{"id":"https://openalex.org/W2124505652","doi":null,"title":"Functional profiling to select chemotherapy in untreated, advanced or metastatic non-small cell lung cancer.","display_name":"Functional profiling to select chemotherapy in untreated, advanced or metastatic non-small cell lung cancer.","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2124505652","mag":"2124505652","pmid":"https://pubmed.ncbi.nlm.nih.gov/23060572"},"language":"en","primary_location":{"id":"pmid:23060572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23060572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001924684","display_name":"Robert Alan Nagourney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801202167","display_name":"MemorialCare Long Beach Medical Center","ror":"https://ror.org/021kgjd57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801202167","https://openalex.org/I4210125374"]},{"id":"https://openalex.org/I4210111322","display_name":"Long Beach Medical Center","ror":"https://ror.org/02rt3gt49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111322","https://openalex.org/I4210125374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A Nagourney","raw_affiliation_strings":["Memorial Medical Center of Long Beach, Todd Cancer Institute, Long Beach, CA, USA. rnagourney@rational-t.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Medical Center of Long Beach, Todd Cancer Institute, Long Beach, CA, USA. rnagourney@rational-t.com","institution_ids":["https://openalex.org/I2801202167","https://openalex.org/I4210111322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044285662","display_name":"Jonathan B. Blitzer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan B Blitzer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Robert L Shuman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert L Shuman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016289067","display_name":"T. Asciuto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas J Asciuto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065560940","display_name":"Eknath A. Deo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eknath A Deo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Marylyn Paulsen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marylyn Paulsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074263106","display_name":"Robert L. Newcomb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert L Newcomb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006369244","display_name":"Steven Scott Evans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve S Evans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.98,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.80275054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"32","issue":"10","first_page":"4453","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.05180000141263008,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/metastatic-lung-cancer","display_name":"metastatic lung cancer","score":0.871999979019165},{"id":"https://openalex.org/keywords/chemotherapy-selection","display_name":"chemotherapy selection","score":0.8169999718666077},{"id":"https://openalex.org/keywords/drug-induced-cell-death","display_name":"drug-induced cell death","score":0.871999979019165},{"id":"https://openalex.org/keywords/functional-profiling","display_name":"functional profiling","score":0.6420000195503235},{"id":"https://openalex.org/keywords/primary-tumor-cultures","display_name":"primary tumor cultures","score":0.49900001287460327},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5519999861717224},{"id":"https://openalex.org/keywords/time-to-progression","display_name":"time to progression","score":0.7770000100135803},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7339109778404236},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6560072898864746},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6303771734237671},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6060907244682312},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5807774662971497},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4442659616470337},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44271910190582275},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33914393186569214},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17860808968544006}],"mesh":[{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012983","descriptor_name":"Soft Tissue Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012983","descriptor_name":"Soft Tissue Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23060572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23060572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2124505652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23060572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1564426280","https://openalex.org/W1871271676","https://openalex.org/W1909141355","https://openalex.org/W1935885922","https://openalex.org/W1967802960","https://openalex.org/W1969525589","https://openalex.org/W1977088192","https://openalex.org/W1983730183","https://openalex.org/W2021292361","https://openalex.org/W2024812794","https://openalex.org/W2037139573","https://openalex.org/W2043696829","https://openalex.org/W2052853635","https://openalex.org/W2084001490","https://openalex.org/W2086421866","https://openalex.org/W2102610315","https://openalex.org/W2104830962","https://openalex.org/W2106042158","https://openalex.org/W2112503651","https://openalex.org/W2115157373","https://openalex.org/W2119366998","https://openalex.org/W2131321361","https://openalex.org/W2133296598","https://openalex.org/W2136644329","https://openalex.org/W2139248078","https://openalex.org/W2143143350","https://openalex.org/W2145005661","https://openalex.org/W2145835533","https://openalex.org/W2146276249","https://openalex.org/W2277967930","https://openalex.org/W2324548112","https://openalex.org/W2407270868"],"related_works":["https://openalex.org/W2246064193","https://openalex.org/W2249725088","https://openalex.org/W2528014407","https://openalex.org/W4416357241","https://openalex.org/W2338690884","https://openalex.org/W4393093966","https://openalex.org/W4280494313","https://openalex.org/W7014729864","https://openalex.org/W7062672266","https://openalex.org/W7112700446"],"abstract_inverted_index":{"BACKGROUND/AIM:":[0],"To":[1],"assess":[2],"the":[3,9],"impact":[4],"of":[5,11,75,87,104,110,118],"drug":[6],"selection":[7],"upon":[8],"treatment":[10],"advanced":[12],"and":[13,48,58,94,113,127,135,142],"metastatic":[14],"non-small":[15],"cell":[16,28],"lung":[17],"cancer":[18],"(NSCLC),":[19],"we":[20],"applied":[21],"a":[22,98,107,114,129],"functional":[23,123],"platform":[24,124],"that":[25],"measures":[26],"drug-induced":[27,54],"death":[29],"in":[30,137],"human":[31],"tumor":[32],"primary-culture":[33],"micro-spheroids":[34],"isolated":[35,45],"from":[36],"surgical":[37],"specimens.":[38],"PATIENTS":[39],"AND":[40],"METHODS:":[41],"At":[42],"diagnosis,":[43],"microspheroids":[44],"by":[46,56],"mechanical":[47],"enzymatic":[49],"disaggregation":[50],"were":[51,62,77],"examined":[52],"for":[53],"cell-death":[55],"morphology":[57],"staining":[59],"characteristics.":[60],"Drugs":[61],"administered":[63],"using":[64],"standard":[65],"protocols.":[66],"Thirty-one":[67],"patients,":[68],"who":[69],"received":[70],"at":[71],"least":[72],"one":[73],"cycle":[74],"therapy,":[76],"evaluable.":[78],"All":[79],"patients":[80,89],"signed":[81],"informed":[82],"consent.":[83],"RESULTS:":[84],"Twenty":[85],"out":[86],"31":[88],"responded":[90],"(64.5%),":[91],"1":[92],"completely":[93],"19":[95],"partially,":[96],"providing":[97],"two-fold":[99],"improvement":[100],"over":[101],"historical":[102],"control":[103],"30%":[105],"(p=0.00015),":[106],"median":[108,115],"time-to-progression":[109,134],"8.5":[111],"months":[112],"overall":[116],"survival":[117,136],"21.3":[119],"months.":[120],"CONCLUSION:":[121],"This":[122],"is":[125],"feasible":[126],"provides":[128],"favorable":[130],"objective":[131],"response":[132],"rate,":[133],"advanced,":[138],"metastatic,":[139],"untreated":[140],"NSCLC,":[141],"warrants":[143],"further":[144],"evaluation.":[145]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
