{"id":"https://openalex.org/W2124757429","doi":"https://doi.org/10.1128/mcb.00030-07","title":"DNA Repair and Transcriptional Deficiencies Caused by Mutations in the Drosophila p52 Subunit of TFIIH Generate Developmental Defects and Chromosome Fragility","display_name":"DNA Repair and Transcriptional Deficiencies Caused by Mutations in the Drosophila p52 Subunit of TFIIH Generate Developmental Defects and Chromosome Fragility","publication_year":2007,"publication_date":"2007-03-06","ids":{"openalex":"https://openalex.org/W2124757429","doi":"https://doi.org/10.1128/mcb.00030-07","mag":"2124757429","pmid":"https://pubmed.ncbi.nlm.nih.gov/17339330","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1899989"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.00030-07","doi":"https://doi.org/10.1128/mcb.00030-07","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.00030-07","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1899989","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068843656","display_name":"Mariana Fregoso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mariana Fregoso","raw_affiliation_strings":["Department of Developmental Genetics, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. Universidad 2001, Cuernavaca Morelos 62250, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Genetics, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. Universidad 2001, Cuernavaca Morelos 62250, M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108480472","display_name":"Jean\u2010Philippe Lain\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Philippe Lain\u00e9","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France","institution_ids":["https://openalex.org/I4210086872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068090582","display_name":"Javier Aguilar\u2010Fuentes","orcid":"https://orcid.org/0000-0001-7847-2970","observed_orcids":["https://orcid.org/0000-0001-7847-2970"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Javier Aguilar-Fuentes","raw_affiliation_strings":["Department of Developmental Genetics, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. Universidad 2001, Cuernavaca Morelos 62250, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Genetics, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. Universidad 2001, Cuernavaca Morelos 62250, M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102885878","display_name":"Vincent Mocquet","orcid":"https://orcid.org/0000-0003-4337-5278","observed_orcids":["https://orcid.org/0000-0003-4337-5278"]},"institutions":[{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent Mocquet","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France","institution_ids":["https://openalex.org/I4210086872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074887787","display_name":"Enrique Reynaud","orcid":"https://orcid.org/0000-0001-7972-2230","observed_orcids":["https://orcid.org/0000-0001-7972-2230"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Enrique Reynaud","raw_affiliation_strings":["Department of Developmental Genetics, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. Universidad 2001, Cuernavaca Morelos 62250, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Genetics, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. Universidad 2001, Cuernavaca Morelos 62250, M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052628254","display_name":"Fr\u00e9d\u00e9ric Coin","orcid":"https://orcid.org/0000-0002-5620-8519","observed_orcids":["https://orcid.org/0000-0002-5620-8519"]},"institutions":[{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Coin","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France","institution_ids":["https://openalex.org/I4210086872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110882011","display_name":"Jean\u2010Marc Egly","orcid":"https://orcid.org/0000-0002-5960-6571","observed_orcids":["https://orcid.org/0000-0002-5960-6571"]},"institutions":[{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Marc Egly","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France","institution_ids":["https://openalex.org/I4210086872"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037003258","display_name":"Mario Zurita","orcid":"https://orcid.org/0000-0002-8404-2173","observed_orcids":["https://orcid.org/0000-0002-8404-2173"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mario Zurita","raw_affiliation_strings":["Department of Developmental Genetics, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. Universidad 2001, Cuernavaca Morelos 62250, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Genetics, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. Universidad 2001, Cuernavaca Morelos 62250, M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9792,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.71952084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"27","issue":"10","first_page":"3640","last_page":"3650"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tfiih","display_name":"TFIIH","score":0.9369999766349792},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.8849999904632568},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.6430000066757202},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.9150000214576721},{"id":"https://openalex.org/keywords/transcription","display_name":"transcription","score":0.4909999966621399},{"id":"https://openalex.org/keywords/uv-sensitivity","display_name":"UV sensitivity","score":0.5860000252723694},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.7730000019073486},{"id":"https://openalex.org/keywords/chromosome-fragility","display_name":"chromosome fragility","score":0.9729999899864197},{"id":"https://openalex.org/keywords/trichothiodystrophy","display_name":"trichothiodystrophy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/developmental-defects","display_name":"developmental defects","score":0.6930000185966492},{"id":"https://openalex.org/keywords/tumor-formation","display_name":"tumor formation","score":0.675000011920929},{"id":"https://openalex.org/keywords/protein-complex-assembly","display_name":"protein complex formation","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C56149667","wikidata":"https://www.wikidata.org/wiki/Q14908082","display_name":"Transcription factor II