260336756706238},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.9241704940795898},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6950793862342834},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6722531318664551},{"id":"https://openalex.org/C2777116013","wikidata":"https://www.wikidata.org/wiki/Q6692995","display_name":"Low copy number","level":4,"score":0.5684894919395447},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4801853895187378},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.4348365068435669},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1092013418674469},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011815","descriptor_name":"R Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/jb.179.18.5947-5950.1997","doi":"https://doi.org/10.1128/jb.179.18.5947-5950.1997","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.179.18.5947-5950.1997","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:179489","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/179489","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmid:9294457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9294457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:179489","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/179489","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life on land","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3052251505","display_name":"CONJUGATIVE MOBILIZATION OF PLASMID R1162","funder_award_id":"R01GM037462","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G321530036","display_name":null,"funder_award_id":"GM 37462","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W576447047","https://openalex.org/W1489555985","https://openalex.org/W1513386749","https://openalex.org/W1559947219","https://openalex.org/W1571234018","https://openalex.org/W1647570302","https://openalex.org/W1992042701","https://openalex.org/W1992276916","https://openalex.org/W1994503800","https://openalex.org/W2004055273","https://openalex.org/W2044952215","https://openalex.org/W2054941036","https://openalex.org/W2078894194","https://openalex.org/W2090920017","https://openalex.org/W2114671452","https://openalex.org/W2115439273","https://openalex.org/W2122187251","https://openalex.org/W2146495422","https://openalex.org/W2463267938","https://openalex.org/W4296765338"],"related_works":["https://openalex.org/W7097954343","https://openalex.org/W1484289826","https://openalex.org/W2122187251","https://openalex.org/W2996355027","https://openalex.org/W3093153671","https://openalex.org/W7098592205","https://openalex.org/W4238349091","https://openalex.org/W2001452066","https://openalex.org/W1975858717","https://openalex.org/W2113629181"],"abstract_inverted_index":{"R1162":[0,16,53,98],"is":[1,35,106],"a":[2,70,78,100,103],"representative":[3],"member":[4],"of":[5,10,15,29,52,65,89,97,129],"the":[6,48,63,95,114,126],"broad-host-range":[7],"IncQ":[8,137],"group":[9],"multicopy":[11],"plasmids.":[12,138],"Lower-copy-number":[13],"derivatives":[14],"were":[17],"constructed":[18],"in":[19,59,84,99],"vitro":[20],"and":[21,40,61,123],"shown":[22],"to":[23,37,42],"be":[24],"unstable,":[25,66],"indicating":[26],"that":[27,94,105],"partitioning":[28,45],"plasmid":[30,85],"copies":[31],"at":[32,77,109],"cell":[33,55],"division":[34],"due":[36],"random":[38],"distribution":[39],"not":[41],"an":[43],"active":[44,76],"mechanism.":[46],"However,":[47],"normal":[49],"copy":[50,80],"number":[51,81],"reduces":[54,113],"fitness":[56],"during":[57,87],"growth":[58],"broth":[60],"favors":[62],"emergence":[64],"lower-copy-number":[67],"variants.":[68],"As":[69],"result,":[71],"plasmid-borne":[72],"antibiotic":[73,130],"resistance":[74,131],"genes":[75,118,132],"low":[79],"eventually":[82],"result":[83],"loss":[86],"periods":[88],"no":[90],"selection.":[91],"We":[92],"argue":[93],"maintenance":[96],"population":[101],"requires":[102],"gene":[104],"selected":[107],"only":[108],"high":[110],"levels.":[111],"This":[112],"potential":[115],"for":[116],"acquiring":[117],"from":[119],"other":[120],"R":[121],"factors":[122],"could":[124],"explain":[125],"limited":[127],"variety":[128],"contained":[133],"by":[134],"naturally":[135],"occurring":[136]},"counts_by_year":[{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
