{"id":"https://openalex.org/W2124689732","doi":"https://doi.org/10.3978/j.issn.2218-6751.2013.10.13","title":"Immunotherapy in lung cancer.","display_name":"Immunotherapy in lung cancer.","publication_year":2014,"publication_date":"2014-02-01","ids":{"openalex":"https://openalex.org/W2124689732","doi":"https://doi.org/10.3978/j.issn.2218-6751.2013.10.13","mag":"2124689732","pmid":"https://pubmed.ncbi.nlm.nih.gov/25806276","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367610"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3333819","doi":"https://doi.org/10.3978/j.issn.2218-6751.2013.10.13","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367610","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367610","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082389042","display_name":"Liza Cosca Villaruz","orcid":"https://orcid.org/0000-0001-7456-523X","observed_orcids":["https://orcid.org/0000-0001-7456-523X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liza C Villaruz","raw_affiliation_strings":["University of Pittsburgh Cancer Institute, University of Pittsburgh, School of Medicine/Hematology-Oncology, Lung and Thoracic Malignancies Program, Pittsburgh, PA 15232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Cancer Institute, University of Pittsburgh, School of Medicine/Hematology-Oncology, Lung and Thoracic Malignancies Program, Pittsburgh, PA 15232, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114082408","display_name":"Aparna Kalyan","orcid":"https://orcid.org/0000-0003-1686-093X","observed_orcids":["https://orcid.org/0000-0003-1686-093X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aparna Kalyan","raw_affiliation_strings":["University of Pittsburgh Cancer Institute, University of Pittsburgh, School of Medicine/Hematology-Oncology, Lung and Thoracic Malignancies Program, Pittsburgh, PA 15232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Cancer Institute, University of Pittsburgh, School of Medicine/Hematology-Oncology, Lung and Thoracic Malignancies Program, Pittsburgh, PA 15232, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025286759","display_name":"Hassane M. Zarour","orcid":"https://orcid.org/0000-0003-2525-2688","observed_orcids":["https://orcid.org/0000-0003-2525-2688"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hassane Zarour","raw_affiliation_strings":["University of Pittsburgh Cancer Institute, University of Pittsburgh, School of Medicine/Hematology-Oncology, Lung and Thoracic Malignancies Program, Pittsburgh, PA 15232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Cancer Institute, University of Pittsburgh, School of Medicine/Hematology-Oncology, Lung and Thoracic Malignancies Program, Pittsburgh, PA 15232, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078629724","display_name":"Mark A. Socinski","orcid":"https://orcid.org/0000-0003-2915-9325","observed_orcids":["https://orcid.org/0000-0003-2915-9325","https://orcid.org/0000-0002-8213-0137"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A Socinski","raw_affiliation_strings":["University of Pittsburgh Cancer Institute, University of Pittsburgh, School of Medicine/Hematology-Oncology, Lung and Thoracic Malignancies Program, Pittsburgh, PA 15232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Cancer Institute, University of Pittsburgh, School of Medicine/Hematology-Oncology, Lung and Thoracic Malignancies Program, Pittsburgh, PA 15232, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0258,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.95403168,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"2","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer-immunotherapy","display_name":"lung cancer immunotherapy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.8199999928474426},{"id":"https://openalex.org/keywords/ctla-4-blockade","display_name":"CTLA-4 blockade","score":0.953000009059906},{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":0.9290000200271606},{"id":"https://openalex.org/keywords/pd-1-pd-l1-blockade","display_name":"PD-1/PD-L1 blockade","score":0.878000020980835},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.8339999914169312},{"id":"https://openalex.org/keywords/mage-a3","display_name":"MAGE-A3","score":0.9789999723434448},{"id":"https://openalex.org/keywords/muc1","display_name":"MUC1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9860000014305115},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.890999972820282},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.794021725654602},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.7420018315315247},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.687786877155304},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6639304757118225},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.5827716588973999},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5824393033981323},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5634499788284302},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5592871904373169},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5271660685539246},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4992945194244385},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4745759963989258},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4731294512748718},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2739490270614624},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16144117712974548}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3333819","doi":"https://doi.org/10.3978/j.issn.2218-6751.2013.10.13","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367610","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4367610","doi":"https://doi.org/10.3978/j.issn.2218-6751.2013.10.13","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367610","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Lung