{"id":"https://openalex.org/W2124635004","doi":"https://doi.org/10.1046/j.1460-9568.1999.00556.x","title":"Relationships between trait and state anxiety and the central benzodiazepine receptor: a PET study","display_name":"Relationships between trait and state anxiety and the central benzodiazepine receptor: a PET study","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W2124635004","doi":"https://doi.org/10.1046/j.1460-9568.1999.00556.x","mag":"2124635004","pmid":"https://pubmed.ncbi.nlm.nih.gov/10103141"},"language":"en","primary_location":{"id":"doi:10.1046/j.1460-9568.1999.00556.x","doi":"https://doi.org/10.1046/j.1460-9568.1999.00556.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1460-9568.1999.00556.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1460-9568.1999.00556.x","source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1460-9568.1999.00556.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109846169","display_name":"Pascale Abadie","orcid":"https://orcid.org/0009-0001-9861-5884","observed_orcids":["https://orcid.org/0009-0001-9861-5884"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Abadie","raw_affiliation_strings":["INSERM U 320, Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U 320, Caen, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104507431","display_name":"J.-P. Boulenger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. P. Boulenger","raw_affiliation_strings":["2","INSERM U 320, Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2","institution_ids":[]},{"raw_affiliation_string":"INSERM U 320, Caen, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Benali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"K. Benali","raw_affiliation_strings":["INSERM U 320, Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U 320, Caen, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070032516","display_name":"Louisa Barr\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210154143","display_name":"Cyceron","ror":"https://ror.org/04zeq1c51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210154143"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L. Barr\u00e9","raw_affiliation_strings":["CEA/DSV GDM-TEP, Cyceron, University of Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA/DSV GDM-TEP, Cyceron, University of Caen, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210154143","https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006612081","display_name":"E. Zarifian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114068","display_name":"Centre Hospitalier Universitaire de Caen Normandie","ror":"https://ror.org/027arzy69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210114068"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E. Zarifian","raw_affiliation_strings":["University Department of Psychiatry, Centre Esquirol, CHU Co\u0302te de Nacre, France","University Department of Psychiatry, Centre Esquirol, CHU C\u00f4te de Nacre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Psychiatry, Centre Esquirol, CHU Co\u0302te de Nacre, France","institution_ids":["https://openalex.org/I4210114068"]},{"raw_affiliation_string":"University Department of Psychiatry, Centre Esquirol, CHU C\u00f4te de Nacre, France","institution_ids":["https://openalex.org/I4210114068"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012826856","display_name":"Jean\u2010Claude Baron","orcid":"https://orcid.org/0000-0002-5264-2588","observed_orcids":["https://orcid.org/0000-0002-5264-2588"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J. C. Baron","raw_affiliation_strings":["2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5012826856"],"corresponding_institution_ids":[],"apc_list":{"value":3560,"currency":"USD","value_usd":3560},"apc_paid":null,"fwci":7.4311,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.96909264,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"4","first_page":"1470","last_page":"1478"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.47780001163482666,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.47780001163482666,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.2515000104904175,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.2249000072479248,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/central-benzodiazepine-receptor","display_name":"central benzodiazepine receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/trait-anxiety","display_name":"trait anxiety","score":0.9129999876022339},{"id":"https://openalex.org/keywords/state-anxiety","display_name":"state