{"id":"https://openalex.org/W2124199173","doi":"https://doi.org/10.1016/j.vaccine.2014.09.027","title":"A cluster randomized non-inferiority field trial on the immunogenicity and safety of tetanus toxoid vaccine kept in controlled temperature chain compared to cold chain","display_name":"A cluster randomized non-inferiority field trial on the immunogenicity and safety of tetanus toxoid vaccine kept in controlled temperature chain compared to cold chain","publication_year":2014,"publication_date":"2014-09-26","ids":{"openalex":"https://openalex.org/W2124199173","doi":"https://doi.org/10.1016/j.vaccine.2014.09.027","mag":"2124199173","pmid":"https://pubmed.ncbi.nlm.nih.gov/25261378"},"language":"en","primary_location":{"id":"doi:10.1016/j.vaccine.2014.09.027","doi":"https://doi.org/10.1016/j.vaccine.2014.09.027","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2014.09.027","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0264410X14012869/pdf","source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0264410X14012869/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057367232","display_name":"Aitana Juan-Giner","orcid":"https://orcid.org/0000-0001-6768-5874","observed_orcids":["https://orcid.org/0000-0001-6768-5874"]},"institutions":[{"id":"https://openalex.org/I4387152612","display_name":"Epicentre","ror":"https://ror.org/034w22c34","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210128224","https://openalex.org/I4387152612"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Aitana Juan-Giner","raw_affiliation_strings":["Epicentre, 8 rue Saint Sabin, 75011 Paris, France. Electronic address: aitana.juan@epicentre.msf.org","Epicentre, 8 rue Saint Sabin, 75011 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epicentre, 8 rue Saint Sabin, 75011 Paris, France. Electronic address: aitana.juan@epicentre.msf.org","institution_ids":["https://openalex.org/I4387152612"]},{"raw_affiliation_string":"Epicentre, 8 rue Saint Sabin, 75011 Paris, France","institution_ids":["https://openalex.org/I4387152612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055683820","display_name":"Camille Domicent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158280","display_name":"Institut Scientifique de Sant\u00e9 Publique","ror":"https://ror.org/04ws26165","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210158280"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Camille Domicent","raw_affiliation_strings":["Institut Scientifique de Sant\u00e9 Publique, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Scientifique de Sant\u00e9 Publique, Brussels, Belgium","institution_ids":["https://openalex.org/I4210158280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025596419","display_name":"C\u00e9line Langendorf","orcid":"https://orcid.org/0000-0002-0811-7540","observed_orcids":["https://orcid.org/0000-0002-0811-7540"]},"institutions":[{"id":"https://openalex.org/I4387152612","display_name":"Epicentre","ror":"https://ror.org/034w22c34","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210128224","https://openalex.org/I4387152612"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9line Langendorf","raw_affiliation_strings":["Epicentre, 8 rue Saint Sabin, 75011 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epicentre, 8 rue Saint Sabin, 75011 Paris, France","institution_ids":["https://openalex.org/I4387152612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065798102","display_name":"Martha H. Roper","orcid":"https://orcid.org/0000-0002-0897-3793","observed_orcids":["https://orcid.org/0000-0002-0897-3793"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martha H. Roper","raw_affiliation_strings":["Consultant, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant, New Haven, CT, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003787982","display_name":"Paul Baoundoh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Baoundoh","raw_affiliation_strings":["M\u00e9decins Sans Fronti\u00e8res, N'Djamena, Chad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M\u00e9decins Sans Fronti\u00e8res, N'Djamena, Chad","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014364399","display_name":"Florence Fermon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164708","display_name":"M\u00e9decins Sans Fronti\u00e8res","ror":"https://ror.org/0506t0t42","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210128224","https://openalex.org/I4210164708"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Florence Fermon","raw_affiliation_strings":["M\u00e9decins Sans Fronti\u00e8res, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M\u00e9decins Sans Fronti\u00e8res, Paris, France","institution_ids":["https://openalex.org/I4210164708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085563114","display_name":"Primitive Gakima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Primitive Gakima","raw_affiliation_strings":["M\u00e9decins Sans Fronti\u00e8res, N'Djamena, Chad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M\u00e9decins Sans Fronti\u00e8res, N'Djamena, Chad","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059414312","display_name":"Simona Zipursky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105654","display_name":"World Health Organization","ror":"https://ror.org/01f80g185","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105654"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Simona Zipursky","raw_affiliation_strings":["World Health Organization, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"World Health