{"id":"https://openalex.org/W2124276340","doi":"https://doi.org/10.1124/jpet.104.077974","title":"Cannabinoid CB1 Receptor Antagonists as Promising New Medications for Drug Dependence","display_name":"Cannabinoid CB1 Receptor Antagonists as Promising New Medications for Drug Dependence","publication_year":2005,"publication_date":"2005-02-15","ids":{"openalex":"https://openalex.org/W2124276340","doi":"https://doi.org/10.1124/jpet.104.077974","mag":"2124276340","pmid":"https://pubmed.ncbi.nlm.nih.gov/15525797"},"language":"en","primary_location":{"id":"doi:10.1124/jpet.104.077974","doi":"https://doi.org/10.1124/jpet.104.077974","is_oa":false,"landing_page_url":"https://doi.org/10.1124/jpet.104.077974","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2124276340"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067734183","display_name":"Bernard Le Foll","orcid":"https://orcid.org/0000-0002-6406-4973","observed_orcids":["https://orcid.org/0000-0002-6406-4973"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1327069482","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernard Le Foll","raw_affiliation_strings":["Preclinical Pharmacology Section, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. blefoll@intra.nida.nih.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Pharmacology Section, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. blefoll@intra.nida.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110935158","display_name":"Steven R. Goldberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven R. Goldberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":4.8047,"has_fulltext":false,"cited_by_count":294,"citation_normalized_percentile":{"value":0.97488584,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"312","issue":"3","first_page":"875","last_page":"883"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cannabinoid-cb1-receptor-antagonist","display_name":"cannabinoid CB1 receptor antagonist","score":0.9649999737739563},{"id":"https://openalex.org/keywords/rimonabant","display_name":"rimonabant","score":0.968999981880188},{"id":"https://openalex.org/keywords/drug-addiction","display_name":"drug addiction","score":0.9210000038146973},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.9490000009536743},{"id":"https://openalex.org/keywords/delta9-tetrahydrocannabinol","display_name":"delta-9-tetrahydrocannabinol","score":0.796999990940094},{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cocaine","display_name":"cocaine","score":0.7960000038146973},{"id":"https://openalex.org/keywords/opiates","display_name":"opiates","score":0.7670000195503235},{"id":"https://openalex.org/keywords/alcohol","display_name":"alcohol","score":0.9380000233650208},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.6859999895095825},{"id":"https://openalex.org/keywords/cb1-receptor-knockout-mice","display_name":"CB1 receptor knockout mice","score":0.527999997138977},{"id":"https://openalex.org/keywords/smoking-cessation","display_name":"smoking cessation","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.7448481321334839},{"id":"https://openalex.org/C2776433454","wikidata":"https://www.wikidata.org/wiki/Q412529","display_name":"Rimonabant","level":5,"score":0.7360935211181641},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6716840863227844},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.6714087128639221},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5996406078338623},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.5959140062332153},{"id":"https://openalex.org/C2778555786","wikidata":"https://www.wikidata.org/wiki/Q7448011","display_name":"Self-administration","level":2,"score":0.5655940175056458},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.4981698989868164},{"id":"https://openalex.org/C64948172","wikidata":"https://www.wikidata.org/wiki/Q1653277","display_name":"Brain stimulation reward","level":4,"score":0.48808109760284424},{"id":"https://openalex.org/C2777650357","wikidata":"https://www.wikidata.org/wiki/Q1569460","display_name":"Mesolimbic pathway","level":5,"score":0.48019254207611084},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.46499693393707275},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4379941523075104},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.4306645393371582},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.3778175115585327},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3613889813423157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3560870885848999},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33652758598327637},{"id":"https://openalex.org/C2780948874","wikidata":"https://www.wikidata.org/wiki/Q640562","display_name":"Ventral tegmental area","level":4,"score":0.30787986516952515},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2212028205394745},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.14859601855278015}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003213","descriptor_name":"Conditioning, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012646","descriptor_name":"Self Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1124/jpet.104.077974","doi":"https://doi.org/10.1124/jpet.104.077974","is_oa":false,"landing_page_url":"https://doi.org/10.1124/jpet.104.077974","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},{"id":"pmid:15525797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15525797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pharmacology and experimental therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.847.5287","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.847.5287","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jpet.aspetjournals.org/content/early/2004/11/03/jpet.104.077974.