{"id":"https://openalex.org/W2124139300","doi":"https://doi.org/10.1126/science.1185100","title":"Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal","display_name":"Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal","publication_year":2010,"publication_date":"2010-03-25","ids":{"openalex":"https://openalex.org/W2124139300","doi":"https://doi.org/10.1126/science.1185100","mag":"2124139300","pmid":"https://pubmed.ncbi.nlm.nih.gov/20339076","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2864730"},"language":"en","primary_location":{"id":"doi:10.1126/science.1185100","doi":"https://doi.org/10.1126/science.1185100","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1185100","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2864730","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053124609","display_name":"Agnel J. Sfeir","orcid":"https://orcid.org/0000-0003-1633-8535","observed_orcids":["https://orcid.org/0000-0003-1633-8535"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Agnel Sfeir","raw_affiliation_strings":["The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011142724","display_name":"Shaheen Kabir","orcid":"https://orcid.org/0000-0002-9035-1124","observed_orcids":["https://orcid.org/0000-0002-9035-1124"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shaheen Kabir","raw_affiliation_strings":["The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004515111","display_name":"Megan van Overbeek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Megan van Overbeek","raw_affiliation_strings":["The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070569969","display_name":"Giulia B. Celli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giulia B. Celli","raw_affiliation_strings":["The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065113600","display_name":"Titia de Lange","orcid":"https://orcid.org/0000-0002-9267-367X","observed_orcids":["https://orcid.org/0000-0002-9267-367X"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Titia de Lange","raw_affiliation_strings":["The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004515111","https://openalex.org/A5011142724","https://openalex.org/A5053124609","https://openalex.org/A5065113600"],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":null,"apc_paid":null,"fwci":17.4739,"has_fulltext":false,"cited_by_count":278,"citation_normalized_percentile":{"value":0.99598907,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"327","issue":"5973","first_page":"1657","last_page":"1661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rap1","display_name":"Rap1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/shelterin","display_name":"shelterin","score":0.8100000023841858},{"id":"https://openalex.org/keywords/trf2","display_name":"TRF2","score":0.8450000286102295},{"id":"https://openalex.org/keywords/telomere-recombination","display_name":"telomere recombination","score":0.9089999794960022},{"id":"https://openalex.org/keywords/homology-directed-repair","display_name":"homology-directed repair","score":0.9789999723434448},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9769999980926514},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.8040000200271606},{"id":"https://openalex.org/keywords/dna-damage-signaling","display_name":"DNA damage signaling","score":0.6819999814033508},{"id":"https://openalex.org/keywords/telomere-maintenance","display_name":"telomere maintenance","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2776879488","wikidata":"https://www.wikidata.org/wiki/Q3959366","display_name":"Shelterin","level":5,"score":0.9860397577285767},{"id":"https://openalex.org/C2776179587","wikidata":"https://www.wikidata.org/wiki/Q54461864","display_name":"Rap1","level":3,"score":0.8788654804229736},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.8654166460037231},{"id":"https://openalex.org/C202265312","wikidata":"https://www.wikidata.org/wiki/Q7697810","display_name":"Telomere-binding protein","level":5,"score":0.643479585647583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5844921469688416},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5288603901863098},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4738716781139374},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.46391358971595764},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4519226551055908},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.44300028681755066},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.43616488575935364},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.4359493553638458},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.43509992957115173},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.3526723384857178},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27572619915008545},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.24844783544540405},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.2450312077999115},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.15553247928619385},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.068173348903656}],"mesh":[{"descriptor_ui":"D000089804","descriptor_name":"Shelterin Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012854","descriptor_name":"Sister