{"id":"https://openalex.org/W2124600534","doi":null,"title":"RANKL protein is expressed at the pannus-bone interface at sites of erosion in rheumatoid arthritis","display_name":"RANKL protein is expressed at the pannus-bone interface at sites of erosion in rheumatoid arthritis","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2124600534","mag":"2124600534"},"language":"en","primary_location":{"id":"mag:2124600534","doi":null,"is_oa":false,"landing_page_url":"https://espace.library.uq.edu.au/view/UQ:197142","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034604471","display_name":"Allison Robyn Pettit","orcid":"https://orcid.org/0000-0003-4707-7892","observed_orcids":["https://orcid.org/0000-0003-4707-7892"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. R. Pettit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018214967","display_name":"Nicole C. Walsh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole C. Walsh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080984126","display_name":"Steven R. Goldring","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven R. Goldring","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024038808","display_name":"Ellen M. Gravallese","orcid":"https://orcid.org/0000-0002-0981-0996","observed_orcids":["https://orcid.org/0000-0002-0981-0996"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ellen M. Gravallese","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0981-0996","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17659523,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.5351999998092651,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.5351999998092651,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.4602000117301941,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.8489999771118164},{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.7960000038146973},{"id":"https://openalex.org/keywords/rank","display_name":"RANK","score":0.8600000143051147},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/bone-erosion","display_name":"bone erosion","score":0.9950000047683716},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/synovium","display_name":"synovium","score":0.9020000100135803},{"id":"https://openalex.org/keywords/subchondral-bone-erosion","display_name":"subchondral bone erosion","score":0.8360000252723694},{"id":"https://openalex.org/keywords/bone-microenvironment","display_name":"bone microenvironment","score":0.8309999704360962},{"id":"https://openalex.org/keywords/osteoclast-precursor-cells","display_name":"osteoclast precursor cells","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.9480788707733154},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.8396399021148682},{"id":"https://openalex.org/C2780426850","wikidata":"https://www.wikidata.org/wiki/Q3357478","display_name":"Osteoprotegerin","level":4,"score":0.6826797127723694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.591346025466919},{"id":"https://openalex.org/C2909639871","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANK Ligand","level":5,"score":0.5468645691871643},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5446585416793823},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.49410632252693176},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4543463885784149},{"id":"https://openalex.org/C2777746085","wikidata":"https://www.wikidata.org/wiki/Q1506304","display_name":"Pannus","level":3,"score":0.45327815413475037},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4516448676586151},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.4178040027618408},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.41309720277786255},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3587588369846344},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.354525625705719},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.2591792941093445}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2124600534","doi":null,"is_oa":false,"landing_page_url":"https://espace.library.uq.edu.au/view/UQ:197142","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2107773968","https://openalex.org/W2168231056","https://openalex.org/W2002593275","https://openalex.org/W1843249608","https://openalex.org/W2149688359","https://openalex.org/W4404173438","https://openalex.org/W2110670923","https://openalex.org/W2116389455","https://openalex.org/W2033937368","https://openalex.org/W2267905390"],"abstract_inverted_index":{"Bone":[0,37],"erosion":[1,38,128,223,244,284,321,340],"is":[2,11,69,116,304],"a":[3],"characteristic":[4],"feature":[5],"of":[6,25,32,79,98,104,142,159,220,231,266,282,308,317,330,333,338],"rheumatoid":[7],"arthritis":[8,27],"(RA)":[9],"and":[10,16,46,81,107,125,185,194,206,228,246,285,311,322,332],"associated":[12],"with":[13,17,182,196],"significant":[14],"morbidity":[15],"poor":[18],"prognosis.":[19],"We":[20],"previously":[21],"reported":[22,89],"the":[23,29,65,96,112,153,213,225,267,275,293,297,305,328,336],"generation":[24,73],"inflammatory":[26,75,342],"in":[28,42,50,52,58,74,90,111,129,212,243,258,264,274,292,335,341],"receptor":[30,84,102],"activator":[31,103],"NF-kB":[33,105],"ligand":[34],"(RANKL)-/-":[35],"mouse.":[36],"was":[39,161,200,216,256,272],"dramatically":[40],"reduced":[41],"arthritic":[43,53,59],"RANKL-/-":[44,60],"mice,":[45,55],"osteoclast-like":[47],"cells,":[48],"abundant":[49],"erosions":[51],"control":[54],"were":[56,145,240],"absent":[57],"mice.":[61],"These":[62],"data":[63],"support":[64,326],"hypothesis":[66],"that":[67,291],"RANKL":[68,80,210,286,331],"required":[70],"for":[71,327],"osteoclast":[72,237],"arthritis.":[76,343],"The":[77,288],"expression":[78,110,211,255,299,314],"its":[82,100],"decoy":[83],"osteoprotegerin":[85],"(OPG)":[86],"has":[87],"been":[88],"RA":[91,113,137,160,294,318],"synovial":[92,268],"soft":[93],"tissues.":[94],"However,":[95],"identification":[97],"RANKL,":[99,204,309],"receptor,":[101],"(RANK),":[106],"OPG":[108,207,254,312],"protein":[109,208,313],"bone":[114,127,181,193,195,214,222,233,251,277,283,295,320,339],"microenvironment":[115,215,296],"essential":[117],"to":[118,123,202,218],"fully":[119],"characterize":[120,203],"their":[121],"contribution":[122],"osteoclastogenesis":[124],"subsequent":[126],"RA.":[130],"Tissues":[131],"from":[132,176,192,261],"20":[133],"orthopedic":[134],"surgeries":[135],"on":[136,250],"patients":[138],"fulfilling":[139],"American":[140],"College":[141],"Rheumatology":[143],"criteria":[144],"collected":[146],"as":[147,150],"discarded":[148],"materials,":[149],"approved":[151],"by":[152],"Institutional":[154],"Review":[155],"Board.":[156],"Average":[157],"duration":[158],"16":[162],"yrs":[163],"(range":[164],"4":[165],"-":[166],"31":[167],"yrs).":[168],"Six":[169],"tissue":[170],"samples":[171,179,187],"contained":[172,180,188],"only":[173],"synovium/tenosynovium":[174],"remote":[175,191,260],"bone,":[177,262],"7":[178,186],"adjacent":[183,197],"synovium,":[184],"both":[189],"synovium":[190,259],"synovium.":[198],"Immunohistochemistry":[199],"used":[201],"RANK,":[205],"expression.":[209,287],"confined":[217],"sites":[219,230,245,281,316],"osteoclast-mediated":[221],"at":[224,229,280,315],"pannus-bone":[226],"interface":[227],"subchondral":[232],"erosion.":[234],"RANK":[235,310],"expressing":[236],"precursor":[238],"cells":[239,249,265],"also":[241],"present":[242],"most":[247],"multinucleated":[248],"expressed":[252],"RANK.":[253],"prominent":[257],"particularly":[263],"lining":[269],"layer,":[270],"but":[271],"minimal":[273],"local":[276],"microenvironment,":[278],"especially":[279],"results":[289],"indicate":[290],"RANKL/OPG":[298],"balance":[300],"favors":[301],"osteoclastogenesis.":[302],"This":[303],"first":[306],"demonstration":[307],"focal":[319],"provides":[323],"additional":[324],"strong":[325],"importance":[329],"osteoclasts":[334],"process":[337]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}