{"id":"https://openalex.org/W2124235302","doi":"https://doi.org/10.1507/endocrj.40.571","title":"Human Corticotropin-Releasing Hormone (hCRH) Test: Sex and Age Differences in Plasma ACTH and Cortisol Responses and their Reproducibility in Healthy Adults.","display_name":"Human Corticotropin-Releasing Hormone (hCRH) Test: Sex and Age Differences in Plasma ACTH and Cortisol Responses and their Reproducibility in Healthy Adults.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2124235302","doi":"https://doi.org/10.1507/endocrj.40.571","mag":"2124235302","pmid":"https://pubmed.ncbi.nlm.nih.gov/7951523"},"language":"en","primary_location":{"id":"doi:10.1507/endocrj.40.571","doi":"https://doi.org/10.1507/endocrj.40.571","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.40.571","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1993/40/5/40_5_571/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/endocrj1993/40/5/40_5_571/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108590304","display_name":"KOSHI TANAKA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KOSHI TANAKA","raw_affiliation_strings":["Third Department of Medicine, Teikyo University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Medicine, Teikyo University School of Medicine","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066672568","display_name":"N Shimizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NAOKATA SHIMIZU","raw_affiliation_strings":["Third Department of Medicine, Teikyo University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Medicine, Teikyo University School of Medicine","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107447054","display_name":"Hiroo Imura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROO IMURA","raw_affiliation_strings":["Second Division, Department of Medicine, Kyoto University Faculty of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Division, Department of Medicine, Kyoto University Faculty of Medicine","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110044358","display_name":"Junichi Fukata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"JUNICHI FUKATA","raw_affiliation_strings":["Second Division, Department of Medicine, Kyoto University Faculty of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Division, Department of Medicine, Kyoto University Faculty of Medicine","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026474548","display_name":"Itsuro Hibi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I4405282054","display_name":"National Children's Hospital","ror":"https://ror.org/058vv9y91","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I1293811555","https://openalex.org/I4210117550","https://openalex.org/I4405282054"]}],"countries":["PH","US"],"is_corresponding":false,"raw_author_name":"ITSURO HIBI","raw_affiliation_strings":["Endocrine Research Laboratory, Division of Endocrinology and Metabolism, National Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Laboratory, Division of Endocrinology and Metabolism, National Children's Hospital","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I4405282054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022418773","display_name":"Toshiaki Tanaka","orcid":"https://orcid.org/0000-0002-1199-9302","observed_orcids":["https://orcid.org/0000-0002-1199-9302"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I4405282054","display_name":"National Children's Hospital","ror":"https://ror.org/058vv9y91","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I1293811555","https://openalex.org/I4210117550","https://openalex.org/I4405282054"]}],"countries":["PH","US"],"is_corresponding":false,"raw_author_name":"TOSHIAKI TANAKA","raw_affiliation_strings":["Endocrine Research Laboratory, Division of Endocrinology and Metabolism, National Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Laboratory, Division of Endocrinology and Metabolism, National Children's Hospital","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I4405282054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103564559","display_name":"Shoichi Nakagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHOICHI NAKAGAWA","raw_affiliation_strings":["Second Department of Medicine, Hokkaido University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Medicine, Hokkaido University School of Medicine","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100836670","display_name":"Kenji Fujieda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KENJI FUJIEDA","raw_affiliation_strings":["Department of Pediatrics, Hokkaido University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Hokkaido University School of Medicine","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112641102","display_name":"Kazuo Takebe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KAZUO TAKEBE","raw_affiliation_strings":["Third Department of Internal Medicine, Hirosaki University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Hirosaki University School of Medicine","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112658230","display_name":"KAORU YOSHINAGA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KAORU YOSHINAGA","raw_affiliation_strings":["Second Department of Internal Medicine, Tohoku University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Tohoku University School of Medicine","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111523686","display_name":"Kintomo Takakura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KINTOMO TAKAKURA","raw_affiliation_strings":["Department of Neurosurgery, Tokyo Women's Medical College","Department of Neurosurgery, University of Tokyo Faculty of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Tokyo Women's Medical College","institution_ids":["https://openalex.org/I4210136522"]},{"raw_affiliation_string":"Department of Neurosurgery, University of Tokyo Faculty of Medicine","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112642247","display_name":"Seizo Suwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115195","display_name":"Kanagawa Children's Medical