{"id":"https://openalex.org/W2124128113","doi":null,"title":"Relationships between plasma insulin-like growth factor-I and insulin-like growth factor binding protein-3 and second breast cancer risk in a prevention trial of fenretinide.","display_name":"Relationships between plasma insulin-like growth factor-I and insulin-like growth factor binding protein-3 and second breast cancer risk in a prevention trial of fenretinide.","publication_year":2003,"publication_date":"2003-10-15","ids":{"openalex":"https://openalex.org/W2124128113","mag":"2124128113","pmid":"https://pubmed.ncbi.nlm.nih.gov/14581342"},"language":"en","primary_location":{"id":"pmid:14581342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14581342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065678804","display_name":"Andrea DeCensi","orcid":"https://orcid.org/0000-0003-2635-4491","observed_orcids":["https://orcid.org/0000-0003-2635-4491"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Decensi","raw_affiliation_strings":["Division of Chemoprevention, European Institute of Oncology, Milan 20141, Italy. andrea.decensi@ieo.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemoprevention, European Institute of Oncology, Milan 20141, Italy. andrea.decensi@ieo.it","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108460148","display_name":"Umberto Veronesi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Umberto Veronesi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044146626","display_name":"Rosalba Miceli","orcid":"https://orcid.org/0000-0003-0954-375X","observed_orcids":["https://orcid.org/0000-0003-0954-375X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosalba Miceli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055344568","display_name":"Harriet Ann Johansson","orcid":"https://orcid.org/0000-0002-4131-2030","observed_orcids":["https://orcid.org/0000-0002-4131-2030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harriet Johansson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090715927","display_name":"Luigi Mariani","orcid":"https://orcid.org/0000-0001-6208-4084","observed_orcids":["https://orcid.org/0000-0001-6208-4084","https://orcid.org/0000-0002-1971-5095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luigi Mariani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064081749","display_name":"Tiziana Camerini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tiziana Camerini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051900722","display_name":"Maria Gaetana Di Mauro","orcid":"https://orcid.org/0000-0002-2200-9060","observed_orcids":["https://orcid.org/0000-0002-2200-9060"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Gaetana Di Mauro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090431998","display_name":"Elena Cavadini","orcid":"https://orcid.org/0009-0004-5164-1489","observed_orcids":["https://orcid.org/0009-0004-5164-1489"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Cavadini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105464389","display_name":"Giuseppe De Palo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giuseppe De Palo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107749429","display_name":"Alberto Costa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alberto Costa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Marjorie Perloff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marjorie Perloff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054125731","display_name":"Winfred F. Malone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Winfred F Malone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035474342","display_name":"Franca Formelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Franca Formelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7501,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.8588852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"13","first_page":"4722","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8429999947547913},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-binding-protein-3","display_name":"insulin-like growth factor binding protein-3","score":0.9760000109672546},{"id":"https://openalex.org/keywords/igf-i-igfbp-3-ratio","display_name":"IGF-I/IGFBP-3 ratio","score":0.8960000276565552},{"id":"https://openalex.org/keywords/second-primary-breast-cancer","display_name":"second primary breast cancer","score":0.828000009059906},{"id":"https://openalex.org/keywords/fenretinide","display_name":"fenretinide","score":0.8510000109672546},{"id":"https://openalex.org/keywords/breast-cancer-chemoprevention","display_name":"breast cancer chemoprevention","score":0.8560000061988831},{"id":"https://openalex.org/keywords/premenopausal-women","display_name":"premenopausal women","score":0.9240000247955322},{"id":"https://openalex.org/keywords/surrogate-markers","display_name":"surrogate markers","score":0.45899999141693115},{"id":"https://openalex.org/keywords/aromatase-inhibitors","display_name":"aromatase