{"id":"https://openalex.org/W2124134646","doi":"https://doi.org/10.1534/genetics.113.159780","title":"Nuclear RNAi Contributes to the Silencing of Off-Target Genes and Repetitive Sequences in Caenorhabditis elegans","display_name":"Nuclear RNAi Contributes to the Silencing of Off-Target Genes and Repetitive Sequences in Caenorhabditis elegans","publication_year":2014,"publication_date":"2014-02-16","ids":{"openalex":"https://openalex.org/W2124134646","doi":"https://doi.org/10.1534/genetics.113.159780","mag":"2124134646","pmid":"https://pubmed.ncbi.nlm.nih.gov/24532782","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4012473"},"language":"en","primary_location":{"id":"doi:10.1534/genetics.113.159780","doi":"https://doi.org/10.1534/genetics.113.159780","is_oa":true,"landing_page_url":"https://doi.org/10.1534/genetics.113.159780","pdf_url":"https://www.genetics.org/content/genetics/197/1/121.full.pdf","source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.genetics.org/content/genetics/197/1/121.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067271713","display_name":"Xufei Zhou","orcid":"https://orcid.org/0000-0001-7119-8390","observed_orcids":["https://orcid.org/0000-0001-7119-8390"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xufei Zhou","raw_affiliation_strings":["School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028575754","display_name":"Fei Xu","orcid":"https://orcid.org/0000-0003-0719-3901","observed_orcids":["https://orcid.org/0000-0003-0719-3901"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Xu","raw_affiliation_strings":["School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, People's Republic of China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100751428","display_name":"Hui Mao","orcid":"https://orcid.org/0000-0001-5640-1952","observed_orcids":["https://orcid.org/0000-0001-5640-1952"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Mao","raw_affiliation_strings":["School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People\u2019s Republic of China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023960743","display_name":"Jiaojiao Ji","orcid":"https://orcid.org/0000-0003-1571-6135","observed_orcids":["https://orcid.org/0000-0003-1571-6135"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaojiao Ji","raw_affiliation_strings":["School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People\u2019s Republic of China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Meng Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Yin","raw_affiliation_strings":["School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People\u2019s Republic of China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073973850","display_name":"Xuezhu Feng","orcid":"https://orcid.org/0000-0003-1440-210X","observed_orcids":["https://orcid.org/0000-0003-1440-210X"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuezhu Feng","raw_affiliation_strings":["School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People\u2019s Republic of China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013457687","display_name":"Shouhong Guang","orcid":"https://orcid.org/0000-0001-7700-9634","observed_orcids":["https://orcid.org/0000-0001-7700-9634"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shouhong Guang","raw_affiliation_strings":["Corresponding authors: School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People\u2019s Republic of China","School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding authors: School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People\u2019s Republic of China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, People's Republic of China","institution_ids":["https://openalex.org/I126520041"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013457687","https://openalex.org/A5073973850"],"corresponding_institution_ids":["https://openalex.org/I126520041"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":0.7709,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.65842277,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"197","issue":"1","first_page":"121","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.836899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.836899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.0348999984562397,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/repetitive-dna","display_name":"repetitive DNA","score":0.6790000200271606},{"id":"https://openalex.org/keywords/small-rna","display_name":"small RNA","score":0.7580000162124634},{"id":"https://openalex.org/keywords/double-stranded-rna","display_name":"double-stranded RNA","score":0.8700000047683716},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.9133230447769165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8462879061698914},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.8067353367805481},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.6903454661369324},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.6790388226509094},{"id":"https://openalex.org/C60723119","wikidata":"https://www.wikidata.org/wiki/Q7833577","display_name":"Trans-acting siRNA","level":5,"score":0.6016248464584351},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5918296575546265},{"id":"https://openalex.org/C201853390","wikidata":"https://www.wikidata.org/wiki/Q413236","display_name":"Argonaute","level":5,"score":0.5276032090187073},{"id":"https://openalex.org/C155330019","wikidata":"https://www.wikidata.org/wiki/Q21106117","display_name":"RNA-induced silencing