{"id":"https://openalex.org/W2124908338","doi":"https://doi.org/10.1002/emmm.201000115","title":"Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection","display_name":"Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection","publication_year":2011,"publication_date":"2011-01-26","ids":{"openalex":"https://openalex.org/W2124908338","doi":"https://doi.org/10.1002/emmm.201000115","mag":"2124908338","pmid":"https://pubmed.ncbi.nlm.nih.gov/21268281","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3395110"},"language":"en","primary_location":{"id":"doi:10.1002/emmm.201000115","doi":"https://doi.org/10.1002/emmm.201000115","is_oa":true,"landing_page_url":"https://doi.org/10.1002/emmm.201000115","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/emmm.201000115","source":{"id":"https://openalex.org/S163075119","display_name":"EMBO Molecular Medicine","issn_l":"1757-4676","issn":["1757-4676","1757-4684"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/emmm.201000115","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005262827","display_name":"Lorena P. N. Tuchscherr","orcid":"https://orcid.org/0000-0002-9328-5302","observed_orcids":["https://orcid.org/0000-0002-9328-5302"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lorena Tuchscherr","raw_affiliation_strings":["Institute of Medical Microbiology, University Hospital of M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology, University Hospital of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074513891","display_name":"Eva Medina","orcid":"https://orcid.org/0000-0002-5935-3260","observed_orcids":["https://orcid.org/0000-0002-5935-3260"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eva Medina","raw_affiliation_strings":["Helmholtz Center for Infection Research (HZI), Braunschweig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz Center for Infection Research (HZI), Braunschweig, Germany","institution_ids":["https://openalex.org/I4210124929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101870502","display_name":"Muzaffar Hussain","orcid":"https://orcid.org/0000-0002-2404-7650","observed_orcids":["https://orcid.org/0000-0002-2404-7650"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Muzaffar Hussain","raw_affiliation_strings":["Institute of Medical Microbiology, University Hospital of M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology, University Hospital of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088938966","display_name":"Wolfgang V\u00f6lker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang V\u00f6lker","raw_affiliation_strings":["Leibniz-Institute for Arteriosclerosis Research, University Hospital of M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leibniz-Institute for Arteriosclerosis Research, University Hospital of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029753187","display_name":"Vanessa Heitmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vanessa Heitmann","raw_affiliation_strings":["Institute of Medical Microbiology, University Hospital of M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology, University Hospital of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084912742","display_name":"Silke Niemann","orcid":"https://orcid.org/0000-0002-9807-2541","observed_orcids":["https://orcid.org/0000-0002-9807-2541"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Silke Niemann","raw_affiliation_strings":["Institute of Medical Microbiology, University Hospital of M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology, University Hospital of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085622358","display_name":"Dirk Holzinger","orcid":"https://orcid.org/0000-0002-8062-8820","observed_orcids":["https://orcid.org/0000-0002-8062-8820"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dirk Holzinger","raw_affiliation_strings":["Institute of Immunology, University Hospital of M\u00fcnster, M\u00fcnster, Germany","Interdisciplinary Center of Clinical Research (IZKF), University Hospital of M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, University Hospital of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]},{"raw_affiliation_string":"Interdisciplinary Center of Clinical Research (IZKF), University Hospital of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063516762","display_name":"Johannes Roth","orcid":"https://orcid.org/0000-0001-7035-8348","observed_orcids":["https://orcid.org/0000-0001-7035-8348"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Roth","raw_affiliation_strings":["Institute of Immunology, University Hospital of M\u00fcnster, M\u00fcnster, Germany","Interdisciplinary Center of Clinical Research (IZKF), University Hospital of M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, University Hospital of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]},{"raw_affiliation_string":"Interdisciplinary Center of Clinical Research (IZKF), University Hospital of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086481621","display_name":"Richard A. Proctor","orcid":"https://orcid.org/0000-0003-3011-7958","observed_orcids":["https://orcid.org/0000-0003-3011-7958"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Proctor","raw_affiliation_strings":["Departments of Medicine and Medical Microbiology/Immunology, University of Wisconsin Medical School, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Medical Microbiology/Immunology, University of Wisconsin Medical School, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070963176","display_name":"Karsten Becker","orcid":"https://orcid.org/0000-0002-6391-1341","observed_orcids":["https://orcid.org/0000-0002-6391-1341"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karsten Becker","raw_affiliation_strings":["Institute of Medical Microbiology, University Hospital of M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology, University Hospital of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026896969","display_name":"Georg Peters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Georg