{"id":"https://openalex.org/W2124284331","doi":"https://doi.org/10.1097/00063198-200011000-00005","title":"The art and science of continuous positive airway pressure therapy in obstructive sleep apnea","display_name":"The art and science of continuous positive airway pressure therapy in obstructive sleep apnea","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W2124284331","doi":"https://doi.org/10.1097/00063198-200011000-00005","mag":"2124284331","pmid":"https://pubmed.ncbi.nlm.nih.gov/11100958"},"language":"en","primary_location":{"id":"doi:10.1097/00063198-200011000-00005","doi":"https://doi.org/10.1097/00063198-200011000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00063198-200011000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S188383068","display_name":"Current Opinion in Pulmonary Medicine","issn_l":"1070-5287","issn":["1070-5287","1531-6971"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pulmonary Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101722531","display_name":"Atul Malhotra","orcid":"https://orcid.org/0000-0002-7021-9302","observed_orcids":["https://orcid.org/0000-0002-7021-9302"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atul Malhotra","raw_affiliation_strings":["Pulmonary and Critical Care Medicine Section VA Boston Healthcare System, and the Harvard Medical School, Massachusetts, USA","Pulmonary and Critical Care Medicine Section VA Boston Healthcare System, and the Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine Section VA Boston Healthcare System, and the Harvard Medical School, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801671727"]},{"raw_affiliation_string":"Pulmonary and Critical Care Medicine Section VA Boston Healthcare System, and the Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102942816","display_name":"Najib T. Ayas","orcid":"https://orcid.org/0000-0003-0259-7464","observed_orcids":["https://orcid.org/0000-0003-0259-7464"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Najib T. Ayas","raw_affiliation_strings":["Pulmonary and Critical Care Medicine Section VA Boston Healthcare System, and the Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine Section VA Boston Healthcare System, and the Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801671727"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112200375","display_name":"Lawrence J. Epstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lawrence J. Epstein","raw_affiliation_strings":["Pulmonary and Critical Care Medicine Section VA Boston Healthcare System, and the Harvard Medical School, Boston, Massachusetts, USA","to Dr. Lawrence J. Epstein, Pulmonary Section, 1400 VFW Parkway, West Roxbury, MA 02132, USA; e-mail: [email\u00a0protected]","e-mail: [email\u00a0protected]","to Dr. Lawrence J. Epstein, Pulmonary Section, 1400 VFW Parkway, West Roxbury, MA 02132, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine Section VA Boston Healthcare System, and the Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801671727"]},{"raw_affiliation_string":"to Dr. Lawrence J. Epstein, Pulmonary Section, 1400 VFW Parkway, West Roxbury, MA 02132, USA; e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"to Dr. Lawrence J. Epstein, Pulmonary Section, 1400 VFW Parkway, West Roxbury, MA 02132, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112200375"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801671727"],"apc_list":null,"apc_paid":null,"fwci":0.9499,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.76392765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"6","issue":"6","first_page":"490","last_page":"495"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.9729999899864197},{"id":"https://openalex.org/keywords/continuous-positive-airway-pressure","display_name":"continuous positive airway pressure","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cpap-adherence","display_name":"CPAP adherence","score":0.8199999928474426},{"id":"https://openalex.org/keywords/heated-humidification","display_name":"heated humidification","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cardiovascular-complications","display_name":"cardiovascular complications","score":0.4519999921321869},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7110000252723694},{"id":"https://openalex.org/keywords/neurocognitive-sequelae","display_name":"neuropsychological sequelae","score":0.8949999809265137},{"id":"https://openalex.org/keywords/pharyngeal-collapse","display_name":"pharyngeal collapse","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9646262526512146},{"id":"https://openalex.org/C2779547634","wikidata":"https://www.wikidata.org/wiki/Q5165502","display_name":"Continuous positive airway pressure","level":3,"score":0.9431828260421753},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.8340659737586975},{"id":"https://openalex.org/C204832983","wikidata":"https://www.wikidata.org/wiki/Q331466","display_name":"Positive pressure","level":2,"score":0.6075376272201538},{"id":"https://openalex.org/C2779485045","wikidata":"https://www.wikidata.org/wiki/Q1759644","display_name":"Oral appliance","level":3,"score":0.5672615766525269},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5625851154327393},{"id":"https://openalex.org/C2775867611","wikidata":"https://www.wikidata.org/wiki/Q1024207","display_name":"Positive airway pressure","level":3,"score":0.5595880746841431},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.527737021446228},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.49810266494750977},{"id":"https://openalex.org/C2777935920","wikidata":"https://www.wikidata.org/wiki/Q213600","display_name":"Sleep apnea","level":2,"score":0.4573783576488495},{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.43701714277267456},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3188610076904297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17957469820976257},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.10020279884338379},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011175","descriptor_name":"Positive-Pressure