{"id":"https://openalex.org/W2124397449","doi":"https://doi.org/10.1093/jhered/esp047","title":"Distinguishing Among Evolutionary Models for the Maintenance of Gene Duplicates","display_name":"Distinguishing Among Evolutionary Models for the Maintenance of Gene Duplicates","publication_year":2009,"publication_date":"2009-07-13","ids":{"openalex":"https://openalex.org/W2124397449","doi":"https://doi.org/10.1093/jhered/esp047","mag":"2124397449","pmid":"https://pubmed.ncbi.nlm.nih.gov/19596713"},"language":"en","primary_location":{"id":"doi:10.1093/jhered/esp047","doi":"https://doi.org/10.1093/jhered/esp047","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jhered/esp047","pdf_url":null,"source":{"id":"https://openalex.org/S84833568","display_name":"Journal of Heredity","issn_l":"0022-1503","issn":["0022-1503","1465-7333","1471-8505"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heredity","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038671526","display_name":"Matthew W. Hahn","orcid":"https://orcid.org/0000-0002-5731-8808","observed_orcids":["https://orcid.org/0000-0002-5731-8808"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. W. Hahn","raw_affiliation_strings":["Department of Biology and School of Informatics, Indiana University, Bloomington, IN 47405, USA. mwh@indiana.edu","From the Department of Biology and School of Informatics, 1001 E. 3rd Street, Indiana University, Bloomington, IN 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and School of Informatics, Indiana University, Bloomington, IN 47405, USA. mwh@indiana.edu","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"raw_affiliation_string":"From the Department of Biology and School of Informatics, 1001 E. 3rd Street, Indiana University, Bloomington, IN 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038671526"],"corresponding_institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"],"apc_list":{"value":3560,"currency":"USD","value_usd":3560},"apc_paid":null,"fwci":2.3571,"has_fulltext":false,"cited_by_count":428,"citation_normalized_percentile":{"value":0.90731293,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"100","issue":"5","first_page":"605","last_page":"617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.18629999458789825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.9739999771118164},{"id":"https://openalex.org/keywords/neofunctionalization","display_name":"neofunctionalization","score":0.996999979019165},{"id":"https://openalex.org/keywords/subfunctionalization","display_name":"subfunctionalization","score":1.0},{"id":"https://openalex.org/keywords/functional-conservation","display_name":"functional conservation","score":0.6570000052452087},{"id":"https://openalex.org/keywords/population-genetic-models","display_name":"population genetic models","score":0.8389999866485596},{"id":"https://openalex.org/keywords/evolutionary-novelty","display_name":"evolutionary innovation","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8374485969543457},{"id":"https://openalex.org/C107110972","wikidata":"https://www.wikidata.org/wiki/Q6992868","display_name":"Neofunctionalization","level":4,"score":0.8245760202407837},{"id":"https://openalex.org/C2779922708","wikidata":"https://www.wikidata.org/wiki/Q7631143","display_name":"Subfunctionalization","level":5,"score":0.7945206165313721},{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.7516191005706787},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5706680417060852},{"id":"https://openalex.org/C2778738651","wikidata":"https://www.wikidata.org/wiki/Q16546687","display_name":"Novelty","level":2,"score":0.558726966381073},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.5474187135696411},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5437350273132324},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.5067575573921204},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5056958198547363},{"id":"https://openalex.org/C2992278830","wikidata":"https://www.wikidata.org/wiki/Q483921","display_name":"Adaptive evolution","level":3,"score":0.4393378794193268},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38275569677352905},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35834670066833496},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.24083110690116882},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.16562247276306152},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11226868629455566},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0897214412689209},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C27206212","wikidata":"https://www.wikidata.org/wiki/Q34178","display_name":"Theology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003434","descriptor_name":"Crossing