{"id":"https://openalex.org/W2124375853","doi":"https://doi.org/10.7326/0003-4819-144-11-200606060-00007","title":"An Evaluation of d -Dimer in the Diagnosis of Pulmonary Embolism","display_name":"An Evaluation of d -Dimer in the Diagnosis of Pulmonary Embolism","publication_year":2006,"publication_date":"2006-06-06","ids":{"openalex":"https://openalex.org/W2124375853","doi":"https://doi.org/10.7326/0003-4819-144-11-200606060-00007","mag":"2124375853","pmid":"https://pubmed.ncbi.nlm.nih.gov/16754923"},"language":"en","primary_location":{"id":"doi:10.7326/0003-4819-144-11-200606060-00007","doi":"https://doi.org/10.7326/0003-4819-144-11-200606060-00007","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-144-11-200606060-00007","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002200808","display_name":"Clive Kearon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Clive Kearon","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109247748","display_name":"Jeffrey S. Ginsberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jeffrey S. Ginsberg","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107844944","display_name":"James D. Douketis","orcid":"https://orcid.org/0000-0001-5288-0394","observed_orcids":["https://orcid.org/0000-0001-5288-0394"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"James Douketis","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108112469","display_name":"Alexander G.G. Turpie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alexander G. Turpie","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037848403","display_name":"Shannon M. Bates","orcid":"https://orcid.org/0000-0003-2183-113X","observed_orcids":["https://orcid.org/0000-0003-2183-113X"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Shannon M. Bates","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084117447","display_name":"Agnes Y. Y. Lee","orcid":"https://orcid.org/0000-0003-1915-6681","observed_orcids":["https://orcid.org/0000-0003-1915-6681"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Agnes Y. Lee","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079941141","display_name":"Mark Andrew Crowther","orcid":"https://orcid.org/0000-0003-4986-4873","observed_orcids":["https://orcid.org/0000-0003-4986-4873"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mark A. Crowther","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082464840","display_name":"Jeffrey Ian Weitz","orcid":"https://orcid.org/0000-0002-1092-7550","observed_orcids":["https://orcid.org/0000-0002-1092-7550"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jeffrey I. Weitz","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087869533","display_name":"Patrick A. Brill-Edwards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Patrick Brill-Edwards","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108101318","display_name":"Philip S. Wells","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Philip Wells","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018260212","display_name":"David R. Anderson","orcid":"https://orcid.org/0000-0003-0845-1722","observed_orcids":["https://orcid.org/0000-0003-0845-1722"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David R. Anderson","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105839238","display_name":"Michael J. Kovacs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael J. Kovacs","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012144838","display_name":"Lori\u2010Ann Linkins","orcid":"https://orcid.org/0000-0002-9308-173X","observed_orcids":["https://orcid.org/0000-0002-9308-173X"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lori-Ann Linkins","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070655789","display_name":"Jim A. Julian","orcid":"https://orcid.org/0000-0003-0476-5396","observed_orcids":["https://orcid.org/0000-0003-0476-5396"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jim A. Julian","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103736691","display_name":"Laura R. Bonilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Laura R. Bonilla","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109917247","display_name":"Michael Gent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael Gent","raw_affiliation_strings":["From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From