complex","level":5,"score":0.5021412372589111},{"id":"https://openalex.org/C147724379","wikidata":"https://www.wikidata.org/wiki/Q2367421","display_name":"Piwi-interacting RNA","level":5,"score":0.4879262149333954},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47959721088409424},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.44915667176246643},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.42793524265289307},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4156271517276764},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3656243681907654},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3490517735481262}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1534/genetics.113.159780","doi":"https://doi.org/10.1534/genetics.113.159780","is_oa":true,"landing_page_url":"https://doi.org/10.1534/genetics.113.159780","pdf_url":"https://www.genetics.org/content/genetics/197/1/121.full.pdf","source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"pmid:24532782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24532782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4012473","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4012473/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1534/genetics.113.159780","doi":"https://doi.org/10.1534/genetics.113.159780","is_oa":true,"landing_page_url":"https://doi.org/10.1534/genetics.113.159780","pdf_url":"https://www.genetics.org/content/genetics/197/1/121.full.pdf","source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1828425977","display_name":null,"funder_award_id":"973 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3071212118","display_name":"\u6a21\u5f0f\u751f\u7269\u79c0\u4e3d\u7ebf\u866b\u4e2dNRDE\u901a\u8def\u4ecb\u5bfc\u7684siRNA\u57fa\u56e0\u5e72\u6270\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"31171254","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5469850996","display_name":null,"funder_award_id":"2011CBA01100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8926470935","display_name":null,"funder_award_id":"31371323","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124134646.pdf","grobid_xml":"https://content.openalex.org/works/W2124134646.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1647075334","https://openalex.org/W1967615311","https://openalex.org/W1971643509","https://openalex.org/W1992170226","https://openalex.org/W1995048848","https://openalex.org/W2003402227","https://openalex.org/W2005721786","https://openalex.org/W2013793916","https://openalex.org/W2027891004","https://openalex.org/W2032640887","https://openalex.org/W2038492783","https://openalex.org/W2040850476","https://openalex.org/W2057558367","https://openalex.org/W2076329927","https://openalex.org/W2083207344","https://openalex.org/W2096052887","https://openalex.org/W2100336754","https://openalex.org/W2117131162","https://openalex.org/W2124774982","https://openalex.org/W2126985046","https://openalex.org/W2134424319","https://openalex.org/W2135031920","https://openalex.org/W2138841516","https://openalex.org/W2142305917","https://openalex.org/W2148966035","https://openalex.org/W2155946128","https://openalex.org/W2167999293","https://openalex.org/W2170551349","https://openalex.org/W2417667123"],"related_works":["https://openalex.org/W2391711927","https://openalex.org/W2120023529","https://openalex.org/W6941058116","https://openalex.org/W3147965930","https://openalex.org/W2099931758","https://openalex.org/W2083081085","https://openalex.org/W2004417489","https://openalex.org/W3104143290","https://openalex.org/W2168051144","https://openalex.org/W2034206562"],"abstract_inverted_index":{"Small":[0],"RNAs":[1,14,158],"recognize,":[2],"bind,":[3],"and":[4,54,120,145],"regulate":[5],"other":[6],"complementary":[7],"cellular":[8],"RNAs.":[9],"The":[10],"introduction":[11,83],"of":[12,23,40,47,57,73,84,87,103,118,149,182],"small":[13,48,150,157,183],"to":[15,66,69,159],"eukaryotic":[16],"cells":[17],"frequently":[18],"results":[19],"in":[20,106,176],"unintended":[21],"silencing":[22,37,62,105],"related,":[24],"but":[25,94,141],"not":[26,95,138],"identical,":[27],"RNAs:":[28],"a":[29],"process":[30],"termed":[31],"off-target":[32,104,135,168],"gene":[33,36,52,61,128,152],"silencing.":[34],"Off-target":[35,60],"is":[38,63,99],"one":[39],"the":[41,45,55,74,82,90,100,115,122,172,180],"major":[42],"concerns":[43],"during":[44,114],"application":[46],"RNA-based":[49,184],"technologies":[50],"for":[51],"discovery":[53],"treatment":[56],"human":[58],"disease.":[59],"commonly":[64],"thought":[65],"be":[67,139],"due":[68],"inherent":[70],"biochemical":[71],"limitations":[72],"RNAi":[75,92,124,134,174],"machinery.":[76],"Here":[77],"we":[78,111,131],"show":[79,112],"that":[80,113,133],"following":[81],"exogenous":[85],"sources":[86],"double-stranded":[88],"RNA,":[89],"nuclear":[91,123,173],"pathway,":[93],"its":[96],"cytoplasmic":[97],"counterparts,":[98],"primary":[101],"source":[102],"Caenorhabditis":[107],"elegans.":[108],"In":[109],"addition,":[110],"normal":[116],"course":[117],"growth":[119],"development":[121],"pathway":[125,175],"regulates":[126],"repetitive":[127],"families.":[129],"Therefore,":[130],"speculate":[132],"effects":[136,169],"might":[137,155,178],"\"mistakes\"":[140],"rather":[142],"an":[143],"intentional":[144],"genetically":[146],"programmed":[147],"aspect":[148],"RNA-mediated":[151],"silencing,":[153],"which":[154],"allow":[156],"silence":[160],"rapidly":[161],"evolving":[162],"parasitic":[163],"nucleic":[164],"acids.":[165],"Finally,":[166],"reducing":[167],"by":[170],"manipulating":[171],"vivo":[177],"improve":[179],"efficacy":[181],"technologies.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}