{"id":"https://openalex.org/W2124690990","doi":"https://doi.org/10.1093/nar/gkv740","title":"Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD","display_name":"Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD","publication_year":2015,"publication_date":"2015-07-21","ids":{"openalex":"https://openalex.org/W2124690990","doi":"https://doi.org/10.1093/nar/gkv740","mag":"2124690990","pmid":"https://pubmed.ncbi.nlm.nih.gov/26202968","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4787822"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkv740","doi":"https://doi.org/10.1093/nar/gkv740","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkv740","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/nar/gkv740","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058526482","display_name":"Mitsunori Koga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsunori Koga","raw_affiliation_strings":["Frontier Research Core for Life Sciences, University of Toyama, Toyama 930-0194, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontier Research Core for Life Sciences, University of Toyama, Toyama 930-0194, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046819962","display_name":"Megumi Hayashi","orcid":"https://orcid.org/0009-0007-7521-9030","observed_orcids":["https://orcid.org/0009-0007-7521-9030"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Megumi Hayashi","raw_affiliation_strings":["Frontier Research Core for Life Sciences, University of Toyama, Toyama 930-0194, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontier Research Core for Life Sciences, University of Toyama, Toyama 930-0194, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045724776","display_name":"Daisuke Kaida","orcid":"https://orcid.org/0000-0003-4014-5231","observed_orcids":["https://orcid.org/0000-0003-4014-5231"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Daisuke Kaida","raw_affiliation_strings":["Frontier Research Core for Life Sciences, University of Toyama, Toyama 930-0194, Japan kaida@med.u-toyama.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontier Research Core for Life Sciences, University of Toyama, Toyama 930-0194, Japan kaida@med.u-toyama.ac.jp","institution_ids":["https://openalex.org/I42766147"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045724776"],"corresponding_institution_ids":["https://openalex.org/I42766147"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":2.1921,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.88601412,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"43","issue":"17","first_page":"8258","last_page":"8267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":0.8560000061988831},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.8029999732971191},{"id":"https://openalex.org/keywords/ser2-phosphorylation","display_name":"Ser2 phosphorylation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ser5-phosphorylation","display_name":"Ser5 phosphorylation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/splicing-inhibition","display_name":"splicing inhibition","score":0.9589999914169312},{"id":"https://openalex.org/keywords/spliceostatin-a","display_name":"spliceostatin A","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pladienolide-b","display_name":"pladienolide B","score":1.0},{"id":"https://openalex.org/keywords/mrna-splicing","display_name":"mRNA splicing","score":0.6740000247955322},{"id":"https://openalex.org/keywords/transcription","display_name":"transcription","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.8747892379760742},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8204882740974426},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.802582859992981},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6612849235534668},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.6586827635765076},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.52504563331604},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5209278464317322},{"id":"https://openalex.org/C67585878","wikidata":"https://www.wikidata.org/wiki/Q7243183","display_name":"Primary transcript","level":5,"score":0.5148190855979919},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45641782879829407},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.440839946269989},{"id":"https://openalex.org/C10447831","wikidata":"https://www.wikidata.org/wiki/Q7392918","display_name":"SR protein","level":5,"score":0.4330011010169983},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4055885374546051},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3511000871658325},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3465723991394043},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3205481171607971},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2769627869129181},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.2764556407928467},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011714","descriptor_name":"Pyrans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012342","descriptor_name":"RNA, Small Nuclear","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013141","descriptor_name":"Spiro Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042925","descriptor_name":"Positive Transcriptional Elongation Factor