{"id":"https://openalex.org/W2124358693","doi":"https://doi.org/10.1093/gerona/58.8.b687","title":"Denervation Stimulates Apoptosis But Not Id2 Expression in Hindlimb Muscles of Aged Rats","display_name":"Denervation Stimulates Apoptosis But Not Id2 Expression in Hindlimb Muscles of Aged Rats","publication_year":2003,"publication_date":"2003-08-01","ids":{"openalex":"https://openalex.org/W2124358693","doi":"https://doi.org/10.1093/gerona/58.8.b687","mag":"2124358693","pmid":"https://pubmed.ncbi.nlm.nih.gov/12902526"},"language":"en","primary_location":{"id":"doi:10.1093/gerona/58.8.b687","doi":"https://doi.org/10.1093/gerona/58.8.b687","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/58.8.b687","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016404345","display_name":"Stephen E. Alway","orcid":"https://orcid.org/0000-0002-0378-4707","observed_orcids":["https://orcid.org/0000-0002-0378-4707"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. E. Alway","raw_affiliation_strings":["Laboratory of Muscle, Sarcopenia and Muscle Diseases, Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown 26506-9227, USA. sa;way@hsc.uwv.edu","Laboratory of Muscle, Sarcopenia and Muscle Diseases, Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown 26506-9227, USA. sa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Muscle, Sarcopenia and Muscle Diseases, Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown 26506-9227, USA. sa;way@hsc.uwv.edu","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Laboratory of Muscle, Sarcopenia and Muscle Diseases, Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown 26506-9227, USA. sa","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042024511","display_name":"Hans Degens","orcid":"https://orcid.org/0000-0001-7399-4841","observed_orcids":["https://orcid.org/0000-0001-7399-4841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Degens","raw_affiliation_strings":["way@hsc.uwv.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"way@hsc.uwv.edu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004312967","display_name":"Gururaj Krishnamurthy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Krishnamurthy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030998177","display_name":"Archana Chaudhrai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Chaudhrai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4408,"currency":"USD","value_usd":4408},"apc_paid":null,"fwci":3.017,"has_fulltext":false,"cited_by_count":99,"citation_normalized_percentile":{"value":0.92661236,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"58","issue":"8","first_page":"B687","last_page":"B697"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10333","display_name":"Meat and Animal Product Quality","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/denervation","display_name":"denervation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/id2","display_name":"Id2","score":0.875},{"id":"https://openalex.org/keywords/muscle-aging","display_name":"muscle aging","score":0.6600000262260437},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hindlimb-muscles","display_name":"hindlimb muscles","score":0.9309999942779541},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.8859999775886536},{"id":"https://openalex.org/keywords/soleus-muscle","display_name":"soleus muscle","score":0.9940000176429749},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9890000224113464},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":1.0},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.6140000224113464},{"id":"https://openalex.org/keywords/id1","display_name":"Id1","score":0.5249999761581421},{"id":"https://openalex.org/keywords/id3-algorithm","display_name":"ID3","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2776805190","wikidata":"https://www.wikidata.org/wiki/Q1187030","display_name":"Denervation","level":2,"score":0.9518913626670837},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7411607503890991},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7388573884963989},{"id":"https://openalex.org/C2776104385","wikidata":"https://www.wikidata.org/wiki/Q1954164","display_name":"Soleus muscle","level":3,"score":0.6905965805053711},{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.6847465634346008},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.5598050355911255},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5272045731544495},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.510356605052948},{"id":"https://openalex.org/C2775872116","wikidata":"https://www.wikidata.org/wiki/Q943203","display_name":"Gastrocnemius muscle","level":3,"score":0.4542763829231262},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.4402967691421509},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4276408553123474},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3185955286026001},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.27685320377349854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06744891405105591}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009121","descriptor_name":"Muscle Denervation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051796","descriptor_name":"Inhibitor of Differentiation Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051797","descriptor_name":"Inhibitor of Differentiation Protein 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/gerona/58.8.b687","doi":"https://doi.org/10.1093/gerona/58.8.b687","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/58.8.b687","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","raw_type":"journal-article"},{"id":"pmid:12902526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12902526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journals of gerontology. Series A, Biological sciences and medical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.873.9159","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.873.9159","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://biomedgerontology.oxfordjournals.org/content/58/8/B687.full.pdf","raw_type":"text"},{"id":"pmh:oai:e-space.mmu.ac.uk:35372","doi":null,"is_oa":false,"landing_page_url":"https://e-space.mmu.ac.uk/35372/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401617","display_name":"e-space (Manchester Metropolitan