{"id":"https://openalex.org/W2124694773","doi":"https://doi.org/10.1128/iai.63.12.4764-4769.1995","title":"Role of C5a-ase in group B streptococcal resistance to opsonophagocytic killing","display_name":"Role of C5a-ase in group B streptococcal resistance to opsonophagocytic killing","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W2124694773","doi":"https://doi.org/10.1128/iai.63.12.4764-4769.1995","mag":"2124694773","pmid":"https://pubmed.ncbi.nlm.nih.gov/7591133","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/173682"},"language":"en","primary_location":{"id":"doi:10.1128/iai.63.12.4764-4769.1995","doi":"https://doi.org/10.1128/iai.63.12.4764-4769.1995","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.63.12.4764-4769.1995","pdf_url":"https://iai.asm.org/content/iai/63/12/4764.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iai.asm.org/content/iai/63/12/4764.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040566852","display_name":"Shinji Takahashi","orcid":"https://orcid.org/0000-0002-6906-5406","observed_orcids":["https://orcid.org/0000-0002-6906-5406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Takahashi","raw_affiliation_strings":["Department of Microbiology, Joshi-Eiyoh University, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Joshi-Eiyoh University, Saitama, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112686872","display_name":"Yoshiko Nagano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Nagano","raw_affiliation_strings":["Department of Microbiology, Joshi-Eiyoh University, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Joshi-Eiyoh University, Saitama, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020183565","display_name":"Noriyuki Nagano","orcid":"https://orcid.org/0000-0002-3657-8029","observed_orcids":["https://orcid.org/0000-0002-3657-8029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Nagano","raw_affiliation_strings":["Department of Microbiology, Joshi-Eiyoh University, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Joshi-Eiyoh University, Saitama, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021778959","display_name":"O Hayashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Hayashi","raw_affiliation_strings":["Department of Microbiology, Joshi-Eiyoh University, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Joshi-Eiyoh University, Saitama, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107600070","display_name":"Fumiaki TAGUCHI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Taguchi","raw_affiliation_strings":["Department of Microbiology, Joshi-Eiyoh University, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Joshi-Eiyoh University, Saitama, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109935153","display_name":"Yoshiyuki Okuwaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Okuwaki","raw_affiliation_strings":["Department of Microbiology, Joshi-Eiyoh University, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Joshi-Eiyoh University, Saitama, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3605,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.78207404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"63","issue":"12","first_page":"4764","last_page":"4769"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.20000000298023224,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-agalactiae","display_name":"Streptococcus agalactiae","score":0.8980000019073486},{"id":"https://openalex.org/keywords/c5a","display_name":"C5a","score":0.7670000195503235},{"id":"https://openalex.org/keywords/opsonophagocytic-killing","display_name":"opsonophagocytic killing","score":0.9179999828338623},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.9309999942779541},{"id":"https://openalex.org/keywords/chemoattractant-activity","display_name":"chemoattractant activity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7709641456604004},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7570130228996277},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5415284037590027},{"id":"https://openalex.org/C168507396","wikidata":"https://www.wikidata.org/wiki/Q14859847","display_name":"Antibody opsonization","level":4,"score":0.5122644305229187},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.49076899886131287},{"id":"https://openalex.org/C2778663903","wikidata":"https://www.wikidata.org/wiki/Q140018","display_name":"Streptococcaceae","level":3,"score":0.4877625107765198},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.45993566513061523},{"id":"https://openalex.org/C2778276568","wikidata":"https://www.wikidata.org/wiki/Q190161","display_name":"Streptococcus","level":3,"score":0.44588154554367065},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.24690592288970947},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.10089945793151855},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09216159582138062},{"id":"https://openalex.org/C89372155","wikidata":"https://www.wikidata.org/wiki/Q420107","display_name":"Opsonin","level":3,"score":0.08472496271133423},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08251795172691345},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009895","descriptor_name":"Opsonin Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013292","descriptor_name":"Streptococcus agalactiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013292","descriptor_name":"Streptococcus agalactiae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015936","descriptor_name":"Complement C5a","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018829","descriptor_name":"Adhesins, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.63.12.4764-4769.1995","doi":"https://doi.org/10.1128/iai.63.12.4764-4769.1995","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.63.12.4764-4769.1995","pdf_url":"https://iai.asm.org/content/iai/63/12/4764.