{"id":"https://openalex.org/W2124153237","doi":"https://doi.org/10.1126/science.1144090","title":"Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis","display_name":"Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis","publication_year":2007,"publication_date":"2007-08-09","ids":{"openalex":"https://openalex.org/W2124153237","doi":"https://doi.org/10.1126/science.1144090","mag":"2124153237","pmid":"https://pubmed.ncbi.nlm.nih.gov/17690295"},"language":"en","primary_location":{"id":"doi:10.1126/science.1144090","doi":"https://doi.org/10.1126/science.1144090","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1144090","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019965214","display_name":"Andrew S. Brack","orcid":"https://orcid.org/0000-0002-8798-7084","observed_orcids":["https://orcid.org/0000-0002-8798-7084"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew S. Brack","raw_affiliation_strings":["Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA","Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA","Geriatric Research, Education, and Clinical Center (GRECC) and Neurology Service, Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA 94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Geriatric Research, Education, and Clinical Center (GRECC) and Neurology Service, Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA 94304, USA","institution_ids":["https://openalex.org/I204866599"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039842019","display_name":"Michael J. Conboy","orcid":"https://orcid.org/0000-0002-6434-4772","observed_orcids":["https://orcid.org/0000-0002-6434-4772"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Conboy","raw_affiliation_strings":["Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA","Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA","Geriatric Research, Education, and Clinical Center (GRECC) and Neurology Service, Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA 94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Geriatric Research, Education, and Clinical Center (GRECC) and Neurology Service, Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA 94304, USA","institution_ids":["https://openalex.org/I204866599"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017872507","display_name":"Sudeep Roy","orcid":"https://orcid.org/0000-0002-7825-0152","observed_orcids":["https://orcid.org/0000-0002-7825-0152"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudeep Roy","raw_affiliation_strings":["Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA","Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA","Geriatric Research, Education, and Clinical Center (GRECC) and Neurology Service, Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA 94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Geriatric Research, Education, and Clinical Center (GRECC) and Neurology Service, Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA 94304, USA","institution_ids":["https://openalex.org/I204866599"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100620078","display_name":"Mark Andrew Lee","orcid":"https://orcid.org/0000-0002-5285-8266","observed_orcids":["https://orcid.org/0000-0002-5285-8266"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Lee","raw_affiliation_strings":["Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA","Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA","Geriatric Research, Education, and Clinical Center (GRECC) and Neurology Service, Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA 94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Geriatric Research, Education, and Clinical Center (GRECC) and Neurology Service, Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA 94304, USA","institution_ids":["https://openalex.org/I204866599"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056685479","display_name":"Calvin Jay Kuo","orcid":"https://orcid.org/0000-0002-7427-5985","observed_orcids":["https://orcid.org/0000-0002-7427-5985","https://orcid.org/0000-0001-8401-9136"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Calvin J. Kuo","raw_affiliation_strings":["Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA","Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA","Geriatric Research, Education, and Clinical Center (GRECC) and Neurology Service, Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA 94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Geriatric Research, Education, and Clinical Center (GRECC) and Neurology Service, Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA 94304, USA","institution_ids":["https://openalex.org/I204866599"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009653245","display_name":"Charles Keller","orcid":"https://orcid.org/0000-0003-2505-7487","observed_orcids":["https://orcid.org/0000-0003-2505-7487"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Keller","raw_affiliation_strings":["Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA","Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA","Geriatric Research, Education, and Clinical Center (GRECC) and Neurology Service, Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA 94304, USA","Department of Cellular & Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Geriatric Research, Education, and Clinical Center (GRECC) and Neurology Service, Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA 94304, USA","institution_ids":["https://openalex.org/I204866599"]},{"raw_affiliation_string":"Department of Cellular & Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001282854","display_name":"Thomas A. Rando","orcid":"https://orcid.org/0000-0001-5843-8564","observed_orcids":["https://orcid.org/0000-0001-5843-8564"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas A. Rando","raw_affiliation_strings":["Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA","Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA","Geriatric Research, Education, and Clinical Center (GRECC) and Neurology Service, Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA 94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Geriatric Research, Education, and Clinical Center (GRECC) and Neurology Service, Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA 94304, USA","institution_ids":["https://openalex.org/I204866599"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001282854"],"corresponding_institution_ids":["https://openalex.org/I165951966","https://openalex.org/I204866599","https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":22.1385,"has_fulltext":false,"cited_by_count":1562,"citation_normalized_percentile":{"value":0.99802814,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"317","issue":"5839","first_page":"807","last_page":"810"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9449999928474426},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6349999904632568},{"id":"https://openalex.org/keywords/muscle-stem-cells","display_name":"muscle