{"id":"https://openalex.org/W2124767565","doi":"https://doi.org/10.1093/aob/mcf221","title":"Ca2+-induced High Amplitude Swelling and Cytochrome c Release From Wheat (Triticum aestivum L.) Mitochondria Under Anoxic Stress","display_name":"Ca2+-induced High Amplitude Swelling and Cytochrome c Release From Wheat (Triticum aestivum L.) Mitochondria Under Anoxic Stress","publication_year":2002,"publication_date":"2002-09-04","ids":{"openalex":"https://openalex.org/W2124767565","doi":"https://doi.org/10.1093/aob/mcf221","mag":"2124767565","pmid":"https://pubmed.ncbi.nlm.nih.gov/12324275","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4240387"},"language":"en","primary_location":{"id":"doi:10.1093/aob/mcf221","doi":"https://doi.org/10.1093/aob/mcf221","is_oa":true,"landing_page_url":"https://doi.org/10.1093/aob/mcf221","pdf_url":"https://academic.oup.com/aob/article-pdf/90/4/509/453902/mcf221.pdf","source":{"id":"https://openalex.org/S2254258","display_name":"Annals of Botany","issn_l":"0305-7364","issn":["0305-7364","1095-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Botany","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/aob/article-pdf/90/4/509/453902/mcf221.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082816604","display_name":"Eija Virolainen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"E. VIROLAINEN","raw_affiliation_strings":["Department of Biosciences, Division of Plant Physiology, PO Box 56, FIN-00014 Helsinki University, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences, Division of Plant Physiology, PO Box 56, FIN-00014 Helsinki University, Finland","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082816604"],"corresponding_institution_ids":["https://openalex.org/I133731052"],"apc_list":{"value":2743,"currency":"GBP","value_usd":3617},"apc_paid":null,"fwci":1.4354,"has_fulltext":true,"cited_by_count":114,"citation_normalized_percentile":{"value":0.79023901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"90","issue":"4","first_page":"509","last_page":"516"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.053700000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition-pore","display_name":"mitochondrial permeability transition pore","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mitochondrial-swelling","display_name":"mitochondrial swelling","score":0.8309999704360962},{"id":"https://openalex.org/keywords/anoxia","display_name":"anoxia","score":0.7170000076293945},{"id":"https://openalex.org/keywords/oxygen-deprivation","display_name":"oxygen deprivation","score":0.718999981880188},{"id":"https://openalex.org/keywords/calcium-ions","display_name":"calcium ions","score":0.574999988079071},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.8019999861717224},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.8149999976158142},{"id":"https://openalex.org/keywords/inorganic-phosphate","display_name":"inorganic phosphate","score":0.7519999742507935},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.6430000066757202},{"id":"https://openalex.org/keywords/plant-stress-response","display_name":"plant stress response","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.769447386264801},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.750481128692627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7103832960128784},{"id":"https://openalex.org/C13591479","wikidata":"https://www.wikidata.org/wiki/Q6881880","display_name":"Mitochondrial permeability transition pore","level":4,"score":0.6551641225814819},{"id":"https://openalex.org/C193349765","wikidata":"https://www.wikidata.org/wiki/Q2061363","display_name":"Apoptosome","level":5,"score":0.5873288512229919},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.5210082530975342},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5090500712394714},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5032665133476257},{"id":"https://openalex.org/C173358068","wikidata":"https://www.wikidata.org/wiki/Q6881847","display_name":"Mitochondrial apoptosis-induced channel","level":4,"score":0.5001544952392578},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.48917511105537415},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4821983873844147},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.4463401138782501},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4392626881599426},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.4288964569568634},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2930888533592224},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06388962268829346},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003574","descriptor_name":"Cytochrome c Group","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003574","descriptor_name":"Cytochrome c Group","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007476","descriptor_name":"Ionophores","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014908","descriptor_name":"Triticum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014908","descriptor_name":"Triticum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/aob/mcf221","doi":"https://doi.org/10.1093/aob/mcf221","is_oa":true,"landing_page_url":"https://doi.org/10.1093/aob/mcf221","pdf_url":"https://academic.oup.com/aob/article-pdf/90/4/509/453902/mcf221.pdf","source":{"id":"https://openalex.org/S2254258","display_name":"Annals of