{"id":"https://openalex.org/W2124285243","doi":"https://doi.org/10.1152/jn.00003.2006","title":"Dendritic Calcium Plateau Potentials Modulate Input\u2013Output Properties of Juxtaglomerular Cells in the Rat Olfactory Bulb","display_name":"Dendritic Calcium Plateau Potentials Modulate Input\u2013Output Properties of Juxtaglomerular Cells in the Rat Olfactory Bulb","publication_year":2006,"publication_date":"2006-07-20","ids":{"openalex":"https://openalex.org/W2124285243","doi":"https://doi.org/10.1152/jn.00003.2006","mag":"2124285243","pmid":"https://pubmed.ncbi.nlm.nih.gov/16855116"},"language":"en","primary_location":{"id":"doi:10.1152/jn.00003.2006","doi":"https://doi.org/10.1152/jn.00003.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.00003.2006","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101971577","display_name":"Zhishang Zhou","orcid":"https://orcid.org/0000-0002-3739-6235","observed_orcids":["https://orcid.org/0000-0002-3739-6235"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhishang Zhou","raw_affiliation_strings":["Department of Neurobiology, School of Medicine, Yale University, 333 Cedar Street, New Haven, CT 06510, USA. zhouzhishang@ninds.nih.gov","Department of Neurobiology, School of Medicine, Yale University, 333 Cedar Street, New Haven, CT 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, School of Medicine, Yale University, 333 Cedar Street, New Haven, CT 06510, USA. zhouzhishang@ninds.nih.gov","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Neurobiology, School of Medicine, Yale University, 333 Cedar Street, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112721189","display_name":"Wenhui Xiong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenhui Xiong","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000421658","display_name":"Arjun V. Masurkar","orcid":"https://orcid.org/0000-0002-2498-2059","observed_orcids":["https://orcid.org/0000-0002-2498-2059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arjun V. Masurkar","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei R. Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei R. Chen","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052931874","display_name":"Gordon M. Shepherd","orcid":"https://orcid.org/0000-0002-1455-8262","observed_orcids":["https://orcid.org/0000-0002-1455-8262"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon M. Shepherd","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2987,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.78608787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"96","issue":"5","first_page":"2354","last_page":"2363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.6729000210762024,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.6729000210762024,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.23989999294281006,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/juxtaglomerular-cells","display_name":"juxtaglomerular cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/olfactory-bulb","display_name":"olfactory bulb","score":0.921999990940094},{"id":"https://openalex.org/keywords/nickel-block","display_name":"nickel block","score":0.7409999966621399},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potentials","display_name":"excitatory postsynaptic potentials","score":0.8159999847412109},{"id":"https://openalex.org/keywords/low-pass-filtering","display_name":"low-pass filtering","score":0.8870000243186951},{"id":"https://openalex.org/keywords/pacemaker-neurons","display_name":"pacemaker neurons","score":0.6850000023841858},{"id":"https://openalex.org/keywords/intrinsic-membrane-properties","display_name":"intrinsic membrane properties","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C2780496858","wikidata":"https://www.wikidata.org/wiki/Q644945","display_name":"Olfactory bulb","level":3,"score":0.7480083703994751},{"id":"https://openalex.org/C2780030769","wikidata":"https://www.wikidata.org/wiki/Q4968575","display_name":"Plateau (mathematics)","level":2,"score":0.7046787738800049},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.7039598226547241},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.6658235788345337},{"id":"https://openalex.org/C2779617337","wikidata":"https://www.wikidata.org/wiki/Q842429","display_name":"Soma","level":2,"score":0.6585873365402222},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6379436254501343},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5802960395812988},{"id":"https://openalex.org/C84248122","wikidata":"https://www.wikidata.org/wiki/Q5256671","display_name":"Dendrite (mathematics)","level":2,"score":0.4932331442832947},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.4778801500797272},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.46065282821655273},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.45460787415504456},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4499351978302002},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.375381737947464},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.36580729484558105},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.19128546118736267},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08845648169517517},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007606","descriptor_name":"Juxtaglomerular Apparatus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007606","descriptor_name":"Juxtaglomerular Apparatus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007606","descriptor_name":"Juxtaglomerular Apparatus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009532","descriptor_name":"Nickel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009830","descriptor_name":"Olfactory Bulb","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009830","descriptor_name":"Olfactory Bulb","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009830","descriptor_name":"Olfactory Bulb","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/jn.00003.2006","doi":"https://doi.org/10.1152/jn.00003.