{"id":"https://openalex.org/W2124313358","doi":"https://doi.org/10.1111/j.1743-6109.2010.01753.x","title":"Transforming Growth Factor (TGF)-\u03b2 Type I Receptor Kinase (ALK5) Inhibitor Alleviates Profibrotic TGF-\u03b21 Responses in Fibroblasts Derived from Peyronie\u2019s Plaque","display_name":"Transforming Growth Factor (TGF)-\u03b2 Type I Receptor Kinase (ALK5) Inhibitor Alleviates Profibrotic TGF-\u03b21 Responses in Fibroblasts Derived from Peyronie\u2019s Plaque","publication_year":2010,"publication_date":"2010-03-11","ids":{"openalex":"https://openalex.org/W2124313358","doi":"https://doi.org/10.1111/j.1743-6109.2010.01753.x","mag":"2124313358","pmid":"https://pubmed.ncbi.nlm.nih.gov/20233292"},"language":"en","primary_location":{"id":"doi:10.1111/j.1743-6109.2010.01753.x","doi":"https://doi.org/10.1111/j.1743-6109.2010.01753.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1743-6109.2010.01753.x","pdf_url":null,"source":{"id":"https://openalex.org/S159512450","display_name":"The Journal of Sexual Medicine","issn_l":"1743-6095","issn":["1743-6095","1743-6109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Sexual Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100870927","display_name":"Shuguang Piao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Shuguang Piao","raw_affiliation_strings":["Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea","institution_ids":["https://openalex.org/I191879574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101887223","display_name":"Min Ji Choi","orcid":"https://orcid.org/0000-0002-5476-356X","observed_orcids":["https://orcid.org/0000-0002-5476-356X"]},"institutions":[{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Ji Choi","raw_affiliation_strings":["Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea","institution_ids":["https://openalex.org/I191879574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090001122","display_name":"Munkhbayar Tumurbaatar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Munkhbayar Tumurbaatar","raw_affiliation_strings":["Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea","institution_ids":["https://openalex.org/I191879574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111827514","display_name":"Woo Jean Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woo Jean Kim","raw_affiliation_strings":["Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea","institution_ids":["https://openalex.org/I191879574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037047329","display_name":"Hai\u2010Rong Jin","orcid":"https://orcid.org/0000-0002-0476-1531","observed_orcids":["https://orcid.org/0000-0002-0476-1531"]},"institutions":[{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hai-Rong Jin","raw_affiliation_strings":["Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea","institution_ids":["https://openalex.org/I191879574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050577935","display_name":"Sun Hwa Shin","orcid":"https://orcid.org/0000-0003-4052-9542","observed_orcids":["https://orcid.org/0000-0003-4052-9542"]},"institutions":[{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun Hwa Shin","raw_affiliation_strings":["Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea","institution_ids":["https://openalex.org/I191879574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022849387","display_name":"Buyankhuu Tuvshintur","orcid":"https://orcid.org/0000-0003-3644-786X","observed_orcids":["https://orcid.org/0000-0003-3644-786X"]},"institutions":[{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Buyankhuu Tuvshintur","raw_affiliation_strings":["Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea","institution_ids":["https://openalex.org/I191879574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079807858","display_name":"Guo Nan Yin","orcid":"https://orcid.org/0000-0002-2512-7337","observed_orcids":["https://orcid.org/0000-0002-2512-7337"]},"institutions":[{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Guo Nan Yin","raw_affiliation_strings":["Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea","institution_ids":["https://openalex.org/I191879574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111847094","display_name":"Jae Sook Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Sook Song","raw_affiliation_strings":["Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea","institution_ids":["https://openalex.org/I191879574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052356454","display_name":"Mi\u2010Hye Kwon","orcid":"https://orcid.org/0000-0002-1660-1770","observed_orcids":["https://orcid.org/0000-0002-1660-1770"]},"institutions":[{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mi-Hye Kwon","raw_affiliation_strings":["Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea","institution_ids":["https://openalex.org/I191879574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100413941","display_name":"Sang-Jin Lee","orcid":"https://orcid.org/0000-0002-4478-1043","observed_orcids":["https://orcid.org/0000-0002-4478-1043"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang-Jin Lee","raw_affiliation_strings":["Research Institute, National Cancer Center , Goyang , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute, National Cancer Center , Goyang , South Korea","institution_ids":["https://openalex.org/I4210120052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052154367","display_name":"Jee\u2010Young