McMaster University and the Henderson Research Centre, Hamilton, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada; Dalhousie University, Halifax, Nova Scotia, Canada; and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I129902397","https://openalex.org/I153718931","https://openalex.org/I98251732"]}]},{"author_position":"last","author":{"id":null,"display_name":"for the Canadian Pulmonary Embolism Diagnosis Study (CANPEDS) Group*","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"for the Canadian Pulmonary Embolism Diagnosis Study (CANPEDS) Group*","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":14.9883,"has_fulltext":false,"cited_by_count":181,"citation_normalized_percentile":{"value":0.99102264,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"144","issue":"11","first_page":"812","last_page":"821"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-embolism","display_name":"pulmonary embolism","score":0.9940000176429749},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.9039999842643738},{"id":"https://openalex.org/keywords/clinical-probability","display_name":"clinical probability","score":0.6919999718666077},{"id":"https://openalex.org/keywords/ventilation-perfusion-scan","display_name":"ventilation-perfusion scan","score":0.9350000023841858},{"id":"https://openalex.org/keywords/anticoagulation-withdrawal","display_name":"anticoagulation withdrawal","score":0.8489999771118164},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.39899998903274536},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9500179290771484},{"id":"https://openalex.org/C174446222","wikidata":"https://www.wikidata.org/wiki/Q7239190","display_name":"Pre- and post-test probability","level":2,"score":0.8017489910125732},{"id":"https://openalex.org/C2776265017","wikidata":"https://www.wikidata.org/wiki/Q220570","display_name":"Pulmonary embolism","level":2,"score":0.7121375799179077},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5240203142166138},{"id":"https://openalex.org/C2779519742","wikidata":"https://www.wikidata.org/wiki/Q198526","display_name":"D-dimer","level":2,"score":0.47659868001937866},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.475040465593338},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4317486584186554},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.4109116494655609},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3793184459209442},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3475598096847534}],"mesh":[{"descriptor_ui":"D005338","descriptor_name":"Fibrin Fibrinogen Degradation Products","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007297","descriptor_name":"Inpatients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010045","descriptor_name":"Outpatients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011655","descriptor_name":"Pulmonary Embolism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.7326/0003-4819-144-11-200606060-00007","doi":"https://doi.org/10.7326/0003-4819-144-11-200606060-00007","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-144-11-200606060-00007","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:16754923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16754923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Comparative Study"},{"id":"mag:1565531449","doi":null,"is_oa":false,"landing_page_url":"http://www.medlabstats.com/students/STARD-designed-D-Dimer-study.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Annals of Internal Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1531730344","https://openalex.org/W1608617639","https://openalex.org/W1775714549","https://openalex.org/W1966605730","https://openalex.org/W1981156855","https://openalex.org/W2039530948","https://openalex.org/W2052303494","https://openalex.org/W2053059847","https://openalex.org/W2065379041","https://openalex.org/W2076482946","https://openalex.org/W2096913021","https://openalex.org/W2112170924","https://openalex.org/W2117040540","https://openalex.org/W2119383841","https://openalex.org/W2126646660","https://openalex.org/W2133619004","https://openalex.org/W2146272590","https://openalex.org/W2170419612"],"related_works":["https://openalex.org/W7073786516","https://openalex.org/W2127410697","https://openalex.org/W2202059958","https://openalex.org/W2144862584","https://openalex.org/W4251176469","https://openalex.org/W2585403279","https://openalex.org/W1775714549","https://openalex.org/W2036590735","https://openalex.org/W2133619004","https://openalex.org/W2343865713"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1],"may":[2],"be":[3,44,416],"safe":[4],"to":[5,97,306,347,385,394],"omit":[6],"additional":[7,40,286,297,328,339,412],"diagnostic":[8,41,161,287,329,389,413],"testing":[9,42,162,288,298,330,340,390,414],"in":[10,31,47,63,265,278,290,320,332,434,439],"selected":[11],"patients":[12,48,86,282,294,324,336,358,365,400],"with":[13,49,80,87,110,121,401,443],"suspected":[14,50,81,444],"pulmonary":[15],"embolism":[16],"(PE)":[17],"who":[18,52,283,295,325,337,378,407],"have":[19,53,408],"a":[20,32,67,111,122,130,173,402],"negative":[21,54,88,409,430],"D-dimer":[22,57,91,410,431],"test,":[23],"but":[24],"this":[25],"approach":[26],"has":[27],"never":[28],"been":[29],"evaluated":[30],"randomized,":[33],"controlled":[34],"trial.":[35],"OBJECTIVE:":[36],"To":[37],"determine":[38],"if":[39,244],"can":[43,415],"safely":[45],"withheld":[46,241,417],"PE":[51,116,245,406],"erythrocyte":[55,89],"agglutination":[56,90],"test":[58,92],"results.":[59],"DESIGN:":[60],"Randomized":[61],"comparisons":[62],"2":[64,105],"subgroups":[65],"of":[66,83,115,128,138,180,185,199,220,225,257,261,280,292,322,334,388,405,422,436,441],"prospective":[68],"multicenter":[69],"study.":[70],"SETTING:":[71],"7":[72,204,229,373],"university":[73],"hospitals.":[74],"PATIENTS:":[75],"1126":[76,267],"outpatients":[77,437],"or":[78,124,147,215,242,313,393],"inpatients":[79,442],"PE;":[82],"these,":[84],"456":[85],"results":[93,387,432],"were":[94,102,382],"randomly":[95,363],"assigned":[96,364],"the":[98,169,181,186,189,193,200,213,221,226,234,266,271,311,369,386,420],"intervention":[99,153,167,211],"groups.":[100],"Patients":[101],"classified":[103],"into":[104],"clinical":[106,113,126,427],"probability":[107,114,127,156,404,428],"groups:":[108],"those":[109,120],"low":[112,403],"(low-probability":[117],"group)":[118],"and":[119,135,205,230,236,289,331,372,429,438],"moderate":[123],"high":[125],"PE,":[129],"nondiagnostic":[131],"ventilation-perfusion":[132,174],"lung":[133,175,194],"scan,":[134],"no":[136,159,285,327],"evidence":[137],"proximal":[139,182,222],"deep":[140,183,223],"venous":[141,251],"thrombosis":[142],"on":[143,188],"bilateral":[144],"ultrasonography":[145,179,198,219],"(moderate-":[146],"high-probability":[148,216,314],"group).":[149],"INTERVENTIONS:":[150],"The":[151,165,209,352],"experimental":[152,237],"for":[154,163,168,212],"both":[155],"groups":[157],"was":[158,172,196,202,218,240,246,263],"further":[160],"PE.":[164,445],"control":[166,210,235],"low-probability":[170,272],"group":[171,217,396],"scan":[176,195],"followed":[177],"by":[178],"veins":[184,224],"legs":[187,201,227],"same":[190],"day.":[191],"If":[192],"nondiagnostic,":[197],"repeated":[203],"14":[206,231],"days":[207],"later.":[208],"moderate-":[214,312],"after":[228],"days.":[232],"In":[233,270,310,399],"groups,":[238],"anticoagulation":[239],"withdrawn":[243],"not":[247,355,367,383],"diagnosed.":[248],"MEASUREMENTS:":[249],"Symptomatic":[250],"thromboembolism":[252],"(VTE)":[253],"during":[254,276,318,424],"6":[255],"months":[256],"follow-up.":[258,376,425],"RESULTS:":[259],"Prevalence":[260],"VTE":[262,274,316,423],"15.2%":[264],"enrolled":[268],"patients.":[269],"group,":[273,315],"occurred":[275,317],"follow-up":[277,319,380],"0":[279,333],"182":[281],"had":[284,296,326,338],"1":[291,321],"185":[293],"(difference,":[299,341],"-0.5":[300],"percentage":[301,308,343,349],"point":[302],"[95%":[303],"CI,":[304],"-3.0":[305],"1.6":[307],"points]).":[309,350],"41":[323,335],"2.4":[342],"points":[344],"[CI,":[345],"-6.4":[346],"12.6":[348],"LIMITATIONS:":[351],"authors":[353],"could":[354],"enroll":[356],"2000":[357],"as":[359],"originally":[360],"planned;":[361],"3":[362],"did":[366],"receive":[368],"allocated":[370],"intervention,":[371],"received":[374],"inadequate":[375],"Personnel":[377],"performed":[379],"evaluations":[381],"blinded":[384],"at":[391],"enrollment":[392],"allocation":[395],"assignments.":[397],"CONCLUSION:":[398],"results,":[411],"without":[418],"increasing":[419],"frequency":[421],"Low":[426],"occur":[433],"50%":[435],"20%":[440]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}