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.00003.2006","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},{"id":"pmid:16855116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16855116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurophysiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1217962268","display_name":null,"funder_award_id":"DC-003918","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G4477607614","display_name":null,"funder_award_id":"DC-000086","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G5726419131","display_name":"Functional Dynamics of Olfactory Bulb Dendrites","funder_award_id":"R01DC003918","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W18318716","https://openalex.org/W106141043","https://openalex.org/W128191062","https://openalex.org/W173349528","https://openalex.org/W1484628435","https://openalex.org/W1555762208","https://openalex.org/W1716632673","https://openalex.org/W1961943243","https://openalex.org/W1973090520","https://openalex.org/W1974326501","https://openalex.org/W1984508253","https://openalex.org/W1992352154","https://openalex.org/W1992455733","https://openalex.org/W2001030178","https://openalex.org/W2007221253","https://openalex.org/W2008118471","https://openalex.org/W2012369607","https://openalex.org/W2017230689","https://openalex.org/W2022253710","https://openalex.org/W2024525681","https://openalex.org/W2035845442","https://openalex.org/W2042220820","https://openalex.org/W2042752467","https://openalex.org/W2043068492","https://openalex.org/W2044195886","https://openalex.org/W2045324476","https://openalex.org/W2047541854","https://openalex.org/W2060063624","https://openalex.org/W2060200234","https://openalex.org/W2061512758","https://openalex.org/W2061824022","https://openalex.org/W2069186336","https://openalex.org/W2073399843","https://openalex.org/W2073546303","https://openalex.org/W2077040167","https://openalex.org/W2077778849","https://openalex.org/W2078961866","https://openalex.org/W2082782774","https://openalex.org/W2130371690","https://openalex.org/W2133258871","https://openalex.org/W2135673917","https://openalex.org/W2137432586","https://openalex.org/W2141788722","https://openalex.org/W2144724443","https://openalex.org/W2147502381","https://openalex.org/W2150022225","https://openalex.org/W2151889193","https://openalex.org/W2154138317","https://openalex.org/W2165340969","https://openalex.org/W2189027870","https://openalex.org/W2312624037","https://openalex.org/W2409169767","https://openalex.org/W2911553709","https://openalex.org/W4231815232"],"related_works":["https://openalex.org/W2066404383","https://openalex.org/W1981398582","https://openalex.org/W2087027257","https://openalex.org/W4411099459","https://openalex.org/W2000131587","https://openalex.org/W2060200234","https://openalex.org/W2169568834","https://openalex.org/W2064900194","https://openalex.org/W2003748551","https://openalex.org/W128191062"],"abstract_inverted_index":{"Understanding":[0],"the":[1,15,23,55,79,94,97,101,138,146,153,156,161,192,197,203,216,221],"intrinsic":[2,193],"membrane":[3,194],"properties":[4,195,201],"of":[5,18,70,85,104,155,183,196,202,220],"juxtaglomerular":[6],"(JG)":[7],"cells":[8,47,163,209],"is":[9],"a":[10,40,115,123,127],"necessary":[11],"step":[12],"toward":[13],"understanding":[14],"neural":[16],"basis":[17],"olfactory":[19,35],"signal":[20],"processing":[21],"within":[22],"glomeruli.":[24],"We":[25],"used":[26],"patch-clamp":[27],"recordings":[28],"and":[29,48,151,218],"two-photon":[30,111],"Ca(2+)":[31,106,117,133],"imaging":[32],"in":[33,45,54,215],"rat":[34],"bulb":[36],"slices":[37],"to":[38,74,136,144,164,169,173,188,210],"analyze":[39],"long-lasting":[41],"plateau":[42,59,80,98,129,147,185,204],"potential":[43,148,205],"generated":[44,63],"JG":[46,88,162,198,208],"characterize":[49],"its":[50],"functional":[51],"input-output":[52],"roles":[53],"glomerular":[56,222],"network.":[57,223],"The":[58,131,176],"potentials":[60,142,186],"were":[61],"initially":[62],"by":[64,191],"dendritic":[65,105,116,124,132],"calcium":[66],"channels.":[67,107],"Bath":[68],"application":[69],"Ni(2+)":[71,86],"(250":[72],"microM":[73],"1":[75],"mM)":[76],"totally":[77],"blocked":[78,96],"potential.":[81,130],"A":[82],"local":[83],"puff":[84],"on":[87,93],"cell":[89],"dendrites,":[90],"but":[91,125],"not":[92,126],"soma,":[95],"potentials,":[99],"indicating":[100],"critical":[102],"contribution":[103],"Imaging":[108],"studies":[109],"with":[110,122],"microscopy":[112],"showed":[113],"that":[114,149],"increase":[118],"was":[119],"always":[120],"correlated":[121],"somatic":[128],"conductance":[134],"contributed":[135],"boosting":[137],"initial":[139],"excitatory":[140],"postsynaptic":[141],"(EPSPs)":[143],"produce":[145],"shunted":[150],"reduced":[152],"amplitudes":[154],"following":[157],"EPSPs.":[158],"This":[159],"enables":[160],"act":[165],"as":[166,212],"low-pass":[167],"filters":[168],"convert":[170],"high-frequency":[171],"inputs":[172],"low-frequency":[174],"outputs.":[175],"low":[177],"frequency":[178],"(2.6":[179],"+/-":[180],"0.8":[181],"Hz)":[182],"rhythmic":[184],"appeared":[187],"be":[189],"determined":[190],"cell.":[199],"These":[200],"may":[206],"enable":[207],"serve":[211],"pacemaker":[213],"neurons":[214],"synchronization":[217],"oscillation":[219]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}