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1465622","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/173682","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:7591133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7591133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:173682","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC173682/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1128/iai.63.12.4764-4769.1995","doi":"https://doi.org/10.1128/iai.63.12.4764-4769.1995","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.63.12.4764-4769.1995","pdf_url":"https://iai.asm.org/content/iai/63/12/4764.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2124694773.pdf"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1532190041","https://openalex.org/W1550039558","https://openalex.org/W1595786236","https://openalex.org/W1678470064","https://openalex.org/W1911107490","https://openalex.org/W1914032399","https://openalex.org/W1930023791","https://openalex.org/W1989069389","https://openalex.org/W1996075092","https://openalex.org/W2026050314","https://openalex.org/W2079096224","https://openalex.org/W2091636943","https://openalex.org/W2096104074","https://openalex.org/W2126515020","https://openalex.org/W2140443073","https://openalex.org/W2148464276","https://openalex.org/W2250068495"],"related_works":["https://openalex.org/W1914032399","https://openalex.org/W2146611367","https://openalex.org/W2129921736","https://openalex.org/W1927454956","https://openalex.org/W39345642","https://openalex.org/W2098988112","https://openalex.org/W1922352103","https://openalex.org/W1524639485","https://openalex.org/W2111167294","https://openalex.org/W2061343172"],"abstract_inverted_index":{"Type":[0],"III":[1],"group":[2],"B":[3],"streptococci":[4],"(GBS)":[5],"can":[6],"be":[7],"subdivided":[8],"into":[9],"three":[10,93],"subtypes,":[11],"RDP":[12,52,127,142,179],"III-1,":[13],"III-2,":[14],"and":[15,66,181,209,212,245,269],"III-3,":[16],"on":[17,43,74],"the":[18,36,39,67,103,115,119,126,134,141,149,154,178,206,210,229,234,237,261,272,288],"basis":[19],"of":[20,23,41,46,69,72,81,91,118,123,125,133,140,153,177,225,239,263,275,279,287],"numerical":[21],"analysis":[22],"HindIII":[24],"restriction":[25],"endonuclease":[26],"digestion":[27],"patterns":[28],"(HindIII":[29],"RDP)":[30],"with":[31,85,105,161,164,170,195,219,252,281],"their":[32],"chromosomal":[33],"DNAs.":[34],"In":[35,174],"present":[37],"study,":[38],"effect":[40,68],"C5a":[42,73,86,104,162,165,254,282],"opsonophagocytic":[44,64,75,89,155],"killing":[45,76,90,98,124,176,204,265,274],"a":[47,58,110],"representative":[48],"strain":[49,129,208],"from":[50,131,284],"each":[51],"type":[53],"was":[54,77,99,232],"investigated":[55],"by":[56,101],"using":[57],"novel":[59],"optical":[60],"method":[61],"for":[62],"determining":[63],"killing,":[65],"C5a-ase":[70,172],"treatment":[71,111],"also":[78,113],"investigated.":[79],"Pre-stimulation":[80],"polymorphonuclear":[82],"leukocytes":[83],"(PMNs)":[84],"significantly":[87],"increased":[88,285],"all":[92],"strains.":[94,137],"The":[95,121,138,223],"increase":[96],"in":[97,202,228,242],"abolished":[100],"pretreating":[102],"GBS":[106,171,276],"that":[107,112,166,260,271],"express":[108],"C5a-ase,":[109],"destroyed":[114],"chemoattractant":[116],"activity":[117],"C5a.":[120],"kinetics":[122],"III-2":[128,143,207],"differed":[130],"those":[132],"other":[135],"two":[136],"survival":[139],"bacteria":[144,226,240],"continued":[145],"to":[146],"decline":[147],"over":[148],"entire":[150],"60-min":[151],"incubation":[152,221],"assay":[156],"when":[157,191,248],"PMNs":[158,192,249,280],"were":[159,193,250],"prestimulated":[160,194,251],"or":[163,188,197,255],"had":[167],"been":[168],"inactivated":[169],"(dC5a).":[173],"contrast,":[175],"III-1":[180,211],"III-3":[182,213],"strains":[183,214],"almost":[184],"ceased":[185],"after":[186],"20":[187],"60":[189],"min":[190],"dC5a":[196],"C5a,":[198],"respectively.":[199],"A":[200],"difference":[201],"bacterial":[203,264],"between":[205],"therefore":[215],"became":[216],"increasingly":[217],"apparent":[218],"prolonged":[220],"time.":[222],"percentage":[224],"surviving":[227,241],"extracellular":[230,246],"fluid":[231],"approximately":[233],"same":[235],"as":[236],"percentages":[238],"both":[243],"intracellular":[244],"locations":[247],"either":[253],"dC5a.":[256],"These":[257],"data":[258],"imply":[259],"majority":[262],"occurred":[266],"following":[267,277],"phagocytosis":[268],"suggest":[270],"enhanced":[273],"prestimulation":[278],"resulted":[283],"ingestion":[286],"bacteria.":[289]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}