{"id":"https://openalex.org/W2124802849","doi":"https://doi.org/10.1371/journal.pone.0010235","title":"20-HETE Mediates Ozone-Induced, Neutrophil-Independent Airway Hyper-Responsiveness in Mice","display_name":"20-HETE Mediates Ozone-Induced, Neutrophil-Independent Airway Hyper-Responsiveness in Mice","publication_year":2010,"publication_date":"2010-04-20","ids":{"openalex":"https://openalex.org/W2124802849","doi":"https://doi.org/10.1371/journal.pone.0010235","mag":"2124802849","pmid":"https://pubmed.ncbi.nlm.nih.gov/20422032","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2857875"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0010235","doi":"https://doi.org/10.1371/journal.pone.0010235","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0010235","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010235&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010235&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065791417","display_name":"Philip R. Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip R. Cooper","raw_affiliation_strings":["Department of Medicine and the Airways Biology Initiative, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and the Airways Biology Initiative, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Clementina Mesaros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Clementina Mesaros","raw_affiliation_strings":["Center of Excellence in Environmental Toxicology, Center for Cancer Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Environmental Toxicology, Center for Cancer Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jie Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Zhang","raw_affiliation_strings":["Department of Medicine and the Airways Biology Initiative, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and the Airways Biology Initiative, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023258176","display_name":"Peter Christmas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I53559539","display_name":"Radford University","ror":"https://ror.org/04647g470","country_code":"US","type":"education","lineage":["https://openalex.org/I53559539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Christmas","raw_affiliation_strings":["Biology Department, Radford University, Radford, Virginia, United States of America","Harvard Medical School, Massachusetts General Hospital East, Charlestown, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Radford University, Radford, Virginia, United States of America","institution_ids":["https://openalex.org/I53559539"]},{"raw_affiliation_string":"Harvard Medical School, Massachusetts General Hospital East, Charlestown, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056513833","display_name":"Christopher M. Stark","orcid":"https://orcid.org/0000-0003-1146-7063","observed_orcids":["https://orcid.org/0000-0003-1146-7063"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. Stark","raw_affiliation_strings":["Harvard Medical School, Massachusetts General Hospital East, Charlestown, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Massachusetts General Hospital East, Charlestown, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031793608","display_name":"Karim Douaidy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karim Douaidy","raw_affiliation_strings":["Harvard Medical School, Massachusetts General Hospital East, Charlestown, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Massachusetts General Hospital East, Charlestown, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046375687","display_name":"Michael A. Mittelman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Mittelman","raw_affiliation_strings":["Department of Medicine and the Airways Biology Initiative, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and the Airways Biology Initiative, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085550092","display_name":"Roy Jason Soberman","orcid":"https://orcid.org/0000-0002-2817-0517","observed_orcids":["https://orcid.org/0000-0002-2817-0517"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy J. Soberman","raw_affiliation_strings":["Harvard Medical School, Massachusetts General Hospital East, Charlestown, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Massachusetts General Hospital East, Charlestown, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079384190","display_name":"Ian A. Blair","orcid":"https://orcid.org/0000-0003-0366-8658","observed_orcids":["https://orcid.org/0000-0003-0366-8658"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian A. Blair","raw_affiliation_strings":["Center of Excellence in Environmental Toxicology, Center for Cancer Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Environmental Toxicology, Center for Cancer Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082888399","display_name":"Reynold A. Panettieri","orcid":"https://orcid.org/0000-0003-0834-4636","observed_orcids":["https://orcid.org/0000-0003-0834-4636"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Reynold A. Panettieri","raw_affiliation_strings":["Center of Excellence in Environmental Toxicology, Center for Cancer Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","Department of Medicine and the Airways Biology Initiative, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Environmental Toxicology, Center for