{"id":"https://openalex.org/W2124227044","doi":"https://doi.org/10.1101/gad.13.7.768","title":"Molecular mechanism of nucleotide excision repair","display_name":"Molecular mechanism of nucleotide excision repair","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W2124227044","doi":"https://doi.org/10.1101/gad.13.7.768","mag":"2124227044","pmid":"https://pubmed.ncbi.nlm.nih.gov/10197977"},"language":"en","primary_location":{"id":"doi:10.1101/gad.13.7.768","doi":"https://doi.org/10.1101/gad.13.7.768","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.13.7.768","pdf_url":"http://genesdev.cshlp.org/content/13/7/768.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://genesdev.cshlp.org/content/13/7/768.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021842648","display_name":"Wouter L. de Laat","orcid":"https://orcid.org/0000-0002-6393-595X","observed_orcids":["https://orcid.org/0000-0002-6393-595X"]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W. L. de Laat","raw_affiliation_strings":["Medical Genetic Center, Department of Cell Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Genetic Center, Department of Cell Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113590844","display_name":"N.G.J. Jaspers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"N. G.J. Jaspers","raw_affiliation_strings":["Medical Genetic Center, Department of Cell Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Genetic Center, Department of Cell Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052209499","display_name":"Jan H.J. Hoeijmakers","orcid":"https://orcid.org/0000-0003-3526-7795","observed_orcids":["https://orcid.org/0000-0003-3526-7795"]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"J. H.J. Hoeijmakers","raw_affiliation_strings":["Medical Genetic Center, Department of Cell Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Genetic Center, Department of Cell Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052209499"],"corresponding_institution_ids":["https://openalex.org/I913958620"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1138,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"7","first_page":"768","last_page":"785"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":1.0},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cyclobutane-pyrimidine-dimers","display_name":"cyclobutane pyrimidine dimers","score":0.9150000214576721},{"id":"https://openalex.org/keywords/6-4-photoproducts","display_name":"6-4 photoproducts","score":0.9670000076293945},{"id":"https://openalex.org/keywords/xeroderma-pigmentosum","display_name":"xeroderma pigmentosum","score":0.9309999942779541},{"id":"https://openalex.org/keywords/xpa","display_name":"XPA","score":0.6129999756813049},{"id":"https://openalex.org/keywords/xpc","display_name":"XPC","score":0.7850000262260437},{"id":"https://openalex.org/keywords/tfiih","display_name":"TFIIH","score":0.972000002861023},{"id":"https://openalex.org/keywords/xpd-helicase","display_name":"XPD helicase","score":0.890999972820282},{"id":"https://openalex.org/keywords/replication-protein-a","display_name":"replication protein A","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9294582605361938},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.695350170135498},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.567138671875},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5166850090026855},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.489376962184906},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.37156274914741516},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33171945810317993},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.324947714805603},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000099250","descriptor_name":"DNA Excision Repair Protein ERCC-5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019473","descriptor_name":"Transcription Factors, TFII","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051716","descriptor_name":"Replication Protein A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051758","descriptor_name":"Transcription Factor TFIIH","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051760","descriptor_name":"Xeroderma Pigmentosum Group A Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1101/gad.13.7.768","doi":"https://doi.org/10.1101/gad.13.7.768","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.13.7.768","pdf_url":"http://genesdev.cshlp.org/content/13/7/768.