{"id":"https://openalex.org/W2124598613","doi":"https://doi.org/10.1083/jcb.137.1.221","title":"Interleukin 1\u03b2-converting Enzyme Related Proteases/Caspases Are Involved in TRAIL-induced Apoptosis of Myeloma and Leukemia Cells","display_name":"Interleukin 1\u03b2-converting Enzyme Related Proteases/Caspases Are Involved in TRAIL-induced Apoptosis of Myeloma and Leukemia Cells","publication_year":1997,"publication_date":"1997-04-07","ids":{"openalex":"https://openalex.org/W2124598613","doi":"https://doi.org/10.1083/jcb.137.1.221","mag":"2124598613","pmid":"https://pubmed.ncbi.nlm.nih.gov/9105050","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2139852"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.137.1.221","doi":"https://doi.org/10.1083/jcb.137.1.221","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.137.1.221","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2139852","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033363853","display_name":"Sara M Mariani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sara M. Mariani","raw_affiliation_strings":["Tumor Immunology, German Cancer Research Center, Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Immunology, German Cancer Research Center, Heidelberg","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023657550","display_name":"Bernd Matiba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bernd Matiba","raw_affiliation_strings":["German cancer Research Center (DKFZ);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German cancer Research Center (DKFZ);","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061586749","display_name":"Elena A. Armandola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elena A. Armandola","raw_affiliation_strings":["Tumor Immunology and *Molecular Immunology Program/Division of Immunogenetics, German Cancer Research Center, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Immunology and *Molecular Immunology Program/Division of Immunogenetics, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068388891","display_name":"Peter H. Krammer","orcid":"https://orcid.org/0000-0002-4584-1589","observed_orcids":["https://orcid.org/0000-0002-4584-1589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter H. Krammer","raw_affiliation_strings":["Tumor Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Immunology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023657550"],"corresponding_institution_ids":["https://openalex.org/I17937529"],"apc_list":null,"apc_paid":null,"fwci":4.862,"has_fulltext":false,"cited_by_count":144,"citation_normalized_percentile":{"value":0.96504508,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"137","issue":"1","first_page":"221","last_page":"229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.9959999918937683},{"id":"https://openalex.org/keywords/interleukin-1-beta-converting-enzyme","display_name":"interleukin-1 beta converting enzyme","score":0.8769999742507935},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.9509999752044678},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6700000166893005},{"id":"https://openalex.org/keywords/myeloma-cells","display_name":"myeloma cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/leukemia-cells","display_name":"leukemia cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tnf-family-ligands","display_name":"TNF family ligands","score":0.847000002861023},{"id":"https://openalex.org/keywords/parp-cleavage","display_name":"PARP cleavage","score":0.7269999980926514},{"id":"https://openalex.org/keywords/ac-devd-cho","display_name":"Ac-DEVD-CHO","score":0.906000018119812},{"id":"https://openalex.org/keywords/ac-yvad-cmk","display_name":"Ac-YVAD-cmk","score":0.953000009059906},{"id":"https://openalex.org/keywords/receptor-sensitivity","display_name":"receptor sensitivity","score":0.32499998807907104},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.729628324508667},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7167091369628906},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.6754426956176758},{"id":"https://openalex.org/C170301204","wikidata":"https://www.wikidata.org/wiki/Q24788681","display_name":"Inhibitor of apoptosis domain","level":5,"score":0.5766169428825378},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.5755174160003662},{"id":"https://openalex.org/C3031857","wikidata":"https://www.wikidata.org/wiki/Q1649375","display_name":"Fas receptor","level":4,"score":0.5594606995582581},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.5358082056045532},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.5238870978355408},{"id":"https://openalex.org/C163421366","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Intrinsic apoptosis","level":5,"score":0.5087845921516418},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.5027034282684326},{"id":"https://openalex.org/C2779637612","wikidata":"https://www.wikidata.org/wiki/Q2354337","display_name":"Phosphatidylserine","level":4,"score":0.4732423722743988},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46411970257759094},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4564535617828369},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.32171863317489624},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2701845169067383},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.17366808652877808},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16164252161979675},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.15813195705413818},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1382782757282257},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.10438892245292664},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000590","descriptor_name":"Amino Acid Chloromethyl Ketones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D020170","descriptor_name":"Caspase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1083/jcb.137.1.221","doi":"https://doi.org/10.1083/jcb.137.1.221","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.137.1.221","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2139852","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2139852","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:9105050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9105050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.273.4184","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.273.4184","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7c/00/J_Cell_Biol_1997_Apr_7_137(1)_221-229.