{"id":"https://openalex.org/W2124919885","doi":"https://doi.org/10.1016/j.jpedsurg.2010.03.019","title":"Role of RET codonic mutations in the surgical management of medullary thyroid carcinoma in pediatric age multiple endocrine neoplasm type 2 syndromes","display_name":"Role of RET codonic mutations in the surgical management of medullary thyroid carcinoma in pediatric age multiple endocrine neoplasm type 2 syndromes","publication_year":2010,"publication_date":"2010-08-01","ids":{"openalex":"https://openalex.org/W2124919885","doi":"https://doi.org/10.1016/j.jpedsurg.2010.03.019","mag":"2124919885","pmid":"https://pubmed.ncbi.nlm.nih.gov/20713208"},"language":"en","primary_location":{"id":"doi:10.1016/j.jpedsurg.2010.03.019","doi":"https://doi.org/10.1016/j.jpedsurg.2010.03.019","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jpedsurg.2010.03.019","pdf_url":null,"source":{"id":"https://openalex.org/S39924113","display_name":"Journal of Pediatric Surgery","issn_l":"0022-3468","issn":["0022-3468","1531-5037"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085699638","display_name":"Claudio Spinelli","orcid":"https://orcid.org/0000-0002-8229-0253","observed_orcids":["https://orcid.org/0000-0002-8229-0253"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Claudio Spinelli","raw_affiliation_strings":["Department of Surgery, University of Pisa, 56126 Pisa, Italy. c.spinelli@dc.med.unipi.it","Department of Surgery, University of Pisa, 56126 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pisa, 56126 Pisa, Italy. c.spinelli@dc.med.unipi.it","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Department of Surgery, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005153246","display_name":"Martina Di Giacomo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martina Di Giacomo","raw_affiliation_strings":["Department of Surgery, University of Pisa, 56126 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014222717","display_name":"Sara Costanzo","orcid":"https://orcid.org/0000-0002-4367-7607","observed_orcids":["https://orcid.org/0000-0002-4367-7607"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Costanzo","raw_affiliation_strings":["Department of Surgery, University of Pisa, 56126 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027117186","display_name":"Rossella Elisei","orcid":"https://orcid.org/0000-0002-5333-9257","observed_orcids":["https://orcid.org/0000-0002-5333-9257"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rossella Elisei","raw_affiliation_strings":["Department of Endocrinology, University of Pisa, 56126 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010347660","display_name":"Paolo Miccoli","orcid":"https://orcid.org/0000-0002-5540-4083","observed_orcids":["https://orcid.org/0000-0002-5540-4083"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Miccoli","raw_affiliation_strings":["Chief General Surgery Department, University of Pisa, 56126 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chief General Surgery Department, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085699638"],"corresponding_institution_ids":["https://openalex.org/I108290504"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":1.3585,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.80267296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"45","issue":"8","first_page":"1610","last_page":"1616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/ret-mutations","display_name":"RET mutations","score":0.8199999928474426},{"id":"https://openalex.org/keywords/multiple-endocrine-neoplasia-type-2","display_name":"multiple endocrine neoplasia type 2","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.843999981880188},{"id":"https://openalex.org/keywords/genetic-screening","display_name":"genetic screening","score":0.8230000138282776},{"id":"https://openalex.org/keywords/prophylactic-thyroidectomy","display_name":"prophylactic thyroidectomy","score":0.9089999794960022},{"id":"https://openalex.org/keywords/total-thyroidectomy","display_name":"total thyroidectomy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/timing-of-surgery","display_name":"timing of surgery","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.5130000114440918},{"id":"https://openalex.org/keywords/minimally-invasive-thyroidectomy","display_name":"minimally invasive thyroid surgery","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9618061780929565},{"id":"https://openalex.org/C2780103800","wikidata":"https://www.wikidata.org/wiki/Q1553018","display_name":"Multiple endocrine neoplasia","level":3,"score":0.7206431031227112},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.6883656978607178},{"id":"https://openalex.org/C2776512331","wikidata":"https://www.wikidata.org/wiki/Q604075","display_name":"Multiple endocrine neoplasia type 