{"id":"https://openalex.org/W2124709443","doi":"https://doi.org/10.1248/cpb.49.287","title":"Efficient Photocleavage of DNA by Cationic Porphyrin. Acridine Hybrids with the Effective Length of Diamino Alkyl Linkage.","display_name":"Efficient Photocleavage of DNA by Cationic Porphyrin. Acridine Hybrids with the Effective Length of Diamino Alkyl Linkage.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2124709443","doi":"https://doi.org/10.1248/cpb.49.287","mag":"2124709443","pmid":"https://pubmed.ncbi.nlm.nih.gov/11253918"},"language":"en","primary_location":{"id":"doi:10.1248/cpb.49.287","doi":"https://doi.org/10.1248/cpb.49.287","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.49.287","pdf_url":"https://www.jstage.jst.go.jp/article/cpb/49/3/49_3_287/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/cpb/49/3/49_3_287/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103411390","display_name":"Yoshinobu Ishikawa","orcid":"https://orcid.org/0009-0004-0624-9111","observed_orcids":["https://orcid.org/0009-0004-0624-9111"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinobu ISHIKAWA","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Kumamoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Kumamoto University","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111923174","display_name":"Aya Yamashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aya YAMASHITA","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Kumamoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Kumamoto University","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035203295","display_name":"Tadayuki Uno","orcid":"https://orcid.org/0000-0003-2056-5781","observed_orcids":["https://orcid.org/0000-0003-2056-5781"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadayuki UNO","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Kumamoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Kumamoto University","institution_ids":["https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I96036126"],"apc_list":null,"apc_paid":null,"fwci":1.5131,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.79096029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"49","issue":"3","first_page":"287","last_page":"293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.5595999956130981,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.5595999956130981,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.3093000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.093299999833107,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cationic-porphyrins","display_name":"cationic porphyrins","score":0.8619999885559082},{"id":"https://openalex.org/keywords/dna-photocleavage","display_name":"DNA photocleavage","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tmpyp","display_name":"TMPyP","score":0.7559999823570251},{"id":"https://openalex.org/keywords/plasmid-dna-cleavage","display_name":"plasmid DNA cleavage","score":0.7509999871253967},{"id":"https://openalex.org/keywords/intercalation","display_name":"intercalation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/induced-circular-dichroism","display_name":"induced circular dichroism","score":0.9710000157356262},{"id":"https://openalex.org/keywords/linker-length","display_name":"linker length","score":0.46299999952316284},{"id":"https://openalex.org/keywords/calf-thymus-dna","display_name":"calf thymus DNA","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8989377021789551},{"id":"https://openalex.org/C2779480358","wikidata":"https://www.wikidata.org/wiki/Q422926","display_name":"Porphyrin","level":2,"score":0.8489202260971069},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.7120765447616577},{"id":"https://openalex.org/C2776924795","wikidata":"https://www.wikidata.org/wiki/Q342713","display_name":"Acridine","level":2,"score":0.650675356388092},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.6442593932151794},{"id":"https://openalex.org/C192468462","wikidata":"https://www.wikidata.org/wiki/Q533543","display_name":"Chromophore","level":2,"score":0.6388130187988281},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.6114399433135986},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5796595215797424},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.5200462341308594},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5050941109657288},{"id":"https://openalex.org/C137824038","wikidata":"https://www.wikidata.org/wiki/Q175562","display_name":"Intercalation (chemistry)","level":2,"score":0.4903838634490967},{"id":"https://openalex.org/C183882617","wikidata":"https://www.wikidata.org/wiki/Q3046749","display_name":"Cationic polymerization","level":2,"score":0.4759102463722229},{"id":"https://openalex.org/C2779102032","wikidata":"https://www.wikidata.org/wiki/Q342717","display_name":"Acridine