{"id":"https://openalex.org/W2124159328","doi":null,"title":"Elevated malondialdehyde correlates with the extent of primary tumor and predicts poor prognosis of oropharyngeal cancer.","display_name":"Elevated malondialdehyde correlates with the extent of primary tumor and predicts poor prognosis of oropharyngeal cancer.","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2124159328","mag":"2124159328","pmid":"https://pubmed.ncbi.nlm.nih.gov/19846978"},"language":"en","primary_location":{"id":"pmid:19846978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19846978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069113068","display_name":"Richard Salzman","orcid":"https://orcid.org/0000-0001-5705-5510","observed_orcids":["https://orcid.org/0000-0001-5705-5510"]},"institutions":[{"id":"https://openalex.org/I4210136987","display_name":"St. Anne's University Hospital Brno","ror":"https://ror.org/049bjee35","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210136987"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Richard Salzman","raw_affiliation_strings":["Department of Otorhinolaryngology and Head and Neck Surgery, St. Anne's University Hospital, Pekarsk\u00e1 53, 656 91, Brno, Czech Republic. rikisali@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology and Head and Neck Surgery, St. Anne's University Hospital, Pekarsk\u00e1 53, 656 91, Brno, Czech Republic. rikisali@gmail.com","institution_ids":["https://openalex.org/I4210136987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047885441","display_name":"Luk\u00e1\u0161 P\u00e1cal","orcid":"https://orcid.org/0000-0003-1118-7424","observed_orcids":["https://orcid.org/0000-0003-1118-7424"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luk\u00e1s P\u00e1cal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004273273","display_name":"Josef Tomandl","orcid":"https://orcid.org/0000-0001-6554-3733","observed_orcids":["https://orcid.org/0000-0001-6554-3733"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Josef Tomandl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038317007","display_name":"Kate\u0159ina Ka\u0148kov\u00e1","orcid":"https://orcid.org/0000-0002-5574-1768","observed_orcids":["https://orcid.org/0000-0002-5574-1768"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katerina Kankov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070362237","display_name":"Eva T\u00f3thov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva T\u00f3thov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110597069","display_name":"B\u0159etislav G\u00e1l","orcid":"https://orcid.org/0000-0003-3351-4449","observed_orcids":["https://orcid.org/0000-0003-3351-4449"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bretislav G\u00e1l","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089741302","display_name":"Rom Kost\u0159ica","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rom Kostrica","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051087982","display_name":"Peter Salzman","orcid":"https://orcid.org/0000-0001-8114-4863","observed_orcids":["https://orcid.org/0000-0001-8114-4863"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Salzman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0077,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.79121887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"10","first_page":"4227","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oropharyngeal-squamous-cell-carcinoma","display_name":"oropharyngeal squamous cell carcinoma","score":0.9279999732971191},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7919999957084656},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.5410000085830688},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.6600000262260437},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.7440000176429749},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.7680000066757202},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.828000009059906},{"id":"https://openalex.org/keywords/disease-free-interval","display_name":"disease-free interval","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.9251141548156738},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7788957953453064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.669869065284729},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.6351097226142883},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6020277738571167},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5670607089996338},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.47495055198669434},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.45306357741355896},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.43455222249031067},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4020802676677704},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37953537702560425},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32998037338256836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08069372177124023},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19846978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19846978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2124159328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19846978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1657827244","https://openalex.org/W1798073226","https://openalex.org/W1987107897","https://openalex.org/W2023576490","https://openalex.org/W2027904485","https://openalex.org/W2048553024","https://openalex.org/W2048792736","https://openalex.org/W2053236299","https://openalex.org/W2054055335","https://openalex.org/W2075088447","https://openalex.org/W2122193075","https://openalex.org/W2134601043","https://openalex.org/W2145896272","https://openalex.org/W2168324221","https://openalex.org/W2169500697","https://openalex.org/W2404073998","https://openalex.org/W2465265569","https://openalex.org/W2567450855"],"related_works":["https://openalex.org/W2600377138","https://openalex.org/W2607395182","https://openalex.org/W3197664186","https://openalex.org/W2599726082","https://openalex.org/W2012353415","https://openalex.org/W2909538693","https://openalex.org/W2621833183","https://openalex.org/W2002959373","https://openalex.org/W3093204031","https://openalex.org/W7220886513"],"abstract_inverted_index":{"The":[0,34,57,145],"aim":[1],"of":[2,13,20,27,41,77,151,166,173],"the":[3,8,28,61,69,90,109,117,164],"study":[4,37],"was":[5,50,82,123],"to":[6,99,131],"investigate":[7],"relationship":[9],"between":[10],"plasma":[11],"levels":[12,59],"malondialdehyde":[14],"(MDA),":[15],"a":[16,39,157,170],"routinely":[17],"used":[18],"marker":[19],"oxidative":[21],"stress,":[22],"and":[23,31,79,113,125,133,148,159],"squamous":[24],"cell":[25],"carcinoma":[26],"oral":[29],"cavity":[30],"oropharynx":[32],"(OSCC).":[33],"prospective":[35],"cohort":[36],"comprised":[38],"total":[40],"67":[42],"patients":[43,64,70,85,138,168],"who":[44,86],"underwent":[45],"surgery":[46],"for":[47,163],"OSCC.":[48],"MDA":[49,58,78,97,120,140,152],"assessed":[51],"using":[52],"high":[53,171],"performance":[54],"liquid":[55],"chromatography.":[56],"in":[60,68,102,116,129,137],"pooled":[62],"T1-2":[63],"were":[65],"lower":[66],"than":[67],"with":[71,119,139,169],"T3-4":[72],"tumors.":[73],"A":[74],"negative":[75],"correlation":[76],"tumor":[80],"grade":[81],"shown.":[83],"Seventeen":[84],"manifested":[87],"recurrence":[88],"during":[89],"49.6":[91],"months":[92,127,135],"follow-up":[93],"had":[94],"significantly":[95],"increased":[96],"compared":[98],"those":[100],"staying":[101],"complete":[103],"remission.":[104],"Kaplan-Meier":[105],"analysis":[106],"revealed":[107],"that":[108],"median":[110,122],"disease-free":[111],"interval":[112],"overall":[114],"survival":[115],"group":[118],">":[121],"19.3":[124],"22.5":[126],"respectively,":[128,136],"contrast":[130],"31.5":[132],"31.6":[134],"<":[141],"or":[142],"=":[143],"median.":[144],"prognostic":[146,161],"value":[147],"low":[149],"cost":[150],"measurement":[153],"could":[154],"make":[155],"it":[156],"versatile":[158],"useful":[160],"tool":[162],"identification":[165],"OSCC":[167],"risk":[172],"recurrence.":[174]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