2","level":5,"score":0.6841057538986206},{"id":"https://openalex.org/C2777074255","wikidata":"https://www.wikidata.org/wiki/Q1351681","display_name":"Thyroidectomy","level":3,"score":0.6679279804229736},{"id":"https://openalex.org/C195121873","wikidata":"https://www.wikidata.org/wiki/Q1131385","display_name":"Medullary cavity","level":2,"score":0.6010976433753967},{"id":"https://openalex.org/C2780120053","wikidata":"https://www.wikidata.org/wiki/Q3493538","display_name":"Medullary thyroid cancer","level":4,"score":0.5623926520347595},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.5549724698066711},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5209625959396362},{"id":"https://openalex.org/C2776667971","wikidata":"https://www.wikidata.org/wiki/Q6807316","display_name":"Medullary carcinoma","level":4,"score":0.4556681215763092},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44989579916000366},{"id":"https://openalex.org/C2776869705","wikidata":"https://www.wikidata.org/wiki/Q2661443","display_name":"Endocrine disease","level":4,"score":0.439769446849823},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.43710631132125854},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.41756904125213623},{"id":"https://openalex.org/C2779512018","wikidata":"https://www.wikidata.org/wiki/Q536269","display_name":"Pheochromocytoma","level":2,"score":0.41537100076675415},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.3966541290283203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28839996457099915},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.23633769154548645},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.22940149903297424},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07873010635375977},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.07329672574996948},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D013965","descriptor_name":"Thyroidectomy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018276","descriptor_name":"Carcinoma, Medullary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018276","descriptor_name":"Carcinoma, Medullary","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D018276","descriptor_name":"Carcinoma, Medullary","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D018813","descriptor_name":"Multiple Endocrine Neoplasia Type 2a","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018813","descriptor_name":"Multiple Endocrine Neoplasia Type 2a","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D018813","descriptor_name":"Multiple Endocrine Neoplasia Type 2a","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020535","descriptor_name":"Video-Assisted Surgery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051096","descriptor_name":"Proto-Oncogene Proteins c-ret","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jpedsurg.2010.03.019","doi":"https://doi.org/10.1016/j.jpedsurg.2010.03.019","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jpedsurg.2010.03.019","pdf_url":null,"source":{"id":"https://openalex.org/S39924113","display_name":"Journal of Pediatric Surgery","issn_l":"0022-3468","issn":["0022-3468","1531-5037"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Surgery","raw_type":"journal-article"},{"id":"pmid:20713208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20713208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric surgery","raw_type":"Comparative Study"},{"id":"pmh:oai:arpi.unipi.it:11568/191288","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/191288","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:arpi.unipi.it:11568/757903","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/757903","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1581876628","https://openalex.org/W1608813682","https://openalex.org/W1884965467","https://openalex.org/W1965244573","https://openalex.org/W1968566336","https://openalex.org/W1972453943","https://openalex.org/W1998919953","https://openalex.org/W2021338177","https://openalex.org/W2030522431","https://openalex.org/W2046644766","https://openalex.org/W2061326870","https://openalex.org/W2062862086","https://openalex.org/W2073477565","https://openalex.org/W2075544466","https://openalex.org/W2077595358","https://openalex.org/W2078191005","https://openalex.org/W2083518511","https://openalex.org/W2088333792","https://openalex.org/W2114578972","https://openalex.org/W2118826457","https://openalex.org/W2146718153","https://openalex.org/W2411059853","https://openalex.org/W2614344301","https://openalex.org/W6714956679"],"related_works":["https://openalex.org/W2558780437","https://openalex.org/W2298935772","https://openalex.org/W2969149283","https://openalex.org/W2044661480","https://openalex.org/W2610546012","https://openalex.org/W2008200004","https://openalex.org/W3201911820","https://openalex.org/W2131969659","https://openalex.org/W2096850303","https://openalex.org/W2500338006"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
