{"id":"https://openalex.org/W2124677225","doi":"https://doi.org/10.1016/j.pain.2008.02.027","title":"Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): A 6-month, double-blind, placebo-controlled trial with pregabalin","display_name":"Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): A 6-month, double-blind, placebo-controlled trial with pregabalin","publication_year":2008,"publication_date":"2008-04-09","ids":{"openalex":"https://openalex.org/W2124677225","doi":"https://doi.org/10.1016/j.pain.2008.02.027","mag":"2124677225","pmid":"https://pubmed.ncbi.nlm.nih.gov/18400400"},"language":"en","primary_location":{"id":"doi:10.1016/j.pain.2008.02.027","doi":"https://doi.org/10.1016/j.pain.2008.02.027","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pain.2008.02.027","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069490679","display_name":"Leslie J. Crofford","orcid":"https://orcid.org/0000-0002-6347-5738","observed_orcids":["https://orcid.org/0000-0002-6347-5738"]},"institutions":[{"id":"https://openalex.org/I1285210727","display_name":"University of Kentucky HealthCare","ror":"https://ror.org/05vvzn852","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722"]},{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leslie J. Crofford","raw_affiliation_strings":["University of Kentucky, Internal Medicine, Room J-503 Kentucky Clinic, 740 S. Limestone Street, Lexington, KY 40536-0284, USA Seattle Rheumatology Associates, Seattle, WA, USA Pfizer Global Research & Development, Ann Arbor, MI, USA MMS Holdings Inc., Canton, MI, USA","University of Kentucky, Internal Medicine, Room J-503 Kentucky Clinic, 740 S. Limestone Street, Lexington, KY 40536-0284, USA","fax: +1 859 257 8258"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky, Internal Medicine, Room J-503 Kentucky Clinic, 740 S. Limestone Street, Lexington, KY 40536-0284, USA Seattle Rheumatology Associates, Seattle, WA, USA Pfizer Global Research & Development, Ann Arbor, MI, USA MMS Holdings Inc., Canton, MI, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"University of Kentucky, Internal Medicine, Room J-503 Kentucky Clinic, 740 S. Limestone Street, Lexington, KY 40536-0284, USA","institution_ids":["https://openalex.org/I1285210727","https://openalex.org/I143302722"]},{"raw_affiliation_string":"fax: +1 859 257 8258","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081778211","display_name":"Philip J. Mease","orcid":"https://orcid.org/0000-0002-6620-0457","observed_orcids":["https://orcid.org/0000-0002-6620-0457"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip J. Mease","raw_affiliation_strings":["Seattle Rheumatology Associates, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Rheumatology Associates, Seattle, WA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038775847","display_name":"Susan Lee Simpson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan L. Simpson","raw_affiliation_strings":["Pfizer Global Research & Development, Ann Arbor, MI, USA","Development, Ann Arbor, MI, USA","Pfizer Global Research &amp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research & Development, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Development, Ann Arbor, MI, USA","institution_ids":[]},{"raw_affiliation_string":"Pfizer Global Research &amp","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James P. Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Young","raw_affiliation_strings":["Pfizer Global Research & Development, Ann Arbor, MI, USA","Development, Ann Arbor, MI, USA","Pfizer Global Research &amp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research & Development, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Development, Ann Arbor, MI, USA","institution_ids":[]},{"raw_affiliation_string":"Pfizer Global Research &amp","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032364601","display_name":"Susan A. Martin","orcid":"https://orcid.org/0000-0002-9594-5036","observed_orcids":["https://orcid.org/0000-0002-9594-5036"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan A. Martin","raw_affiliation_strings":["Pfizer Global Research & Development, Ann Arbor, MI, USA","Development, Ann Arbor, MI, USA","Pfizer Global Research &amp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research & Development, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Development, Ann Arbor, MI, USA","institution_ids":[]},{"raw_affiliation_string":"Pfizer Global Research &amp","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056724494","display_name":"George M. Haig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George M. Haig","raw_affiliation_strings":["Pfizer Global Research & Development, Ann Arbor, MI, USA","Development, Ann Arbor, MI, USA","Pfizer Global Research &amp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research & Development, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Development, Ann Arbor, MI, USA","institution_ids":[]},{"raw_affiliation_string":"Pfizer Global Research &amp","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104909894","display_name":"Uma Sharma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uma Sharma","raw_affiliation_strings":["MMS Holdings Inc., Canton, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MMS Holdings Inc., Canton, MI, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069490679"],"corresponding_institution_ids":["https://openalex.org/I1285210727","https://openalex.org/I143302722"],"apc_list":null,"apc_paid":null,"fwci":25.2507,"has_fulltext":false,"cited_by_count":237,"citation_normalized_percentile":{"value":0.99874995,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"136","issue":"3","first_page":"419","last_page":"431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibromyalgia","display_name":"fibromyalgia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pregabalin","display_name":"pregabalin","score":1.0},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.5690000057220459},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.6520000100135803},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.8339999914169312},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.6539999842643738},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2776468701","wikidata":"https