Chromatid Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034501","descriptor_name":"Telomere-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D034501","descriptor_name":"Telomere-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034501","descriptor_name":"Telomere-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D035341","descriptor_name":"Telomeric Repeat Binding Protein 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035341","descriptor_name":"Telomeric Repeat Binding Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064447","descriptor_name":"Checkpoint Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/science.1185100","doi":"https://doi.org/10.1126/science.1185100","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1185100","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:20339076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20339076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2864730","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2864730","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2864730","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2864730","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1225949337","display_name":"Mechanism of the telomeric proliferation limit","funder_award_id":"R56AG016642","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2191412367","display_name":"Molecular Cytology of  Human Telomeres:  Telomere protein","funder_award_id":"R37GM049046","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G375960547","display_name":"Molecular cytology of human telomeres-telomere protein","funder_award_id":"R01GM049046","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7307501964","display_name":null,"funder_award_id":"GM049046","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G895249668","display_name":null,"funder_award_id":"AG016642","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000885151","display_name":"Mechanism of the telomeric proliferation limit","funder_award_id":"R01AG016642","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1972655555","https://openalex.org/W1982199027","https://openalex.org/W1990507848","https://openalex.org/W1997432012","https://openalex.org/W2012677653","https://openalex.org/W2035389897","https://openalex.org/W2038661569","https://openalex.org/W2073204556","https://openalex.org/W2098720917","https://openalex.org/W2123767246","https://openalex.org/W2124112426","https://openalex.org/W2124242199","https://openalex.org/W2126564248","https://openalex.org/W2141251434","https://openalex.org/W2145952889","https://openalex.org/W2147765162","https://openalex.org/W2153633026","https://openalex.org/W2155514571","https://openalex.org/W2161232591","https://openalex.org/W4301031527"],"related_works":["https://openalex.org/W2588073012","https://openalex.org/W2334974904","https://openalex.org/W2000067299","https://openalex.org/W2155514571","https://openalex.org/W2990406517","https://openalex.org/W2129428112","https://openalex.org/W7098241684","https://openalex.org/W4365509174","https://openalex.org/W2081378898","https://openalex.org/W2111377330"],"abstract_inverted_index":{"Shelterin":[0],"is":[1],"an":[2],"essential":[3,64],"telomeric":[4,79],"protein":[5],"complex":[6],"that":[7,54,104],"prevents":[8],"DNA":[9,13,115],"damage":[10,116],"signaling":[11,71],"and":[12,72,83,118],"repair":[14,94],"at":[15,106],"mammalian":[16],"chromosome":[17],"ends.":[18],"Here":[19],"we":[20],"report":[21],"on":[22],"the":[23,26,63,90,112,120],"role":[24],"of":[25,34,66,68,92,114],"TRF2-interacting":[27],"factor":[28],"Rap1,":[29],"a":[30,52],"conserved":[31],"shelterin":[32],"subunit":[33],"unknown":[35],"function.":[36],"We":[37],"removed":[38],"Rap1":[39,59,80,86],"from":[40],"mouse":[41],"telomeres":[42,107],"either":[43],"through":[44],"gene":[45],"deletion":[46],"or":[47],"by":[48],"replacing":[49],"TRF2":[50],"with":[51],"mutant":[53],"does":[55],"not":[56],"bind":[57],"Rap1.":[58],"was":[60,87],"dispensable":[61],"for":[62,89],"functions":[65],"TRF2--repression":[67],"ATM":[69],"kinase":[70],"nonhomologous":[73],"end":[74],"joining":[75],"(NHEJ)--and":[76],"mice":[77],"lacking":[78],"were":[81],"viable":[82],"fertile.":[84],"However,":[85],"critical":[88],"repression":[91],"homology-directed":[93],"(HDR),":[95],"which":[96],"can":[97,108],"alter":[98],"telomere":[99],"length.":[100],"The":[101],"data":[102],"reveal":[103],"HDR":[105],"take":[109],"place":[110],"in":[111],"absence":[113],"foci":[117],"underscore":[119],"functional":[121],"compartmentalization":[122],"within":[123],"shelterin.":[124]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":30},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":34}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}