Botany","issn_l":"0305-7364","issn":["0305-7364","1095-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Botany","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3209599","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4240387","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:12324275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12324275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of botany","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4240387","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4240387/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Bot","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/aob/mcf221","doi":"https://doi.org/10.1093/aob/mcf221","is_oa":true,"landing_page_url":"https://doi.org/10.1093/aob/mcf221","pdf_url":"https://academic.oup.com/aob/article-pdf/90/4/509/453902/mcf221.pdf","source":{"id":"https://openalex.org/S2254258","display_name":"Annals of Botany","issn_l":"0305-7364","issn":["0305-7364","1095-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Botany","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310086","display_name":"Helsingin Yliopisto","ror":"https://ror.org/040af2s02"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124767565.pdf","grobid_xml":"https://content.openalex.org/works/W2124767565.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W153349786","https://openalex.org/W210075245","https://openalex.org/W1497532563","https://openalex.org/W1508911271","https://openalex.org/W1549532521","https://openalex.org/W1562704705","https://openalex.org/W1920479129","https://openalex.org/W1972262318","https://openalex.org/W1972733192","https://openalex.org/W1973316433","https://openalex.org/W1980349602","https://openalex.org/W1988607189","https://openalex.org/W1995628673","https://openalex.org/W2002521529","https://openalex.org/W2005571058","https://openalex.org/W2007517675","https://openalex.org/W2012751277","https://openalex.org/W2034974926","https://openalex.org/W2036181141","https://openalex.org/W2036302841","https://openalex.org/W2048875504","https://openalex.org/W2049225661","https://openalex.org/W2049411026","https://openalex.org/W2065936908","https://openalex.org/W2067489969","https://openalex.org/W2070038134","https://openalex.org/W2070897635","https://openalex.org/W2075572616","https://openalex.org/W2090677935","https://openalex.org/W2091797856","https://openalex.org/W2092843498","https://openalex.org/W2100808476","https://openalex.org/W2102734972","https://openalex.org/W2114045225","https://openalex.org/W2114110309","https://openalex.org/W2115940925","https://openalex.org/W2128635872","https://openalex.org/W2141011989","https://openalex.org/W2164632722"],"related_works":["https://openalex.org/W2048875504","https://openalex.org/W2049411026","https://openalex.org/W2799455482","https://openalex.org/W2085843102","https://openalex.org/W2384470923","https://openalex.org/W7097789805","https://openalex.org/W3120055305","https://openalex.org/W1988164602","https://openalex.org/W130430081","https://openalex.org/W2397485981"],"abstract_inverted_index":{"Under":[0],"stress":[1],"conditions,":[2],"mitochondria":[3,97,108],"sense":[4],"metabolic":[5],"changes,":[6],"e.g.":[7],"in":[8,42,128,181,196,223],"pH,":[9],"cytoplasmic":[10],"Ca(2+),":[11],"energy":[12],"status,":[13],"and":[14,19,29,87,112,173,192,213],"reactive":[15],"oxygen":[16,220],"species":[17],"(ROS),":[18],"respond":[20],"by":[21,30,96,133],"induction":[22],"of":[23,50,54,71,76,83,90,103,107,124,147,152,159,202,219],"the":[24,36,48,52,55,69,77,84,88,101,197],"permeability":[25],"transition":[26],"pore":[27],"(PTP)":[28],"releasing":[31],"cytochrome":[32,153,166,178,214],"c,":[33],"thus":[34],"initiating":[35],"programmed":[37],"cell":[38],"death":[39],"(PCD)":[40],"cascade":[41,56],"animal":[43],"cells.":[44],"In":[45,62],"plant":[46],"cells,":[47],"presence":[49,102],"all":[51],"components":[53],"has":[57],"not":[58,116,140],"yet":[59],"been":[60],"shown.":[61],"wheat":[63,203],"(Triticum":[64],"aestivum":[65],"L.)":[66],"root":[67,204],"mitochondria,":[68,205],"onset":[70],"anoxia":[72],"caused":[73,177],"rapid":[74],"dissipation":[75],"inner":[78],"membrane":[79,208],"potential,":[80,209],"initial":[81],"shrinkage":[82],"mitochondrial":[85,129,198],"matrix":[86],"release":[89,151,168,180,216],"previously":[91],"accumulated":[92],"Ca(2+).":[93],"Ca(2+)":[94,114,174,190,194,210],"uptake":[95],"was":[98,139,155],"dependent":[99],"on":[100],"inorganic":[104],"phosphate.":[105],"Treatment":[106],"with":[109,189],"high":[110,120],"micromolar":[111],"millimolar":[113],"(but":[115],"Mg(2+))":[117],"concentrations":[118],"induced":[119],"amplitude":[121],"swelling,":[122,212],"indicative":[123],"PTP":[125],"opening.":[126],"Alterations":[127],"volume":[130],"were":[131],"confirmed":[132],"transmission":[134],"electron":[135],"microscopy.":[136],"Mitochondrial":[137],"swelling":[138],"sensitive":[141],"to":[142,164,225],"cyclosporin":[143],"A":[144],"(CsA)-an":[145],"inhibitor":[146],"mammalian":[148],"PTP.":[149],"The":[150],"c":[154,167,179,215],"monitored":[156],"under":[157,217],"lack":[158,218],"oxygen.":[160],"Anoxia":[161],"alone":[162],"failed":[163],"induce":[165],"from":[169],"mitochondria.":[170],"Oxygen":[171],"deprivation":[172],"ions":[175],"together":[176],"a":[182],"CsA-insensitive":[183],"manner.":[184],"This":[185],"process":[186],"correlated":[187],"positively":[188],"concentration":[191],"required":[193],"localization":[195],"matrix.":[199],"Functional":[200],"characteristics":[201],"such":[206],"as":[207],"transport,":[211],"are":[221],"discussed":[222],"relation":[224],"PCD.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}