Cancer Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Medicine and the Airways Biology Initiative, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082888399"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.3802,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.87621507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"4","first_page":"e10235","last_page":"e10235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/20-hydroxyeicosatetraenoic-acid","display_name":"20-hydroxyeicosatetraenoic acid","score":0.9079999923706055},{"id":"https://openalex.org/keywords/ozone-exposure","display_name":"ozone exposure","score":0.7919999957084656},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.9959999918937683},{"id":"https://openalex.org/keywords/oxidized-lipids","display_name":"oxidized lipids","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cytochrome-p450-inhibition","display_name":"cytochrome P450 inhibition","score":0.8799999952316284},{"id":"https://openalex.org/keywords/1-aminobenzotriazole","display_name":"1-aminobenzotriazole","score":0.9169999957084656},{"id":"https://openalex.org/keywords/carbachol-induced-contraction","display_name":"carbachol-induced contraction","score":0.7009999752044678},{"id":"https://openalex.org/keywords/precision-cut-lung-slices","display_name":"precision-cut lung slices","score":0.7580000162124634},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.8379999995231628},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.6899999976158142},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.7610588073730469},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.5718992352485657},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5487540364265442},{"id":"https://openalex.org/C508106653","wikidata":"https://www.wikidata.org/wiki/Q36933","display_name":"Ozone","level":2,"score":0.5118088126182556},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47292429208755493},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.45513972640037537},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.4288957715034485},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42645758390426636},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41903212666511536},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3636360764503479},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36262619495391846},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3520897626876831},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3014323115348816},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.16992557048797607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16662269830703735},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002217","descriptor_name":"Carbachol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010126","descriptor_name":"Ozone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012130","descriptor_name":"Respiratory Hypersensitivity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0010235","doi":"https://doi.org/10.1371/journal.pone.0010235","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0010235","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010235&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2857875","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2857875","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:20422032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20422032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.355.4601","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.355.4601","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/56/0a/PLoS_One_2010_Apr_20_5(4)_e10235.tar.gz","raw_type":"text"},{"id":"pmh:oai:dash.harvard.edu:1/8191180","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:8191180","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:fa0f4f46b66544d783f1a7ebf26f9f07","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fa0f4f46b66544d783f1a7ebf26f9f07","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 5, Iss 4, p e10235 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0010235","doi":"https://doi.org/10.1371/journal.pone.0010235","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0010235","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010235&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1148524537","display_name":"CYP4F3 in renal inflammation","funder_award_id":"R01DK074821","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3521757652","display_name":"Leukotrienes and Lung Inflammation","funder_award_id":"R01AI068871","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5059817785","display_name":"Molecular dosimetry of endogeneous genotoxins","funder_award_id":"R01CA091016","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G683728459","display_name":null,"funder_award_id":"R01 RO1DK74821","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000872793","display_name":"Center of Excellence in Environmental Toxicology","funder_award_id":"P30ES013508","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124802849.pdf","grobid_xml":"https://content.openalex.org/works/W2124802849.