Cancer Res","raw_type":"Text"},{"id":"pmid:25806276","doi":"https://doi.org/10.3978/j.issn.2218-6751.2013.10.13","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25806276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational lung cancer research","raw_type":"Journal Article"},{"id":"mag:2124689732","doi":"https://doi.org/10.3978/j.issn.2218-6751.2013.10.13","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25806276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3333819","doi":"https://doi.org/10.3978/j.issn.2218-6751.2013.10.13","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4367610","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1487731794","https://openalex.org/W1568317937","https://openalex.org/W1666874820","https://openalex.org/W1767351348","https://openalex.org/W1893277967","https://openalex.org/W1952803891","https://openalex.org/W1964056896","https://openalex.org/W1982097770","https://openalex.org/W1982393289","https://openalex.org/W1983061784","https://openalex.org/W1984545852","https://openalex.org/W1993615391","https://openalex.org/W2010121426","https://openalex.org/W2018092044","https://openalex.org/W2019402729","https://openalex.org/W2019607817","https://openalex.org/W2026092903","https://openalex.org/W2043944632","https://openalex.org/W2047872172","https://openalex.org/W2056893124","https://openalex.org/W2057893793","https://openalex.org/W2073310925","https://openalex.org/W2078111185","https://openalex.org/W2094179246","https://openalex.org/W2097995306","https://openalex.org/W2098414192","https://openalex.org/W2099803791","https://openalex.org/W2100158834","https://openalex.org/W2100669312","https://openalex.org/W2101653483","https://openalex.org/W2103525785","https://openalex.org/W2106720606","https://openalex.org/W2107598346","https://openalex.org/W2107752337","https://openalex.org/W2108023441","https://openalex.org/W2108348820","https://openalex.org/W2114300639","https://openalex.org/W2114903025","https://openalex.org/W2115786482","https://openalex.org/W2123914905","https://openalex.org/W2125837906","https://openalex.org/W2127387126","https://openalex.org/W2128973831","https://openalex.org/W2134403422","https://openalex.org/W2136731993","https://openalex.org/W2147415023","https://openalex.org/W2147996829","https://openalex.org/W2149121521","https://openalex.org/W2155464214","https://openalex.org/W2155599713","https://openalex.org/W2156769579","https://openalex.org/W2157215695","https://openalex.org/W2160834915","https://openalex.org/W2165948908","https://openalex.org/W2166288651","https://openalex.org/W2167523219","https://openalex.org/W2221465106","https://openalex.org/W2560367415","https://openalex.org/W2566863750","https://openalex.org/W2598819900","https://openalex.org/W2599211667","https://openalex.org/W2603617453"],"related_works":["https://openalex.org/W2465405903","https://openalex.org/W2347737489","https://openalex.org/W2147415023","https://openalex.org/W4321457619","https://openalex.org/W2517643621","https://openalex.org/W365883963","https://openalex.org/W2017591230","https://openalex.org/W3030855191","https://openalex.org/W2518941616","https://openalex.org/W2054854216"],"abstract_inverted_index":{"Immunotherapy":[0],"has":[1],"emerged":[2],"in":[3,11,86,144,179],"recent":[4],"years":[5],"as":[6,63,65,159],"a":[7],"promising":[8],"therapeutic":[9],"approach":[10],"lung":[12,90,96,119,145,180],"cancer.":[13,181],"Two":[14],"approaches":[15],"are":[16],"of":[17,30,55,68,102,156,177],"particular":[18],"interest:":[19],"immune":[20,31,80,151],"checkpoint":[21,48,81],"inhibition,":[22],"which":[23,40,109],"aims":[24],"to":[25,44,153,170],"counteract":[26],"the":[27,51,56,69,76,123,131,149,157,168,173],"physiologic":[28],"mechanisms":[29],"tolerance":[32],"co-opted":[33],"by":[34],"some":[35],"tumors,":[36],"and":[37,75,93,130,147,175],"vaccine":[38],"therapy,":[39],"enables":[41],"enhanced":[42],"exposure":[43],"tumor":[45,138,158],"antigen.":[46],"Immune":[47],"therapies":[49,82,108],"include":[50,105,122],"monoclonal":[52],"antibody":[53,66],"blockade":[54,67],"cytotoxic":[57],"T-lymphocyte":[58],"antigen-4":[59],"(CTLA-4)":[60],"with":[61,99],"ipilimumab,":[62],"well":[64],"programmed":[70],"cell":[71,89,95],"death-1":[72],"(PD-1)":[73],"receptor":[74,135],"PD-1":[77],"ligand.":[78],"These":[79],"have":[83,140],"been":[84,142],"evaluated":[85,143],"both":[87],"non-small":[88],"cancer":[91,97,146],"(NSCLC)":[92],"small":[94],"(SCLC)":[98],"early":[100],"evidence":[101,169],"activity.":[103],"Vaccines":[104],"antigen":[106],"specific":[107,111],"induce":[110],"antitumor":[112],"immunity":[113],"against":[114],"relevant":[115],"tumor-associated":[116],"antigens.":[117],"In":[118],"cancer,":[120],"these":[121],"melanoma-associated":[124],"antigen-A3":[125],"(MAGE-A3),":[126],"membrane-associated":[127],"glycoprotein":[128],"(MUC-1),":[129],"epidermal":[132],"growth":[133],"factor":[134],"(EGFR).":[136],"Whole":[137],"vaccines":[139],"also":[141],"influence":[148],"patient's":[150],"system":[152],"allow":[154],"recognition":[155],"foreign":[160],"creating":[161],"de":[162],"novo":[163],"immunity.":[164],"This":[165],"review":[166],"summarizes":[167],"date":[171],"for":[172],"efficacy":[174],"safety":[176],"immunotherapies":[178]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}