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},{"id":"pmid:10197977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10197977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & development","raw_type":"Journal Article"},{"id":"pmh:oai:pure.eur.nl:openaire/612ace72-1024-4d11-b998-5457bd7dc81b","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/612ace72-1024-4d11-b998-5457bd7dc81b","pdf_url":"https://pure.eur.nl/files/46587621/10197977.pdf","source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"de Laat, WL, Jaspers, K & Hoeijmakers, J 1999, 'Molecular mechanism of nucleotide excision repair', Genes & Development, vol. 13, pp. 768-785. < http://hdl.handle.net/1765/9075 >","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/612ace72-1024-4d11-b998-5457bd7dc81b","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/612ace72-1024-4d11-b998-5457bd7dc81b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genes &amp; Development, 13, 768 - 785. Cold Spring Harbor Laboratory Press","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:repub.eur.nl:9075","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/9075","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genes &amp; Development","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repub.eur.nl:9075","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/9075","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genes &amp; Development","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1101/gad.13.7.768","doi":"https://doi.org/10.1101/gad.13.7.768","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.13.7.768","pdf_url":"http://genesdev.cshlp.org/content/13/7/768.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320322777","display_name":"KWF Kankerbestrijding","ror":"https://ror.org/0368jnd28"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124227044.pdf","grobid_xml":"https://content.openalex.org/works/W2124227044.grobid-xml"},"referenced_works_count":221,"referenced_works":["https://openalex.org/W12794080","https://openalex.org/W113088029","https://openalex.org/W128683993","https://openalex.org/W183746846","https://openalex.org/W282058052","https://openalex.org/W1005028082","https://openalex.org/W1488607169","https://openalex.org/W1489183905","https://openalex.org/W1492288851","https://openalex.org/W1516514485","https://openalex.org/W1517222706","https://openalex.org/W1546888157","https://openalex.org/W1550656265","https://openalex.org/W1552586455","https://openalex.org/W1554850792","https://openalex.org/W1558439345","https://openalex.org/W1558614105","https://openalex.org/W1570121117","https://openalex.org/W1574197136","https://openalex.org/W1584822940","https://openalex.org/W1603476921","https://openalex.org/W1605214441","https://openalex.org/W1606394252","https://openalex.org/W1608564947","https://openalex.org/W1679236006","https://openalex.org/W1773876596","https://openalex.org/W1785654530","https://openalex.org/W1791227751","https://openalex.org/W1805239396","https://openalex.org/W1809038905","https://openalex.org/W1889725400","https://openalex.org/W1903827703","https://openalex.org/W1913632830","https://openalex.org/W1925096888","https://openalex.org/W1933350980","https://openalex.org/W1961821398","https://openalex.org/W1963868441","https://openalex.org/W1965446460","https://openalex.org/W1966720879","https://openalex.org/W1967762148","https://openalex.org/W1967902178","https://openalex.org/W1968198873","https://openalex.org/W1968499461","https://openalex.org/W1969769040","https://openalex.org/W1970456889","https://openalex.org/W1973511453","https://openalex.org/W1973517823","https://openalex.org/W1975365355","https://openalex.org/W1975494947","https://openalex.org/W1975853177","https://openalex.org/W1980972910","https://openalex.org/W1982034145","https://openalex.org/W1982635017","https://openalex.org/W1983290059","https://openalex.org/W1985056911","https://openalex.org/W1986743116","https://openalex.org/W1990198168","https://openalex.org/W1991063481","https://openalex.org/W1991547782","https://openalex.org/W1991640607","https://openalex.org/W1992082799","https://openalex.org/W1992431849","https://openalex.org/W1996172944","https://openalex.org/W2000140771","https://openalex.org/W2000814287","https://openalex.org/W2000889791","https://openalex.org/W2000936373","https://openalex.org/W2000983378","https://openalex.org/W2001637607","https://openalex.org/W2002295835","https://openalex.