{"id":"https://openalex.org/W2124256845","doi":null,"title":"The Effect of Alpha-Lipoic Acid on Learning and Memory Deficit in a Rat Model of Temporal Lobe Epilepsy","display_name":"The Effect of Alpha-Lipoic Acid on Learning and Memory Deficit in a Rat Model of Temporal Lobe Epilepsy","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2124256845","mag":"2124256845"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:85ca6d5db8bb4882b0587bd5db4385ac","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/85ca6d5db8bb4882b0587bd5db4385ac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Basic and Clinical Neuroscience, Vol 3, Iss 3, Pp 58-66 (2012)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073707783","display_name":"Tourandokht Baluchnejadmojarad","orcid":"https://orcid.org/0000-0002-2703-728X","observed_orcids":["https://orcid.org/0000-0002-2703-728X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tourandokht Baluchnejadmojarad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070346344","display_name":"Mehrdad Roghani","orcid":"https://orcid.org/0000-0002-9209-8484","observed_orcids":["https://orcid.org/0000-0002-9209-8484"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehrdad Roghani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038409029","display_name":"Mitra Kamran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitra Kamran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032930971","display_name":"Narges Karimi","orcid":"https://orcid.org/0000-0001-5912-3732","observed_orcids":["https://orcid.org/0000-0001-5912-3732"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Narges Karimi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-lipoic-acid","display_name":"alpha-lipoic acid","score":1.0},{"id":"https://openalex.org/keywords/temporal-lobe-epilepsy","display_name":"temporal lobe epilepsy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/kainic-acid-induced-epilepsy","display_name":"kainic acid-induced epilepsy","score":0.8809999823570251},{"id":"https://openalex.org/keywords/learning-and-memory-impairment","display_name":"learning and memory impairment","score":0.8730000257492065},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.7639999985694885},{"id":"https://openalex.org/keywords/antioxidant-neuroprotection","display_name":"antioxidant neuroprotection","score":0.8100000023841858},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9259999990463257},{"id":"https://openalex.org/keywords/nitrite","display_name":"nitrite","score":0.7620000243186951},{"id":"https://openalex.org/keywords/spontaneous-seizures","display_name":"spontaneous seizures","score":0.6919999718666077},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6240000128746033},{"id":"https://openalex.org/keywords/epilepsy-treatment","display_name":"epilepsy treatment","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7374194860458374},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.7158829569816589},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6330350637435913},{"id":"https://openalex.org/C2910140794","wikidata":"https://www.wikidata.org/wiki/Q312229","display_name":"Alpha-Lipoic Acid","level":3,"score":0.6221870183944702},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5125410556793213},{"id":"https://openalex.org/C2779491571","wikidata":"https://www.wikidata.org/wiki/Q312229","display_name":"Lipoic acid","level":3,"score":0.45418158173561096},{"id":"https://openalex.org/C2081992","wikidata":"https://www.wikidata.org/wiki/Q5133838","display_name":"Clinical neuroscience","level":3,"score":0.4449097812175751},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.438857764005661},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.35721686482429504},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.3510451018810272},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.34541118144989014},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28755149245262146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23423674702644348},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15588539838790894},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14847123622894287},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:doaj.org/article:85ca6d5db8bb4882b0587bd5db4385ac","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/85ca6d5db8bb4882b0587bd5db4385ac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Basic and Clinical Neuroscience, Vol 3, Iss 3, Pp 58-66 (2012)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:dd18e8e40ca04229bc9afc00711da8e2","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/dd18e8e40ca04229bc9afc00711da8e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Basic and Clinical Neuroscience, Vol 3, Iss 3, Pp 58-66 (2012)","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W111233702","https://openalex.org/W238106794","https://openalex.org/W1500963622","https://openalex.org/W1564875712","https://openalex.org/W1607065540","https://openalex.org/W1970475719","https://openalex.org/W1976940800","https://openalex.org/W1977476783","https://openalex.org/W1978042177","https://openalex.org/W1983221766","https://openalex.org/W1988023571","https://openalex.org/W1988905501","https://openalex.org/W1992670283","https://openalex.org/W1994706550","https://openalex.org/W1995186464","https://openalex.org/W1995444099","https://openalex.org/W1998306945","https://openalex.org/W2000828660","https://openalex.org/W2006457855","https://openalex.org/W2010904428","https://openalex.org/W2013926783","https://openalex.org/W2014545614","https://openalex.org/W2015380328","https://openalex.org/W2016293448","https://openalex.org/W2019983337","https://openalex.org/W2020287650","https://openalex.org/W2026048677","https://openalex.org/W2026528160","https://openalex.org/W2031575360","https://openalex.org/W2041491220","https://openalex.org/W2041736030","https://openalex.org/W2045871887","https://openalex.org/W2047093898","https://openalex.org/W2055031312","https://openalex.org/W2055073729","https://openalex.org/W2057162169","https://openalex.org/W2059223526","https://openalex.org/W2078333644","https://openalex.org/W2080630839","https://openalex.org/W2084773300","https://openalex.org/W2085534129","https://openalex.org/W2090522955","https://openalex.org/W2092271268","https://openalex.org/W2092700031","https://openalex.org/W2093238337","https://openalex.org/W2099956125","https://openalex.org/W2101243709","https://openalex.org/W2102514120","https://openalex.org/W2103946141","https://openalex.org/W2111680392","https://openalex.org/W2113588185","https://openalex.org/W2128635872","https://openalex.org/W2139911439","https://openalex.org/W2145397350","https://openalex.org/W2163542118","https://openalex.org/W2164933567"],"related_works":["https://openalex.org/W2285890955","https://openalex.org/W2355224116","https://openalex.org/W2080630839","https://openalex.org/W2041146248","https://openalex.org/W2495619250","https://openalex.org/W4220907266","https://openalex.org/W4408978005","https://openalex.org/W2784694994","https://openalex.org/W3000379444","https://openalex.org/W7220529417"],"abstract_inverted_index":{"Introduction":[0],":":[1],"Epilepsy":[2],"is":[3,27],"a":[4,67],"chronic":[5],"neurological":[6],"disorder":[7],"in":[8,17,80,95,102,130,164,191,201,214,224,230,263],"which":[9],"patients":[10,31,55],"experience":[11],"spontaneous":[12,177,180,209],"recurrent":[13],"seizures":[14,39,57],"and":[15,19,128,141,145,188,218,221,241,244],"deficiency":[16],"learning":[18,140],"memory.":[20],"Although":[21],"the":[22,85,107,157,173,192,206,225,238],"most":[23],"commonly":[24],"recommended":[25],"therapy":[26],"drug":[28],"treatment,":[29],"some":[30,70],"do":[32],"not":[33,77],"achieve":[34],"adequate":[35],"control":[36],"of":[37,48,82,88,98,161,198,208,259],"their":[38],"on":[40],"existing":[41],"drugs.":[42,62],"New":[43],"medications":[44],"with":[45,90,116,132],"novel":[46],"mechanisms":[47],"action":[49,75],"are":[50,58],"needed":[51],"to":[52,60,155,267],"help":[53],"those":[54],"whose":[56],"resistant":[59],"currently-available":[61],"While":[63],"alpha-lipoic":[64,91,199],"acid":[65,92,126,163,235,253],"as":[66],"antioxidant":[68,269],"has":[69,76],"neuroprotective":[71],"properties,":[72],"but":[73],"this":[74],"been":[78],"investigated":[79],"models":[81],"epilepsy.":[83],"Therefore,":[84],"protective":[86],"effect":[87,160],"pretreatment":[89,254],"was":[93],"evaluated":[94],"experimental":[96],"model":[97],"temporal":[99],"lobe":[100],"epilepsy":[101,159],"male":[103,111],"rats.":[104,167,232],"Methods:":[105],"In":[106],"present":[108],"study,":[109],"Wistar":[110],"rats":[112,175,264],"were":[113],"injected":[114],"intrahippocampally":[115],"0.9%":[117],"saline(Sham-operated":[118],"group),":[119],"kainic":[120,133,256],"acid(4":[121],"\u03bcg)":[122],"alone,":[123],"or":[124],"\u03b1-lipoic":[125,162],"(25mg":[127],"50mg/kg)":[129],"association":[131],"acid(4\u03bcg).":[134],"We":[135],"performed":[136],"behavior":[137],"monitoring(spontaneous":[138],"seizure,":[139],"memory":[142,262],"by":[143],"Y-maze":[144,215],"passive":[146,193,226],"avoidance":[147,194,227],"test),":[148],"intracranial":[149],"electroencepholography":[150],"(iEEG)":[151],"recording,":[152],"histological":[153],"analysis,":[154],"evaluate":[156],"anti-":[158],"kainate-induced":[165],"epileptic":[166],"Results:":[168],"Behavior":[169],"data":[170],"showed":[171],"that":[172,251],"kainate":[174],"exhibit":[176],"seizures,":[178,210],"lower":[179],"alternation":[181,212],"score":[182,213],"inY-maze":[183],"tasks":[184],"(p<0.01),":[185],"impaired":[186,219],"retention":[187,220],"recall":[189,222],"capability":[190,223],"test":[195,228],"(p<0.05).":[196],"Administration":[197],"acid,":[200],"both":[202],"doses,":[203],"significantly":[204],"decrease":[205],"number":[207],"improved":[211],"task":[216],"(p<0.005)":[217],"(p<0.01)":[229],"kainite":[231],"Moreover,":[233],"lipoic":[234,252],"could":[236],"improve":[237],"lipid":[239],"peroxidation":[240],"nitrite":[242],"level":[243],"superoxid":[245],"dismutase":[246],"activity.Conclusion:":[247],"This":[248],"study":[249],"indicates":[250],"attenuates":[255],"acid-induced":[257],"impairment":[258],"short-term":[260],"spatial":[261],"probably":[265],"due":[266],"its":[268],"activity.":[270]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}