{"id":"https://openalex.org/W2124667377","doi":"https://doi.org/10.1016/s0006-3495(95)80114-1","title":"Cooperative subunit interactions in C-type inactivation of K channels","display_name":"Cooperative subunit interactions in C-type inactivation of K channels","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W2124667377","doi":"https://doi.org/10.1016/s0006-3495(95)80114-1","mag":"2124667377","pmid":"https://pubmed.ncbi.nlm.nih.gov/8599651","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1236482"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-3495(95)80114-1","doi":"https://doi.org/10.1016/s0006-3495(95)80114-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0006-3495(95)80114-1","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0006-3495(95)80114-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"E.M. Ogielska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.M. Ogielska","raw_affiliation_strings":["Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026207857","display_name":"William N. Zagotta","orcid":"https://orcid.org/0000-0002-7631-8168","observed_orcids":["https://orcid.org/0000-0002-7631-8168"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W.N. Zagotta","raw_affiliation_strings":["Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023729627","display_name":"Toshinori Hoshi","orcid":"https://orcid.org/0000-0002-0702-1918","observed_orcids":["https://orcid.org/0000-0002-0702-1918"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Hoshi","raw_affiliation_strings":["Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072746141","display_name":"Stefan H. Heinemann","orcid":"https://orcid.org/0000-0002-4144-0251","observed_orcids":["https://orcid.org/0000-0002-4144-0251"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.H. Heinemann","raw_affiliation_strings":["Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029042960","display_name":"Joan E. Haab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Haab","raw_affiliation_strings":["Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051410023","display_name":"Richard W. Aldrich","orcid":"https://orcid.org/0000-0001-7254-5876","observed_orcids":["https://orcid.org/0000-0001-7254-5876"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.W. Aldrich","raw_affiliation_strings":["Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":3.7161,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.94390804,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"69","issue":"6","first_page":"2449","last_page":"2457"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-type-inactivation","display_name":"C-type inactivation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tetrameric-channel","display_name":"tetrameric channel","score":0.6800000071525574},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.8019999861717224},{"id":"https://openalex.org/keywords/inactivation-rate","display_name":"inactivation rate","score":0.7480000257492065},{"id":"https://openalex.org/keywords/n-type-inactivation","display_name":"N-type inactivation","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.7741011381149292},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7061083316802979},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.657982587814331},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.616293728351593},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.44641977548599243},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.43789297342300415},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.41288289427757263},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3661500811576843},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28709495067596436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19431868195533752},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.05554598569869995},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051637","descriptor_name":"Shaker Superfamily of Potassium Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0006-3495(95)80114-1","doi":"https://doi.org/10.1016/s0006-3495(95)80114-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0006-3495(95)80114-1","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1455944","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC1236482","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1236482","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1236482","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophys J","raw_type":"Text"},{"id":"pmid:8599651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8599651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical journal","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/s0006-3495(95)80114-1","doi":"https://doi.org/10.1016/s0006-3495(95)80114-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0006-3495(95)80114-1","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1281904913","display_name":"MOLECULAR AND CELLULAR SIGNALLING IN SYNAPTIC PLASTICITY","funder_award_id":"5p50mh048108-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G182361111","display_name":"GATING OF ION CHANNELS IN EXCITABLE CELLS","funder_award_id":"5r01ns023294-14","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G236088066","display_name":null,"funder_award_id":"GM08327","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3628753639","display_name":"NEURAL INTEGRATION","funder_award_id":"T32GM008327","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3978475546","display_name":null,"funder_award_id":"NS-23294","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5075512226","display_name":null,"funder_award_id":"MH 48108","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1233451781","https://openalex.org/W1543746107","https://openalex.org/W1551993148","https://openalex.org/W1966667742","https://openalex.org/W1969870358","https://openalex.org/W1995426787","https://openalex.org/W1996071311","https://openalex.org/W1997711484","https://openalex.org/W2013413397","https://openalex.org/W2020164841","https://openalex.org/W2024464936","https://openalex.org/W2025440222","https://openalex.org/W2031226921","https://openalex.org/W2042183734","https://openalex.org/W2045457678","https://openalex.org/W2053926890","https://openalex.org/W2059093744","https://openalex.org/W2068312639","https://openalex.org/W2073892495","https://openalex.org/W2077585013","https://openalex.org/W2080615794","https://openalex.org/W2082585200","https://openalex.org/W2084366254","https://openalex.org/W2087306949","https://openalex.org/W2088734315","https://openalex.org/W2092936514","https://openalex.org/W2094349878","https://openalex.org/W2101625991","https://openalex.org/W2126725618","https://openalex.org/W2127849783","https://openalex.org/W2165071497","https://openalex.org/W2165830038","https://openalex.org/W2275222709","https://openalex.org/W2319794630","https://openalex.org/W4253271002"],"related_works":["https://openalex.org/W1522351604","https://openalex.org/W1995426787","https://openalex.org/W2793066722","https://openalex.org/W1985759871","https://openalex.org/W4403237690","https://openalex.org/W2161839172","https://openalex.org/W2108765087","https://openalex.org/W1966943380","https://openalex.org/W1526621956","https://openalex.org/W2031187957"],"abstract_inverted_index":{"C-type":[0,38,79,108,120],"inactivation":[1,11,39,45,59,109,121],"of":[2,16,20,28,32,47,53,64,97],"potassium":[3],"channels":[4,48],"is":[5,67,101],"distinct":[6],"from":[7,50],"N-terminal":[8],"mediated":[9],"(N-type)":[10],"and":[12,61,86],"involves":[13,82],"a":[14,74,89,92],"closing":[15],"the":[17,21,26,29,33,37,44,58,62,78,98,125],"outer":[18],"mouth":[19],"channel.":[22],"We":[23],"have":[24],"investigated":[25],"role":[27],"individual":[30,99],"subunits":[31,66,100],"tetrameric":[34],"channel":[35],"in":[36,95,107,123],"conformational":[40,80,93],"change":[41,81,94],"by":[42,73,113],"comparing":[43],"rates":[46],"constructed":[49],"different":[51],"combinations":[52],"subunits.":[54,129],"The":[55],"relationship":[56],"between":[57,116],"rate":[60],"number":[63],"fast":[65],"exponential,":[68],"as":[69],"would":[70],"be":[71],"predicted":[72],"cooperative":[75],"mechanism":[76,90],"where":[77,91],"all":[83],"four":[84],"subunits,":[85],"rules":[87],"out":[88],"any":[96],"sufficient":[102],"for":[103],"inactivation.":[104],"Subunit":[105],"interactions":[106],"are":[110],"further":[111],"supported":[112],"an":[114],"interaction":[115],"separate":[117,128],"mutations":[118],"affecting":[119],"when":[122],"either":[124],"same":[126],"or":[127]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}