{"id":"https://openalex.org/W2124349371","doi":"https://doi.org/10.1073/pnas.0705407104","title":"PAS kinase is required for normal cellular energy balance","display_name":"PAS kinase is required for normal cellular energy balance","publication_year":2007,"publication_date":"2007-09-18","ids":{"openalex":"https://openalex.org/W2124349371","doi":"https://doi.org/10.1073/pnas.0705407104","mag":"2124349371","pmid":"https://pubmed.ncbi.nlm.nih.gov/17878307"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0705407104","doi":"https://doi.org/10.1073/pnas.0705407104","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0705407104","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2000499","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049400334","display_name":"Huai-Xiang Hao","orcid":"https://orcid.org/0000-0001-8291-6511","observed_orcids":["https://orcid.org/0000-0001-8291-6511"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huai-Xiang Hao","raw_affiliation_strings":["*Department of Biochemistry and","Department of Biochemistry University of Utah School of Medicine Salt Lake City UT 84112 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Biochemistry and","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry University of Utah School of Medicine Salt Lake City UT 84112 USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080541805","display_name":"Caleb M. Cardon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caleb M. Cardon","raw_affiliation_strings":["*Department of Biochemistry and","University of Utah,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Biochemistry and","institution_ids":[]},{"raw_affiliation_string":"University of Utah,","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054534207","display_name":"Wojtek Swiatek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wojtek Swiatek","raw_affiliation_strings":["*Department of Biochemistry and","DEPARTMENT OF BIOCHEMISTRY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Biochemistry and","institution_ids":[]},{"raw_affiliation_string":"DEPARTMENT OF BIOCHEMISTRY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028572976","display_name":"Robert C. Cooksey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C. Cooksey","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, University of Utah School of Medicine, Salt Lake City, UT 84112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, University of Utah School of Medicine, Salt Lake City, UT 84112","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012109498","display_name":"Tammy Smith","orcid":"https://orcid.org/0000-0001-9828-2381","observed_orcids":["https://orcid.org/0000-0001-9828-2381"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tammy L. Smith","raw_affiliation_strings":["*Department of Biochemistry and","University of Utah,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Biochemistry and","institution_ids":[]},{"raw_affiliation_string":"University of Utah,","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James Wilde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Wilde","raw_affiliation_strings":["*Department of Biochemistry and","University of Utah,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Biochemistry and","institution_ids":[]},{"raw_affiliation_string":"University of Utah,","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069855582","display_name":"Sihem Boudina","orcid":"https://orcid.org/0000-0002-4711-1109","observed_orcids":["https://orcid.org/0000-0002-4711-1109"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sihem Boudina","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, University of Utah School of Medicine, Salt Lake City, UT 84112","ENDOCRINOLOGY/DIABETES RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, University of Utah School of Medicine, Salt Lake City, UT 84112","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"ENDOCRINOLOGY/DIABETES RESEARCH","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024349156","display_name":"E. Dale Abel","orcid":"https://orcid.org/0000-0001-5290-0738","observed_orcids":["https://orcid.org/0000-0001-5290-0738"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Dale Abel","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, University of Utah School of Medicine, Salt Lake City, UT 84112","MOLECULAR MEDICINE PROGRAM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, University of Utah School of Medicine, Salt Lake City, UT 84112","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"MOLECULAR MEDICINE PROGRAM","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036033738","display_name":"Donald A. McClain","orcid":"https://orcid.org/0000-0002-3310-2359","observed_orcids":["https://orcid.org/0000-0002-3310-2359"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald A. McClain","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, University of Utah School of Medicine, Salt Lake City, UT 84112","ENDOCRINOLOGY/DIABETES RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, University of Utah School of Medicine, Salt Lake City, UT 84112","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"ENDOCRINOLOGY/DIABETES RESEARCH","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063404794","display_name":"Jared P. Rutter","orcid":"https://orcid.org/0000-0002-2710-9765","observed_orcids":["https://orcid.org/0000-0002-2710-9765"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jared Rutter","raw_affiliation_strings":["*Department of Biochemistry and","DEPARTMENT OF BIOCHEMISTRY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Biochemistry and","institution_ids":[]},{"raw_affiliation_string":"DEPARTMENT OF BIOCHEMISTRY","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5555,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.81946552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"104","issue":"39","first_page":"15466","last_page":"15471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pask","display_name":"PASK","score":0.6660000085830688},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cellular-energy-homeostasis","display_name":"cellular energy homeostasis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.902999997138977},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/triglyceride-storage","display_name":"triglyceride storage","score":0.8370000123977661},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.6209999918937683},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8880000114440918},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":1.0},{"id":"https://openalex.org/keywords/oxidative-metabolism","display_name":"oxidative