Center","ror":"https://ror.org/022h0tq76","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115195"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SEIZO SUWA","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Kanagawa Children's Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Kanagawa Children's Medical Center","institution_ids":["https://openalex.org/I4210115195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101135801","display_name":"Katsuhiko Tachibana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115195","display_name":"Kanagawa Children's Medical Center","ror":"https://ror.org/022h0tq76","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115195"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KATSUHIKO TACHIBANA","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Kanagawa Children's Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Kanagawa Children's Medical Center","institution_ids":["https://openalex.org/I4210115195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113941488","display_name":"Kiyohiko Kato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KIYOHIKO KATO","raw_affiliation_strings":["Department of Pediatrics, Yamanashi Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Yamanashi Medical College","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110247327","display_name":"Teruya Yoshimi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13491362","display_name":"Hamamatsu University","ror":"https://ror.org/057vy9683","country_code":"JP","type":"education","lineage":["https://openalex.org/I13491362"]},{"id":"https://openalex.org/I3123035732","display_name":"Hamamatsu University School of Medicine","ror":"https://ror.org/00ndx3g44","country_code":"JP","type":"education","lineage":["https://openalex.org/I3123035732"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TERUYA YOSHIMI","raw_affiliation_strings":["Second Department of Internal Medicine, Hamamatsu University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Hamamatsu University School of Medicine","institution_ids":["https://openalex.org/I13491362","https://openalex.org/I3123035732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108746092","display_name":"Kiyoshi Miura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KIYOSHI MIURA","raw_affiliation_strings":["Third Department of Internal Medicine, Gifu University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Gifu University School of Medicine","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022374141","display_name":"Akio Kuwayama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AKIO KUWAYAMA","raw_affiliation_strings":["First Department of Neurosurgery, Nagoya National Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Neurosurgery, Nagoya National Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112002529","display_name":"Zensuke Ota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"ZENSUKE OTA","raw_affiliation_strings":["Third Department of Internal Medicine, Okayama University Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Okayama University Medical School","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015016528","display_name":"Yuzuru Kato","orcid":"https://orcid.org/0000-0002-4001-3792","observed_orcids":["https://orcid.org/0000-0002-4001-3792"]},"institutions":[{"id":"https://openalex.org/I4405285000","display_name":"Shimane Medical University","ror":"https://ror.org/04kg5pk90","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828","https://openalex.org/I4405285000"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YUZURU KATO","raw_affiliation_strings":["First Division, Department of Medicine, Shimane Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Division, Department of Medicine, Shimane Medical University","institution_ids":["https://openalex.org/I4405285000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103631940","display_name":"Shiro Saito","orcid":"https://orcid.org/0000-0002-3869-1869","observed_orcids":["https://orcid.org/0000-0002-3869-1869"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHIRO SAITO","raw_affiliation_strings":["First Department of Internal Medicine, School of Medicine, The University of Tokushima"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, School of Medicine, The University of Tokushima","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109500127","display_name":"Jiro Takahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]},{"id":"https://openalex.org/I4210135297","display_name":"Kagawa University Hospital","ror":"https://ror.org/033sspj46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I201933988","https://openalex.org/I4210135297"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"JIRO TAKAHARA","raw_affiliation_strings":["First Department of Internal Medicine, Kagawa Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Kagawa Medical School","institution_ids":["https://openalex.org/I201933988","https://openalex.org/I4210135297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109070741","display_name":"Kozo Hashimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I77063589","display_name":"K\u014dchi University","ror":"https://ror.org/01xxp6985","country_code":"JP","type":"education","lineage":["https://openalex.org/I77063589"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KOZO HASHIMOTO","raw_affiliation_strings":["Second Department of Internal Medicine, Kochi Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Kochi Medical School","institution_ids":["https://openalex.org/I77063589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113564437","display_name":"Hajime Nawata","orcid":"https://orcid.org/0009-0005-4166-9493","observed_orcids":["https://orcid.org/0009-0005-4166-9493"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HAJIME NAWATA","raw_affiliation_strings":["Third Department of Internal Medicine, Faculty of Medicine, Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Faculty of Medicine, Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113566574","display_name":"Shigeru Matsukura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHIGERU MATSUKURA","raw_affiliation_strings":["Third Department of Internal