Over, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011123","descriptor_name":"Polyploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018626","descriptor_name":"Retroelements","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/jhered/esp047","doi":"https://doi.org/10.1093/jhered/esp047","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jhered/esp047","pdf_url":null,"source":{"id":"https://openalex.org/S84833568","display_name":"Journal of Heredity","issn_l":"0022-1503","issn":["0022-1503","1465-7333","1471-8505"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heredity","raw_type":"journal-article"},{"id":"pmid:19596713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19596713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heredity","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.411.7684","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.411.7684","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://sites.bio.indiana.edu/~hahnlab/Publications/Hahn2009.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.562.8840","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.562.8840","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jhered.oxfordjournals.org/content/100/5/605.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":134,"referenced_works":["https://openalex.org/W1488871786","https://openalex.org/W1494075612","https://openalex.org/W1497994697","https://openalex.org/W1511771787","https://openalex.org/W1537921928","https://openalex.org/W1551836412","https://openalex.org/W1590434348","https://openalex.org/W1796126005","https://openalex.org/W1820644981","https://openalex.org/W1849631302","https://openalex.org/W1857738277","https://openalex.org/W1878895891","https://openalex.org/W1905804931","https://openalex.org/W1964612763","https://openalex.org/W1968761150","https://openalex.org/W1970732273","https://openalex.org/W1971231926","https://openalex.org/W1981347911","https://openalex.org/W1982603712","https://openalex.org/W1985535920","https://openalex.org/W1985959742","https://openalex.org/W1986617857","https://openalex.org/W1988714210","https://openalex.org/W1992140809","https://openalex.org/W1992532041","https://openalex.org/W1993859467","https://openalex.org/W1994677936","https://openalex.org/W1995438082","https://openalex.org/W1995514688","https://openalex.org/W1995902068","https://openalex.org/W1996490834","https://openalex.org/W1997237756","https://openalex.org/W1999889695","https://openalex.org/W1999960938","https://openalex.org/W2001463236","https://openalex.org/W2006560737","https://openalex.org/W2008529382","https://openalex.org/W2013798014","https://openalex.org/W2016206397","https://openalex.org/W2018486257","https://openalex.org/W2019591778","https://openalex.org/W2022490019","https://openalex.org/W2023926109","https://openalex.org/W2024675966","https://openalex.org/W2025032015","https://openalex.org/W2026415696","https://openalex.org/W2032247293","https://openalex.org/W2034464839","https://openalex.org/W2035702416","https://openalex.org/W2035733413","https://openalex.org/W2039557099","https://openalex.org/W2040804874","https://openalex.org/W2041624900","https://openalex.org/W2045040686","https://openalex.org/W2045391589","https://openalex.org/W2049072264","https://openalex.org/W2051947493","https://openalex.org/W2055821541","https://openalex.org/W2056384440","https://openalex.org/W2058795503","https://openalex.org/W2059805279","https://openalex.org/W2060444887","https://openalex.org/W2062255150","https://openalex.org/W2064495883","https://openalex.org/W2071325036","https://openalex.org/W2073778187","https://openalex.org/W2074827720","https://openalex.org/W2076032878","https://openalex.org/W2079197003","https://openalex.org/W2081933515","https://openalex.org/W2084246692","https://openalex.org/W2085151059","https://openalex.org/W2087501975","https://openalex.org/W2093113214","https://openalex.org/W2093806758","https://openalex.org/W2095021929","https://openalex.org/W2095829109","https://openalex.org/W2098352755","https://openalex.org/W2098566436","https://openalex.org/W2103111028","https://openalex.org/W2103731920","https://openalex.org/W2105232382","https://openalex