Han","orcid":"https://orcid.org/0000-0003-3224-4029","observed_orcids":["https://orcid.org/0000-0003-3224-4029"]},"institutions":[{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]},{"id":"https://openalex.org/I4210153373","display_name":"Inha University Hospital","ror":"https://ror.org/04gj5px28","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I191879574","https://openalex.org/I4210153373"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jee-Young Han","raw_affiliation_strings":["Department of Pathology, Inha University School of Medicine , Incheon , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Inha University School of Medicine , Incheon , South Korea","institution_ids":["https://openalex.org/I191879574","https://openalex.org/I4210153373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321802","display_name":"Seong\u2010Jin Kim","orcid":"https://orcid.org/0000-0001-9701-0632","observed_orcids":["https://orcid.org/0000-0001-9701-0632"]},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong-Jin Kim","raw_affiliation_strings":["Laboratory of Cell Regulation and Carcinogenesis, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science , Incheon , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Regulation and Carcinogenesis, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science , Incheon , South Korea","institution_ids":["https://openalex.org/I12832649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041994476","display_name":"Ji\u2010Kan Ryu","orcid":"https://orcid.org/0000-0003-0025-6025","observed_orcids":["https://orcid.org/0000-0003-0025-6025"]},"institutions":[{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Ji-Kan Ryu","raw_affiliation_strings":["Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea","institution_ids":["https://openalex.org/I191879574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110277369","display_name":"Jun\u2013Kyu Suh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jun-Kyu Suh","raw_affiliation_strings":["Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine , Incheon , South Korea","institution_ids":["https://openalex.org/I191879574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5041994476","https://openalex.org/A5110277369"],"corresponding_institution_ids":["https://openalex.org/I191879574"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":3.1409,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.91329895,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"10","first_page":"3385","last_page":"3395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13313","display_name":"Dupuytren's Contracture and Treatments","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13313","display_name":"Dupuytren's Contracture and Treatments","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.2328999936580658,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9620000123977661},{"id":"https://openalex.org/keywords/alk5-inhibitor","display_name":"ALK5 inhibitor","score":0.8920000195503235},{"id":"https://openalex.org/keywords/smad2-3-phosphorylation","display_name":"Smad2/3 phosphorylation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.7749999761581421},{"id":"https://openalex.org/keywords/plaque-fibrosis","display_name":"plaque fibrosis","score":0.6430000066757202},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tunica-albuginea","display_name":"tunica albuginea","score":0.859000027179718},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/smad-nuclear-translocation","display_name":"Smad nuclear translocation","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2779145901","wikidata":"https://www.wikidata.org/wiki/Q874586","display_name":"Peyronie's disease","level":3,"score":0.7414926886558533},{"id":"https://openalex.org/C2780350170","wikidata":"https://www.wikidata.org/wiki/Q7853103","display_name":"Tunica albuginea (penis)","level":3,"score":0.7162244319915771},{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.6784003973007202},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.657448410987854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5079784989356995},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.4774754047393799},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.4660291373729706},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4322899281978607},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42513972520828247},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4166925549507141},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4112316370010376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30969977378845215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23652604222297668},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.17410698533058167},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.12364912033081055},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08271554112434387},{"id":"https://openalex.org/C2779929075","wikidata":"https://www.wikidata.org/wiki/Q184674","display_name":"Erectile dysfunction","level":2,"score":0.06991618871688843},{"id":"https://openalex.org/C2777786686","wikidata":"https://www.wikidata.org/wiki/Q58","display_name":"Penis","level":2,"score":0.05687221884727478},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010411","descriptor_name":"Penile Induration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010411","descriptor_name":"Penile Induration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051899","descriptor_name":"Smad2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051900","descriptor_name":"Smad3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1743-6109.2010.01753.x","doi":"https://doi.org/10.1111/j.1743-6109.2010.01753.