{"id":"https://openalex.org/W2124806986","doi":"https://doi.org/10.1128/mcb.11.5.2547-2557.1991","title":"A Heparin Sulfate-Regulated Human Keratinocyte Autocrine Factor Is Similar or Identical to Amphiregulin","display_name":"A Heparin Sulfate-Regulated Human Keratinocyte Autocrine Factor Is Similar or Identical to Amphiregulin","publication_year":1991,"publication_date":"1991-05-01","ids":{"openalex":"https://openalex.org/W2124806986","doi":"https://doi.org/10.1128/mcb.11.5.2547-2557.1991","mag":"2124806986","pmid":"https://pubmed.ncbi.nlm.nih.gov/2017164","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/360024"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.11.5.2547-2557.1991","doi":"https://doi.org/10.1128/mcb.11.5.2547-2557.1991","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.11.5.2547-2557.1991","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/360024","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012032956","display_name":"Paul W. Cook","orcid":"https://orcid.org/0009-0001-7079-4753","observed_orcids":["https://orcid.org/0009-0001-7079-4753"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P W Cook","raw_affiliation_strings":["Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039350203","display_name":"Paul A. Mattox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P A Mattox","raw_affiliation_strings":["Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110271910","display_name":"W Keeble","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W W Keeble","raw_affiliation_strings":["Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073971261","display_name":"Mark R. Pittelkow","orcid":"https://orcid.org/0000-0001-7913-0294","observed_orcids":["https://orcid.org/0000-0001-7913-0294"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M R Pittelkow","raw_affiliation_strings":["Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061228415","display_name":"Gregory D. Plowman","orcid":"https://orcid.org/0000-0002-6465-309X","observed_orcids":["https://orcid.org/0000-0002-6465-309X"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G D Plowman","raw_affiliation_strings":["Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082161558","display_name":"MOHAMMED SHOYAB","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Shoyab","raw_affiliation_strings":["Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067506966","display_name":"John P. Adelman","orcid":"https://orcid.org/0000-0002-1135-1549","observed_orcids":["https://orcid.org/0000-0002-1135-1549"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J P Adelman","raw_affiliation_strings":["Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004604292","display_name":"Gary D. Shipley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G D Shipley","raw_affiliation_strings":["Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy Oregon Health Sciences University Portland 97201","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":null,"apc_paid":null,"fwci":12.4532,"has_fulltext":false,"cited_by_count":246,"citation_normalized_percentile":{"value":0.98936636,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"5","first_page":"2547","last_page":"2557"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.04410000145435333,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.031099999323487282,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amphiregulin","display_name":"amphiregulin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/heparin-sulfate","display_name":"heparin sulfate","score":0.8330000042915344},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.8820000290870667},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.7440000176429749},{"id":"https://openalex.org/keywords/mitogenic-activity","display_name":"mitogenic activity","score":0.9110000133514404},{"id":"https://openalex.org/keywords/growth-factor-regulation","display_name":"growth factor regulation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.703000009059906},{"id":"https://openalex.org/keywords/mammary-tumors","display_name":"mammary tumors","score":0.5450000166893005},{"id":"https://openalex.org/keywords/cell-density-dependence","display_name":"cell density dependence","score":0.4690000116825104},{"id":"https://openalex.org/keywords/antigenic-relatedness","display_name":"antigenic relatedness","score":0.625}],"concepts":[{"id":"https://openalex.org/C2780806702","wikidata":"https://www.wikidata.org/wiki/Q14866198","display_name":"Amphiregulin","level":4,"score":0.9755805730819702},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.8670164346694946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7758495807647705},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.6041644811630249},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5914849638938904},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5836893916130066},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.5094974637031555},{"id":"https://openalex.org/C118995209","wikidata":"https://www.wikidata.org/wiki/Q5636366","display_name":"HaCaT","level":3,"score":0.4836224615573883},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.47850552201271057},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4444531500339508},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3426426649093628},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11141583323478699},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006497","descriptor_name":"Heparan Sulfate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015345","descriptor_name":"Oligonucleotide Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066255","descriptor_name":"EGF