{"id":"https://openalex.org/W2124644222","doi":"https://doi.org/10.1111/j.1525-142x.2010.00414.x","title":"Catching the phylogenic history through the ontogenic hourglass: a phylogenomic analysis ofDrosophilabody segmentation genes","display_name":"Catching the phylogenic history through the ontogenic hourglass: a phylogenomic analysis ofDrosophilabody segmentation genes","publication_year":2010,"publication_date":"2010-05-01","ids":{"openalex":"https://openalex.org/W2124644222","doi":"https://doi.org/10.1111/j.1525-142x.2010.00414.x","mag":"2124644222","pmid":"https://pubmed.ncbi.nlm.nih.gov/20565539"},"language":"en","primary_location":{"id":"doi:10.1111/j.1525-142x.2010.00414.x","doi":"https://doi.org/10.1111/j.1525-142x.2010.00414.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1525-142x.2010.00414.x","pdf_url":null,"source":{"id":"https://openalex.org/S51549918","display_name":"Evolution & Development","issn_l":"1520-541X","issn":["1520-541X","1525-142X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evolution & Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049779291","display_name":"Amir Yassin","orcid":"https://orcid.org/0000-0002-2590-5434","observed_orcids":["https://orcid.org/0000-0002-2590-5434"]},"institutions":[{"id":"https://openalex.org/I1338124936","display_name":"American Museum of Natural History","ror":"https://ror.org/03thb3e06","country_code":"US","type":"archive","lineage":["https://openalex.org/I1338124936"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amir Yassin","raw_affiliation_strings":["Sackler Institute for Comparative Genomics, American Museum of Natural History, 79th St. at Central Park West, NY 10024, USA. ayassin@amnh.org","Sackler Institute for Comparative Genomics, American Museum of Natural History, 79th St. at Central Park West, NY 10024, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sackler Institute for Comparative Genomics, American Museum of Natural History, 79th St. at Central Park West, NY 10024, USA. ayassin@amnh.org","institution_ids":["https://openalex.org/I1338124936"]},{"raw_affiliation_string":"Sackler Institute for Comparative Genomics, American Museum of Natural History, 79th St. at Central Park West, NY 10024, USA","institution_ids":["https://openalex.org/I1338124936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003057355","display_name":"E. Kurt Lienau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1338124936","display_name":"American Museum of Natural History","ror":"https://ror.org/03thb3e06","country_code":"US","type":"archive","lineage":["https://openalex.org/I1338124936"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Kurt Lienau","raw_affiliation_strings":["Sackler Institute for Comparative Genomics, American Museum of Natural History, 79th St. at Central Park West, NY 10024, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sackler Institute for Comparative Genomics, American Museum of Natural History, 79th St. at Central Park West, NY 10024, USA","institution_ids":["https://openalex.org/I1338124936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036725265","display_name":"Apurva Narechania","orcid":"https://orcid.org/0009-0007-0003-9246","observed_orcids":["https://orcid.org/0009-0007-0003-9246"]},"institutions":[{"id":"https://openalex.org/I1338124936","display_name":"American Museum of Natural History","ror":"https://ror.org/03thb3e06","country_code":"US","type":"archive","lineage":["https://openalex.org/I1338124936"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Apurva Narechania","raw_affiliation_strings":["Sackler Institute for Comparative Genomics, American Museum of Natural History, 79th St. at Central Park West, NY 10024, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sackler Institute for Comparative Genomics, American Museum of Natural History, 79th St. at Central Park West, NY 10024, USA","institution_ids":["https://openalex.org/I1338124936"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011665083","display_name":"Rob DeSalle","orcid":"https://orcid.org/0000-0002-6490-7109","observed_orcids":["https://orcid.org/0000-0002-6490-7109"]},"institutions":[{"id":"https://openalex.org/I1338124936","display_name":"American Museum of Natural History","ror":"https://ror.org/03thb3e06","country_code":"US","type":"archive","lineage":["https://openalex.org/I1338124936"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rob DeSalle","raw_affiliation_strings":["Sackler Institute for Comparative Genomics, American Museum of Natural History, 79th St. at Central Park West, NY 10024, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sackler Institute for Comparative Genomics, American Museum of Natural History, 79th St. at Central Park West, NY 