{"id":"https://openalex.org/W2124584113","doi":"https://doi.org/10.1046/j.1365-2958.1997.2321612.x","title":"Integration host factor is a transcriptional cofactor of pilE in Neisseria gonorrhoeae","display_name":"Integration host factor is a transcriptional cofactor of pilE in Neisseria gonorrhoeae","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W2124584113","doi":"https://doi.org/10.1046/j.1365-2958.1997.2321612.x","mag":"2124584113","pmid":"https://pubmed.ncbi.nlm.nih.gov/9157237"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2958.1997.2321612.x","doi":"https://doi.org/10.1046/j.1365-2958.1997.2321612.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2958.1997.2321612.x","pdf_url":null,"source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105194110","display_name":"Stuart A. Hill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stuart A. Hill","raw_affiliation_strings":["Laboratory of Microbial Structure and Function, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA. Stuart_Hill@nih.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Microbial Structure and Function, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA. Stuart_Hill@nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4405287673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058983331","display_name":"D. Scott Samuels","orcid":"https://orcid.org/0000-0001-8352-7593","observed_orcids":["https://orcid.org/0000-0001-8352-7593"]},"institutions":[{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Scott Samuels","raw_affiliation_strings":["Laboratory of Vectors and Pathogens, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Vectors and Pathogens, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA","institution_ids":["https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081601053","display_name":"John H. Carlson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John H. Carlson","raw_affiliation_strings":["Laboratory of Microbial Structure and Function,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Microbial Structure and Function,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109224337","display_name":"Jeanne M. Wilson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeanne Wilson","raw_affiliation_strings":["Laboratory of Microbial Structure and Function,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Microbial Structure and Function,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079873841","display_name":"Dan Hogan","orcid":"https://orcid.org/0000-0003-1636-2594","observed_orcids":["https://orcid.org/0000-0003-1636-2594"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan Hogan","raw_affiliation_strings":["Laboratory of Microbial Structure and Function,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Microbial Structure and Function,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018616821","display_name":"Lori L. Lubke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lori Lubke","raw_affiliation_strings":["Laboratory of Vectors and Pathogens, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Vectors and Pathogens, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA","institution_ids":["https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077894116","display_name":"Robert J. Belland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert J. Belland","raw_affiliation_strings":["Laboratory of Microbial Structure and Function,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Microbial Structure and Function,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5105194110"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4405287673"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":1.3137,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.80409042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"23","issue":"4","first_page":"649","last_page":"656"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integration-host-factor","display_name":"integration host factor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hemorrhoids","display_name":"hemorrhoids","score":0.7490000128746033},{"id":"https://openalex.org/keywords/neisseria-gonorrhoeae","display_name":"Neisseria gonorrhoeae","score":0.9929999709129333},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.9110000133514404},{"id":"https://openalex.org/keywords/dna-binding-proteins","display_name":"DNA-binding proteins","score":0.8259999752044678},{"id":"https://openalex.org/keywords/promoter-binding-sites","display_name":"promoter binding sites","score":0.6209999918937683},{"id":"https://openalex.org/keywords/dna-kinking","display_name":"DNA kinking","score":0.7210000157356262},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2779166590","wikidata":"https://www.wikidata.org/wiki/Q131129","display_name":"Neisseria gonorrhoeae","level":2,"score":0.9359732866287231},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9175996780395508},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5356924533843994},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5174787044525146},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.4647155702114105},{"id":"https://openalex.org/C2777627835","wikidata":"https://www.wikidata.org/wiki/Q16963978","display_name":"Host factor","level":3,"score":0.45103487372398376},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3190488815307617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1867891550064087},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.051512300968170166},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.049424827098846436}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009344","descriptor_name":"Neisseria gonorrhoeae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009344","descriptor_name":"Neisseria gonorrhoeae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034982","descriptor_name":"Integration Host Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036781","descriptor_name":"Fimbriae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2958.1997.2321612.x","doi":"https://doi.org/10.1046/j.1365-2958.1997.2321612.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2958.1997.2321612.x","pdf_url":null,"source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},{"id":"pmid:9157237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9157237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2167000063","https://openalex.org/W2056752318","https://openalex.org/W2052514587","https://openalex.org/W2168580735","https://openalex.org/W2042651784","https://openalex.org/W2100276017","https://openalex.org/W286317168","https://openalex.org/W1998456347","https://openalex.org/W2037462049","https://openalex.org/W2090273404"],"abstract_inverted_index":{"Integration":[0],"host":[1],"factor":[2],"(IHF)":[3],"is":[4,142],"a":[5,96,101,143],"small,":[6],"heterodimeric":[7],"DNA-binding":[8],"protein":[9],"with":[10,85],"pleiotropic":[11],"function.":[12],"IHF":[13,27,126,141],"was":[14,36,109,133],"purified":[15],"to":[16,28,46],"apparent":[17],"homogeneity":[18],"from":[19,58],"Neisseria":[20],"gonorrhoeae.":[21],"Gel-retardation":[22],"assays":[23,42],"demonstrated":[24],"binding":[25,127],"of":[26,53,64,79,116,125,146],"the":[29,54,65,106,123,129],"pilE":[30,50,59,80,98,103,130],"promoter":[31,60,81],"region.":[32],"The":[33],"IHF-binding":[34,56,107],"site":[35],"identified":[37],"by":[38,70],"DNase":[39],"I":[40],"protection":[41],"and":[43,113],"mapped":[44],"proximal":[45],"three":[47],"previously":[48],"defined":[49],"promoters.":[51],"Removal":[52],"putative":[55],"domain":[57,108],"DNA":[61,66,82],"negated":[62],"retardation":[63],"fragment":[67],"when":[68],"assessed":[69],"gel-shift":[71],"analysis.":[72],"Kleinschmidt":[73],"electron":[74],"microscopy":[75],"showed":[76,120],"pronounced":[77],"kinking":[78],"following":[83],"incubation":[84],"IHF.":[86],"Isogenic":[87],"N.":[88],"gonorrhoeae":[89],"strains":[90],"were":[91],"constructed":[92],"that":[93,121,140],"contained":[94],"either":[95],"wild-type":[97],"locus":[99,104],"or":[100],"deleted":[102],"where":[105],"removed.":[110],"Primer-extension":[111],"analysis":[112],"Northern":[114],"blotting":[115],"total":[117],"gonococcal":[118],"RNA":[119],"in":[122],"absence":[124],"at":[128],"promoter,":[131],"transcription":[132],"reduced":[134],"10-fold.":[135],"Together,":[136],"these":[137],"data":[138],"indicate":[139],"transcriptional":[144],"co-activator":[145],"pilE.":[147]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