.org/W2105857125","https://openalex.org/W2111229238","https://openalex.org/W2113420705","https://openalex.org/W2115919001","https://openalex.org/W2116925118","https://openalex.org/W2116929155","https://openalex.org/W2118654970","https://openalex.org/W2120985092","https://openalex.org/W2124873881","https://openalex.org/W2125042717","https://openalex.org/W2130175333","https://openalex.org/W2131558479","https://openalex.org/W2132678666","https://openalex.org/W2133174791","https://openalex.org/W2133514124","https://openalex.org/W2135123683","https://openalex.org/W2135160221","https://openalex.org/W2136578623","https://openalex.org/W2137688091","https://openalex.org/W2141201180","https://openalex.org/W2143389463","https://openalex.org/W2144550200","https://openalex.org/W2144690533","https://openalex.org/W2146443354","https://openalex.org/W2147429782","https://openalex.org/W2148105436","https://openalex.org/W2148468916","https://openalex.org/W2151318268","https://openalex.org/W2151487377","https://openalex.org/W2151778540","https://openalex.org/W2152075687","https://openalex.org/W2152876917","https://openalex.org/W2154406573","https://openalex.org/W2155417974","https://openalex.org/W2155707112","https://openalex.org/W2155896987","https://openalex.org/W2156340505","https://openalex.org/W2157394198","https://openalex.org/W2158292347","https://openalex.org/W2159092341","https://openalex.org/W2159629613","https://openalex.org/W2162673429","https://openalex.org/W2163865385","https://openalex.org/W2166085889","https://openalex.org/W2168570965","https://openalex.org/W2168816336","https://openalex.org/W2169749633","https://openalex.org/W2170637828","https://openalex.org/W2324925011","https://openalex.org/W2482833590","https://openalex.org/W2764687937","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7098711953","https://openalex.org/W7096323376","https://openalex.org/W7096292736","https://openalex.org/W2020920927","https://openalex.org/W2332462668","https://openalex.org/W7100433455","https://openalex.org/W1488871786","https://openalex.org/W2038464976","https://openalex.org/W2162137086","https://openalex.org/W7071404970"],"abstract_inverted_index":{"Determining":[0],"the":[1,6,15,70,91,101,112,124,144,156,162,168],"evolutionary":[2,19],"forces":[3,174],"responsible":[4],"for":[5,155,167],"maintenance":[7],"of":[8,49,57,85,96,98,104,116,126,141,146,158,170],"gene":[9,105,147],"duplicates":[10],"is":[11,128,150],"key":[12],"to":[13,18,63,130],"understanding":[14],"processes":[16],"leading":[17],"adaptation":[20],"and":[21,36,47,90],"novelty.":[22],"In":[23,77],"his":[24],"highly":[25],"prescient":[26],"book,":[27],"Susumu":[28],"Ohno":[29],"recognized":[30],"that":[31,61,122],"duplicate":[32],"genes":[33],"are":[34,107],"fixed":[35],"maintained":[37],"within":[38],"a":[39,55,82],"population":[40,58],"with":[41,111],"3":[42],"distinct":[43],"outcomes:":[44],"neofunctionalization,":[45],"subfunctionalization,":[46],"conservation":[48],"function.":[50],"Subsequent":[51],"researchers":[52],"have":[53],"proposed":[54],"multitude":[56],"genetic":[59],"models":[60],"lead":[62],"these":[64,86,177],"outcomes,":[65],"each":[66,97],"differing":[67],"largely":[68],"in":[69,94,175],"role":[71],"played":[72],"by":[73],"adaptive":[74,117,171],"natural":[75,118,133],"selection.":[76],"this":[78],"paper,":[79],"I":[80,120],"present":[81],"nonmathematical":[83],"review":[84],"models,":[87],"their":[88],"predictions,":[89],"evidence":[92,154,166],"collected":[93],"support":[95],"them.":[99],"Though":[100],"various":[102],"outcomes":[103],"duplication":[106,127],"often":[108],"strictly":[109],"associated":[110],"presence":[113],"or":[114,172],"absence":[115],"selection,":[119],"argue":[121],"determining":[123,131],"outcome":[125,160],"orthogonal":[129],"whether":[132],"selection":[134],"has":[135],"acted.":[136],"Despite":[137],"an":[138],"ever-growing":[139],"field":[140],"research":[142],"into":[143],"fate":[145],"duplicates,":[148],"there":[149],"not":[151],"yet":[152],"clear":[153],"preponderance":[157],"one":[159],"over":[161],"others,":[163],"much":[164],"less":[165],"importance":[169],"nonadaptive":[173],"maintaining":[176],"duplicates.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":47},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":28},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":38},{"year":2013,"cited_by_count":26},{"year":2012,"cited_by_count":39}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}