{"id":"https://openalex.org/W2124804313","doi":"https://doi.org/10.1091/mbc.e04-11-0999","title":"The Yeast Endosomal Na + (K + )/H + Exchanger Nhx1 Regulates Cellular pH to Control Vesicle Trafficking","display_name":"The Yeast Endosomal Na + (K + )/H + Exchanger Nhx1 Regulates Cellular pH to Control Vesicle Trafficking","publication_year":2005,"publication_date":"2005-01-05","ids":{"openalex":"https://openalex.org/W2124804313","doi":"https://doi.org/10.1091/mbc.e04-11-0999","mag":"2124804313","pmid":"https://pubmed.ncbi.nlm.nih.gov/15635088","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/551501"},"language":"en","primary_location":{"id":"doi:10.1091/mbc.e04-11-0999","doi":"https://doi.org/10.1091/mbc.e04-11-0999","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e04-11-0999","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2124804313"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC551501/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091118370","display_name":"Christopher Leonard Brett","orcid":"https://orcid.org/0000-0002-0730-3405","observed_orcids":["https://orcid.org/0000-0002-0730-3405"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher L. Brett","raw_affiliation_strings":["Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205","Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205","Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Md 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Md 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082925126","display_name":"Deepali Nivas Tukaye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepali N. Tukaye","raw_affiliation_strings":["Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sanchita Mukherjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanchita Mukherjee","raw_affiliation_strings":["Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205","University of New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"University of New Mexico","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017285382","display_name":"Rajini Rao","orcid":"https://orcid.org/0000-0002-1833-5971","observed_orcids":["https://orcid.org/0000-0002-1833-5971"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajini Rao","raw_affiliation_strings":["Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.3336,"has_fulltext":false,"cited_by_count":297,"citation_normalized_percentile":{"value":0.95233822,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"16","issue":"3","first_page":"1396","last_page":"1405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/na-h-exchanger-1","display_name":"NHX1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/na-h-exchanger","display_name":"Na+/H+ exchanger","score":0.8769999742507935},{"id":"https://openalex.org/keywords/endosomal-ph","display_name":"endosomal pH","score":0.9190000295639038},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.7990000247955322},{"id":"https://openalex.org/keywords/endocytic-pathway","display_name":"endocytic pathway","score":0.8190000057220459},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8169999718666077},{"id":"https://openalex.org/keywords/low-ph-stress","display_name":"low pH stress","score":0.6119999885559082},{"id":"https://openalex.org/keywords/potassium-transport","display_name":"potassium transport","score":0.7279999852180481},{"id":"https://openalex.org/keywords/endosomal-acidification","display_name":"endosomal acidification","score":0.6890000104904175},{"id":"https://openalex.org/keywords/pharmacological-inhibition","display_name":"pharmacological inhibition","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8382664918899536},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.719541072845459},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.6447715759277344},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.589604914188385},{"id":"https://openalex.org/C114574056","wikidata":"https://www.wikidata.org/wiki/Q7553395","display_name":"Sodium\u2013hydrogen antiporter","level":3,"score":0.4415279030799866},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4411011338233948},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32956385612487793},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.14778932929039001},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.1450461745262146},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.08869653940200806},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.06536942720413208},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012414","descriptor_name":"Rubidium Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D043563","descriptor_name":"Receptors, Pheromone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051964","descriptor_name":"Receptors, Mating Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1091/mbc.e04-11-0999","doi":"https://doi.org/10.1091/mbc.e04-11-0999","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e04-11-0999","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},{"id":"pmid:15635088","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15635088","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology of the cell","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:551501","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC551501/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.319.2581","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.319.2581","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.molbiolcell.org/content/early/2005/01/05/mbc.E04-11-0999.