B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkv740","doi":"https://doi.org/10.1093/nar/gkv740","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkv740","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4787822","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4787822/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4787822/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:26202968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26202968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkv740","doi":"https://doi.org/10.1093/nar/gkv740","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkv740","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G88675574","display_name":"Study on the splicing checkpoint mechanism to prevent pre-mRNA accumulation caused by splicing abnormality","funder_award_id":"25711001","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320324271","display_name":"Astellas Foundation for Research on Metabolic Disorders","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320325449","display_name":"Kanae Foundation for the Promotion of Medical Science","ror":null},{"id":"https://openalex.org/F4320327650","display_name":"Ditmanson Medical Foundation Chia-Yi Christian Hospital","ror":"https://ror.org/01em2mv62"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124690990.pdf","grobid_xml":"https://content.openalex.org/works/W2124690990.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1507700987","https://openalex.org/W1553320576","https://openalex.org/W1964099801","https://openalex.org/W1967731271","https://openalex.org/W1981915772","https://openalex.org/W1983489516","https://openalex.org/W1984059453","https://openalex.org/W1986026506","https://openalex.org/W1996505914","https://openalex.org/W2001406822","https://openalex.org/W2003168089","https://openalex.org/W2003757297","https://openalex.org/W2010413312","https://openalex.org/W2012078049","https://openalex.org/W2017614398","https://openalex.org/W2021678907","https://openalex.org/W2022936085","https://openalex.org/W2024267851","https://openalex.org/W2032742580","https://openalex.org/W2047562490","https://openalex.org/W2048268130","https://openalex.org/W2052095003","https://openalex.org/W2060554618","https://openalex.org/W2063296736","https://openalex.org/W2070603335","https://openalex.org/W2073430514","https://openalex.org/W2078910412","https://openalex.org/W2080834951","https://openalex.org/W2081581101","https://openalex.org/W2091069693","https://openalex.org/W2095934571","https://openalex.org/W2100649212","https://openalex.org/W2100959401","https://openalex.org/W2104531065","https://openalex.org/W2109962448","https://openalex.org/W2114830509","https://openalex.org/W2116313207","https://openalex.org/W2117800899","https://openalex.org/W2118585964","https://openalex.org/W2119141376","https://openalex.org/W2121649903","https://openalex.org/W2123814549","https://openalex.org/W2129214044","https://openalex.org/W2130874433","https://openalex.org/W2133452708","https://openalex.org/W2136605296","https://openalex.org/W2143350291","https://openalex.org/W2146757649","https://openalex.org/W2147390648","https://openalex.org/W2155742225","https://openalex.org/W2156080468","https://openalex.org/W2160720092","https://openalex.org/W2196899564","https://openalex.org/W3022823009","https://openalex.org/W3215839487"],"related_works":["https://openalex.org/W2167931447","https://openalex.org/W2003757297","https://openalex.org/W1598695505","https://openalex.org/W2399619985","https://openalex.org/W2144803283","https://openalex.org/W4385691792","https://openalex.org/W2105050021","https://openalex.org/W7033813709","https://openalex.org/W2985005367","https://openalex.org/W1987314819"],"abstract_inverted_index":{"Phosphorylation":[0],"of":[1,5,9,55,107,117,124,132,142],"the":[2,6,52,110,115],"C-terminal":[3],"domain":[4],"largest":[7],"subunit":[8],"RNA":[10],"polymerase":[11],"II":[12,126],"(Pol":[13],"II),":[14],"especially":[15],"Ser2":[16],"and":[17,25,33,73,97,127],"Ser5":[18],"residues,":[19],"plays":[20],"important":[21],"roles":[22],"in":[23,129],"transcription":[24,96],"mRNA":[26,41],"processing,":[27,42],"including":[28],"5'":[29],"end":[30,35],"capping,":[31],"splicing":[32,49,64,68,138],"3'":[34],"processing.":[36],"These":[37],"phosphorylation":[38,53],"events":[39],"stimulate":[40],"however,":[43],"it":[44],"is":[45],"not":[46,101,108],"clear":[47],"whether":[48],"activity":[50],"affects":[51],"status":[54],"Pol":[56,125,134],"II.":[57],"In":[58,94],"this":[59],"study,":[60],"we":[61],"found":[62],"that":[63,137],"inhibition":[65,106,139],"by":[66,77],"potent":[67],"inhibitors":[69,99],"spliceostatin":[70],"A":[71],"(SSA)":[72],"pladienolide":[74],"B":[75],"or":[76,88],"antisense":[78],"oligos":[79],"against":[80],"snRNAs":[81],"decreased":[82],"phospho-Ser2":[83,103,130,143],"level,":[84,104],"but":[85],"had":[86],"little":[87],"no":[89],"effects":[90],"on":[91],"phospho-Ser5":[92],"level.":[93],"contrast,":[95],"translation":[98],"did":[100],"decrease":[102,116,128],"therefore":[105],"all":[109],"gene":[111],"expression":[112],"processes":[113],"cause":[114],"phospho-Ser2.":[118],"SSA":[119],"treatment":[120],"caused":[121],"early":[122],"dissociation":[123],"level":[131],"chromatin-bound":[133],"II,":[135],"suggesting":[136],"causes":[140],"downregulation":[141],"through":[144],"at":[145],"least":[146],"these":[147],"two":[148],"mechanisms.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":10}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