10024, USA","institution_ids":["https://openalex.org/I1338124936"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049779291"],"corresponding_institution_ids":["https://openalex.org/I1338124936"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.6069,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.64275582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"3","first_page":"288","last_page":"295"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.2842000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12606","display_name":"Diptera species taxonomy and behavior","score":0.10170000046491623,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hourglass-model","display_name":"hourglass model","score":0.8560000061988831},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.718999981880188},{"id":"https://openalex.org/keywords/evolutionary-developmental-biology","display_name":"evolutionary developmental biology","score":0.6859999895095825},{"id":"https://openalex.org/keywords/phylogenetic-incongruence","display_name":"phylogenetic incongruence","score":0.8690000176429749},{"id":"https://openalex.org/keywords/branch-support","display_name":"branch support","score":0.656000018119812},{"id":"https://openalex.org/keywords/developmental-constraints","display_name":"developmental constraints","score":0.5630000233650208},{"id":"https://openalex.org/keywords/chromosomal-linkage","display_name":"chromosomal linkage","score":0.593999981880188},{"id":"https://openalex.org/keywords/rate-heterogeneity","display_name":"rate heterogeneity","score":0.5299999713897705},{"id":"https://openalex.org/keywords/phylogenomics","display_name":"phylogenomics","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8854281902313232},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.7861859798431396},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.6162840723991394},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.579265832901001},{"id":"https://openalex.org/C44465124","wikidata":"https://www.wikidata.org/wiki/Q713623","display_name":"Clade","level":4,"score":0.44946956634521484},{"id":"https://openalex.org/C148737382","wikidata":"https://www.wikidata.org/wiki/Q32831","display_name":"Body plan","level":3,"score":0.4412859380245209},{"id":"https://openalex.org/C176771619","wikidata":"https://www.wikidata.org/wiki/Q7189434","display_name":"Phylogenetic comparative methods","level":4,"score":0.4302327036857605},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26557251811027527},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2654302716255188}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1525-142x.2010.00414.x","doi":"https://doi.org/10.1111/j.1525-142x.2010.00414.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1525-142x.2010.00414.x","pdf_url":null,"source":{"id":"https://openalex.org/S51549918","display_name":"Evolution & Development","issn_l":"1520-541X","issn":["1520-541X","1525-142X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evolution & Development","raw_type":"journal-article"},{"id":"pmid:20565539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20565539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evolution & development","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.419.4803","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.419.4803","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://research.amnh.org/users/desalle/pdf/Yassin.2010.EvolDev.hourglass.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W373995060","https://openalex.org/W1511255518","https://openalex.org/W1933795817","https://openalex.org/W1967464318","https://openalex.org/W1993570130","https://openalex.org/W1994018924","https://openalex.org/W1998652190","https://openalex.org/W2007025047","https://openalex.org/W2017051353","https://openalex.org/W2017641297","https://openalex.org/W2025839948","https://openalex.org/W2032261613","https://openalex.org/W2035622691","https://openalex.org/W2037782528","https://openalex.org/W2041791362","https://openalex.org/W2043066342","https://openalex.org/W2069386222","https://openalex.org/W2071130759","https://openalex.org/W2078320544","https://openalex.org/W2078921046","https://openalex.org/W2086920518","https://openalex.org/W2090002702","https://openalex.org/W2090413996","https://openalex.org/W2099762535","https://openalex.org/W2101797035","https://openalex.org/W2105334464","https://openalex.org/W2106882534","https://openalex.org/W2110899053","https://openalex.org/W2113017061","https://openalex.org/W2114324651","https://openalex.org/W2117695991","https://openalex.org/W2128935959","https://openalex.org/W2132208795","https://openalex.org/W2133104753","https://openalex.org/W2135589046","https://openalex.org/W2140058066","https://openalex.org/W2148687854