org/W2003282728","https://openalex.org/W2004431479","https://openalex.org/W2004660918","https://openalex.org/W2005011630","https://openalex.org/W2006471304","https://openalex.org/W2007910316","https://openalex.org/W2007998684","https://openalex.org/W2008329454","https://openalex.org/W2008561915","https://openalex.org/W2011083044","https://openalex.org/W2015429343","https://openalex.org/W2015532523","https://openalex.org/W2015853472","https://openalex.org/W2016430241","https://openalex.org/W2019595755","https://openalex.org/W2020761966","https://openalex.org/W2021498593","https://openalex.org/W2021581979","https://openalex.org/W2021798512","https://openalex.org/W2023476869","https://openalex.org/W2023735321","https://openalex.org/W2024172421","https://openalex.org/W2024434976","https://openalex.org/W2025504171","https://openalex.org/W2026933272","https://openalex.org/W2028805078","https://openalex.org/W2031039047","https://openalex.org/W2032798652","https://openalex.org/W2033180282","https://openalex.org/W2033676950","https://openalex.org/W2033997324","https://openalex.org/W2034685457","https://openalex.org/W2035746057","https://openalex.org/W2038352482","https://openalex.org/W2039068784","https://openalex.org/W2039740270","https://openalex.org/W2040150820","https://openalex.org/W2040512937","https://openalex.org/W2041261463","https://openalex.org/W2041666540","https://openalex.org/W2044000184","https://openalex.org/W2048725347","https://openalex.org/W2049812251","https://openalex.org/W2051512786","https://openalex.org/W2051883249","https://openalex.org/W2054212919","https://openalex.org/W2055079963","https://openalex.org/W2056063131","https://openalex.org/W2057692066","https://openalex.org/W2059299769","https://openalex.org/W2059340538","https://openalex.org/W2059901912","https://openalex.org/W2062028908","https://openalex.org/W2062582450","https://openalex.org/W2064235474","https://openalex.org/W2064477710","https://openalex.org/W2066255476","https://openalex.org/W2066288618","https://openalex.org/W2070821144","https://openalex.org/W2071225439","https://openalex.org/W2078882775","https://openalex.org/W2079212338","https://openalex.org/W2079912627","https://openalex.org/W2080176881","https://openalex.org/W2081049803","https://openalex.org/W2081290278","https://openalex.org/W2081341310","https://openalex.org/W2081512480","https://openalex.org/W2082394755","https://openalex.org/W2082606230","https://openalex.org/W2084370157","https://openalex.org/W2084607632","https://openalex.org/W2087732988","https://openalex.org/W2088000870","https://openalex.org/W2089712104","https://openalex.org/W2090441795","https://openalex.org/W2090903262","https://openalex.org/W2091370689","https://openalex.org/W2091566576","https://openalex.org/W2093267013","https://openalex.org/W2097183131","https://openalex.org/W2098711782","https://openalex.org/W2099450421","https://openalex.org/W2102265131","https://openalex.org/W2102375831","https://openalex.org/W2104881338","https://openalex.org/W2105725083","https://openalex.org/W2109113345","https://openalex.org/W2109493296","https://openalex.org/W2111868018","https://openalex.org/W2111924246","https://openalex.org/W2112894423","https://openalex.org/W2115030154","https://openalex.org/W2115416778","https://openalex.org/W2115852070","https://openalex.org/W2116298638","https://openalex.org/W2118359991","https://openalex.org/W2120244560","https://openalex.org/W2120434953","https://openalex.org/W2123678649","https://openalex.org/W2124821548","https://openalex.org/W2125625919","https://openalex.org/W2128004417","https://openalex.org/W2131135801","https://openalex.org/W2132438813","https://openalex.org/W2132640465","https://openalex.org/W2137605101","https://openalex.org/W2137842510","https://openalex.org/W2138092377","https://openalex.org/W2139768549","https://openalex.org/W2140118545","https://openalex.org/W2140749034","https://openalex.org/W2141359223","https://openalex.org/W2141601266","https://openalex.org/W2141787155","https://openalex.org/W2142341469","https://openalex.org/W2142355539","https://openalex.org/W2142485616","https://openalex.org/W2142786878","https://openalex.org/W2148606858","https://openalex.org/W2148900195","https://openalex.org/W2150072036","https://openalex.org/W2151332646","https://openalex.org/W2152173447","https://openalex.org/W2154933591","https://openalex.org/W2158316009","https://openalex.org/W2159315273","https://openalex.org/W2160010807","https://openalex.org