://www.wikidata.org/wiki/Q412174","display_name":"Pregabalin","level":2,"score":0.9870110750198364},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8560956716537476},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8433248996734619},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.6536508798599243},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6188094615936279},{"id":"https://openalex.org/C2777831278","wikidata":"https://www.wikidata.org/wiki/Q540571","display_name":"Fibromyalgia","level":2,"score":0.5545350313186646},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5352407693862915},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5024819374084473},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.48513779044151306},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.46237868070602417},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26614993810653687},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069583","descriptor_name":"Pregabalin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005356","descriptor_name":"Fibromyalgia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015990","descriptor_name":"Placebo Effect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018759","descriptor_name":"Adrenergic Uptake Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.pain.2008.02.027","doi":"https://doi.org/10.1016/j.pain.2008.02.027","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pain.2008.02.027","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},{"id":"pmid:18400400","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18400400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1784634067","https://openalex.org/W1868536540","https://openalex.org/W1972387365","https://openalex.org/W1992436256","https://openalex.org/W1994334998","https://openalex.org/W2005051633","https://openalex.org/W2011913908","https://openalex.org/W2023776675","https://openalex.org/W2029662381","https://openalex.org/W2054260401","https://openalex.org/W2060886633","https://openalex.org/W2066796908","https://openalex.org/W2068602147","https://openalex.org/W2070246197","https://openalex.org/W2080255943","https://openalex.org/W2080477042","https://openalex.org/W2082970080","https://openalex.org/W2085295826","https://openalex.org/W2104695445","https://openalex.org/W2114202011","https://openalex.org/W2115803707","https://openalex.org/W2117636258","https://openalex.org/W2131066455","https://openalex.org/W2132309748","https://openalex.org/W2140099904","https://openalex.org/W2143659787","https://openalex.org/W2152802140","https://openalex.org/W2158523533","https://openalex.org/W2159977024","https://openalex.org/W2160269874","https://openalex.org/W2253364553","https://openalex.org/W2398803574","https://openalex.org/W2948965307","https://openalex.org/W3021088058","https://openalex.org/W3149708277","https://openalex.org/W3194956376","https://openalex.org/W6667034288","https://openalex.org/W6675773212","https://openalex.org/W6844297308"],"related_works":["https://openalex.org/W2025318224","https://openalex.org/W1969435625","https://openalex.org/W2148029309","https://openalex.org/W1935029288","https://openalex.org/W2585937821","https://openalex.org/W2142027176","https://openalex.org/W4234826894","https://openalex.org/W7029344532","https://openalex.org/W2105919192","https://openalex.org/W2162351636"],"abstract_inverted_index":{"This":[0],"was":[1,121,134,173,224],"a":[2,28,99],"multicenter,":[3],"double-blind":[4],"(DB),":[5],"placebo-controlled,":[6],"randomized":[7,164],"discontinuation":[8],"trial":[9,26,204],"to":[10,68,136,165,168,171],"evaluate":[11],"the":[12,115,125,186,195,207],"efficacy":[13],"of":[14,19,66,101,111,117,130,138,153,157,182,209,256],"pregabalin":[15,67,176,196,221,240,253],"monotherapy":[16],"for":[17,175,233,245,258],"durability":[18,255],"effect":[20,257],"on":[21,49,107],"fibromyalgia":[22],"(FM)":[23],"pain.":[24,261],"The":[25],"included":[27],"6-week":[29],"open-label":[30],"(OL)":[31],"pregabalin-treatment":[32],"period":[33],"followed":[34],"by":[35,191,203],"26-week":[36],"DB":[37],"treatment":[38,120],"with":[39,44,122],"placebo":[40,123,178,187,213,242],"or":[41,103,124,151],"pregabalin.":[42,131,169],"Adults":[43],"FM":[45,260],"and":[46,98,238],"40-mm":[47],"score":[48],"100-mm":[50],"pain":[51,96,147],"visual":[52],"analog":[53],"scale":[54],"(VAS)":[55],"were":[56,163],"eligible.":[57],"During":[58,73],"OL":[59,74,149,232],"weeks":[60,75],"1-3,":[61],"patients":[62,77,89,159,214,243],"received":[63,78],"escalating":[64],"dosages":[65,82],"determine":[69],"their":[70,79],"optimal":[71,80,127],"dosages.":[72],"4-6,":[76],"fixed":[81,128],"(300,":[83],"450,":[84],"600mg/d).":[85],"To":[86],"be":[87],"randomized,":[88],"must":[90],"have":[91],"had":[92,189,199],"50%":[93],"decrease":[94],"in":[95,146],"VAS":[97],"self-rating":[100],"\"much\"":[102],"\"very":[104],"much\"":[105],"improved":[106],"Patient":[108],"Global":[109],"Impression":[110],"Change":[112],"(PGIC)":[113],"at":[114],"end":[116,208],"OL.":[118],"Double-blind":[119],"patient's":[126],"dosage":[129],"Primary":[132],"outcome":[133],"time":[135],"loss":[137],"therapeutic":[139],"response":[140,202],"(LTR),":[141],"defined":[142],"as":[143],"<30%":[144],"reduction":[145],"(from":[148],"baseline)":[150],"worsening":[152],"FM.":[154],"A":[155],"total":[156],"1051":[158],"entered":[160],"OL;":[161],"287":[162],"placebo,":[166],"279":[167],"Time":[170],"LTR":[172,190,216],"longer":[174],"versus":[177,218],"(P<.0001).":[179],"Kaplan-Meier":[180],"estimates":[181],"time-to-event":[183],"showed":[184],"half":[185,194],"group":[188,197],"Day":[192],"19;":[193],"still":[198],"not":[200],"lost":[201],"end.":[205],"At":[206],"DB,":[210],"174":[211],"(61%)":[212],"met":[215],"criteria":[217],"90":[219],"(32%)":[220],"patients.":[222],"Pregabalin":[223],"well":[225],"tolerated,":[226],"though":[227],"178":[228],"(17%)":[229],"discontinued":[230,244],"during":[231,247],"treatment-related":[234],"adverse":[235],"events":[236],"(AE),":[237],"more":[239],"than":[241],"AEs":[246],"DB.":[248],"In":[249],"those":[250],"who":[251],"respond,":[252],"demonstrated":[254],"relieving":[259]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":26}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
