{"id":"https://openalex.org/W2124880023","doi":"https://doi.org/10.1158/1078-0432.ccr-08-2619","title":"Preclinical Results of Camptothecin-Polymer Conjugate (IT-101) in Multiple Human Lymphoma Xenograft Models","display_name":"Preclinical Results of Camptothecin-Polymer Conjugate (IT-101) in Multiple Human Lymphoma Xenograft Models","publication_year":2009,"publication_date":"2009-06-24","ids":{"openalex":"https://openalex.org/W2124880023","doi":"https://doi.org/10.1158/1078-0432.ccr-08-2619","mag":"2124880023","pmid":"https://pubmed.ncbi.nlm.nih.gov/19549776","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3245217"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-08-2619","doi":"https://doi.org/10.1158/1078-0432.ccr-08-2619","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-08-2619","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3245217","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065104304","display_name":"Tontanai Numbenjapon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tontanai Numbenjapon","raw_affiliation_strings":["1Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope,","Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, City of Hope Comprehensive Cancer Center, Duarte, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope,","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]},{"raw_affiliation_string":"Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, City of Hope Comprehensive Cancer Center, Duarte, California, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101615048","display_name":"Jianyi Wang","orcid":"https://orcid.org/0000-0002-7299-9154","observed_orcids":["https://orcid.org/0000-0002-7299-9154"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianyi Wang","raw_affiliation_strings":["1Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope,","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082864167","display_name":"David M. Colcher","orcid":"https://orcid.org/0000-0001-6647-2850","observed_orcids":["https://orcid.org/0000-0001-6647-2850"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Colcher","raw_affiliation_strings":["1Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope,","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051528550","display_name":"Thomas Schluep","orcid":"https://orcid.org/0000-0002-2986-7287","observed_orcids":["https://orcid.org/0000-0002-2986-7287"]},"institutions":[{"id":"https://openalex.org/I4210095590","display_name":"Calando Pharmaceuticals (United States)","ror":"https://ror.org/00976p334","country_code":"US","type":"company","lineage":["https://openalex.org/I4210095590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Schluep","raw_affiliation_strings":["4Insert Therapeutics Inc., and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Insert Therapeutics Inc., and","institution_ids":["https://openalex.org/I4210095590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010404427","display_name":"Mark E. Davis","orcid":"https://orcid.org/0000-0001-8294-1477","observed_orcids":["https://orcid.org/0000-0001-8294-1477","https://orcid.org/0000-0001-5886-4790","https://orcid.org/0000-0003-2480-7338"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark E. Davis","raw_affiliation_strings":["5Chemical Engineering, California Institute of Technology, Pasadena, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Chemical Engineering, California Institute of Technology, Pasadena, California","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052299775","display_name":"Julienne Duringer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095590","display_name":"Calando Pharmaceuticals (United States)","ror":"https://ror.org/00976p334","country_code":"US","type":"company","lineage":["https://openalex.org/I4210095590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julienne Duringer","raw_affiliation_strings":["4Insert Therapeutics Inc., and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Insert Therapeutics Inc., and","institution_ids":["https://openalex.org/I4210095590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091067752","display_name":"Leo Kretzner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leo Kretzner","raw_affiliation_strings":["2Translational Research Laboratory, Clinical and Molecular Pharmacology, and","City of Hope National Med Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Translational Research Laboratory, Clinical and Molecular Pharmacology, and","institution_ids":[]},{"raw_affiliation_string":"City of Hope National Med Center","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009104622","display_name":"Yun Yen","orcid":"https://orcid.org/0000-0003-0815-412X","observed_orcids":["https://orcid.org/0000-0003-0815-412X"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Yen","raw_affiliation_strings":["2Translational Research Laboratory, Clinical and Molecular Pharmacology, and","City of Hope National Med Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Translational Research Laboratory, Clinical and Molecular Pharmacology, and","institution_ids":[]},{"raw_affiliation_string":"City of Hope National Med Center","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039374832","display_name":"Stephen J. Forman","orcid":"https://orcid.org/0000-0002-2803-4152","observed_orcids":["https://orcid.org/0000-0002-2803-4152"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Forman","raw_affiliation_strings":["3Hematology and Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, Duarte, California; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Hematology and Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, Duarte, California; and","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072320451","display_name":"Andrew Antony Raubitschek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Raubitschek","raw_affiliation_strings":["1Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope,","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9984,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.86465586,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"13","first_page":"4365","last_page":"4373"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camptothecin","display_name":"camptothecin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.8939999938011169},{"id":"https://openalex.org/keywords/sn-38","display_name":"SN-38","score":0.8619999885559082},{"id":"https://openalex.org/keywords/topoisomerase-i-inhibition","display_name":"topoisomerase I inhibition","score":0.8560000061988831},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.7979999780654907},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.765999972820282},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.777999997138977},{"id":"https://openalex.org/keywords/drug-release-kinetics","display_name":"drug release