/W2163864783","https://openalex.org/W2164903782","https://openalex.org/W2165535395","https://openalex.org/W2165712756","https://openalex.org/W2166182249","https://openalex.org/W2166593574","https://openalex.org/W2169295539","https://openalex.org/W2169397218","https://openalex.org/W2171161861","https://openalex.org/W2171775098","https://openalex.org/W2172916891","https://openalex.org/W2173751778","https://openalex.org/W2189281745","https://openalex.org/W2290020609","https://openalex.org/W2741005445","https://openalex.org/W3145894777","https://openalex.org/W4247875307","https://openalex.org/W4285719527","https://openalex.org/W6600617704","https://openalex.org/W6601428791","https://openalex.org/W6601822323","https://openalex.org/W6698742671","https://openalex.org/W6999954569"],"related_works":["https://openalex.org/W1501527150","https://openalex.org/W3092923623","https://openalex.org/W2116298638","https://openalex.org/W321749438","https://openalex.org/W2558054604","https://openalex.org/W80043557","https://openalex.org/W2907375210","https://openalex.org/W3159093265","https://openalex.org/W1558944608","https://openalex.org/W2122007055"],"abstract_inverted_index":{"From":[0],"its":[1,38],"very":[2,503],"beginning,":[3],"life":[4],"has":[5,52,208,221,623],"faced":[6],"the":[7,11,28,76,117,135,144,157,167,191,202,205,238,247,250,254,265,268,271,279,288,295,299,304,317,334,376,384,398,410,421,427,434,445,542,598,627,631,646,665],"fundamental":[8],"problem":[9],"that":[10,74,482,538,556],"form":[12],"in":[13,55,154,187,211,256,264,286,310,316,350,364,418,437,469,564,626,638],"which":[14],"genetic":[15],"information":[16],"is":[17,19,25,60,262,284,373,442,463,501],"stored":[18],"not":[20,524],"chemically":[21],"inert.":[22],"DNA":[23,49,70,83,145,259,281,296,352],"integrity":[24],"challenged":[26],"by":[27,91,116,131,444,507],"damaging":[29],"effect":[30],"of":[31,48,58,79,82,88,113,121,138,143,204,249,267,270,303,325,331,346,368,378,391,400,416,420,430,474,496,520,535,611,630,645,664],"numerous":[32,125],"chemical":[33,127],"and":[34,68,106,160,201,228,240,261,283,290,320,344,479,493,515,580,593],"physical":[35],"agents,":[36],"compromizing":[37],"function.":[39],"To":[40],"protect":[41],"this":[42,132],"Achilles":[43],"heel,":[44],"an":[45,257],"intricate":[46],"network":[47],"repair":[50,63,169,183,272,330,345,392,495,540,574],"systems":[51],"evolved":[53],"early":[54],"evolution.":[56],"One":[57],"these":[59,521,612],"nucleotide":[61],"excision":[62],"(NER),":[64],"a":[65,80,150,225,365,431,454,457,466,502,565,569,655],"highly":[66],"versatile":[67],"sophisticated":[69],"damage":[71,89,255,422,441],"removal":[72,302,435],"pathway":[73],"counteracts":[75],"deleterious":[77],"effects":[78],"multitude":[81],"lesions,":[84,140],"including":[85,383],"major":[86,111],"types":[87],"induced":[90],"environmental":[92],"sources.":[93],"The":[94,231,389,472,532],"most":[95],"relevant":[96],"lesions":[97,332,348,551],"subject":[98],"to":[99,148,162,219,338,561,572,608,661],"NER":[100,139,155,196,326,342,357,370,613,650,666],"are":[101,129,405,488,523,652],"cyclobutane":[102],"pyrimidine":[103],"dimers":[104],"(CPDs)":[105],"(6-4)":[107],"photoproducts":[108],"(6-4PPs),":[109],"two":[110,475,485],"kinds":[112],"injury":[114],"produced":[115],"shortwave":[118],"UV":[119],"component":[120,367],"sunlight.":[122],"In":[123,190,425,439],"addition,":[124,426],"bulky":[126],"adducts":[128],"eliminated":[130],"process.":[133],"Within":[134],"divergent":[136],"spectrum":[137],"significant":[141],"distortion":[142],"helix":[146],"appears":[147],"be":[149,328,562],"common":[151,366],"denominator.":[152],"Defects":[153],"underlie":[156],"extreme":[158],"photosensitivity":[159,508],"predisposition":[161],"skin":[163],"cancer":[164],"observed":[165],"with":[166,465,527,587,636,654],"prototype":[168],"syndrome":[170,461,601],"xeroderma":[171],"pigmentosum":[172],"(XP).":[173],"Seven":[174],"XP":[175,360,530,588],"complementation":[176,476],"groups":[177,361,477],"have":[178,198,545],"been":[179,199,209,222],"identified,":[180],"representing":[181],"distinct":[182,458],"genes":[184],"XPA\u2013G":[185],"(discussed":[186],"detail":[188],"below).":[189],"last":[192],"decade,":[193],"all":[194,379],"key":[195],"factors":[197,314,380,614,667],"cloned":[200],"core":[203],"\u2018cut-and-paste\u2019":[206],"reaction":[207],"reconstituted":[210],"vitro":[212],"from":[213,409,597],"purified":[214],"components.":[215],"Recently,":[216],"XPC":[