Medicine, Miyazaki Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Miyazaki Medical College","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053594587","display_name":"Noboru Yanaihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NOBORU YANAIHARA","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Shizuoka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Shizuoka","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":24,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8215,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.73316039,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"40","issue":"5","first_page":"571","last_page":"579"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.05950000137090683,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acth-response","display_name":"ACTH response","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cortisol-response","display_name":"cortisol response","score":0.9789999723434448},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9629999995231628},{"id":"https://openalex.org/keywords/age-differences","display_name":"age differences","score":0.996999979019165},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.9430000185966492},{"id":"https://openalex.org/keywords/healthy-adults","display_name":"healthy adults","score":0.7310000061988831},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.7381585836410522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6742821931838989},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6316795349121094},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6237737536430359},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.6181151866912842},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5684450268745422},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5025062561035156},{"id":"https://openalex.org/C2778458438","wikidata":"https://www.wikidata.org/wiki/Q386664","display_name":"Corticotropin-releasing hormone","level":3,"score":0.45577338337898254},{"id":"https://openalex.org/C2987276129","wikidata":"https://www.wikidata.org/wiki/Q12140","display_name":"Drug administration","level":2,"score":0.44911468029022217},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11220094561576843},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000304","descriptor_name":"Adrenal Cortex Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005483","descriptor_name":"Flushing","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010901","descriptor_name":"Pituitary Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010913","descriptor_name":"Pituitary-Adrenal System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010913","descriptor_name":"Pituitary-Adrenal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012636","descriptor_name":"Secretory Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1507/endocrj.40.571","doi":"https://doi.org/10.1507/endocrj.40.571","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.40.571","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1993/40/5/40_5_571/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},{"id":"pmid:7951523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7951523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine journal","raw_type":"Clinical Trial"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0007113841","doi":null,"is_oa":true,"landing_page_url":"https://pure.teikyo.jp/en/publications/06a4d16b-038a-414a-a8de-4eb3cd6a1ebc","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endocrine Journal","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1507/endocrj.40.571","doi":"https://doi.org/10.1507/endocrj.40.571","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.40.571","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1993/40/5/40_5_571/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323532","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74"},{"id":"https://openalex.org/F4320323533","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124235302.pdf","grobid_xml":"https://content.openalex.org/works/W2124235302.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1493629431","https://openalex.org/W1969884045","https://openalex.org/W1991675638","https://openalex.org/W2019595831","https://openalex.org/W2021228833","https://openalex.org/W2028608508","https://openalex.org/W2071457351","https://openalex.org/W2073388455","https://openalex.org/W2087092592","https://openalex.org/W2095036452","https://openalex.org/W2114038584"],"related_works":["https://openalex.org/W2071457351","https://openalex.org/W2170353500","https://openalex.org/W2069615588","https://openalex.org/W1969884045","https://openalex.org/W1991675638","https://openalex.org/W2409770244","https://openalex.org/W2078611870","https://openalex.org/W2003567728","https://openalex.org/W3081066861","https://openalex.org/W2072306793"],"abstract_inverted_index":{"The":[0],"effectiveness":[1],"and":[2,22,34,46,53,93],"safety":[3],"of":[4,31,39,42],"MCI-028,":[5],"a":[6,13,78],"synthetic":[7],"human":[8],"corticotropin-releasing":[9],"hormone":[10],"(hCRH),":[11],"as":[12,91],"diagnostic":[14],"drug":[15],"were":[16,44,55,97,100],"examined":[17],"in":[18,62,69,72],"65":[19],"healthy":[20,24],"male":[21,74],"24":[23],"female":[25],"adult":[26],"volunteers.":[27],"Mean":[28],"maximum":[29],"concentrations":[30],"plasma":[32],"ACTH":[33],"cortisol":[35],"after":[36,81],"intravenous":[37],"administration":[38,80],"100":[40],"micrograms":[41],"MCI-028":[43],"3.0":[45],"2.0":[47],"times":[48],"their":[49],"basal":[50],"concentrations,":[51],"respectively,":[52],"there":[54],"no":[56],"significant":[57],"age":[58],"or":[59],"sex":[60],"differences":[61],"the":[63,70],"responses.":[64],"Good":[65],"reproducibility":[66],"was":[67],"observed":[68],"responses":[71],"59":[73],"subjects":[75],"who":[76],"received":[77],"second":[79],"1":[82],"to":[83],"2":[84],"weeks.":[85],"Although":[86],"slight":[87],"adverse":[88],"reactions":[89],"such":[90],"mild":[92],"transient":[94],"hot":[95],"flushing":[96],"observed,":[98],"these":[99],"not":[101],"serious.":[102]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}