kinetics","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8669999837875366},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.8102394342422485},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.7693294286727905},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.7164788246154785},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.6778314709663391},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6598684787750244},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6117444038391113},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5583131313323975},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5387993454933167},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5298124551773071},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5022561550140381},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.4869726598262787},{"id":"https://openalex.org/C2780508388","wikidata":"https://www.wikidata.org/wiki/Q1750127","display_name":"SN-38","level":5,"score":0.4293763339519501},{"id":"https://openalex.org/C2781209748","wikidata":"https://www.wikidata.org/wiki/Q419953","display_name":"Topotecan","level":3,"score":0.41191691160202026},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41129904985427856},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4069989323616028},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37556779384613037},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3026883006095886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27709707617759705},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21123719215393066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15989109873771667},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12106424570083618},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003505","descriptor_name":"Cyclodextrins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003505","descriptor_name":"Cyclodextrins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059004","descriptor_name":"Topoisomerase I Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/1078-0432.ccr-08-2619","doi":"https://doi.org/10.1158/1078-0432.ccr-08-2619","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-08-2619","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:19549776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19549776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:3245217","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3245217","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"},{"id":"pmh:oai:authors.library.caltech.edu:15564","doi":null,"is_oa":false,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20090903-095514247","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3245217","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3245217","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4283778863","display_name":"City of Hope Lymphoma SPORE","funder_award_id":"P50CA107399","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W37120966","https://openalex.org/W175938947","https://openalex.org/W1258570584","https://openalex.org/W1488086007","https://openalex.org/W1499537359","https://openalex.org/W1523784594","https://openalex.org/W1584024009","https://openalex.org/W1678689855","https://openalex.org/W1838547618","https://openalex.org/W1862918409","https://openalex.org/W1871308790","https://openalex.org/W1897082568","https://openalex.org/W1933973263","https://openalex.org/W1952371628","https://openalex.org/W1973100539","https://openalex.org/W1981898511","https://openalex.org/W2000941201","https://openalex.org/W2006824814","https://openalex.org/W2008193655","https://openalex.org/W2011909208","https://openalex.org/W2028908766","https://openalex.org/W2031083024","https://openalex.org/W2040726239","https://openalex.org/W2057331147","https://openalex.org/W2076334524","https://openalex.org/W2078751203","https://openalex.org/W2088411284","https://openalex.org/W2096122707","https://openalex.org/W2104639026","https://openalex.org/W2117210765","https://openalex.org/W2117964879","https://openalex.org/W2121805411","https://openalex.org/W2122489231","https://openalex.org/W2137971888","https://openalex.org/W2144134201","https://openalex.org/W2144767350","https://openalex.org/W2150125341","https://openalex.org/W2152434506","https://openalex.org/W2152490459","https://openalex.org/W2165351839","https://openalex.org/W2187750921","https://openalex.org/W2328232339","https://openalex.org/W2394583354","https://openalex.org/W2429945373"],"related_works":["https://openalex.org/W2573480279","https://openalex.org/W2573990768","https://openalex.org/W2121805411","https://openalex.org/W7096754962","https://openalex.org/W165178680","https://openalex.org/W2152434506","https://openalex.org/W2162497962","https://openalex.org/W2043328144","https://openalex.org/W1796664015","https://openalex.org/W2122489231"],"abstract_inverted_index":{"PURPOSE:":[0],"Camptothecin":[1],"(CPT)":[2],"has":[3,18,40],"potent":[4],"broad-spectrum":[5],"antitumor":[6],"activity":[7],"by":[8],"inhibiting":[9],"type":[10],"I":[11,115,162,202],"DNA":[12,113,160],"topoisomerase":[13],"(DNA":[14],"topo":[15,114,161],"I).":[16],"It":[17],"not":[19],"been":[20,41],"used":[21,44],"clinically":[22],"because":[23],"it":[24],"is":[25],"water-insoluble":[26],"and":[27,43,95,118,128,146,149,155,176],"highly":[28],"toxic.":[29],"As":[30,142],"a":[31,35,62,200],"result,":[32],"irinotecan":[33],"(CPT-11),":[34],"water-soluble":[36],"analogue":[37],"of":[38,66,78,92,111,121,172],"CPT,":[39],"developed":[42,61],"as":[45,80],"salvage":[46],"chemotherapy":[47],"in":[48,89,133,189,205],"patients":[49,206],"with":[50,54,82,144,182,207],"relapsed/refractory":[51,208],"lymphoma,":[52],"but":[53],"only":[55],"modest":[56],"activity.":[57],"Recently,":[58],"we":[59,72],"have":[60],"cyclodextrin-based":[63],"polymer":[64],"conjugate":[65],"20-(S)-CPT":[67],"(IT-101).":[68],"In":[69,104],"this":[70],"study,":[71],"evaluated":[73],"the":[74,108,170,197],"preclinical":[75],"antilymphoma":[76,119],"efficacy":[77],"IT-101":[79,127,148,166],"compared":[81,143,181],"CPT-11.":[83],"EXPERIMENTAL":[84],"DESIGN:":[85],"We":[86],"determined":[87],"an":[88],"vitro":[90,134],"cytotoxicity":[91,135],"IT-101,":[93],"CPT-11,":[94],"their":[96],"metabolites":[97],"against":[98,136],"multiple":[99],"human":[100,105,178],"lymphoma":[101,106,138],"cell":[102,139],"lines.":[103],"xenografts,":[107],"pharmacokinetics,":[109],"inhibitions":[110],"tumor":[112,159],"catalytic":[116,163],"activity,":[117],"activities":[120],"these":[122],"compounds":[123],"were":[124],"evaluated.":[125],"RESULTS:":[126],"CPT":[129,150],"had":[130,151],"very":[131],"high":[132],"all":[137],"lines":[140],"tested.":[141],"CPT-11":[145,183],"SN-38,":[147],"longer":[152],"release":[153],"kinetics":[154],"significantly":[156,168],"inhibit":[157],"higher":[158],"activities.":[164],"Furthermore,":[165],"showed":[167],"prolonged":[169],"survival":[171],"animals":[173],"bearing":[174],"s.c.":[175],"disseminated":[177],"xenografts":[179],"when":[180],"at":[184],"its":[185],"maximum":[186],"tolerated":[187],"dose":[188],"mice.":[190],"CONCLUSIONS:":[191],"The":[192],"promising":[193],"present":[194],"results":[195],"provide":[196],"basis":[198],"for":[199],"phase":[201],"clinical":[203],"trial":[204],"lymphoma.":[209]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}