Peters","raw_affiliation_strings":["Institute of Medical Microbiology, University Hospital of M\u00fcnster, M\u00fcnster, Germany","Interdisciplinary Center of Clinical Research (IZKF), University Hospital of M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology, University Hospital of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]},{"raw_affiliation_string":"Interdisciplinary Center of Clinical Research (IZKF), University Hospital of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010473894","display_name":"Bettina L\u00f6ffler","orcid":"https://orcid.org/0009-0009-6792-9328","observed_orcids":["https://orcid.org/0009-0009-6792-9328"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bettina L\u00f6ffler","raw_affiliation_strings":["Institute of Medical Microbiology, University Hospital of M\u00fcnster, M\u00fcnster, Germany","Interdisciplinary Center of Clinical Research (IZKF), University Hospital of M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology, University Hospital of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]},{"raw_affiliation_string":"Interdisciplinary Center of Clinical Research (IZKF), University Hospital of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010473894"],"corresponding_institution_ids":["https://openalex.org/I4210103666"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":{"value":7990,"currency":"USD","value_usd":7990},"fwci":19.9568,"has_fulltext":true,"cited_by_count":431,"citation_normalized_percentile":{"value":0.99733308,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"3","issue":"3","first_page":"129","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":1.0},{"id":"https://openalex.org/keywords/phenotypic-switching","display_name":"phenotypic switching","score":0.8119999766349792},{"id":"https://openalex.org/keywords/small-colony-variants","display_name":"small colony variants","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chronic-infection","display_name":"chronic infection","score":0.8009999990463257},{"id":"https://openalex.org/keywords/intracellular-persistence","display_name":"intracellular persistence","score":0.7160000205039978},{"id":"https://openalex.org/keywords/host-immune-evasion","display_name":"host immune evasion","score":0.7799999713897705},{"id":"https://openalex.org/keywords/virulence-factor-expression","display_name":"virulence factor expression","score":0.8980000019073486},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.8302364349365234},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.8027644157409668},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.7841435670852661},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7073103189468384},{"id":"https://openalex.org/C2781011225","wikidata":"https://www.wikidata.org/wiki/Q7181400","display_name":"Phenotypic switching","level":4,"score":0.6708886027336121},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6687090992927551},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6398553848266602},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5992998480796814},{"id":"https://openalex.org/C3019392825","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic infection","level":3,"score":0.5924241542816162},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4846513867378235},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.47647687792778015},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4639078974723816},{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.45134279131889343},{"id":"https://openalex.org/C180223184","wikidata":"https://www.wikidata.org/wiki/Q4839986","display_name":"Bacterial genetics","level":4,"score":0.4182341694831848},{"id":"https://openalex.org/C2777334864","wikidata":"https://www.wikidata.org/wiki/Q34879","display_name":"Staphylococcal infections","level":4,"score":0.412864625453949},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.1957826018333435},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1896522343158722},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1520157754421234}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010586","descriptor_name":"Phagocytes","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D050296","descriptor_name":"Microbial Viability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057131","descriptor_name":"Immune Evasion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1002/emmm.201000115","doi":"https://doi.org/10.1002/emmm.201000115","is_oa":true,"landing_page_url":"https://doi.org/10.1002/emmm.201000115","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/emmm.201000115","source":{"id":"https://openalex.org/S163075119","display_name":"EMBO Molecular Medicine","issn_l":"1757-4676","issn":["1757-4676","1757-4684"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3395110","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3395110","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Mol Med","raw_type":"Text"},{"id":"pmid:21268281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21268281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:repository.helmholtz-hzi.de:10033/346878","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10033/346878","pdf_url":"https://repository.helmholtz-hzi.de/bitstream/10033/346878/1/tuchscherr%20et%20al_final.pdf","source":{"id":"https://openalex.org/S4377196474","display_name":"HZI (Helmholtz Centre for Infection Research)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124929","host_organization_name":"Helmholtz Centre for Infection Research","host_organization_lineage":["https://openalex.org/I4210124929"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.988.9640","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.988.9640","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://hzi.openrepository.com/hzi/bitstream/10033/346878/1/tuchscherr%20et%20al_final.pdf","raw_type":"text"},{"id":"pmh:oai:hzi.openrepository.com:10033/346878","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10033/346878","pdf_url":null,"source":{"id":"https://openalex.org/S4377196474","display_name":"HZI (Helmholtz Centre for Infection Research)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124929","host_organization_name":"Helmholtz Centre for Infection Research","host_organization_lineage":["https://openalex.org/I4210124929"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1002/emmm.201000115","doi":"https://doi.org/10.1002/emmm.201000115","is_oa":true,"landing_page_url":"https://doi.org/10.1002/emmm.201000115","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/emmm.201000115","source":{"id":"https://openalex.org/S163075119","display_name":"EMBO Molecular Medicine","issn_l":"1757-4676","issn":["1757-4676","1757-4684"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G765817073","display_name":"Medizinische Infektionsgenomik: Metagenomics und Host-Pathogen Interactomics in diabetischen Fu\u00dfinfektionen - Teilprojekt M\u00fcnster","funder_award_id":"0315830B","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G8397296360","display_name":null,"funder_award_id":"01KI0700","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G8982889038","display_name":null,"funder_award_id":"HA 3177/2\u20101","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124908338.pdf","grobid_xml":"https://content.openalex.org/works/W2124908338.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W921467170","https://openalex.org/W1938591788","https://openalex.org/W1963585637","https://openalex.org/W1969143507","https://openalex.org/W1971305074","https://openalex.org/W1974556408","https://openalex.org/W1975789761","https://openalex.org/W1980580626","https://openalex.org/W1985002373","https://openalex.org/W1999277244","https://openalex.org/W2012121835","https://openalex.org/W2012256930","https://openalex.org/W2022839004","https://openalex.org/W2028419507","https://openalex.org/W2034640788","https://openalex.org/W2039660022","https://openalex.org/W2042446299","https://openalex.org/W2045825103","https://openalex.org/W2048425837","https://openalex.org/W2050911379","https://openalex.org/W2052899289","https://openalex.org/W2054472394","https://openalex.org/W2060421577","https://openalex.org/W2060706944","https://openalex.org/W2068713513","https://openalex.org/W2079774537","https://openalex.org/W2081183044","https://openalex.org/W2085850813","https://openalex.org/W2088293790","https://openalex.org/W2088960594","https://openalex.org/W2093643135","https://openalex.org/W2099943609","https://openalex.org/W2109132453","https://openalex.org/W2113067152","https://openalex.org/W2114660268","https://openalex.org/W2122020611","https://openalex.org/W2124616140","https://openalex.org/W2125066910","https://openalex.org/W2134765452","https://openalex.org/W2136989595","https://openalex.org/W2137092505","https://openalex.org/W2137448773","https://openalex.org/W2138699870","https://openalex.org/W2146327400","https://openalex.org/W2148323109","https://openalex.org/W2149586621","https://openalex.org/W2151722492","https://openalex.org/W2152001954","https://openalex.org/W2157603347","https://openalex.org/W2158199036","https://openalex.org/W2158467440","https://openalex.org/W2314649741","https://openalex.org/W2328536907","https://openalex.org/W2341370902","https://openalex.org/W2398919906","https://openalex.org/W4213353716","https://openalex.org/W4251800447"],"related_works":["https://openalex.org/W7095108501","https://openalex.org/W1861965265","https://openalex.org/W2086731907","https://openalex.org/W2218673609","https://openalex.org/W2134765452","https://openalex.org/W7023762730","https://openalex.org/W2078268465","https://openalex.org/W2087881133","https://openalex.org/W3027527949","https://openalex.org/W2083492619"],"abstract_inverted_index":{"Staphylococcus":[0],"aureus":[1,82],"is":[2,37,52,62,149],"a":[3,54,169],"frequent":[4],"cause":[5],"for":[6,96,171],"serious,":[7],"chronic":[8,21,172],"and":[9,75,83,114,124,138,173],"therapy-refractive":[10,174],"infections":[11],"in":[12,18,73,76,110],"spite":[13],"of":[14,153],"susceptibility":[15],"to":[16,43,48,64,127,161],"antibiotics":[17],"vitro.":[19],"In":[20],"infections,":[22],"altered":[23],"bacterial":[24,101,146],"phenotypes,":[25,106],"such":[26],"as":[27],"small":[28],"colony":[29],"variants":[30],"(SCVs),":[31],"have":[32],"been":[33],"found.":[34],"Yet,":[35],"it":[36],"largely":[38],"unclear":[39],"whether":[40],"the":[41,46,49,117,128,135,154,159],"ability":[42],"interconvert":[44],"from":[45],"wild-type":[47,131],"SCV":[50,105,119],"phenotype":[51,147],"only":[53],"rare":[55],"clinical":[56],"and/or":[57,94],"just":[58],"laboratory":[59],"phenomenon":[60],"or":[61],"essential":[63],"sustain":[65],"an":[66,150],"infection.":[67],"Here,":[68],"we":[69,84],"performed":[70],"different":[71],"long-term":[72],"vitro":[74],"vivo":[77],"infection":[78,155],"models":[79],"with":[80],"S.":[81],"show":[85],"that":[86,145,157],"viable":[87],"bacteria":[88,160],"can":[89,167],"persist":[90],"within":[91],"host":[92,164],"cells":[93],"tissues":[95],"several":[97],"weeks.":[98],"Persistence":[99],"induced":[100],"phenotypic":[102],"diversity,":[103],"including":[104],"accompanied":[107],"by":[108],"changes":[109],"virulence":[111],"factor":[112],"expression":[113],"auxotrophism.":[115],"However,":[116],"recovered":[118],"phenotypes":[120],"were":[121],"highly":[122],"dynamic":[123],"rapidly":[125],"reverted":[126],"fully":[129],"virulent":[130],"form":[132],"when":[133],"leaving":[134],"intracellular":[136],"location":[137],"infecting":[139],"new":[140],"cells.":[141],"Our":[142],"findings":[143],"demonstrate":[144],"switching":[148],"integral":[151],"part":[152],"process":[156],"enables":[158],"hide":[162],"inside":[163],"cells,":[165],"which":[166],"be":[168],"reservoir":[170],"infections.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":34},{"year":2019,"cited_by_count":39},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":26},{"year":2016,"cited_by_count":28},{"year":2015,"cited_by_count":32},{"year":2014,"cited_by_count":31},{"year":2013,"cited_by_count":28},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}