{"id":"https://openalex.org/W2124668683","doi":"https://doi.org/10.1002/jcb.24454","title":"The current state of bone loss research: Data from spaceflight and microgravity simulators","display_name":"The current state of bone loss research: Data from spaceflight and microgravity simulators","publication_year":2012,"publication_date":"2012-11-13","ids":{"openalex":"https://openalex.org/W2124668683","doi":"https://doi.org/10.1002/jcb.24454","mag":"2124668683","pmid":"https://pubmed.ncbi.nlm.nih.gov/23150462"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.24454","doi":"https://doi.org/10.1002/jcb.24454","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.24454","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022356715","display_name":"Mamta Patel Nagaraja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124779","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80","country_code":"US","type":"government","lineage":["https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mamta Patel Nagaraja","raw_affiliation_strings":["NASA Lyndon B. Johnson Space Center, Houston, TX 77058, USA. mamta.nagaraja@nasa.gov","NASA Lyndon B. Johnson Space Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NASA Lyndon B. Johnson Space Center, Houston, TX 77058, USA. mamta.nagaraja@nasa.gov","institution_ids":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]},{"raw_affiliation_string":"NASA Lyndon B. Johnson Space Center, Houston, Texas","institution_ids":["https://openalex.org/I4210149382"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111387176","display_name":"Diana Risin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana Risin","raw_affiliation_strings":["NASA Lyndon B. Johnson Space Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NASA Lyndon B. Johnson Space Center, Houston, Texas","institution_ids":["https://openalex.org/I4210149382"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022356715"],"corresponding_institution_ids":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":0.6522,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.5408837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"114","issue":"5","first_page":"1001","last_page":"1008"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.9259999990463257},{"id":"https://openalex.org/keywords/microgravity","display_name":"microgravity","score":0.7910000085830688},{"id":"https://openalex.org/keywords/spaceflight","display_name":"spaceflight","score":0.9629999995231628},{"id":"https://openalex.org/keywords/clinostat","display_name":"clinostat","score":0.8309999704360962},{"id":"https://openalex.org/keywords/bed-rest","display_name":"bed rest","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hindlimb-unloading","display_name":"hindlimb unloading","score":0.9990000128746033},{"id":"https://openalex.org/keywords/in-vitro-bone-model","display_name":"in vitro bone model","score":0.5569999814033508},{"id":"https://openalex.org/keywords/bone-cell-culture","display_name":"bone cell culture","score":0.35600000619888306},{"id":"https://openalex.org/keywords/astronauts","display_name":"astronauts","score":0.4830000102519989},{"id":"https://openalex.org/keywords/cosmonauts","display_name":"cosmonauts","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C103888896","wikidata":"https://www.wikidata.org/wiki/Q5916","display_name":"Spaceflight","level":2,"score":0.8427165746688843},{"id":"https://openalex.org/C2777854218","wikidata":"https://www.wikidata.org/wiki/Q850197","display_name":"Bed rest","level":2,"score":0.5897380113601685},{"id":"https://openalex.org/C2780179797","wikidata":"https://www.wikidata.org/wiki/Q345844","display_name":"Crew","level":2,"score":0.585411787033081},{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.4407652020454407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3330654203891754},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3321671485900879},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3208732604980469},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19296687841415405},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.18978285789489746},{"id":"https://openalex.org/C178802073","wikidata":"https://www.wikidata.org/wiki/Q8421","display_name":"Aeronautics","level":1,"score":0.1644519567489624},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.12211325764656067},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.11717924475669861},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001510","descriptor_name":"Bed Rest","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D013026","descriptor_name":"Space Flight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018474","descriptor_name":"Weightlessness Simulation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019417","descriptor_name":"Hindlimb