{"id":"https://openalex.org/W2124486294","doi":"https://doi.org/10.1016/j.jalz.2006.05.2238","title":"IC\u2013P\u2013033: Adult children of AD parent have smaller hippocampal volumes","display_name":"IC\u2013P\u2013033: Adult children of AD parent have smaller hippocampal volumes","publication_year":2006,"publication_date":"2006-07-01","ids":{"openalex":"https://openalex.org/W2124486294","doi":"https://doi.org/10.1016/j.jalz.2006.05.2238","mag":"2124486294"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2006.05.2238","doi":"https://doi.org/10.1016/j.jalz.2006.05.2238","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2006.05.2238","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2006.05.2238","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2006.05.2238","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110743613","display_name":"Maureen V. Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maureen V. Martin","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436146","display_name":"Lei Wang","orcid":"https://orcid.org/0000-0003-3870-3388","observed_orcids":["https://orcid.org/0000-0003-3870-3388"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lei Wang","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004862239","display_name":"J. Philip Miller","orcid":"https://orcid.org/0000-0003-4568-6846","observed_orcids":["https://orcid.org/0000-0003-4568-6846"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.P. Miller","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110115794","display_name":"Mokhtar H. Gado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mokhtar H. Gado","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033151214","display_name":"Michael I. Miller","orcid":"https://orcid.org/0000-0003-4689-3855","observed_orcids":["https://orcid.org/0000-0003-4689-3855"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael I. Miller","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063630764","display_name":"John C. Morris","orcid":"https://orcid.org/0000-0001-9820-5618","observed_orcids":["https://orcid.org/0000-0001-9820-5618","https://orcid.org/0000-0002-6854-5547"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Morris","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072481624","display_name":"John G. Csernansky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John G. Csernansky","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100436146"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22352898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"3S_Part_22","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hippocampal-volume","display_name":"hippocampal volume","score":0.9240000247955322}],"concepts":[{"id":"https://openalex.org/C2778499278","wikidata":"https://www.wikidata.org/wiki/Q1499420","display_name":"Subiculum","level":4,"score":0.9660120010375977},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.904231071472168},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6852982044219971},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5256779789924622},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4924539029598236},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4392591714859009},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.40171509981155396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36143654584884644},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28089678287506104},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17811167240142822},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2006.05.2238","doi":"https://doi.org/10.1016/j.jalz.2006.05.2238","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2006.05.2238","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2006.05.2238","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2006.05.2238","doi":"https://doi.org/10.1016/j.jalz.2006.05.2238","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2006.05.2238","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2006.05.2238","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G8355933339","display_name":null,"funder_award_id":"916.36.117","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124486294.pdf","grobid_xml":"https://content.openalex.org/works/W2124486294.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4205950791","https://openalex.org/W1984232229","https://openalex.org/W1978227671","https://openalex.org/W1976154578","https://openalex.org/W1988963873","https://openalex.org/W1992992703","https://openalex.org/W2163031770","https://openalex.org/W2008022914","https://openalex.org/W2087567887","https://openalex.org/W2082290432"],"abstract_inverted_index":{"In":[0],"previous":[1,211],"MR":[2,123],"studies":[3],"of":[4,8,20,37,77,85,96,105,121,125,152,176,254,303,305,318,343],"very":[5],"mild":[6],"dementia":[7],"the":[9,21,52,73,78,81,106,111,118,194,251,284,291,298,316,328],"Alzheimer":[10],"type":[11],"(DAT),":[12],"we":[13],"reported":[14],"smaller":[15,97,310,337],"hippocampal":[16,22,38,98,107,191,202,271,311,338],"volumes":[17,312,339],"and":[18,29,40,75,89,100,113,159,162,247,286,340],"deformities":[19],"surface":[23,41,108,203],"zones":[24],"corresponding":[25,109],"to":[26,54,67,110,186,189,315],"underlying":[27],"CA1":[28,112],"subiculum":[30,114],"subfields.":[31],"This":[32,294,325],"finding":[33,326],"suggests":[34,296],"that":[35,94,297,330],"irregularities":[36],"volume":[39,74,99],"shape":[42,76,103,244,248],"distinguish":[43],"subjects":[44,138,146,153,208,255,306,321],"with":[45,87,129,133,135,154,307],"early":[46,59],"DAT":[47,88,134,308],"from":[48,148,168,193,205,209,225],"nondemented":[49],"subjects,":[50],"but":[51,289],"degree":[53],"which":[55],"such":[56],"findings":[57],"represent":[58],"form":[60],"degeneration":[61],"or":[62],"a":[63,130,173,210,216,263,333],"long\u2013standing":[64,334],"\u201canatomic\u201d":[65],"vulnerability":[66],"disease":[68,346],"is":[69,332],"unknown.":[70],"We":[71,92],"assessed":[72],"hippocampus":[79],"in":[80,141,196,221,258,270,283],"middle\u2013aged,":[82],"adult":[83,127],"children":[84,128,300,317],"parents":[86,156],"age\u2013matched":[90],"controls.":[91],"hypothesized":[93],"measures":[95,249],"an":[101],"inward":[102],"deformity":[104],"subfields":[115],"would":[116],"discriminate":[117],"two":[119,252],"groups":[120,253],"subjects.":[122],"scans":[124,188],"35":[126],"biologic":[131,155],"parent":[132],"39":[136],"control":[137,145],"were":[139,228,281],"included":[140],"this":[142,222,226],"study.":[143],"Nineteen":[144],"came":[147,167],"ADRC":[149],"ACS":[150],"sample":[151],"without":[157,172],"DAT,":[158],"20":[160],"age":[161],"gender":[163],"matched":[164,322],"additional":[165],"controls":[166],"our":[169],"schizophrenia":[170],"study":[171,212],"family":[174],"history":[175],"AD":[177],"(Table":[178],"1).":[179],"Large\u2013deformation":[180],"high\u2013dimensional":[181],"brain":[182],"mapping":[183],"was":[184,213,262],"applied":[185],"all":[187,231],"generate":[190],"surfaces":[192],"template":[195],"each":[197,219,236,241],"subject":[198,220,242],"scan.":[199],"An":[200],"average":[201],"constructed":[204],"86":[206],"healthy":[207,319],"used":[214],"as":[215,243,313],"reference.":[217],"For":[218],"study,":[223],"displacements":[224,234],"reference":[227],"computed":[229,239],"for":[230,235,240,250,275,323],"surfaces.":[232],"Mean":[233],"zone":[237],"are":[238,256],"measures.":[245],"Volume":[246],"summarized":[257],"Table":[259],"2.":[260],"There":[261],"significant":[264,278],"group":[265,279],"effect":[266],"(F=5.4,":[267],"df=1.72,":[268],"p=0.022)":[269],"volume.":[272],"After":[273],"adjusting":[274],"multiple":[276],"comparisons,":[277],"differences":[280],"found":[282],"inferior\u2013medial":[285],"superior":[287],"zones,":[288],"not":[290],"lateral":[292],"zone.":[293],"result":[295],"middle\u2013aged":[299],"(45\u201365":[301],"years":[302],"age)":[304],"have":[309],"compared":[314],"non\u2013demented":[320],"age.":[324],"supports":[327],"hypothesis":[329],"there":[331],"relationship":[335],"between":[336],"increased":[341],"risk":[342],"developing":[344],"Alzheimer's":[345],"(AD).":[347],"P01\u2013AG026276,":[348],"P01\u2013AG03991,":[349],"P50\u2013AG05681,":[350],"R01\u2013MH60883,":[351],"R01\u2013MH56584,":[352],"P41\u2013RR15241.":[353]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}