anxiety","score":1.0},{"id":"https://openalex.org/keywords/11c-flumazenil-pet","display_name":"11C-flumazenil PET","score":0.8679999709129333},{"id":"https://openalex.org/keywords/receptor-binding-density","display_name":"receptor binding density","score":0.5889999866485596},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.9580000042915344},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.7900000214576721},{"id":"https://openalex.org/keywords/neocortex","display_name":"neocortex","score":0.9589999914169312},{"id":"https://openalex.org/keywords/benzodiazepine-sensitivity","display_name":"benzodiazepine sensitivity","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C2778409475","wikidata":"https://www.wikidata.org/wiki/Q421920","display_name":"Flumazenil","level":4,"score":0.7191964387893677},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.6850637197494507},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.622829258441925},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6220201849937439},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.6058254241943359},{"id":"https://openalex.org/C205044023","wikidata":"https://www.wikidata.org/wiki/Q4778117","display_name":"Anxiogenic","level":4,"score":0.5771329998970032},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.5209392309188843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4613969027996063},{"id":"https://openalex.org/C89951826","wikidata":"https://www.wikidata.org/wiki/Q1671731","display_name":"Inverse agonist","level":4,"score":0.45964646339416504},{"id":"https://openalex.org/C2992367442","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Trait anxiety","level":3,"score":0.4473963975906372},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3668362498283386},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33269816637039185},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.299580454826355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28903019428253174},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.2327335774898529},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.22804990410804749}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005442","descriptor_name":"Flumazenil","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019655","descriptor_name":"Quantitative Trait, Heritable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1460-9568.1999.00556.x","doi":"https://doi.org/10.1046/j.1460-9568.1999.00556.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1460-9568.1999.00556.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1460-9568.1999.00556.x","source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:10103141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10103141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European journal of neuroscience","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1046/j.1460-9568.1999.00556.x","doi":"https://doi.org/10.1046/j.1460-9568.1999.00556.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1460-9568.1999.00556.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1460-9568.1999.00556.x","source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320314414","display_name":"Covis Pharma","ror":"https://ror.org/05s0pme69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124635004.pdf","grobid_xml":"https://content.openalex.org/works/W2124635004.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W133594102","https://openalex.org/W1965666249","https://openalex.org/W1972032416","https://openalex.org/W1983552236","https://openalex.org/W1984577458","https://openalex.org/W1985808875","https://openalex.org/W1987733559","https://openalex.org/W1990005524","https://openalex.org/W2000019377","https://openalex.org/W2003090874","https://openalex.org/W2007911341","https://openalex.org/W2008861645","https://openalex.org/W2011251830","https://openalex.org/W2014434433","https://openalex.org/W2023908259","https://openalex.org/W2025083501","https://openalex.org/W2027812268","https://openalex.org/W2034382494","https://openalex.org/W2041726742","https://openalex.org/W2044420664","https://openalex.org/W2046422881","https://openalex.org/W2047556230","https://openalex.org/W2049819189","https://openalex.org/W2051340164","https://openalex.org/W2055990086","https://openalex.org/W2059249562","https://openalex.org/W2060056442","https://openalex.org/W2060309546","https://openalex.org/W2066886309","https://openalex.org/W2079296458","https://openalex.org/W2082911868","https://openalex.org/W2084153778","https://openalex.org/W2093837465","https://openalex.org/W2094755979","https://openalex.org/W2096224638","https://openalex.org/W2114634718","https://openalex.org/W2139738030","https://openalex.org/W2164629069","https://openalex.org/W2319937903","https://openalex.org/W2320439911","https://openalex.org/W2405050690","https://openalex.org/W2596171374","https://openalex.org/W4210957923","https://openalex.org/W4240594947"],"related_works":["https://openalex.org/W2085961045","https://openalex.org/W2089236964","https://openalex.org/W2467753232","https://openalex.org/W2928022425","https://openalex.org/W2048021529","https://openalex.org/W2132360324","https://openalex.org/W2706223097","https://openalex.org/W2123233680","https://openalex.org/W2056008907","https://openalex.org/W2058471765"],"abstract_inverted_index":{"The":[0],"central":[1],"benzodiazepine":[2],"receptor":[3],"(cBZr)":[4],"has":[5],"long":[6],"been":[7,51],"implicated":[8],"in":[9,37,55,65,104,108,198,203,227,297,301],"anxiety":[10,135,212,290,319],"disorders":[11],"on":[12,264,310],"the":[13,17,56,61,66,72,97,102,189,204,209,233,240,257,265,295,316],"basis":[14],"of:":[15],"(i)":[16],"well-known":[18],"anxiolytic":[19],"and":[20,26,40,63,99,111,113,117,131,133,157,160,178,182,192,202,207,216,270,279,294,321],"anxiogenic":[21],"properties":[22,59],"of":[23,60,101,174,318,332],"cBZr":[24,103,129,268,296],"agonists":[25],"inverse":[27],"agonists,":[28],"respectively;":[29],"(ii)":[30],"a":[31,42,167,246,287],"possibly":[32],"reduced":[33],"sensitivity":[34],"to":[35,83,94,166,262,324],"benzodiazepines":[36],"anxious":[38],"subjects;":[39],"(iii)":[41],"putative":[43],"endogenous":[44],"ligand.":[45],"Thus,":[46],"two":[47,171,234,241,273],"main":[48],"hypothesis":[49],"have":[50,88,118,313],"advanced,":[52],"namely":[53],"changes":[54,64],"concentration":[57],"or":[58,230,292,299],"latter,":[62],"GABAA":[67],"complex":[68],"conformation,":[69],"which":[70],"contains":[71],"cBZr.":[73],"Neither":[74],"postmortem":[75],"studies":[76,309],"nor":[77],"appropriate":[78],"animal":[79],"models":[80,331],"are":[81],"available":[82],"investigate":[84],"these":[85],"ideas.":[86],"We":[87,137],"used":[89],"positron":[90],"emission":[91],"tomography":[92],"(PET)":[93],"measure":[95],"both":[96],"density":[98],"affinity":[100],"multiple":[105],"brain":[106],"regions":[107],"unmedicated":[109,140,163],"patients":[110,141],"age-":[112,159],"sex-matched":[114],"healthy":[115,162],"volunteers,":[116],"looked":[119],"for":[120,236,286,315],"differences":[121],"between":[122,128,232,267,289],"groups":[123,235],"as":[124,126],"well":[125],"correlations":[127],"parameters":[130,269],"state":[132,293],"trait":[134,291],"scores.":[136],"studied":[138],"10":[139,158],"(sex":[142],"ratio":[143],"1":[144],":":[145,194],"1;":[146],"mean":[147],"age:":[148],"39":[149],"years),":[150],"prospectively":[151],"recruited":[152],"using":[153,170],"DSM":[154],"III-R":[155],"criteria,":[156],"gender-matched":[161],"volunteers.":[164],"Thanks":[165],"PET":[168,210],"procedure":[169],"successive":[172],"administrations":[173],"11C-flumazenil":[175],"(at":[176],"high":[177],"low":[179],"specific":[180],"radioactivity)":[181],"previously":[183],"validated":[184],"by":[185,308],"us,":[186],"we":[187,282],"estimated":[188],"Bmax,":[190,228],"Kd":[191,229],"bound":[193],"free":[195],"(B/F)":[196],"ratios":[197],"11":[199],"neocortical":[200],"areas":[201],"cerebellum.":[205],"Before":[206],"after":[208],"session,":[211],"scores":[213],"from":[214],"Spielberger's":[215],"Covi's":[217],"scales":[218],"were":[219,244],"obtained.":[220],"There":[221],"was":[222],"no":[223,284],"statistically":[224],"significant":[225,249],"difference":[226],"B/F-values":[231],"any":[237],"region.":[238],"Across":[239],"groups,":[242],"there":[243],"only":[245],"few":[247],"marginally":[248],"anxiety-score-PET":[250],"correlations,":[251],"suggesting":[252],"chance":[253],"findings.":[254],"This":[255],"is":[256],"first":[258],"fully":[259],"quantitative":[260],"study":[261],"report":[263],"relationships":[266],"anxiety.":[271,333],"Using":[272],"independent":[274],"approaches":[275],"(i.e.":[276],"group":[277],"comparison":[278],"across-group":[280],"correlations),":[281],"found":[283],"evidence":[285],"link":[288],"neocortex":[298],"cerebellum":[300],"this":[302],"sample.":[303],"These":[304],"findings,":[305],"if":[306],"confirmed":[307],"larger":[311],"samples,":[312],"implications":[314],"pharmacotherapy":[317],"disorders,":[320],"will":[322],"need":[323],"be":[325],"considered":[326],"when":[327],"designing":[328],"new":[329],"neurobiological":[330]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}