H","level":5,"score":0.9566134214401245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.914574384689331},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6832157969474792},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.6246001720428467},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5736930966377258},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.5557469725608826},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.45164722204208374},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4377833604812622},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42534974217414856},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3391657769680023}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002873","descriptor_name":"Chromosome Fragility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043171","descriptor_name":"Chromosomal Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051758","descriptor_name":"Transcription Factor TFIIH","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051758","descriptor_name":"Transcription Factor TFIIH","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1128/mcb.00030-07","doi":"https://doi.org/10.1128/mcb.00030-07","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.00030-07","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:526936","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1899989","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1899989","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1899989","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:17339330","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17339330","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.323.5570","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.323.5570","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mcb.asm.org/content/27/10/3640.full.pdf","raw_type":"text"},{"id":"pmh:oai:HAL:hal-00189989v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00189989","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular and Cellular Biology, 2007, 27 (10), pp.3640-50. ⟨10.1128/MCB.00030-07⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:526936","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1899989","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1491876634","https://openalex.org/W1555790021","https://openalex.org/W1556435247","https://openalex.org/W1606394252","https://openalex.org/W1886853229","https://openalex.org/W1931007673","https://openalex.org/W1966060698","https://openalex.org/W1967425207","https://openalex.org/W1971303948","https://openalex.org/W1978788828","https://openalex.org/W1980428903","https://openalex.org/W1989339075","https://openalex.org/W1996516839","https://openalex.org/W2001524751","https://openalex.org/W2002997979","https://openalex.org/W2003482071","https://openalex.org/W2004431479","https://openalex.org/W2006338892","https://openalex.org/W2028735905","https://openalex.org/W2030900322","https://openalex.org/W2037156172","https://openalex.org/W2038267351","https://openalex.org/W2038543938","https://openalex.org/W2042351321","https://openalex.org/W2052799643","https://openalex.org/W2056638188","https://openalex.org/W2060334131","https://openalex.org/W2060834498","https://openalex.org/W2064041761","https://openalex.org/W2073749111","https://openalex.org/W2080605611","https://openalex.org/W2085593164","https://openalex.org/W2086639667","https://openalex.org/W2090705318","https://openalex.org/W2095033674","https://openalex.org/W2097847550","https://openalex.org/W2103080800","https://openalex.org/W2109734925","https://openalex.org/W2110846824","https://openalex.org/W2115437028","https://openalex.org/W2117249902","https://openalex.org/W2124732880","https://openalex.org/W2127857475","https://openalex.org/W2128774980","https://openalex.org/W2134435289","https://openalex.org/W2148152341","https://openalex.org/W2168524760","https://openalex.org/W2168733738","https://openalex.org/W2169421078","https://openalex.org/W2170564800","https://openalex.org/W2170992955","https://openalex.org/W2175138293","https://openalex.org/W2438131745"],"related_works":["https://openalex.org/W7098241289","https://openalex.org/W2536481202","https://openalex.org/W2050730782","https://openalex.org/W2109734925","https://openalex.org/W3000236334","https://openalex.org/W2105702908","https://openalex.org/W2124821548","https://openalex.org/W1990196168","https://openalex.org/W7036632882","https://openalex.org/W1978788828"],"abstract_inverted_index":{"The":[0,99],"transcription":[1],"and":[2,17,49,72,81,93,96,125,152,182],"DNA":[3],"repair":[4,185],"factor":[5],"TFIIH":[6,35,155],"is":[7,64],"composed":[8],"of":[9,31,58,102,107,111,130,143,161,170],"10":[10],"subunits.":[11],"Mutations":[12],"in":[13,33,40,70,115,121,135,145,172],"the":[14,52,67,112,116,148,159,162,168],"XPB,":[15,153],"XPD,":[16],"p8":[18],"subunits":[19,36],"are":[20,87],"genetically":[21],"linked":[22],"to":[23,141],"human":[24,100,136],"diseases,":[25],"including":[26],"cancer.":[27],"However,":[28],"no":[29],"reports":[30],"mutations":[32,120,133],"other":[34],"have":[37],"been":[38],"reported":[39],"higher":[41],"eukaryotes.":[42],"Here,":[43],"we":[44],"analyze":[45],"at":[46,138],"genetic,":[47],"molecular,":[48],"biochemical":[50],"levels":[51],"Drosophila":[53,71],"melanogaster":[54],"p52":[55,137,151,171],"(DMP52)":[56],"subunit":[57],"TFIIH.":[59],"We":[60],"found":[61],"that":[62,73],"DMP52":[63,76,103,122,131,146],"encoded":[65],"by":[66,119],"gene":[68],"marionette":[69],"a":[74],"defective":[75],"produces":[77],"UV":[78],"light-sensitive":[79],"flies":[80],"specific":[82],"phenotypes":[83],"during":[84],"development:":[85],"organisms":[86],"smaller":[88],"than":[89],"their":[90],"wild-type":[91],"siblings":[92],"present":[94],"tumors":[95],"chromosomal":[97],"instability.":[98],"homologue":[101],"partially":[104],"rescues":[105],"some":[106],"these":[108],"phenotypes.":[109,127],"Some":[110],"defects":[113,144],"observed":[114],"fly":[117],"caused":[118],"generate":[123],"trichothiodystrophy":[124],"cancer-like":[126],"Biochemical":[128],"analysis":[129],"point":[132],"introduced":[134],"positions":[139],"homologous":[140],"those":[142],"destabilize":[147],"interaction":[149],"between":[150],"another":[154],"subunit,":[156],"thus":[157],"compromising":[158],"assembly":[160],"complex.":[163],"This":[164],"study":[165],"significantly":[166],"extends":[167],"role":[169],"regulating":[173],"XPB":[174],"ATPase":[175],"activity":[176],"and,":[177],"consequently,":[178],"both":[179],"its":[180],"transcriptional":[181],"nucleotide":[183],"excision":[184],"functions.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}