217],"(complexed":[218],"hHR23B)":[220],"identified":[223],"as":[224,339,509,511,553,615],"DNA-damage":[226],"sensor":[227,423],"repair-recruitment":[229],"factor.":[230],"general":[232,312],"transcription":[233,558,640],"factor":[234],"complex":[235,282,387,450,635],"TFIIH,":[236],"containing":[237],"XPB":[239],"XPD":[241,628],"helicases,":[242],"mediates":[243],"strand":[244],"separation":[245],"at":[246,483,642],"site":[248],"lesion.":[251,300,401,455],"XPA":[252],"verifies":[253],"open":[258],"conformation":[260],"crucial":[263],"assembly":[266],"remainder":[269],"machinery.":[273],"Replication":[274],"protein":[275],"A":[276,617],"(RPA)":[277],"stabilizes":[278],"opened":[280],"involved":[285],"positioning":[287],"XPG":[289],"ERCC1\u2013XPF":[291],"endonucleases":[292],"responsible":[293],"for":[294,393,491,621],"incisions":[297],"around":[298],"After":[301],"damagecontaining":[305],"oligonucleotide,":[306],"typically":[307],"24\u201332":[308],"nucleotides":[309],"length,":[311],"replication":[313],"fill":[315],"remaining":[318],"gap":[319],"close":[321],"it.":[322],"Two":[323],"modes":[324],"can":[327],"distinguished:":[329],"over":[333],"entire":[335],"genome,":[336],"referred":[337],"global":[340],"genome":[341,411],"(GG\u2013NER),":[343],"transcription-blocking":[347],"present":[349],"transcribed":[351,497],"strands,":[353],"hence":[354],"called":[355],"transcription-coupled":[356,470,539,566],"(TC\u2013NER).":[358],"Most":[359,519],"harbor":[362],"defects":[363,651],"both":[369],"subpathways.":[371],"GG\u2013NER":[372,394],"dependent":[374],"on":[375,397],"activity":[377],"mentioned":[381],"above,":[382],"GG\u2013":[385],"NER-specific":[386],"XPC\u2013hHR23B.":[388,424],"rate":[390,436],"strongly":[395],"depends":[396],"type":[399],"For":[402],"instance,":[403],"6-4PPs":[404],"removed":[406,563],"much":[407],"faster":[408],"than":[412],"CPDs,":[413],"probably":[414],"because":[415],"differences":[417],"affinity":[419],"location":[428],"(accessibility)":[429],"lesion":[432],"influences":[433],"vivo.":[438],"TC\u2013NER,":[440],"detected":[443],"elongating":[446],"RNA":[447],"polymerase":[448,571],"II":[449],"when":[451],"it":[452],"encounters":[453],"Interestingly,":[456],"disorder,":[459],"Cockayne":[460],"(CS),":[462],"associated":[464,653],"specific":[467],"defect":[468],"repair.":[471],"identification":[473],"(CS-A":[478],"CS-B)":[480],"shows":[481],"least":[484,643],"gene":[486],"products":[487],"specifically":[489],"needed":[490],"fast":[492],"efficient":[494],"strands.":[498],"Phenotypically,":[499],"CS":[500,536,543,584],"pleiotropic":[504],"condition":[505],"characterized":[506],"well":[510],"severe":[512],"neurological,":[513],"developmental,":[514],"premature":[516],"aging":[517],"features.":[518],"symptoms":[522,534],"seen":[525],"even":[526],"totally":[528],"NERdeficient":[529],"patients.":[531],"additional":[533,609,662],"suggest":[537],"and/or":[541],"proteins":[544],"functions":[546,663],"beyond":[547],"NER.":[548],"Also,":[549],"non-NERspecific":[550],"(such":[552],"oxidative":[554],"damage)":[555],"stall":[557],"elongation":[559],"appear":[560],"fashion,":[567],"linking":[568],"blocked":[570],"multiple":[573],"pathways.":[575],"Intriguingly,":[576],"some":[577,644],"XP-B,":[578],"XP-D,":[579],"XP-G":[581],"patients":[582],"display":[583],"features":[585],"combined":[586],"manifestations.":[589,648],"Yet":[590],"other":[591],"XP-B":[592],"XP-D":[594],"individuals":[595],"suffer":[596],"CS-like":[599],"brittle-hair":[600],"trichothiodystrophy":[602],"(TTD).":[603],"This":[604],"clinical":[605,658],"conundrum":[606],"points":[607],"roles":[610],"well.":[616],"recent":[618],"mouse":[619],"model":[620],"TTD":[622,647],"linked":[624],"mutations":[625],"subunit":[629],"dual":[632],"functional":[633],"TFIIH":[634],"deficiencies":[637],"basal":[639],"underlying":[641],"Thus,":[649],"surprisingly":[656],"wide":[657],"heterogeneity":[659],"due":[660],"involved.":[668],"1Corresponding":[669],"author.":[670],"E-MAIL":[671],"Hoeijmakers@gen.fgg.eur.nl;":[672],"FAX":[673],"31":[674],"10":[675],"408":[676],"9468.":[677]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":30},{"year":2019,"cited_by_count":31},{"year":2018,"cited_by_count":34},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":44},{"year":2015,"cited_by_count":42},{"year":2014,"cited_by_count":51},{"year":2013,"cited_by_count":40},{"year":2012,"cited_by_count":47}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}