{"id":"https://openalex.org/W2124181024","doi":null,"title":"Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors.","display_name":"Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors.","publication_year":1993,"publication_date":"1993-06-15","ids":{"openalex":"https://openalex.org/W2124181024","mag":"2124181024","pmid":"https://pubmed.ncbi.nlm.nih.gov/8504410"},"language":"en","primary_location":{"id":"pmid:8504410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8504410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031055768","display_name":"M Makos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Makos","raw_affiliation_strings":["Oncology Center, Johns Hopkins Medical Institutions, Baltimore 21231"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Center, Johns Hopkins Medical Institutions, Baltimore 21231","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010169788","display_name":"Barry D. Nelkin","orcid":"https://orcid.org/0000-0002-1552-6377","observed_orcids":["https://orcid.org/0000-0002-1552-6377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B D Nelkin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087591232","display_name":"Robert Evan Reiter","orcid":"https://orcid.org/0000-0002-7962-3985","observed_orcids":["https://orcid.org/0000-0002-7962-3985","https://orcid.org/0000-0002-2654-1628"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R E Reiter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086498350","display_name":"James R. Gnarra","orcid":"https://orcid.org/0000-0002-6369-3110","observed_orcids":["https://orcid.org/0000-0002-6369-3110"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J R Gnarra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022762690","display_name":"James D. Brooks","orcid":"https://orcid.org/0000-0003-4521-7505","observed_orcids":["https://orcid.org/0000-0003-4521-7505","https://orcid.org/0000-0002-8395-7494"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Brooks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068348417","display_name":"William B. Isaacs","orcid":"https://orcid.org/0000-0001-6599-6775","observed_orcids":["https://orcid.org/0000-0001-6599-6775"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Isaacs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107963543","display_name":"William Marston Linehan","orcid":"https://orcid.org/0000-0001-7983-3109","observed_orcids":["https://orcid.org/0000-0001-7983-3109"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Linehan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058612163","display_name":"Stephen B. Baylin","orcid":"https://orcid.org/0000-0003-3697-3798","observed_orcids":["https://orcid.org/0000-0003-3697-3798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S B Baylin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4745,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.93978905,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"53","issue":"12","first_page":"2719","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-hypermethylation","display_name":"DNA hypermethylation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/chromosome-17p","display_name":"chromosome 17p","score":0.9900000095367432},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"kidney cancer","score":0.8550000190734863},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.925000011920929},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.9190000295639038},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.8379999995231628},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.7020000219345093},{"id":"https://openalex.org/keywords/early-stage-renal-cancer","display_name":"early-stage renal cancer","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.641228437423706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6269669532775879},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5726842880249023},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5176825523376465},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5089643001556396},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5010452270507812},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4557587206363678},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.43199506402015686},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35027727484703064},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33394110202789307},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3212524652481079},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26748159527778625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15148040652275085},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1206829845905304}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002872","descriptor_name":"Chromosome Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002886","descriptor_name":"Chromosomes, Human, Pair 17","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8504410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8504410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2124181024","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8504410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3272723199","display_name":"Methylation of the Calcitonin Gene in Human Tumors","funder_award_id":"R01CA043318","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1933457654","https://openalex.org/W1964382251","https://openalex.org/W1969373767","https://openalex.org/W2035358971","https://openalex.org/W2036872469","https://openalex.org/W2040260715","https://openalex.org/W2042316019","https://openalex.org/W2056321925","https://openalex.org/W2090205848","https://openalex.org/W2096028174","https://openalex.org/W2100475900","https://openalex.org/W2119280406","https://openalex.org/W2145929767","https://openalex.org/W2150692393","https://openalex.org/W2166334882","https://openalex.org/W2409591894"],"related_works":["https://openalex.org/W1965800143","https://openalex.org/W1515832180","https://openalex.org/W2125471598","https://openalex.org/W2109700787","https://openalex.org/W2119280406","https://openalex.org/W4307358110","https://openalex.org/W2066924145","https://openalex.org/W2337481134","https://openalex.org/W2039036161","https://openalex.org/W2166334882"],"abstract_inverted_index":{"In":[0,53],"a":[1,9,109],"preceding":[2],"paper":[3],"for":[4],"brain":[5,37],"tumors,":[6,38],"we":[7],"demonstrate":[8],"tight":[10],"association":[11],"between":[12,43],"regional":[13,131],"hypermethylation":[14,48,79,132],"at":[15,32,108],"locus":[16],"D17S5":[17,78,130],"of":[18,24,36,85,102,136],"chromosome":[19,61],"17p":[20,28,104,118,139],"and":[21,46,65],"allelic":[22,29,63,119],"loss":[23,64],"this":[25,44,147],"chromosome.":[26],"Because":[27],"losses":[30],"occur":[31,70],"the":[33,39,47,95,99,103,134,137],"earliest":[34],"stages":[35],"exact":[40],"temporal":[41],"relationship":[42],"event":[45,148],"could":[49],"not":[50],"be":[51],"elucidated.":[52],"renal":[54,92,114,143],"cancers,":[55,144],"two":[56],"linked":[57],"structural":[58],"changes":[59,88,141,156],"on":[60],"17p,":[62],"p53":[66,122],"gene":[67],"mutations,":[68,123],"generally":[69],"late":[71,90],"in":[72,89,112,142],"progression.":[73],"We":[74],"now":[75],"show":[76],"that":[77,129,146],"is":[80,98],"tightly":[81],"coupled":[82],"to":[83,159],"both":[84],"these":[86],"genetic":[87,140,160],"stage":[91],"tumors.":[93],"However,":[94],"methylation":[96],"change":[97],"only":[100],"one":[101],"abnormalities":[105],"which":[106,157],"occurs":[107],"high":[110],"incidence":[111],"early-stage":[113],"cancers":[115],"(hypermethylation,":[116],"50%;":[117],"loss,":[120],"13%;":[121],"0%).":[124],"Our":[125],"results":[126],"firmly":[127],"suggest":[128],"precedes":[133],"appearance":[135],"consistent":[138],"suggesting":[145],"either":[149],"marks,":[150],"or":[151],"may":[152],"even":[153],"cause,":[154],"chromatin":[155],"predispose":[158],"instability.":[161]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