Family of Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066258","descriptor_name":"Amphiregulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/mcb.11.5.2547-2557.1991","doi":"https://doi.org/10.1128/mcb.11.5.2547-2557.1991","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.11.5.2547-2557.1991","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"doi:10.1128/mcb.11.5.2547","doi":"https://doi.org/10.1128/mcb.11.5.2547","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.11.5.2547","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1314427","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/360024","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:360024","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/360024","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:2017164","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2017164","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1314427","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/360024","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6181228464","display_name":"FIBROBLAST GROWTH FACTOR AND NEOPLASTIC TRANSFORMATION","funder_award_id":"R01CA042409","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6653394996","display_name":"CHARACTERIZATION AND FUNCTION OF THE GNRH:SH GENE LOCUS","funder_award_id":"R01HD024562","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320309464","display_name":"Mayo Foundation for Medical Education and Research","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W151446319","https://openalex.org/W1571356676","https://openalex.org/W1572939664","https://openalex.org/W1607785028","https://openalex.org/W1924000143","https://openalex.org/W1969481086","https://openalex.org/W1977707793","https://openalex.org/W1977798903","https://openalex.org/W1983693801","https://openalex.org/W1984240546","https://openalex.org/W1987108079","https://openalex.org/W1990955439","https://openalex.org/W2006424284","https://openalex.org/W2012753499","https://openalex.org/W2012870447","https://openalex.org/W2017692699","https://openalex.org/W2020333197","https://openalex.org/W2021013734","https://openalex.org/W2023423199","https://openalex.org/W2028622989","https://openalex.org/W2036033314","https://openalex.org/W2048905477","https://openalex.org/W2054012934","https://openalex.org/W2055149726","https://openalex.org/W2057489676","https://openalex.org/W2071168485","https://openalex.org/W2071972670","https://openalex.org/W2099543104","https://openalex.org/W2100837269","https://openalex.org/W2130075870","https://openalex.org/W2140475905","https://openalex.org/W2155687594","https://openalex.org/W2155958456","https://openalex.org/W2272947817","https://openalex.org/W4245643596"],"related_works":["https://openalex.org/W2092619681","https://openalex.org/W2378923948","https://openalex.org/W2321882806","https://openalex.org/W2059196563","https://openalex.org/W1675828477","https://openalex.org/W1976162582","https://openalex.org/W1595716544","https://openalex.org/W2111317151","https://openalex.org/W1967957985","https://openalex.org/W1601446742"],"abstract_inverted_index":{"A":[0],"novel":[1],"human":[2,28,108,120,144,195],"keratinocyte-derived":[3],"autocrine":[4,201,216],"factor":[5,62],"(KAF)":[6,218],"was":[7,139,149,166],"purified":[8,99,164],"from":[9],"conditioned":[10],"medium":[11],"by":[12,172,235],"using":[13],"heparin":[14,173,236],"affinity":[15],"chromatography":[16],"as":[17,122,124],"the":[18,24,53,70,91,104,210],"first":[19,92],"step.":[20],"Purified":[21],"KAF":[22,43,56,68,100,184,227],"stimulated":[23,69],"growth":[25,61,71,211,217],"of":[26,55,72,90,98,107,132,163,209],"normal":[27,143],"keratinocytes,":[29,121],"mouse":[30,35],"AKR-2B":[31],"cells,":[32],"and":[33,51,148,175,185,225,228],"a":[34],"keratinocyte":[36],"cell":[37,48,64,77,127,158],"line":[38],"(BALB/MK).":[39],"Heparin":[40],"sulfate":[41],"inhibited":[42,52,171],"mitogenic":[44,161],"activity":[45,162],"on":[46],"all":[47],"types":[49],"tested":[50],"ability":[54],"to":[57,81,103,169,223],"compete":[58],"with":[59,115],"epidermal":[60],"for":[63,214],"surface":[65],"binding.":[66],"Interestingly,":[67],"BALB/MK":[73],"cells":[74,84],"at":[75,85,151],"high":[76,130],"density":[78],"but":[79],"failed":[80],"stimulate":[82],"these":[83],"clonal":[86],"density.":[87],"Protein":[88],"microsequencing":[89],"20":[93],"NH2-terminal":[94],"amino":[95],"acid":[96],"residues":[97],"revealed":[101,182],"identity":[102],"NH2":[105],"terminus":[106],"amphiregulin":[109],"(AR).":[110],"Northern":[111],"(RNA)":[112],"blot":[113],"analysis":[114],"AR-specific":[116,177],"cRNA":[117],"demonstrated":[118],"that":[119,183,194,207,226],"well":[123],"mammary":[125,156],"epithelial":[126],"cultures,":[128],"expressed":[129],"levels":[131,153],"AR":[133,137,165,186,224,229],"mRNA.":[134],"In":[135],"contrast,":[136],"mRNA":[138],"not":[140],"detected":[141],"in":[142,154,199],"fibroblasts":[145],"or":[146,221],"melanocytes":[147],"present":[150,204],"reduced":[152],"several":[155],"tumor":[157],"lines.":[159],"The":[160],"also":[167],"shown":[168,193],"be":[170,232],"sulfate,":[174],"an":[176,200],"enzyme-linked":[178],"immunosorbent":[179],"assay":[180],"(ELISA)":[181],"are":[187],"antigenically":[188],"related.":[189],"We":[190],"have":[191],"previously":[192],"keratinocytes":[196],"can":[197,231],"grow":[198],"manner.":[202],"Our":[203],"study":[205],"demonstrates":[206],"one":[208],"factors":[212],"responsible":[213],"this":[215],"is":[219],"similar":[220],"identical":[222],"bioactivity":[230],"negatively":[233],"regulated":[234],"sulfate.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