stem cells","score":0.8309999704360962},{"id":"https://openalex.org/keywords/satellite-cells","display_name":"satellite cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/skeletal-muscle-fibrosis","display_name":"skeletal muscle fibrosis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/stem-cell-fate","display_name":"stem cell fate","score":0.75},{"id":"https://openalex.org/keywords/frizzled-receptors","display_name":"Frizzled receptors","score":0.8410000205039978},{"id":"https://openalex.org/keywords/wnt-inhibitors","display_name":"Wnt inhibitors","score":0.8149999976158142},{"id":"https://openalex.org/keywords/muscle-regeneration","display_name":"muscle regeneration","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.9512273073196411},{"id":"https://openalex.org/C107300179","wikidata":"https://www.wikidata.org/wiki/Q41797887","display_name":"Frizzled","level":4,"score":0.9078019857406616},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6396171450614929},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6273329257965088},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6044483780860901},{"id":"https://openalex.org/C170320316","wikidata":"https://www.wikidata.org/wiki/Q18028667","display_name":"LRP6","level":4,"score":0.582449734210968},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5683290362358093},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.525155246257782},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.4400528073310852},{"id":"https://openalex.org/C182819311","wikidata":"https://www.wikidata.org/wiki/Q18028670","display_name":"LRP5","level":4,"score":0.4377244710922241},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4368784725666046},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.357456237077713},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3192254304885864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21893835067749023}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010227","descriptor_name":"Parabiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010227","descriptor_name":"Parabiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010227","descriptor_name":"Parabiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032496","descriptor_name":"Satellite Cells, Skeletal Muscle","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032496","descriptor_name":"Satellite Cells, Skeletal Muscle","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032496","descriptor_name":"Satellite Cells, Skeletal Muscle","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032496","descriptor_name":"Satellite Cells, Skeletal Muscle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032496","descriptor_name":"Satellite Cells, Skeletal Muscle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032496","descriptor_name":"Satellite Cells, Skeletal Muscle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051157","descriptor_name":"Frizzled Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051157","descriptor_name":"Frizzled Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051157","descriptor_name":"Frizzled Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1144090","doi":"https://doi.org/10.1126/science.1144090","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1144090","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:17690295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17690295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3587743242","display_name":null,"funder_award_id":"AG23806","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4785340793","display_name":"Wnt Proteins During Intestinal Repair and Regeneration","funder_award_id":"5r01dk069989-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5575631990","display_name":null,"funder_award_id":"DK069989","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1573333099","https://openalex.org/W1979046360","https://openalex.org/W1993677820","https://openalex.org/W2001750225","https://openalex.org/W2005063238","https://openalex.org/W2006718453","https://openalex.org/W2022487205","https://openalex.org/W2035596000","https://openalex.org/W2035809306","https://openalex.org/W2043691868","https://openalex.org/W2076738615","https://openalex.org/W2093355627","https://openalex.org/W2102512718","https://openalex.org/W2107106369","https://openalex.org/W2121652346","https://openalex.org/W2131277634","https://openalex.org/W2147456958"],"related_works":["https://openalex.org/W2913541467","https://openalex.org/W4307544679","https://openalex.org/W2080509277","https://openalex.org/W1964589725","https://openalex.org/W2399252004","https://openalex.org/W4207033132","https://openalex.org/W2017632960","https://openalex.org/W2051803999","https://openalex.org/W1972875962","https://openalex.org/W2065666905"],"abstract_inverted_index":{"The":[0],"regenerative":[1],"potential":[2],"of":[3,58,74,93,104],"skeletal":[4],"muscle":[5,23],"declines":[6],"with":[7,14,71,144],"age,":[8],"and":[9,46,84,138],"this":[10,48,66],"impairment":[11],"is":[12,50,69],"associated":[13,70],"an":[15,72,139],"increase":[16,140],"in":[17,54,80,117,133,141],"tissue":[18,142],"fibrosis.":[19],"We":[20,62],"show":[21,64],"that":[22,47,65,98,123],"stem":[24,135],"cells":[25],"(satellite":[26],"cells)":[27],"from":[28,34,95],"aged":[29,81,96,118],"mice":[30,97],"tend":[31],"to":[32,37,44,100],"convert":[33],"a":[35,38,130],"myogenic":[36,82],"fibrogenic":[39],"lineage":[40,67],"as":[41],"they":[42],"begin":[43],"proliferate":[45],"conversion":[49,68],"mediated":[51],"by":[52,88],"factors":[53],"the":[55,59,75,101,113,124],"systemic":[56],"environment":[57],"old":[60],"animals.":[61],"also":[63],"activation":[73],"canonical":[76],"Wnt":[77,89,108,115,125],"signaling":[78,116,126],"pathway":[79,127],"progenitors":[83],"can":[85],"be":[86],"suppressed":[87],"inhibitors.":[90],"Furthermore,":[91],"components":[92],"serum":[94],"bind":[99],"Frizzled":[102],"family":[103],"proteins,":[105],"which":[106],"are":[107],"receptors,":[109],"may":[110,128],"account":[111],"for":[112],"elevated":[114],"cells.":[119],"These":[120],"results":[121],"indicate":[122],"play":[129],"critical":[131],"role":[132],"tissue-specific":[134],"cell":[136],"aging":[137],"fibrosis":[143],"age.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":52},{"year":2025,"cited_by_count":69},{"year":2024,"cited_by_count":64},{"year":2023,"cited_by_count":63},{"year":2022,"cited_by_count":75},{"year":2021,"cited_by_count":106},{"year":2020,"cited_by_count":94},{"year":2019,"cited_by_count":90},{"year":2018,"cited_by_count":103},{"year":2017,"cited_by_count":86},{"year":2016,"cited_by_count":96},{"year":2015,"cited_by_count":102},{"year":2014,"cited_by_count":101},{"year":2013,"cited_by_count":102},{"year":2012,"cited_by_count":88}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}