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W110543184","https://openalex.org/W1533897695","https://openalex.org/W1534942440","https://openalex.org/W1561443084","https://openalex.org/W1593759117","https://openalex.org/W1608227749","https://openalex.org/W1635375164","https://openalex.org/W1685180105","https://openalex.org/W1699530412","https://openalex.org/W1766653312","https://openalex.org/W1788979206","https://openalex.org/W1963496553","https://openalex.org/W1965511684","https://openalex.org/W1965679449","https://openalex.org/W1967332436","https://openalex.org/W1967566314","https://openalex.org/W1976236173","https://openalex.org/W1976328383","https://openalex.org/W1980344452","https://openalex.org/W1983885464","https://openalex.org/W1984039810","https://openalex.org/W1984109009","https://openalex.org/W1985856611","https://openalex.org/W1987289533","https://openalex.org/W1987449453","https://openalex.org/W1987516465","https://openalex.org/W1997255693","https://openalex.org/W1998152406","https://openalex.org/W2001109168","https://openalex.org/W2001865657","https://openalex.org/W2004564420","https://openalex.org/W2009700703","https://openalex.org/W2010739745","https://openalex.org/W2012129826","https://openalex.org/W2013940388","https://openalex.org/W2019242961","https://openalex.org/W2019530923","https://openalex.org/W2019927998","https://openalex.org/W2020713586","https://openalex.org/W2025075297","https://openalex.org/W2032808929","https://openalex.org/W2033369218","https://openalex.org/W2033399541","https://openalex.org/W2035064159","https://openalex.org/W2036055518","https://openalex.org/W2036218676","https://openalex.org/W2037457092","https://openalex.org/W2037711038","https://openalex.org/W2038064315","https://openalex.org/W2038682321","https://openalex.org/W2041670206","https://openalex.org/W2042691855","https://openalex.org/W2043256977","https://openalex.org/W2044456340","https://openalex.org/W2045484191","https://openalex.org/W2048756351","https://openalex.org/W2051071084","https://openalex.org/W2051897235","https://openalex.org/W2051982486","https://openalex.org/W2054203254","https://openalex.org/W2055018246","https://openalex.org/W2055158862","https://openalex.org/W2056188558","https://openalex.org/W2058590053","https://openalex.org/W2059410203","https://openalex.org/W2060123538","https://openalex.org/W2060694966","https://openalex.org/W2060941708","https://openalex.org/W2063118939","https://openalex.org/W2064409585","https://openalex.org/W2070212982","https://openalex.org/W2073734463","https://openalex.org/W2074256319","https://openalex.org/W2075894678","https://openalex.org/W2083175842","https://openalex.org/W2084836373","https://openalex.org/W2086715457","https://openalex.org/W2086781281","https://openalex.org/W2088355418","https://openalex.org/W2089464278","https://openalex.org/W2090375124","https://openalex.org/W2090788664","https://openalex.org/W2091638846","https://openalex.org/W2092939280","https://openalex.org/W2093757762","https://openalex.org/W2097485425","https://openalex.org/W2102035457","https://openalex.org/W2103903337","https://openalex.org/W2106607972","https://openalex.org/W2110515962","https://openalex.org/W2111641138","https://openalex.org/W2112323466","https://openalex.org/W2112924959","https://openalex.org/W2117726420","https://openalex.org/W2130587723","https://openalex.org/W2137134274","https://openalex.org/W2143839686","https://openalex.org/W2153219532","https://openalex.org/W2158972787","https://openalex.org/W2159011576","https://openalex.org/W2160184530","https://openalex.org/W2160313769","https://openalex.org/W2160701769","https://openalex.org/W2161510689","https://openalex.org/W2165269657","https://openalex.org/W2165298640","https://openalex.org/W2171065970","https://openalex.org/W2178258129","https://openalex.org/W2257160382","https://openalex.org/W2259659319","https://openalex.org/W2271658662","https://openalex.org/W2313253915","https://openalex.org/W2322589228","https://openalex.org/W2400822160","https://openalex.org/W2402812446","https://openalex.org/W2403564328","https://openalex.org/W2416716742","https://openalex.org/W4244161634","https://openalex.org/W4245339511","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7096303612","https://openalex.org/W2331358065","https://openalex.org/W1875725323","https://openalex.org/W2140215853","https://openalex.org/W1964935293","https://openalex.org/W7095324033","https://openalex.org/W2119735577","https://openalex.org/W2022696445","https://openalex.org/W76812767","https://openalex.org/W2001109168"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