orange","level":3,"score":0.4639456272125244},{"id":"https://openalex.org/C2780477052","wikidata":"https://www.wikidata.org/wiki/Q412118","display_name":"Tetrahydrothiophene","level":2,"score":0.4282808303833008},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.4170386791229248},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.16786321997642517},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12162020802497864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08910137414932251},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000166","descriptor_name":"Acridines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007364","descriptor_name":"Intercalating Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010777","descriptor_name":"Photochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017551","descriptor_name":"Microdialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/cpb.49.287","doi":"https://doi.org/10.1248/cpb.49.287","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.49.287","pdf_url":"https://www.jstage.jst.go.jp/article/cpb/49/3/49_3_287/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:11253918","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11253918","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/cpb.49.287","doi":"https://doi.org/10.1248/cpb.49.287","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.49.287","pdf_url":"https://www.jstage.jst.go.jp/article/cpb/49/3/49_3_287/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124709443.pdf","grobid_xml":"https://content.openalex.org/works/W2124709443.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W102354607","https://openalex.org/W598354290","https://openalex.org/W642838025","https://openalex.org/W1565488270","https://openalex.org/W1983515750","https://openalex.org/W1983649348","https://openalex.org/W1985656380","https://openalex.org/W1992784057","https://openalex.org/W2012834867","https://openalex.org/W2024335073","https://openalex.org/W2035544503","https://openalex.org/W2039349546","https://openalex.org/W2074118002","https://openalex.org/W2075020161","https://openalex.org/W2076079790","https://openalex.org/W2079752314","https://openalex.org/W2107598720","https://openalex.org/W2108899627","https://openalex.org/W2115639078","https://openalex.org/W2171642857","https://openalex.org/W2172047227","https://openalex.org/W2322715423","https://openalex.org/W2414034473","https://openalex.org/W2466606969","https://openalex.org/W2477765915","https://openalex.org/W2950164178","https://openalex.org/W4388155293"],"related_works":["https://openalex.org/W2094684341","https://openalex.org/W1999435080","https://openalex.org/W2394360049","https://openalex.org/W2080100616","https://openalex.org/W2117615409","https://openalex.org/W2035315345","https://openalex.org/W2026943748","https://openalex.org/W2047435031","https://openalex.org/W2215490676","https://openalex.org/W2067552928"],"abstract_inverted_index":{"Positively":[0],"charged":[1],"porphyrins":[2],"bearing":[3],"an":[4],"acridine":[5,160],"with":[6,52,79,99],"various":[7],"lengths":[8],"of":[9,28,69,85,89,93,105,159,193,200,208],"diamino":[10],"alkyl":[11],"linkage,":[12],"5-[4-[(6-chloro-2-methoxy-9-acridyl)aminoalkylaminocarbonyl]phenyl]-10,15,20-tris(4-N-methylpyridiniumyl)porphine":[13],"triiodide,":[14],"alkyl=ethyl,":[15],"butyl,":[16],"hexyl,":[17],"or":[18],"octyl,":[19],"were":[20],"synthesized.":[21],"They":[22],"exhibited":[23],"more":[24],"enhanced":[25],"photocleavage":[26,81],"activity":[27],"pUC18":[29],"plasmid":[30],"DNA":[31,42,47,76,187,213],"than":[32],"TMPyP,":[33,146],"meso-tetrakis(4-N-methylpyridiniumyl)porphine,":[34],"which":[35],"is":[36],"well":[37],"known":[38],"to":[39,41,45,72,118,152,212],"bind":[40],"tightly":[43],"and":[44,127,147,177],"cleave":[46],"effectively;":[48],"the":[49,53,66,70,80,86,90,94,97,102,106,132,163,166,181,186,191,194,198,206,209,218],"hybrid":[50],"linked":[51],"hexamethylene":[54],"chain":[55],"showed":[56,168],"particularly":[57],"high":[58],"activity.":[59,82],"An":[60],"equilibrium":[61],"dialysis":[62],"experiment":[63],"demonstrated":[64],"that":[65,205],"binding":[67,104,117],"ability":[68],"hybrids":[71,95,167],"calf":[73],"thymus":[74],"(CT)":[75],"correlated":[77],"quantitatively":[78],"The":[83,135],"lack":[84],"substantial":[87],"red-shift":[88],"Soret":[91,175],"maxima":[92],"through":[96],"titration":[98],"CTDNA":[100],"denied":[101],"intercalative":[103],"porphyrin":[107,182,210],"part.":[108],"In":[109,162,189],"their":[110,174,201],"circular":[111],"dichroism":[112],"(CD)":[113],"spectral":[114],"change":[115],"on":[116],"CTDNA,":[119],"two":[120],"negative":[121,137],"peaks":[122],"appeared":[123],"at":[124,128],"275":[125],"nm":[126,130],"285-290":[129],"in":[131,185],"UV":[133],"range.":[134],"latter":[136],"peak":[138,172],"was":[139,214],"observed":[140],"for":[141,145],"hybrids,":[142],"but":[143],"not":[144],"thus":[148],"we":[149],"assigned":[150],"it":[151],"induced":[153],"CD":[154],"(ICD)":[155],"derived":[156],"from":[157],"intercalation":[158],"chromophore.":[161],"visible":[164,202],"range,":[165],"only":[169],"a":[170],"positive":[171],"around":[173],"maxima,":[176],"this":[178],"feature":[179],"suggested":[180],"moiety":[183,211],"lay":[184],"groove.":[188],"addition,":[190],"length":[192],"linker":[195],"markedly":[196],"influenced":[197],"ellipticity":[199],"ICD,":[203],"suggesting":[204],"proximity":[207],"greatly":[215],"affected":[216],"by":[217],"linker.":[219]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}