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2139852","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2139852","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W174558702","https://openalex.org/W1496938524","https://openalex.org/W1517945724","https://openalex.org/W1592205925","https://openalex.org/W1597733532","https://openalex.org/W1598082435","https://openalex.org/W1836073275","https://openalex.org/W1940692702","https://openalex.org/W1963688949","https://openalex.org/W1964977785","https://openalex.org/W1968328677","https://openalex.org/W1970839214","https://openalex.org/W1978857213","https://openalex.org/W1981106016","https://openalex.org/W1981182552","https://openalex.org/W1983532054","https://openalex.org/W1986308149","https://openalex.org/W1990917512","https://openalex.org/W1996180957","https://openalex.org/W2002733542","https://openalex.org/W2004487378","https://openalex.org/W2004645606","https://openalex.org/W2005825891","https://openalex.org/W2007689766","https://openalex.org/W2010298858","https://openalex.org/W2010819488","https://openalex.org/W2015313594","https://openalex.org/W2021126994","https://openalex.org/W2023817459","https://openalex.org/W2025335867","https://openalex.org/W2026614008","https://openalex.org/W2032417513","https://openalex.org/W2033107803","https://openalex.org/W2034325959","https://openalex.org/W2041466047","https://openalex.org/W2043921854","https://openalex.org/W2050927367","https://openalex.org/W2052691929","https://openalex.org/W2056217426","https://openalex.org/W2056924500","https://openalex.org/W2065413461","https://openalex.org/W2067534266","https://openalex.org/W2073914550","https://openalex.org/W2075809552","https://openalex.org/W2076656122","https://openalex.org/W2077502850","https://openalex.org/W2078001244","https://openalex.org/W2081145901","https://openalex.org/W2083363077","https://openalex.org/W2086313080","https://openalex.org/W2094334993","https://openalex.org/W2095393371","https://openalex.org/W2125076585","https://openalex.org/W2130988210","https://openalex.org/W2148911589","https://openalex.org/W2161261662","https://openalex.org/W2166291746","https://openalex.org/W2167016388","https://openalex.org/W3102668775","https://openalex.org/W6658669141"],"related_works":["https://openalex.org/W7098459930","https://openalex.org/W2018837825","https://openalex.org/W2046408479","https://openalex.org/W1988854695","https://openalex.org/W2583048795","https://openalex.org/W4229536629","https://openalex.org/W2326577933","https://openalex.org/W2323955045","https://openalex.org/W2162628305","https://openalex.org/W7099964962"],"abstract_inverted_index":{"The":[0,147],"Fas/APO-1/CD95":[1],"ligand":[2,9],"(CD95L)":[3],"and":[4,14,44,55,116,151,167,245],"the":[5,12,16,30,70,76,90,114,152,157,202,205,251],"recently":[6],"cloned":[7],"TRAIL":[8,72,198,231,246],"belong":[10],"to":[11,18,86,102,105,111,200,214,238,243,248,250],"TNF-family":[13],"share":[15],"ability":[17],"induce":[19],"apoptosis":[20,137,181,216,226],"in":[21,39,135,227,234],"sensitive":[22,104,228],"target":[23,42],"cells.":[24,95],"Little":[25],"information":[26],"is":[27,83],"available":[28],"on":[29],"degree":[31],"of":[32,41,78,93,113,138,161,169,184,204,225],"functional":[33,71],"redundancy":[34],"between":[35],"these":[36,50],"two":[37],"ligands":[38],"terms":[40],"selectivity":[43],"intracellular":[45],"signalling":[46],"pathway(s).":[47],"To":[48,122],"address":[49],"issues,":[51],"we":[52],"have":[53],"expressed":[54],"characterized":[56],"recombinant":[57,79],"mouse":[58],"TRAIL.":[59],"Specific":[60],"detection":[61],"with":[62,89,173,256],"newly":[63],"developed":[64],"rabbit":[65],"anti-TRAIL":[66],"antibodies":[67],"showed":[68],"that":[69,87,188,197],"molecule":[73],"released":[74],"into":[75],"supernatant":[77],"baculovirus-infected":[80],"Sf9":[81,94],"cells":[82,99,120,178,229],"very":[84],"similar":[85,110,237],"associated":[88,172,255],"membrane":[91,163],"fraction":[92],"CD95L":[96,244],"resistant":[97],"myeloma":[98],"were":[100,145],"found":[101],"be":[103],"TRAIL,":[106],"displaying":[107],"apoptotic":[108],"features":[109],"those":[112],"CD95L-":[115],"TRAIL-sensitive":[117],"T":[118],"leukemia":[119],"Jurkat.":[121],"assess":[123],"if":[124],"IL-1beta-converting":[125],"enzyme":[126],"(ICE)":[127],"and/or":[128],"ICE-related":[129],"proteases":[130],"(IRPs)":[131],"(caspases)":[132],"are":[133],"involved":[134],"TRAIL-induced":[136,174],"both":[139],"cell":[140,170],"types,":[141],"peptide":[142],"inhibition":[143],"experiments":[144],"performed.":[146],"irreversible":[148],"IRP/caspase-inhibitor":[149,154],"Ac-YVAD-cmk":[150],"reversible":[153],"Ac-DEVD-CHO":[155],"blocked":[156,191],"morphological":[158],"changes,":[159],"disorganization":[160],"plasma":[162],"phospholipids,":[164],"DNA":[165],"fragmentation,":[166],"loss":[168],"viability":[171],"apoptosis.":[175],"In":[176],"addition,":[177],"undergoing":[179],"TRAIL-mediated":[180],"displayed":[182],"cleavage":[183],"poly(ADP)-ribose":[185],"polymerase":[186],"(PARP)":[187],"was":[189],"completely":[190],"by":[192,218,230],"Ac-DEVD-CHO.":[193],"These":[194],"results":[195],"indicate":[196],"seems":[199,247],"complement":[201],"activity":[203],"CD95":[206],"system":[207],"as":[208],"it":[209],"allows":[210],"cells,":[211],"otherwise":[212],"resistant,":[213],"undergo":[215],"triggered":[217],"specific":[219],"extracellular":[220],"ligands.":[221],"Conversely,":[222],"however,":[223],"induction":[224],"involves":[232],"IRPs/caspases":[233],"a":[235],"fashion":[236],"CD95L.":[239],"Thus,":[240],"differential":[241],"sensitivity":[242],"map":[249],"proximal":[252],"signaling":[253],"events":[254],"receptor":[257],"triggering.":[258]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}