Respiration","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011175","descriptor_name":"Positive-Pressure Respiration","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011175","descriptor_name":"Positive-Pressure Respiration","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011175","descriptor_name":"Positive-Pressure Respiration","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011175","descriptor_name":"Positive-Pressure Respiration","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011175","descriptor_name":"Positive-Pressure Respiration","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00063198-200011000-00005","doi":"https://doi.org/10.1097/00063198-200011000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00063198-200011000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S188383068","display_name":"Current Opinion in Pulmonary Medicine","issn_l":"1070-5287","issn":["1070-5287","1531-6971"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pulmonary Medicine","raw_type":"journal-article"},{"id":"pmid:11100958","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11100958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in pulmonary medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.41999998688697815,"display_name":"Quality education","id":"https://metadata.un.org/sdg/4"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W9332590","https://openalex.org/W109061776","https://openalex.org/W139778875","https://openalex.org/W180111622","https://openalex.org/W184985917","https://openalex.org/W201164920","https://openalex.org/W289207924","https://openalex.org/W1857998630","https://openalex.org/W1869035511","https://openalex.org/W1873034366","https://openalex.org/W1965400451","https://openalex.org/W1970529956","https://openalex.org/W1971121870","https://openalex.org/W1972250721","https://openalex.org/W1975894171","https://openalex.org/W1977228997","https://openalex.org/W1979304007","https://openalex.org/W1980418279","https://openalex.org/W1993809883","https://openalex.org/W1994865619","https://openalex.org/W2003372031","https://openalex.org/W2007136373","https://openalex.org/W2032855965","https://openalex.org/W2035557978","https://openalex.org/W2046298535","https://openalex.org/W2047132452","https://openalex.org/W2056722705","https://openalex.org/W2057413559","https://openalex.org/W2060266906","https://openalex.org/W2062084391","https://openalex.org/W2065484808","https://openalex.org/W2075726900","https://openalex.org/W2078259015","https://openalex.org/W2080022935","https://openalex.org/W2080037122","https://openalex.org/W2082533403","https://openalex.org/W2085814883","https://openalex.org/W2086341683","https://openalex.org/W2093737681","https://openalex.org/W2099908875","https://openalex.org/W2099915725","https://openalex.org/W2100947214","https://openalex.org/W2112975431","https://openalex.org/W2117075490","https://openalex.org/W2124037300","https://openalex.org/W2127297361","https://openalex.org/W2130348431","https://openalex.org/W2136167986","https://openalex.org/W2138207801","https://openalex.org/W2139404323","https://openalex.org/W2141408818","https://openalex.org/W2145566510","https://openalex.org/W2155274369","https://openalex.org/W2158661956","https://openalex.org/W2162645075","https://openalex.org/W2168513641","https://openalex.org/W2288628145","https://openalex.org/W2319970884","https://openalex.org/W2333343699","https://openalex.org/W2344226996","https://openalex.org/W2415496829"],"related_works":["https://openalex.org/W2114646836","https://openalex.org/W3197904159","https://openalex.org/W4386231388","https://openalex.org/W4251665308","https://openalex.org/W2151881130","https://openalex.org/W2124284331","https://openalex.org/W2332012678","https://openalex.org/W2053710374","https://openalex.org/W2397775284","https://openalex.org/W2171318968"],"abstract_inverted_index":{"Despite":[0],"the":[1,29,66,95,148],"high":[2],"prevalence":[3],"of":[4,31,69,84,97,115],"obstructive":[5],"sleep":[6],"apnea":[7],"(OSA)":[8],"syndrome,":[9],"no":[10],"ideal":[11],"therapy":[12,27],"has":[13],"emerged":[14],"to":[15,45,160],"date.":[16],"Based":[17],"on":[18,72,94],"recent":[19,79],"randomized":[20],"trials,":[21],"continuous":[22],"positive":[23,139],"airway":[24,140],"pressure":[25,89,141],"(CPAP)":[26],"is":[28],"treatment":[30,52,61],"choice.":[32],"Although":[33,56],"CPAP":[34,63,109],"can":[35,64,110,142],"prevent":[36],"pharyngeal":[37],"collapse":[38],"in":[39],"virtually":[40],"all":[41],"patients":[42],"who":[43,127],"choose":[44],"wear":[46],"it,":[47],"poor":[48],"patient":[49],"adherence":[50,107],"with":[51,62,90,108,113],"limits":[53],"its":[54],"effectiveness.":[55],"convincing":[57],"data":[58,71,93],"exist":[59],"that":[60],"alleviate":[65],"neurocognitive":[67],"sequelae":[68],"OSA,":[70],"cardiovascular":[73],"complications":[74],"are":[75,103],"more":[76],"limited.":[77],"Several":[78],"reports":[80],"support":[81,122],"a":[82],"lowering":[83],"nocturnal":[85],"and":[86,100,120,123,137],"daytime":[87],"blood":[88],"CPAP,":[91],"but":[92],"prevention":[96],"myocardial":[98],"infarction":[99],"cerebrovascular":[101],"events":[102],"currently":[104],"lacking.":[105],"Patient":[106],"be":[111,143,154],"improved":[112],"optimization":[114],"mask":[116],"comfort,":[117],"heated":[118],"humidification,":[119],"intensive":[121],"education.":[124],"For":[125],"those":[126],"remain":[128],"poorly":[129],"compliant,":[130],"alternative":[131],"therapies":[132],"such":[133],"as":[134],"autotitrating":[135],"devices":[136],"oral":[138],"considered.":[144],"Further":[145],"research":[146],"into":[147],"basic":[149],"mechanisms":[150],"underlying":[151],"OSA":[152],"will":[153],"required":[155],"for":[156],"new":[157],"therapeutic":[158],"targets":[159],"develop.":[161]},"counts_by_year":[{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2025-10-10T00:00:00"}