Organization, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210105654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009854782","display_name":"Mbaihol Tamadji","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mbaihol Tamadji","raw_affiliation_strings":["Expanded Program of Immunization, Ministry of Health, N'Djamena, Chad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Expanded Program of Immunization, Ministry of Health, N'Djamena, Chad","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046960097","display_name":"Rebecca F. Grais","orcid":"https://orcid.org/0000-0002-5037-8218","observed_orcids":["https://orcid.org/0000-0002-5037-8218"]},"institutions":[{"id":"https://openalex.org/I4387152612","display_name":"Epicentre","ror":"https://ror.org/034w22c34","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210128224","https://openalex.org/I4387152612"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rebecca F. Grais","raw_affiliation_strings":["Epicentre, 8 rue Saint Sabin, 75011 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epicentre, 8 rue Saint Sabin, 75011 Paris, France","institution_ids":["https://openalex.org/I4387152612"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5057367232"],"corresponding_institution_ids":["https://openalex.org/I4387152612"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":{"value":3620,"currency":"USD","value_usd":3620},"fwci":1.6429,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.79841713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"32","issue":"47","first_page":"6220","last_page":"6226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12499","display_name":"Diphtheria, Corynebacterium, and Tetanus","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12499","display_name":"Diphtheria, Corynebacterium, and Tetanus","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14126","display_name":"Intramuscular injections and effects","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetanus-toxoid-vaccine","display_name":"tetanus toxoid vaccine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cold-chain","display_name":"cold chain","score":0.9319999814033508},{"id":"https://openalex.org/keywords/vaccine-storage-and-transport","display_name":"vaccine storage and transport","score":0.6729999780654907},{"id":"https://openalex.org/keywords/vaccine-stability","display_name":"vaccine stability","score":0.5910000205039978},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/seroconversion","display_name":"seroconversion","score":0.9490000009536743},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.7400000095367432},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.824999988079071},{"id":"https://openalex.org/keywords/resource-limited-settings","display_name":"resource-limited settings","score":0.7369999885559082},{"id":"https://openalex.org/keywords/women-of-reproductive-age","display_name":"women of reproductive age","score":0.7260000109672546},{"id":"https://openalex.org/keywords/tetanus-prophylaxis","display_name":"tetanus prevention","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C2777451964","wikidata":"https://www.wikidata.org/wiki/Q2141450","display_name":"Seroconversion","level":3,"score":0.8625273704528809},{"id":"https://openalex.org/C2777351567","wikidata":"https://www.wikidata.org/wiki/Q908822","display_name":"Toxoid","level":4,"score":0.8549091219902039},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8226635456085205},{"id":"https://openalex.org/C2779841045","wikidata":"https://www.wikidata.org/wiki/Q47790","display_name":"Tetanus","level":3,"score":0.7237970232963562},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.5837695598602295},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5797857046127319},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5791426301002502},{"id":"https://openalex.org/C2780114722","wikidata":"https://www.wikidata.org/wiki/Q592197","display_name":"Cold chain","level":2,"score":0.5579220056533813},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5196579694747925},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4670775234699249},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3511752486228943},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3315317630767822},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.18290391564369202},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002596","descriptor_name":"Chad","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004356","descriptor_name":"Drug Storage","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012034","descriptor_name":"Refrigeration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013742","descriptor_name":"Tetanus","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013745","descriptor_name":"Tetanus Toxoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064166","descriptor_name":"Vaccine Potency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.vaccine.2014.09.027","doi":"https://doi.org/10.1016/j.vaccine.2014.09.027","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2014.09.027","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0264410X14012869/pdf","source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},{"id":"pmid:25261378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25261378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"Journal Article"},{"id":"pmh:oai:fieldresearch.msf.org:10144/336354","doi":null,"is_oa":true,"landing_page_url":"http://fieldresearch.msf.org/msf/handle/10144/336354","pdf_url":null,"source":{"id":"https://openalex.org/S4306402090","display_name":"Medecins