","https://openalex.org/W2148812946","https://openalex.org/W2160667533","https://openalex.org/W2160846446","https://openalex.org/W2160867220","https://openalex.org/W2163965551","https://openalex.org/W2183707334","https://openalex.org/W2225309729","https://openalex.org/W2314212563","https://openalex.org/W2317621048","https://openalex.org/W2319502789","https://openalex.org/W2327639708","https://openalex.org/W2328362484","https://openalex.org/W2332887878","https://openalex.org/W2506868775","https://openalex.org/W4210951524","https://openalex.org/W4231793298","https://openalex.org/W4242631111","https://openalex.org/W4255016905"],"related_works":["https://openalex.org/W7096720468","https://openalex.org/W2076849630","https://openalex.org/W1982510939","https://openalex.org/W2114480802","https://openalex.org/W2922867062","https://openalex.org/W2148812946","https://openalex.org/W2051418786","https://openalex.org/W2026606265","https://openalex.org/W7100456389","https://openalex.org/W4400743487"],"abstract_inverted_index":{"The":[0],"phylogenetic":[1,21,184,224],"information":[2,185],"content":[3,186],"of":[4,15,23,31,39,42,44,51,68,145,151,160,174,208,246,260,268,281,285,300,324],"different":[5],"developmental":[6,203,271,301,326],"stages":[7,75,189,204],"is":[8,293],"a":[9,107,134,155,236,251],"long-standing":[10],"issue":[11],"in":[12,28,33,54,95,154,244,258],"the":[13,37,40,61,66,77,89,137,143,148,170,175,191,206,228,240,247,255,261,278,282,291,296,321,325],"study":[14],"development":[16,45],"and":[17,104,112,124,163,250],"evolution.":[18],"We":[19,81,131,310],"performed":[20],"analyses":[22,315],"51":[24],"body":[25],"segmentation":[26],"genes":[27,53,302],"12":[29],"species":[30,62,241],"Drosophila":[32,55],"order":[34],"to":[35,216,232,295,305,320],"investigate":[36],"impact":[38,222],"mode":[41],"evolution":[43,330],"on":[46,147,223,328],"phylogeny":[47],"inference.":[48],"Previous":[49],"studies":[50],"these":[52],"using":[56,88,116],"pairwise":[57,332],"phenetic":[58,333],"comparisons":[59],"at":[60,239,254],"group":[63],"level":[64,177,243,257],"revealed":[65],"presence":[67],"an":[69],"\"hourglass":[70],"model\"":[71],"(HG),":[72],"wherein":[73],"mid-embryonic":[74],"are":[76,98],"most":[78,229],"evolutionarily":[79],"constrained.":[80],"utilized":[82],"two":[83],"character-based":[84,314],"approaches:":[85],"taxonomic":[86,176,233],"congruence":[87],"relative":[90],"consensus":[91],"fork":[92],"index":[93,139],"(RCFI),":[94],"which":[96,141],"phylogenies":[97],"inferred":[99],"from":[100,277],"each":[101],"gene":[102],"separately":[103],"compared":[105],"with":[106],"total":[108,149],"evidence":[109],"tree":[110],"(TET),":[111],"partitioned":[113],"simultaneous":[114,313],"analysis":[115],"several":[117],"indices":[118,165],"such":[119],"as":[120],"branch":[121],"support":[122,168,245,259,319],"(BS)":[123],"localized":[125],"incongruence":[126],"length":[127],"difference":[128],"(LILD)":[129],"test.":[130],"also":[132],"proposed":[133],"new":[135],"index,":[136,287],"recapitulatory":[138],"(R),":[140],"divides":[142],"number":[144,150],"synapomorphies":[146],"informative":[152],"characters":[153],"data":[156],"set.":[157],"Polynomial":[158],"adjustment":[159],"both":[161],"BS":[162],"R":[164],"showed":[166],"strong":[167],"for":[169,187],"hourglass":[171,248,322],"model":[172,249,272,323],"regardless":[173],"(species":[178],"subgroup":[179,242],"vs.":[180],"subgenera),":[181],"showing":[182,219],"less":[183],"mid-developmental":[188],"(mainly":[190],"zygotic":[192],"segment":[193],"polarity":[194],"stage).":[195],"Significant":[196],"LILD":[197],"scores":[198],"were":[199,213],"randomly":[200],"distributed":[201],"among":[202,308],"revealing":[205],"absence":[207],"differential":[209],"selective":[210],"constraints,":[211],"but":[212],"significantly":[214],"related":[215],"chromosomal":[217],"location":[218],"physical":[220],"(linkage)":[221],"incongruence.":[225],"RCFI":[226],"was":[227],"sensitive":[230],"measure":[231],"level,":[234],"having":[235],"convex":[237],"parabola":[238,253],"concave":[252],"subgeneric":[256],"adaptive":[262],"penetrance":[263],"model.":[264],"This":[265],"time-dependent":[266],"discrepancy":[267,292],"best":[269],"fit":[270],"parallels":[273],"previous":[274],"conflicting":[275],"results":[276],"vertebrates.":[279],"Because":[280],"quasi-phenetic":[283],"nature":[284],"this":[286],"we":[288],"argue":[289],"that":[290,312],"due":[294],"evolutionary":[297],"rate":[298],"heterogeneity":[299],"rather":[303],"than":[304,331],"fundamental":[306],"differences":[307],"organisms.":[309],"suggest":[311],"give":[316],"better":[317],"macroevolutionary":[318],"constraints":[327],"genome":[329],"comparisons.":[334]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}