{"id":"https://openalex.org/W2124705288","doi":"https://doi.org/10.1002/jso.23946","title":"A ratiometric threshold for determining presence of cancer during fluorescence-guided surgery","display_name":"A ratiometric threshold for determining presence of cancer during fluorescence-guided surgery","publication_year":2015,"publication_date":"2015-06-12","ids":{"openalex":"https://openalex.org/W2124705288","doi":"https://doi.org/10.1002/jso.23946","mag":"2124705288","pmid":"https://pubmed.ncbi.nlm.nih.gov/26074273","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4510011"},"language":"en","primary_location":{"id":"doi:10.1002/jso.23946","doi":"https://doi.org/10.1002/jso.23946","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jso.23946","pdf_url":null,"source":{"id":"https://openalex.org/S13860802","display_name":"Journal of Surgical Oncology","issn_l":"0022-4790","issn":["0022-4790","1096-9098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4510011","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080553517","display_name":"Jason M. Warram","orcid":"https://orcid.org/0000-0001-5230-0011","observed_orcids":["https://orcid.org/0000-0001-5230-0011"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason M. Warram","raw_affiliation_strings":["Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068359745","display_name":"Esther de Boer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esther de Boer","raw_affiliation_strings":["Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053921897","display_name":"Lindsay S. Moore","orcid":"https://orcid.org/0000-0002-2623-8602","observed_orcids":["https://orcid.org/0000-0002-2623-8602"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay S. Moore","raw_affiliation_strings":["Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058361354","display_name":"Cecelia E. Schmalbach","orcid":"https://orcid.org/0000-0001-8497-7270","observed_orcids":["https://orcid.org/0000-0001-8497-7270"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecelia E. Schmalbach","raw_affiliation_strings":["Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032535756","display_name":"Kirk P. Withrow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirk P. Withrow","raw_affiliation_strings":["Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066757523","display_name":"William R. Carroll","orcid":"https://orcid.org/0000-0002-5383-1188","observed_orcids":["https://orcid.org/0000-0002-5383-1188"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Carroll","raw_affiliation_strings":["Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003401361","display_name":"Joshua Richman","orcid":"https://orcid.org/0000-0002-6166-7488","observed_orcids":["https://orcid.org/0000-0002-6166-7488"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua S. Richman","raw_affiliation_strings":["Division of General Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008392120","display_name":"Anthony B. Morlandt","orcid":"https://orcid.org/0000-0002-9267-3960","observed_orcids":["https://orcid.org/0000-0002-9267-3960"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony B. Morlandt","raw_affiliation_strings":["Department of Oral & Maxillofacial Surgery, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral & Maxillofacial Surgery, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036392409","display_name":"Margaret S. Brandwein\u2010Gensler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Brandwein-Gensler","raw_affiliation_strings":["Division of Anatomic Pathology; Department of Pathology; University of Alabama at Birmingham; Birmingham Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Anatomic Pathology; Department of Pathology; University of Alabama at Birmingham; Birmingham Alabama","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086275218","display_name":"Eben Lloyd Rosenthal","orcid":"https://orcid.org/0000-0003-0294-5203","observed_orcids":["https://orcid.org/0000-0003-0294-5203"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eben L. Rosenthal","raw_affiliation_strings":["Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080553517"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":{"value":4570,"currency":"USD","value_usd":4570},"apc_paid":null,"fwci":2.7017,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.88923653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"112","issue":"1","first_page":"2","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorescence-guided-surgery","display_name":"fluorescence-guided surgery","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tumor-margin-delineation","display_name":"tumor margin delineation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.9710000157356262},{"id":"https://openalex.org/keywords/intraoperative-imaging","display_name":"intraoperative imaging","score":0.6809999942779541},{"id":"https://openalex.org/keywords/punch-biopsy","display_name":"punch