Sans Frontieres Field Research (Medecins Sans Frontieres)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210128224","host_organization_name":"M\u00e9decins Sans Fronti\u00e8res","host_organization_lineage":["https://openalex.org/I4210128224"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.vaccine.2014.09.027","doi":"https://doi.org/10.1016/j.vaccine.2014.09.027","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2014.09.027","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0264410X14012869/pdf","source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320307856","display_name":"World Health Organization","ror":"https://ror.org/01f80g185"},{"id":"https://openalex.org/F4320321073","display_name":"Ministry of Social and Family Development, Singapore","ror":"https://ror.org/0434keq61"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124199173.pdf","grobid_xml":"https://content.openalex.org/works/W2124199173.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W66439614","https://openalex.org/W1917711296","https://openalex.org/W1970738675","https://openalex.org/W1988261554","https://openalex.org/W2000358983","https://openalex.org/W2013360991","https://openalex.org/W2030265800","https://openalex.org/W2034726312","https://openalex.org/W2050982645","https://openalex.org/W2052978157","https://openalex.org/W2075863469","https://openalex.org/W2094270588","https://openalex.org/W2102009564","https://openalex.org/W2106839241","https://openalex.org/W2109199813","https://openalex.org/W2128292163","https://openalex.org/W2145422280","https://openalex.org/W2411874297","https://openalex.org/W2417946153"],"related_works":["https://openalex.org/W7203770284","https://openalex.org/W7172514756","https://openalex.org/W7134932839","https://openalex.org/W3046210988","https://openalex.org/W4403214499","https://openalex.org/W4367322890","https://openalex.org/W2041696339","https://openalex.org/W3128142637","https://openalex.org/W2621614757","https://openalex.org/W4416276073"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1],"resource-poor":[2],"settings,":[3],"cold":[4,40,299],"chain":[5,41,300],"requirements":[6],"present":[7],"barriers":[8],"for":[9,32,88,243,293],"vaccine":[10,22],"delivery.":[11],"We":[12],"evaluated":[13],"the":[14,47,189,202,220,232,273,282],"immunogenicity":[15,233],"and":[16,91,122,132,146,159,234,277],"safety":[17,235],"of":[18,51,95,148,168,184,197,201,214,236,249,258],"tetanus":[19],"toxoid":[20],"(TT)":[21],"in":[23,67,134,188,207,219,238,255,281,296],"\"Controlled":[24],"Temperature":[25],"Chain\"":[26],"(CTC;":[27],"up":[28],"to":[29,38,46,55,79,109,177,260],"40":[30],"\u00b0C":[31,242],"<30":[33,244],"days":[34],"before":[35],"administration),":[36],"compared":[37],"standard":[39,118],"(SCC;":[42],"2-8":[43],"\u00b0C).":[44],"Prior":[45],"study,":[48],"stability":[49,279],"parameters":[50],"TT-CTC":[52],"were":[53,77,107,115,129,154,173,186,209,226],"shown":[54],"meet":[56],"international":[57],"requirements.":[58],"METHODS:":[59],"A":[60,166],"cluster":[61],"randomized,":[62],"non-inferiority":[63,264,271],"trial":[64],"was":[65,140,193,204,217],"conducted":[66],"Mo\u00efssala":[68],"district,":[69],"Chad,":[70],"December":[71],"2012-March":[72],"2013.":[73],"Thirty-four":[74],"included":[75,180,187],"clusters":[76],"randomized":[78],"CTC":[80,239,287],"or":[81],"SCC.":[82],"Women":[83],"aged":[84],"14-49":[85],"years,":[86],"eligible":[87],"TT":[89,97,101,237,294],"vaccination":[90],"with":[92,163],"a":[93,256,262,269],"history":[94],"\u22641":[96],"dose,":[98],"received":[99],"two":[100],"doses":[102],"4":[103,123],"weeks":[104,124],"apart.":[105],"Participants":[106],"blinded":[108],"allocation":[110],"strategy.":[111],"Tetanus":[112],"antibody":[113],"titers":[114],"measured":[116],"using":[117],"ELISA":[119],"at":[120,156,160,240,252,268],"inclusion":[121],"post-TT2.":[125],"Primary":[126,175],"outcome":[127],"measures":[128],"post-vaccination":[130],"seroconversion":[131,142,190],"fold-increase":[133],"geometric":[135],"mean":[136],"concentrations":[137],"(GMC).":[138],"Non-inferiority":[139],"by":[141,195],"difference":[143,203],"(TTSCC-TTCTC)":[144],"<5%":[145],"ratio":[147,216],"GMCs":[149],"(TTSCC/TTCTC)":[150],"<1.5.":[151],"Adverse":[152],"events":[153,225],"monitored":[155],"health":[157],"centers":[158],"next":[161],"contact":[162],"participants.":[164],"RESULTS:":[165],"total":[167],"2128":[169],"women":[170],"(CTC=1068;":[171],"SCC=1060)":[172],"recruited.":[174],"intention":[176],"vaccinate":[178],"analysis":[179],"1830":[181],"participants;":[182,198],"272":[183],"these":[185],"analysis.":[191,222],"Seroconversion":[192],"reached":[194],">95%":[196],"upper":[199,212],"95%CI":[200,213],"5.6%.":[205],"Increases":[206],"GMC":[208,215,275],"over":[210],"4-fold;":[211],"1.36":[218],"adjusted":[221],"Few":[223],"adverse":[224],"recorded.":[227],"CONCLUSIONS:":[228],"This":[229],"study":[230],"demonstrates":[231],"<40":[241],"days.":[245],"The":[246],"high":[247],"proportion":[248],"participants":[250],"protected":[251],"baseline":[253],"results":[254,267],"reduction":[257],"power":[259],"detect":[261],"5%":[263],"margin.":[265],"However,":[266],"10%":[270],"margin,":[272],"comparable":[274],"increases":[276],"vaccine's":[278],"demonstrated":[280],"preliminary":[283],"phase":[284],"indicate":[285],"that":[286],"can":[288],"be":[289,302],"an":[290],"alternative":[291],"strategy":[292],"delivery":[295],"situations":[297],"where":[298],"cannot":[301],"maintained.":[303]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}