metabolism","score":0.8629999756813049},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.9440000057220459},{"id":"https://openalex.org/keywords/metabolic-sensors","display_name":"metabolic sensors","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6861690282821655},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.603165328502655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5872548818588257},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5194351673126221},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4588731825351715},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.45645496249198914},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.439503014087677},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.42230454087257385},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.41361916065216064},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.41251814365386963},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3752884864807129},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3709966540336609},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3525317311286926},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23694533109664917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15692639350891113},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1010553240776062}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0705407104","doi":"https://doi.org/10.1073/pnas.0705407104","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0705407104","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:17878307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17878307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2000499","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2000499","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2000499","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2000499","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7200000286102295,"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2269058112","display_name":null,"funder_award_id":"R56 DK071962","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4501312542","display_name":null,"funder_award_id":"DK071962","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G476811148","display_name":null,"funder_award_id":"R01 DK-071962","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G807519830","display_name":"The role of PAS kinase in hepatic lipid metabolism","funder_award_id":"2r01dk071962-05a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1499618890","https://openalex.org/W1607110497","https://openalex.org/W1867229320","https://openalex.org/W1966985989","https://openalex.org/W1967457116","https://openalex.org/W1970692155","https://openalex.org/W1976621212","https://openalex.org/W1999919904","https://openalex.org/W2008632158","https://openalex.org/W2015711200","https://openalex.org/W2019950427","https://openalex.org/W2024992738","https://openalex.org/W2025391287","https://openalex.org/W2028212562","https://openalex.org/W2034810986","https://openalex.org/W2047388563","https://openalex.org/W2050980183","https://openalex.org/W2073346921","https://openalex.org/W2077828459","https://openalex.org/W2084767672","https://openalex.org/W2090611040","https://openalex.org/W2096773810","https://openalex.org/W2107674876","https://openalex.org/W2109098929","https://openalex.org/W2111495765","https://openalex.org/W2118167994","https://openalex.org/W2124246813","https://openalex.org/W2129722153","https://openalex.org/W2130684278","https://openalex.org/W2137261869","https://openalex.org/W2138202978","https://openalex.org/W2138226825","https://openalex.org/W2145490597","https://openalex.org/W2147594695","https://openalex.org/W2152565031","https://openalex.org/W2152948369","https://openalex.org/W2159664830","https://openalex.org/W2160331251","https://openalex.org/W2160448209","https://openalex.org/W2160450046","https://openalex.org/W2160583548","https://openalex.org/W2163382569","https://openalex.org/W2164516260","https://openalex.org/W4244189832","https://openalex.org/W4254261652"],"related_works":["https://openalex.org/W2011482197","https://openalex.org/W3161477666","https://openalex.org/W3169339014","https://openalex.org/W2028667143","https://openalex.org/W1538061282","https://openalex.org/W3122878625","https://openalex.org/W2475280487","https://openalex.org/W2313454058","https://openalex.org/W2593732884","https://openalex.org/W1999791383"],"abstract_inverted_index":{"The":[0],"metabolic":[1,24,38,47,56,65,77,97,163],"syndrome,":[2],"a":[3,29,76,114,148,158],"complex":[4],"set":[5],"of":[6,44,55,113,131],"phenotypes":[7,66],"typically":[8],"associated":[9],"with":[10,72],"obesity":[11,118],"and":[12,34,95,119,134,156],"diabetes,":[13],"is":[14,26,157],"an":[15],"increasing":[16],"threat":[17],"to":[18,31,36,151],"global":[19],"public":[20],"health.":[21],"Fundamentally,":[22],"the":[23,42,45,53,110],"syndrome":[25],"caused":[27,67,105],"by":[28,58,68],"failure":[30],"properly":[32],"sense":[33],"respond":[35],"cellular":[37,46,127,153],"cues.":[39],"We":[40,62,122,141],"studied":[41],"role":[43,74],"sensor":[48],"PAS":[49],"kinase":[50],"(PASK)":[51],"in":[52,87,93,99,138,147],"pathogenesis":[54],"disease":[57],"using":[59],"PASK(-/-)":[60,80],"mice.":[61],"identified":[63],"tissue-specific":[64],"PASK":[69,103,145],"deletion":[70,104],"consistent":[71],"its":[73],"as":[75],"sensor.":[78],"Specifically,":[79],"mice":[81],"exhibited":[82],"impaired":[83],"glucose-stimulated":[84],"insulin":[85,120],"secretion":[86],"pancreatic":[88],"beta-cells,":[89],"altered":[90],"triglyceride":[91],"storage":[92],"liver,":[94],"increased":[96,129],"rate":[98,130],"skeletal":[100],"muscle.":[101],"Further,":[102],"nearly":[106],"complete":[107],"protection":[108],"from":[109],"deleterious":[111],"effects":[112],"high-fat":[115],"diet":[116],"including":[117],"resistance.":[121],"also":[123],"demonstrate":[124],"that":[125,144],"these":[126],"effects,":[128],"oxidative":[132],"metabolism":[133],"ATP":[135],"production,":[136],"occur":[137],"cultured":[139],"cells.":[140],"therefore":[142],"hypothesize":[143],"acts":[146],"cell-autonomous":[149],"manner":[150],"maintain":[152],"energy":[154],"homeostasis":[155],"potential":[159],"therapeutic":[160],"target":[161],"for":[162],"disease.":[164]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}