biopsy","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8066754341125488},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.6456854343414307},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5360190272331238},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5282123684883118},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4285937547683716},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.4141750931739807},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3960633873939514},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3662470281124115},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.32168078422546387},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.25476112961769104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14334887266159058},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.07792437076568604},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025321","descriptor_name":"Surgery, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025321","descriptor_name":"Surgery, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025321","descriptor_name":"Surgery, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/jso.23946","doi":"https://doi.org/10.1002/jso.23946","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jso.23946","pdf_url":null,"source":{"id":"https://openalex.org/S13860802","display_name":"Journal of Surgical Oncology","issn_l":"0022-4790","issn":["0022-4790","1096-9098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Oncology","raw_type":"journal-article"},{"id":"pmid:26074273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26074273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of surgical oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4510011","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4510011","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Surg Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4510011","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4510011","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Surg Oncol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3729922516","display_name":null,"funder_award_id":"R21CA17917","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5312181976","display_name":"Imaging Guided Surgery using Fluorescently Labeled Cetuximab","funder_award_id":"R21CA182953","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5703746443","display_name":"Research Training Program in Surgical Oncology","funder_award_id":"T32CA091078","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G877847219","display_name":"Optical imaging of primary and regional melanoma to guide surgical resection","funder_award_id":"R21CA179171","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320333113","display_name":"Comprehensive Cancer Center, University of Alabama at Birmingham","ror":"https://ror.org/008s83205"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1486086052","https://openalex.org/W1973024035","https://openalex.org/W2041916085","https://openalex.org/W2057103966","https://openalex.org/W2082401863","https://openalex.org/W2082748800","https://openalex.org/W2094978295","https://openalex.org/W2112579958","https://openalex.org/W2114636933","https://openalex.org/W2120243204","https://openalex.org/W2125372543","https://openalex.org/W2126948332","https://openalex.org/W2135575642","https://openalex.org/W2155758341","https://openalex.org/W2164213686","https://openalex.org/W2168544783"],"related_works":["https://openalex.org/W2269996503","https://openalex.org/W7163680158","https://openalex.org/W3012844483","https://openalex.org/W3135469617","https://openalex.org/W4395090838","https://openalex.org/W3165410773","https://openalex.org/W2810142842","https://openalex.org/W4409220813","https://openalex.org/W2045159326","https://openalex.org/W2343809448"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"OBJECTIVE:":[2],"Fluorescence-guided":[3],"imaging":[4,62,139],"to":[5,15,50,66,122,131,153],"assist":[6],"in":[7,69,88],"identification":[8],"of":[9,27,86,116,134,160,164,183,201],"malignant":[10],"margins":[11],"has":[12,30],"the":[13,84,144],"potential":[14],"dramatically":[16],"improve":[17],"oncologic":[18],"surgery.":[19],"However,":[20],"a":[21,37,60,79,126,158,184,189],"standardized":[22],"method":[23],"for":[24,96,146,166,192],"quantitative":[25],"assessment":[26,124],"disease-specific":[28],"fluorescence":[29,68,107,150],"not":[31],"been":[32],"investigated.":[33],"Introduced":[34],"here":[35],"is":[36],"ratiometric":[38,127],"threshold":[39,128,145,172,186],"derived":[40],"from":[41,54,74,110,195],"mean":[42,106],"fluorescent":[43],"tissue":[44,197],"intensity":[45,108],"that":[46],"can":[47,187],"be":[48,154],"used":[49,65],"semi-quantitatively":[51],"delineate":[52],"tumor":[53,149],"normal":[55,196],"tissue.":[56,169],"METHODS:":[57],"Open-field":[58],"and":[59,98,125,162,177],"closed-field":[61],"devices":[63],"were":[64,103,120],"quantify":[67],"punch":[70,111],"biopsy":[71,112],"tissues":[72],"sampled":[73],"primary":[75],"tumors":[76],"collected":[77],"during":[78,198],"phase":[80],"1":[81],"trial":[82],"evaluating":[83],"safety":[85],"cetuximab-IRDye800":[87],"patients":[89],"(n":[90],"=":[91],"11)":[92],"undergoing":[93],"surgical":[94],"intervention":[95],"head":[97],"neck":[99],"cancer.":[100,135,202],"Fluorescence":[101],"ratios":[102],"calculated":[104],"using":[105,140],"(MFI)":[109],"normalized":[113,148],"by":[114],"MFI":[115],"patient-matched":[117],"tissues.":[118],"Ratios":[119],"compared":[121],"pathological":[123],"was":[129,151],"established":[130],"predict":[132],"presence":[133],"RESULTS:":[136],"During":[137],"open-field":[138],"an":[141],"intraoperative":[142],"device,":[143],"muscle":[147],"found":[152],"2.7,":[155],"which":[156],"produced":[157],"sensitivity":[159,175],"90.5%":[161],"specificity":[163,178],"78.6%":[165],"delineating":[167,193],"disease":[168,194],"The":[170],"skin-normalized":[171],"generated":[173],"greater":[174],"(92.9%)":[176],"(81.0%).":[179],"CONCLUSION:":[180],"Successful":[181],"implementation":[182],"semi-quantitative":[185],"provide":[188],"scientific":[190],"methodology":[191],"fluorescence-guided":[199],"resection":[200]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}