Suspension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcb.24454","doi":"https://doi.org/10.1002/jcb.24454","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.24454","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:23150462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23150462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1048362","https://openalex.org/W174716201","https://openalex.org/W339942422","https://openalex.org/W1808022671","https://openalex.org/W1877825263","https://openalex.org/W1910347656","https://openalex.org/W1955559333","https://openalex.org/W1963978862","https://openalex.org/W1968738869","https://openalex.org/W1974305569","https://openalex.org/W1982931874","https://openalex.org/W1983061661","https://openalex.org/W1984300519","https://openalex.org/W1985920636","https://openalex.org/W1991060237","https://openalex.org/W1992401482","https://openalex.org/W1996355444","https://openalex.org/W1997921434","https://openalex.org/W2000231768","https://openalex.org/W2003301745","https://openalex.org/W2006429871","https://openalex.org/W2007451978","https://openalex.org/W2008087136","https://openalex.org/W2008383998","https://openalex.org/W2010231187","https://openalex.org/W2017279358","https://openalex.org/W2035049435","https://openalex.org/W2037156220","https://openalex.org/W2038120614","https://openalex.org/W2048973232","https://openalex.org/W2050518965","https://openalex.org/W2051545868","https://openalex.org/W2055658787","https://openalex.org/W2058903869","https://openalex.org/W2068682682","https://openalex.org/W2070420475","https://openalex.org/W2076372662","https://openalex.org/W2080199971","https://openalex.org/W2080462955","https://openalex.org/W2081531699","https://openalex.org/W2085466629","https://openalex.org/W2088737765","https://openalex.org/W2091643005","https://openalex.org/W2092875599","https://openalex.org/W2094779750","https://openalex.org/W2105834654","https://openalex.org/W2110802982","https://openalex.org/W2112322160","https://openalex.org/W2118532242","https://openalex.org/W2124169310","https://openalex.org/W2127905508","https://openalex.org/W2156503060","https://openalex.org/W2162830045","https://openalex.org/W2165926550","https://openalex.org/W2168081573","https://openalex.org/W2170258399","https://openalex.org/W2183374069","https://openalex.org/W2264374290","https://openalex.org/W2340257712","https://openalex.org/W2400294607","https://openalex.org/W2469442115","https://openalex.org/W4248536483"],"related_works":["https://openalex.org/W3111263499","https://openalex.org/W4223893755","https://openalex.org/W2038875390","https://openalex.org/W2124815360","https://openalex.org/W6989617803","https://openalex.org/W1991818811","https://openalex.org/W2732391","https://openalex.org/W1503413157","https://openalex.org/W4410526434","https://openalex.org/W2257205495"],"abstract_inverted_index":{"Bone":[0],"loss":[1,61,102,141,160],"is":[2,121,151],"a":[3,113,123],"well":[4],"documented":[5,100],"phenomenon":[6,18],"occurring":[7],"in":[8,11,14,26,33,70,78,86,92,103,106,136,142,169,175],"humans":[9,87],"both":[10],"short-":[12],"and":[13,28,30,41,88,116,144,165,168],"long-term":[15],"spaceflights.":[16],"This":[17],"can":[19],"be":[20],"also":[21,31],"reproduced":[22],"on":[23,50,158,182],"the":[24,45,51,56,82,95,110,128,154,184,191],"ground":[25],"human":[27,52],"animals":[29],"modeled":[32],"cell-based":[34],"analogs.":[35],"Since":[36],"space":[37],"flights":[38],"are":[39,75],"infrequent":[40],"expensive":[42],"to":[43,152,187,189],"study":[44],"biomedical":[46],"effects":[47],"of":[48,55,59,73,118,148,195],"microgravity":[49,74],"body,":[53],"much":[54,134],"known":[57],"pathology":[58,111],"bone":[60,101,140,159],"comes":[62],"from":[63,161],"experimental":[64],"studies.":[65],"The":[66,146],"most":[67,155,192],"commonly":[68],"used":[69],"vitro":[71,170],"simulators":[72,80],"clinostats":[76],"while":[77],"vivo":[79],"include":[81],"bed":[83,163],"rest":[84,164],"studies":[85,171],"hindlimb":[89,166],"unloading":[90],"experiments":[91],"animals.":[93],"Despite":[94],"numerous":[96],"reports":[97],"that":[98],"have":[99,131],"wide":[104],"ranges":[105],"multiple":[107],"crew":[108],"members,":[109],"remains":[112],"key":[114],"concern":[115],"development":[117,194],"effective":[119,196],"countermeasures":[120],"still":[122],"major":[124],"task.":[125],"Thus":[126],"far,":[127],"offered":[129],"modalities":[130],"not":[132],"shown":[133],"success":[135],"preventing":[137],"or":[138],"alleviating":[139],"astronauts":[143],"cosmonauts.":[145],"objective":[147],"this":[149,178],"review":[150,179],"capture":[153],"recent":[156],"research":[157,185],"spaceflights,":[162],"unloading,":[167],"utilizing":[172],"cellular":[173],"models":[174],"clinostats.":[176],"Additionally,":[177],"offers":[180],"projections":[181],"where":[183],"has":[186],"focus":[188],"ensure":[190],"rapid":[193],"countermeasures.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}