University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I11983389","host_organization_name":"Manchester Metropolitan University","host_organization_lineage":["https://openalex.org/I11983389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/186274","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/186274","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 58, 8, pp. 687-97","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/186274","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/186274","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 58, 687 - 97","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1391078054","display_name":"Id2 REGULATION OF MUSCLE HYPERTROPHY IN AGING","funder_award_id":"R01AG021530","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3363708801","display_name":"MYOD AND MYOGENIN IN MUSCLE HYPERTROPHY AND SARCOPENIA","funder_award_id":"R01AG017143","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W37286935","https://openalex.org/W84773616","https://openalex.org/W1622668755","https://openalex.org/W1735876586","https://openalex.org/W1782837552","https://openalex.org/W1843994302","https://openalex.org/W1922704337","https://openalex.org/W1956977862","https://openalex.org/W1966817531","https://openalex.org/W1972763299","https://openalex.org/W1975783601","https://openalex.org/W1983165764","https://openalex.org/W1987013771","https://openalex.org/W1995420824","https://openalex.org/W1999586994","https://openalex.org/W2005567975","https://openalex.org/W2012551517","https://openalex.org/W2017198050","https://openalex.org/W2022058104","https://openalex.org/W2023231774","https://openalex.org/W2023529015","https://openalex.org/W2023561026","https://openalex.org/W2027811834","https://openalex.org/W2031017070","https://openalex.org/W2043755590","https://openalex.org/W2056896643","https://openalex.org/W2067511188","https://openalex.org/W2072075909","https://openalex.org/W2075747437","https://openalex.org/W2079300172","https://openalex.org/W2080921526","https://openalex.org/W2086455467","https://openalex.org/W2089977818","https://openalex.org/W2090232685","https://openalex.org/W2101922154","https://openalex.org/W2101927529","https://openalex.org/W2105330140","https://openalex.org/W2106410559","https://openalex.org/W2106612017","https://openalex.org/W2111908063","https://openalex.org/W2116114529","https://openalex.org/W2118072900","https://openalex.org/W2123455365","https://openalex.org/W2125970784","https://openalex.org/W2133388300","https://openalex.org/W2135817592","https://openalex.org/W2137956216","https://openalex.org/W2144264604","https://openalex.org/W2152315418","https://openalex.org/W2160301571","https://openalex.org/W2161955670","https://openalex.org/W2167315148","https://openalex.org/W2172326429","https://openalex.org/W2184471213","https://openalex.org/W2285306797","https://openalex.org/W2396378488","https://openalex.org/W4249424500"],"related_works":["https://openalex.org/W2043580961","https://openalex.org/W6983696961","https://openalex.org/W2090232685","https://openalex.org/W2426476791","https://openalex.org/W1966592897","https://openalex.org/W1992604738","https://openalex.org/W2107008875","https://openalex.org/W1484492220","https://openalex.org/W2045709794","https://openalex.org/W2022279236"],"abstract_inverted_index":{"Inhibitors":[0],"of":[1,7,41,43,80,122,135,265,332,334],"differentiation":[2],"(Id)":[3],"proteins":[4,51],"are":[5,30],"repressors":[6],"myogenic":[8],"regulatory":[9],"factors":[10],"and":[11,17,55,72,94,125,128,151,173,179,193,205,222,228,231,235,249,256,259,267,292],"have":[12,24,301],"been":[13],"implicated":[14],"in":[15,32,63,77,115,133,154,171,191,197,216,219,253,261,295,304,321],"apoptosis":[16,62,285,314],"muscle":[18,277],"atrophy":[19],"during":[20,45,315,336],"aging.":[21],"Indeed,":[22],"we":[23],"previously":[25],"found":[26],"that":[27,274],"Id":[28,319],"levels":[29,121,168,196,294],"elevated":[31,289,318],"muscles":[33,74,114,134,158,175,224,264,322],"from":[34,159,176,225,323],"old":[35,136,163,180,232,268],"rodents,":[36],"possibly":[37],"as":[38,65,106,137,241,286],"a":[39,213,302,329],"consequence":[40,331],"loss":[42,278,333],"alpha-motoneurons":[44,335],"senescence.":[46,337],"To":[47],"determine":[48],"if":[49,56],"Id2":[50,166,299,307],"increase":[52,148,190,215],"after":[53,251],"denervation":[54,187,252],"this":[57],"is":[58,326],"accompanied":[59],"by":[60,243,247,257,288],"increased":[61,246],"aged":[64,87,324],"compared":[66,138],"with":[67,139],"adult":[68,141,178,184],"animals,":[69],"the":[70,102,107,113,199,254,262,275],"gastrocnemius":[71,157,206,223,263],"soleus":[73,155,200,221,255],"were":[75,118,130,169],"denervated":[76,172,296],"1":[78],"limb":[79,104,117],"Fischer":[81],"344":[82],"x":[83],"Brown":[84],"Norway":[85],"rats":[86,185,233],"9":[88],"months":[89,96],"(adult,":[90],"n":[91,98],"=":[92,99],"12)":[93],"33":[95],"(aged,":[97],"9),":[100],"while":[101],"contralateral":[103],"served":[105],"intra-animal":[108],"control.":[109],"After":[110],"14":[111],"days,":[112],"each":[116],"removed.":[119],"The":[120,271,317],"Id1,":[123,149],"Id2,":[124,150],"Id3":[126,152,194,203,209],"mRNA":[127,153],"protein":[129,167,195,239],"significantly":[131,147],"greater":[132],"young":[140,161,177,183,226,266],"rats.":[142,164,181],"Denervation,":[143],"however,":[144],"did":[145],"not":[146,309,328],"or":[156,162],"either":[160],"Also":[165],"similar":[170],"control":[174],"In":[182],"only,":[186],"induced":[188,212],"an":[189],"Id1":[192],"both":[198,220],"(Id1":[201,207],"113%;":[202],"900%)":[204],"86%;":[208],"80%).":[210],"Denervation":[211],"significant":[214],"caspase":[217,290],"8":[218,291],"(101%":[227],"147%,":[229],"respectively)":[230],"(167%":[234],"190%,":[236],"respectively).":[237],"Bax":[238,293],"levels,":[240],"estimated":[242],"western":[244],"blots,":[245],"726%":[248],"1087%":[250],"368%":[258],"49%":[260],"rats,":[269],"respectively.":[270],"data":[272],"suggest":[273],"denervation-induced":[276],"was":[279],"at":[280],"least":[281],"partly":[282],"due":[283],"to":[284,311],"indicated":[287],"muscles.":[297],"While":[298],"may":[300],"role":[303],"aging-induced":[305],"sarcopenia,":[306],"does":[308],"appear":[310],"directly":[312],"regulate":[313],"denervation.":[316],"expression":[320],"animals":[325],"therefore":[327],"direct":[330]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}