{"id":"https://openalex.org/W2124802575","doi":null,"title":"Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth.","display_name":"Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth.","publication_year":1992,"publication_date":"1992-05-01","ids":{"openalex":"https://openalex.org/W2124802575","mag":"2124802575","pmid":"https://pubmed.ncbi.nlm.nih.gov/1568224"},"language":"en","primary_location":{"id":"pmid:1568224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1568224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081978650","display_name":"Peter Schirmacher","orcid":"https://orcid.org/0000-0002-0950-3339","observed_orcids":["https://orcid.org/0000-0002-0950-3339"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Schirmacher","raw_affiliation_strings":["Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109880317","display_name":"W. A. Held","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W A Held","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050952361","display_name":"Daizhi Yang","orcid":"https://orcid.org/0000-0001-7827-3226","observed_orcids":["https://orcid.org/0000-0001-7827-3226"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004916033","display_name":"Francis V. Chisari","orcid":"https://orcid.org/0000-0002-4832-1044","observed_orcids":["https://orcid.org/0000-0002-4832-1044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F V Chisari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035801775","display_name":"Y Rustum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Rustum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109849953","display_name":"C E Rogler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C E Rogler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.4989,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.95374201,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"52","issue":"9","first_page":"2549","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":1.0},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.7829999923706055},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7110000252723694},{"id":"https://openalex.org/keywords/autocrine-growth-factor-signaling","display_name":"autocrine growth factor signaling","score":0.6779999732971191},{"id":"https://openalex.org/keywords/igf-ii-mrna-expression","display_name":"IGF-II mRNA expression","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.6945438981056213},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6943740844726562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.668839693069458},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6317564845085144},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6261922121047974},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5910097360610962},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5854224562644958},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5690382719039917},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5503095388412476},{"id":"https://openalex.org/C2779069268","wikidata":"https://www.wikidata.org/wiki/Q14874349","display_name":"Insulin-like growth factor 2","level":4,"score":0.5486304759979248},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.47182995080947876},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4106886684894562},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4046696424484253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37521541118621826},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31507784128189087},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19698166847229004},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10737457871437073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10442450642585754},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07309460639953613}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000952","descriptor_name":"Antigens, Polyomavirus Transforming","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1568224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1568224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2124802575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1568224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G245122347","display_name":"HEPATITIS CIRRHOSIS CENTER","funder_award_id":"P50DK017702","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5364697583","display_name":"ANDROGEN CONDITIONAL CARCINOGENESIS IN TRANSGENIC MICE","funder_award_id":"R01CA050675","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6291932615","display_name":"HEPADNAVIRUS ASSOCIATED HEPATOCELLULAR CARCINOMA","funder_award_id":"R01CA037232","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W5887255","https://openalex.org/W21751534","https://openalex.org/W185490469","https://openalex.org/W314826190","https://openalex.org/W334309946","https://openalex.org/W1492325161","https://openalex.org/W1495959646","https://openalex.org/W1544473294","https://openalex.org/W1571942380","https://openalex.org/W1755067784","https://openalex.org/W1967407860","https://openalex.org/W1971413146","https://openalex.org/W1975993749","https://openalex.org/W1982882974","https://openalex.org/W1987226596","https://openalex.org/W1990021852","https://openalex.org/W1995723368","https://openalex.org/W1996053339","https://openalex.org/W2003196630","https://openalex.org/W2003594755","https://openalex.org/W2005782838","https://openalex.org/W2017464658","https://openalex.org/W2017690918","https://openalex.org/W2019087981","https://openalex.org/W2021827559","https://openalex.org/W2023660511","https://openalex.org/W2036961244","https://openalex.org/W2044917338","https://openalex.org/W2053134566","https://openalex.org/W2072305097","https://openalex.org/W2075931967","https://openalex.org/W2076684492","https://openalex.org/W2078427368","https://openalex.org/W2087997490","https://openalex.org/W2088353293","https://openalex.org/W2091455117","https://openalex.org/W2091802684","https://openalex.org/W2134109634","https://openalex.org/W2145481755","https://openalex.org/W2148107077","https://openalex.org/W2158129085","https://openalex.org/W2161952569"],"related_works":["https://openalex.org/W2119509261","https://openalex.org/W1971413146","https://openalex.org/W2125310368","https://openalex.org/W2068931651","https://openalex.org/W2082881616","https://openalex.org/W2103465949","https://openalex.org/W3143644241","https://openalex.org/W2352294489","https://openalex.org/W1974712435","https://openalex.org/W2471043347"],"abstract_inverted_index":{"We":[0],"have":[1],"studied":[2],"the":[3,42,61,88],"expression":[4,25,89],"of":[5,41,44],"insulin-like":[6],"growth":[7],"factor":[8],"II":[9],"(IGF-II)":[10],"during":[11],"hepatocarcinogenesis":[12,126],"in":[13,36,66,82,91,102],"four":[14,21,38],"independent":[15],"transgenic":[16],"mouse":[17],"lines.":[18],"In":[19],"all":[20,37],"lines":[22,39],"liver-directed":[23],"transgene":[24],"induces":[26],"a":[27,95,115],"stepwise":[28],"and":[29,58,73,94,122],"relatively":[30],"synchronized":[31],"tumorigenesis.":[32],"IGF-II":[33,69,80,98,112],"reexpression":[34,113],"occurs":[35],"irrespective":[40],"mechanism":[43],"tumor":[45,63],"induction.":[46],"Reexpression":[47],"is":[48,71,114],"chronologically":[49],"associated":[50,75],"with":[51,60,76],"late":[52],"progression":[53,64,118],"steps":[54],"toward":[55],"hepatocellular":[56,83,120],"carcinoma":[57,121],"correlated":[59],"respective":[62],"rate":[65],"each":[67],"line.":[68],"activation":[70],"focal":[72],"topographically":[74],"high":[77],"replicative":[78],"activity.":[79],"mRNAs":[81],"carcinomas":[84],"show":[85],"similarities":[86],"to":[87,119,125],"pattern":[90],"fetal":[92],"liver,":[93],"M(r)":[96],"15,000":[97],"polypeptide":[99],"accumulates":[100],"intracellularly":[101],"distinct":[103],"cytoplasmic":[104],"preferentially":[105],"perinuclear":[106],"compartments.":[107],"These":[108],"data":[109],"indicate":[110],"that":[111],"marker":[116],"for":[117],"may":[123],"contribute":[124],"via":[127],"an":[128],"autocrine":[129],"mechanism.":[130]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