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1743-6109.2010.01753.x","pdf_url":null,"source":{"id":"https://openalex.org/S159512450","display_name":"The Journal of Sexual Medicine","issn_l":"1743-6095","issn":["1743-6095","1743-6109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Sexual Medicine","raw_type":"journal-article"},{"id":"pmid:20233292","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20233292","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of sexual medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322348","display_name":"Korea Science and Engineering Foundation","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1605189746","https://openalex.org/W1923939500","https://openalex.org/W1964256786","https://openalex.org/W2012973556","https://openalex.org/W2016865792","https://openalex.org/W2017463647","https://openalex.org/W2017800749","https://openalex.org/W2020755018","https://openalex.org/W2025955073","https://openalex.org/W2034779792","https://openalex.org/W2044509605","https://openalex.org/W2057161685","https://openalex.org/W2061780160","https://openalex.org/W2062909350","https://openalex.org/W2065096738","https://openalex.org/W2086900559","https://openalex.org/W2093417867","https://openalex.org/W2094202435","https://openalex.org/W2101077425","https://openalex.org/W2105683352","https://openalex.org/W2116902092","https://openalex.org/W2117814548","https://openalex.org/W2119180373","https://openalex.org/W2125757459","https://openalex.org/W2136592357","https://openalex.org/W2136953190","https://openalex.org/W4296588288"],"related_works":["https://openalex.org/W2004918684","https://openalex.org/W2025663773","https://openalex.org/W2146927987","https://openalex.org/W7095360193","https://openalex.org/W2894397335","https://openalex.org/W2054595128","https://openalex.org/W2972280418","https://openalex.org/W2020755018","https://openalex.org/W2209142792","https://openalex.org/W1978577414"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Transforming":[1],"growth":[2],"factor-\u03b21":[3],"(TGF-\u03b21)":[4],"has":[5],"been":[6],"identified":[7],"as":[8],"an":[9],"important":[10],"fibrogenic":[11],"cytokine":[12],"associated":[13],"with":[14,104,115,122,136,161],"Peyronie's":[15],"disease":[16],"(PD).":[17],"AIM:":[18],"The":[19,128,192],"aim":[20],"of":[21,30,49,60,70,181,187,223,232,246,250,257,261],"this":[22],"study":[23,26],"was":[24,83,93,134,148],"to":[25,44,141,163,269],"the":[27,31,46,157,178,207,230,247,255],"differential":[28],"expression":[29],"TGF-\u03b21":[32,123],"and":[33,43,89,119,145,156,172,202,220,225,252],"Smad":[34],"transcription":[35],"factors":[36],"in":[37,72,189,236,254],"plaque":[38,129,193],"tissue":[39,82,92,133,194,210],"from":[40,76,85,95,101,150,195,211,239],"PD":[41,78,87,105,196,241],"patients":[42,197],"determine":[45],"antifibrotic":[47],"effect":[48,180],"SKI2162":[50,116,182,214],"(SK":[51],"Chemicals,":[52],"Seoul,":[53],"South":[54],"Korea),":[55],"a":[56,66,102,265],"novel":[57,266],"small-molecule":[58],"inhibitor":[59],"activin":[61],"receptor-like":[62],"kinase":[63],"5":[64],"(ALK5),":[65],"type":[67],"I":[68],"receptor":[69],"TGF-\u03b2,":[71],"primary":[73,109],"fibroblasts":[74,152,237],"derived":[75,238],"human":[77,240],"plaque.":[79,242],"METHODS:":[80],"Plaque":[81,99],"isolated":[84],"five":[86],"patients,":[88],"tunica":[90,131,208],"albuginea":[91,132,209],"obtained":[94],"four":[96],"control":[97,212],"patients.":[98,213],"tissues":[100],"patient":[103],"were":[106,113,159],"used":[107],"for":[108,153],"fibroblast":[110],"culture.":[111],"Fibroblasts":[112],"pretreated":[114],"(10":[117],"\u00b5M)":[118],"then":[120],"stimulated":[121],"(10ng/mL).":[124],"MAIN":[125],"OUTCOME":[126],"MEASURES:":[127],"or":[130,139],"stained":[135],"Masson's":[137],"trichrome":[138],"antibody":[140,162],"TGF-\u03b21,":[142,200],"phospho-Smad2":[143],"(P-Smad2),":[144],"P-Smad3.":[146],"Protein":[147],"extracted":[149],"treated":[151],"Western":[154],"blotting,":[155],"membranes":[158],"probed":[160],"P-Smad2/Smad2,":[164],"P-Smad3/Smad3,":[165],"plasminogen":[166],"activator":[167],"inhibitor-1,":[168],"fibronectin,":[169],"collagen":[170,173],"I,":[171],"IV.":[174],"We":[175],"also":[176,228],"determined":[177],"inhibitory":[179],"on":[183],"TGF-\u03b21-induced":[184,218],"nuclear":[185,221],"translocation":[186,222],"Smad2/3":[188],"fibroblasts.":[190],"RESULTS:":[191],"showed":[198],"higher":[199],"P-Smad2,":[201],"P-Smad3":[203],"immunoreactivity":[204],"than":[205],"did":[206],"not":[215],"only":[216],"blocked":[217],"phosphorylation":[219],"Smad2":[224],"Smad3,":[226],"but":[227],"inhibited":[229],"production":[231],"extracellular":[233],"matrix":[234],"markers":[235],"CONCLUSION:":[243],"In":[244],"light":[245],"pivotal":[248],"role":[249],"TGF-\u03b2":[251],"Smads":[253],"pathogenesis":[256],"PD,":[258],"pharmacologic":[259],"inhibition":[260],"ALK5":[262],"may":[263],"represent":[264],"targeted":[267],"approach":[268],"treating":[270],"PD.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