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.336.8171","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.336.8171","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.molbiolcell.org/content/16/3/1396.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.615.9407","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.615.9407","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.bs.jhmi.edu/physiology/raolab/pdf/brettcl3.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:551501","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC551501/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5503102455","display_name":"Endosomal Na+/H+ Exchangers From Yeast and Human:  Role and Regulation","funder_award_id":"R01DK054214","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1489970216","https://openalex.org/W1530840777","https://openalex.org/W1586599156","https://openalex.org/W1679275016","https://openalex.org/W1793971028","https://openalex.org/W1851054717","https://openalex.org/W1966471287","https://openalex.org/W1988070591","https://openalex.org/W1989641787","https://openalex.org/W1997301069","https://openalex.org/W1997657755","https://openalex.org/W2012756848","https://openalex.org/W2016166286","https://openalex.org/W2023415094","https://openalex.org/W2025100148","https://openalex.org/W2031579758","https://openalex.org/W2033279834","https://openalex.org/W2038982372","https://openalex.org/W2046585193","https://openalex.org/W2046818599","https://openalex.org/W2052905765","https://openalex.org/W2058224397","https://openalex.org/W2059699772","https://openalex.org/W2062435249","https://openalex.org/W2073411380","https://openalex.org/W2076107153","https://openalex.org/W2078450213","https://openalex.org/W2078950716","https://openalex.org/W2084814184","https://openalex.org/W2085491745","https://openalex.org/W2090140627","https://openalex.org/W2092359073","https://openalex.org/W2097039879","https://openalex.org/W2103526907","https://openalex.org/W2103960076","https://openalex.org/W2106019576","https://openalex.org/W2106705270","https://openalex.org/W2108277395","https://openalex.org/W2109909805","https://openalex.org/W2114170740","https://openalex.org/W2123832957","https://openalex.org/W2133253871","https://openalex.org/W2135021919","https://openalex.org/W2135126732","https://openalex.org/W2149336336","https://openalex.org/W2154100802","https://openalex.org/W2162613182","https://openalex.org/W2169285480","https://openalex.org/W2169655990","https://openalex.org/W2174160083","https://openalex.org/W2410071986","https://openalex.org/W2467262381"],"related_works":["https://openalex.org/W2151909378","https://openalex.org/W2056032802","https://openalex.org/W2168976974","https://openalex.org/W1989641787","https://openalex.org/W2078950716","https://openalex.org/W7097901049","https://openalex.org/W2097039879","https://openalex.org/W2106705270"],"abstract_inverted_index":{"The":[0],"relationship":[1],"between":[2],"endosomal":[3,13,59,139,149],"pH":[4,34,51,73,90,136],"and":[5,17,71,92,95,137],"function":[6],"is":[7],"well":[8],"documented":[9],"in":[10,123],"viral":[11],"entry,":[12],"maturation,":[14],"receptor":[15],"recycling,":[16],"vesicle":[18,76],"targeting":[19],"within":[20],"the":[21,46,62,80,143],"endocytic":[22],"pathway.":[23],"However,":[24],"specific":[25],"molecular":[26],"mechanisms":[27],"that":[28,55,119,128],"either":[29],"sense":[30],"or":[31],"regulate":[32],"luminal":[33,70],"to":[35,53,74,88,111,125,157],"mediate":[36],"these":[37],"processes":[38],"have":[39],"not":[40],"been":[41],"identified.":[42],"Herein":[43],"we":[44,117],"describe":[45],"use":[47],"of":[48,61,66,79,83,147],"novel,":[49],"compartment-specific":[50],"indicators":[52],"demonstrate":[54],"yeast":[56,110],"Nhx1,":[57],"an":[58],"member":[60],"ubiquitous":[63],"NHE":[64,150],"family":[65,146],"Na+/H+":[67],"exchangers,":[68],"regulates":[69],"cytoplasmic":[72],"control":[75],"trafficking":[77,96,114],"out":[78],"endosome.":[81],"Loss":[82],"Nhx1":[84,120],"confers":[85],"growth":[86],"sensitivity":[87],"low":[89],"stress,":[91],"concomitant":[93],"acidification":[94],"defects,":[97],"which":[98],"can":[99],"be":[100],"alleviated":[101],"by":[102],"weak":[103,106],"bases.":[104],"Conversely,":[105],"acids":[107],"cause":[108],"wild-type":[109],"present":[112],"nhx1Delta":[113],"phenotypes.":[115],"Finally,":[116],"report":[118],"transports":[121],"K+":[122],"addition":[124],"Na+,":[126],"suggesting":[127],"a":[129],"single":[130],"mechanism":[131],"may":[132],"responsible":[133],"for":[134,154],"both":[135],"K+-dependent":[138],"processes.":[140],"This":[141],"presents":[142],"newly":[144],"defined":[145],"eukaryotic":[148],"as":[151],"novel":[152],"targets":[153],"pharmacological":[155],"inhibition":[156],"alleviate":[158],"pathological":[159],"states":[160],"associated":[161],"with":[162],"organellar":[163],"alkalinization.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}