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1510867563","https://openalex.org/W1562756701","https://openalex.org/W1567550390","https://openalex.org/W1738236507","https://openalex.org/W1967944064","https://openalex.org/W1986909128","https://openalex.org/W1995142464","https://openalex.org/W1997045912","https://openalex.org/W2002619626","https://openalex.org/W2015119500","https://openalex.org/W2025013548","https://openalex.org/W2031795606","https://openalex.org/W2032274473","https://openalex.org/W2050315322","https://openalex.org/W2058617365","https://openalex.org/W2058734536","https://openalex.org/W2067473360","https://openalex.org/W2070048233","https://openalex.org/W2070814514","https://openalex.org/W2076279510","https://openalex.org/W2081429238","https://openalex.org/W2098394102","https://openalex.org/W2099766085","https://openalex.org/W2100843520","https://openalex.org/W2103304921","https://openalex.org/W2103452894","https://openalex.org/W2108958980","https://openalex.org/W2109249573","https://openalex.org/W2117539467","https://openalex.org/W2117955834","https://openalex.org/W2121823020","https://openalex.org/W2124988665","https://openalex.org/W2126425760","https://openalex.org/W2127075563","https://openalex.org/W2127867032","https://openalex.org/W2129004308","https://openalex.org/W2139901384","https://openalex.org/W2145617878","https://openalex.org/W2146672825","https://openalex.org/W2164746237","https://openalex.org/W2170605512","https://openalex.org/W2171745592","https://openalex.org/W2220987992","https://openalex.org/W2271187091","https://openalex.org/W2293538740","https://openalex.org/W4239132509"],"related_works":["https://openalex.org/W1866553628","https://openalex.org/W2312218314","https://openalex.org/W2322396741","https://openalex.org/W1948079963","https://openalex.org/W2000822189","https://openalex.org/W2411557060","https://openalex.org/W7098941603","https://openalex.org/W7101141867","https://openalex.org/W7058479950","https://openalex.org/W1974860785"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ozone,":[1],"a":[2,183,217,291],"pollutant":[3],"known":[4],"to":[5,41,87,106,123,129,169,251,259],"induce":[6],"airway":[7,18,65,101,189,210],"hyper-responsiveness":[8],"(AHR),":[9],"increases":[10,223,233,285],"morbidity":[11],"and":[12,20,92,144,162,256],"mortality":[13],"in":[14,27,31,154,203,213,224,276,286,294],"patients":[15],"with":[16,104,216,232,283],"obstructive":[17],"diseases":[19],"asthma.":[21],"We":[22],"postulate":[23],"oxidized":[24,225,287],"lipids":[25,226],"mediate":[26],"vivo":[28,277],"ozone-induced":[29,179,297],"AHR":[30,168,250],"murine":[32],"airways.":[33],"METHODOLOGY/PRINCIPAL":[34],"FINDINGS:":[35],"Male":[36],"BALB/c":[37],"mice":[38,125,271],"were":[39,72,85,95,119,152,227,237,281],"exposed":[40,161,195,270],"ozone":[42,130,160,194,247,269,278],"(3":[43],"or":[44,47,77,114,172,205,262],"6":[45],"ppm)":[46],"filtered":[48],"air":[49],"(controls)":[50],"for":[51,149],"2":[52,137],"h.":[53],"Precision":[54],"cut":[55],"lung":[56],"slices":[57],"(PCLS;":[58],"250":[59],"microm":[60],"thickness)":[61],"containing":[62],"an":[63,201],"intrapulmonary":[64],"(":[66],"approximately":[67],"0.01":[68],"mm(2)":[69],"lumen":[70,102],"area)":[71],"prepared":[73],"immediately":[74],"after":[75],"exposure":[76,279],"16":[78],"h":[79,127,138],"later.":[80],"After":[81],"24":[82],"h,":[83],"airways":[84],"contracted":[86],"carbachol":[88],"(CCh).":[89],"Log":[90],"EC(50)":[91],"E(max)":[93],"values":[94],"then":[96],"calculated":[97],"by":[98],"measuring":[99],"the":[100,178,273],"area":[103],"respect":[105],"baseline.":[107],"In":[108,220],"parallel":[109],"studies,":[110],"dexamethasone":[111],"(2.5":[112],"mg/kg),":[113],"1-aminobenzotriazol":[115],"(ABT)":[116],"(50":[117],"mg/kg)":[118,134],"given":[120],"intraperitoneal":[121],"injection":[122],"na\u00efve":[124,218],"18":[126],"prior":[128],"exposure.":[131],"Indomethacin":[132],"(10":[133],"was":[135],"administered":[136],"prior.":[139],"Cell":[140],"counts,":[141],"cytokine":[142],"levels":[143],"liquid":[145],"chromatography-mass":[146],"spectrometry":[147],"(LC-MS)":[148],"lipid":[150],"analysis":[151],"assessed":[153],"bronchoalveolar":[155],"lavage":[156],"(BAL)":[157],"fluid":[158,192,267],"from":[159,193,268],"control":[163],"mice.":[164],"Ozone":[165],"acutely":[166,248],"induced":[167],"CCh.":[170],"Dexamethasone":[171],"indomethacin":[173],"had":[174],"little":[175],"effect":[176],"on":[177],"AHR;":[180],"while,":[181],"ABT,":[182],"cytochrome":[184],"P450":[185],"inhibitor,":[186],"markedly":[187],"attenuated":[188],"sensitivity.":[190],"BAL":[191,266],"animals,":[196],"which":[197],"did":[198],"not":[199],"contain":[200],"increase":[202],"neutrophils":[204],"interleukin":[206],"(IL)-6":[207],"levels,":[208],"increased":[209],"sensitivity":[211],"following":[212,239],"vitro":[214],"incubation":[215],"PCLS.":[219],"parallel,":[221],"significant":[222],"also":[228],"identified":[229],"using":[230],"LC-MS":[231],"of":[234,254,275],"20-HETE":[235,289],"that":[236,246,280],"decreased":[238],"ABT":[240],"treatment.":[241],"CONCLUSIONS/SIGNIFICANCE:":[242],"These":[243],"data":[244],"show":[245],"induces":[249],"CCh":[252],"independent":[253],"inflammation":[255],"is":[257],"insensitive":[258],"steroid":[260],"treatment":[261],"cyclooxygenase":[263],"(COX)":[264],"inhibition.":[265],"mimicked":[272],"effects":[274],"associated":[282],"marked":[284],"lipids.":[288],"plays":[290],"pivotal":[292],"role":[293],"mediating":[295],"acute":[296],"AHR.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}