inhibitors","score":0.515999972820282},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.5299999713897705},{"id":"https://openalex.org/keywords/raloxifene","display_name":"raloxifene","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C2780533455","wikidata":"https://www.wikidata.org/wiki/Q5443576","display_name":"Fenretinide","level":5,"score":0.9290658235549927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7562512159347534},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7326164841651917},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.7298335433006287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.685867428779602},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.5993021726608276},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.5267835259437561},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5058298110961914},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.48284250497817993},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.45200955867767334},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43797868490219116},{"id":"https://openalex.org/C2780378035","wikidata":"https://www.wikidata.org/wiki/Q17143674","display_name":"Insulin-like growth factor-binding protein","level":5,"score":0.4344315528869629},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.40274763107299805},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3987111747264862},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.126967191696167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0831732451915741},{"id":"https://openalex.org/C2775954498","wikidata":"https://www.wikidata.org/wiki/Q420418","display_name":"Retinoid","level":4,"score":0.06506672501564026},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017313","descriptor_name":"Fenretinide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017697","descriptor_name":"Premenopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018972","descriptor_name":"Insulin-Like Growth Factor Binding Protein 3","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:14581342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14581342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Clinical Trial"},{"id":"mag:2124128113","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14581342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4222226832","display_name":"IGF-I MODULATION BY 4-HPR AND BREAST CANCER RISK","funder_award_id":"U01CA072286","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1525444530","https://openalex.org/W1848388241","https://openalex.org/W1970373365","https://openalex.org/W1990582579","https://openalex.org/W2013171114","https://openalex.org/W2020210187","https://openalex.org/W2020636054","https://openalex.org/W2027454234","https://openalex.org/W2032287159","https://openalex.org/W2039529043","https://openalex.org/W2047490464","https://openalex.org/W2056444389","https://openalex.org/W2058816575","https://openalex.org/W2077523349","https://openalex.org/W2077956417","https://openalex.org/W2078902093","https://openalex.org/W2095546315","https://openalex.org/W2098787760","https://openalex.org/W2110828409","https://openalex.org/W2116267465","https://openalex.org/W2117350664","https://openalex.org/W2117530385","https://openalex.org/W2118331135","https://openalex.org/W2118824541","https://openalex.org/W2128412799","https://openalex.org/W2134581787","https://openalex.org/W2139396029","https://openalex.org/W2140764109","https://openalex.org/W2141163594","https://openalex.org/W2142257518","https://openalex.org/W2147907511","https://openalex.org/W2148077102","https://openalex.org/W2150081825","https://openalex.org/W2154015002","https://openalex.org/W2156982018","https://openalex.org/W2166368284","https://openalex.org/W2181993106"],"related_works":["https://openalex.org/W2181993106","https://openalex.org/W2032287159","https://openalex.org/W2148077102","https://openalex.org/W2056444389","https://openalex.org/W4256477026","https://openalex.org/W2104404830","https://openalex.org/W2140134061","https://openalex.org/W2164373820","https://openalex.org/W1919067330","https://openalex.org/W1975130218"],"abstract_inverted_index":{"PURPOSE:":[0],"High":[1],"circulating":[2],"insulin-like":[3],"growth":[4],"factor":[5],"(IGF)":[6],"-I":[7],"and/or":[8],"low":[9,116,255],"IGF-binding":[10],"protein":[11],"(IGFBP)":[12],"-3":[13],"levels":[14,68,257],"are":[15],"associated":[16,119],"with":[17,120],"increased":[18],"breast":[19,34,48,123,188,260],"cancer":[20,35,49,124,189,238,261],"risk":[21,125,190,239],"in":[22,46,50,75,241],"unaffected":[23],"premenopausal":[24],"women.":[25],"We":[26],"determined":[27],"whether":[28,38],"IGF-I":[29,91,99,114,211,252],"and":[30,37,66,72,80,92,94,115,144,161,178,212,220,253],"IGFBP-3":[31,117,256],"predict":[32,258],"second":[33,47,122,259],"risk,":[36],"their":[39,73],"changes":[40],"during":[41,100],"fenretinide":[42,79,101],"explain":[43],"observed":[44,237],"reductions":[45,157,214,240],"women":[51,242],"</=50":[52,243],"years":[53,244],"of":[54,69,90,98,158,163,206,232,245],"age.":[55,246],"EXPERIMENTAL":[56],"DESIGN:":[57],"Within":[58],"a":[59,229],"Phase":[60],"III":[61],"trial,":[62],"we":[63],"measured":[64],"baseline":[65],"1-year":[67],"IGF-I,":[70,130,159,233],"IGFBP-3,":[71,93,145,160],"ratio":[74,132],"302":[76],"subjects":[77],"on":[78],"220":[81],"controls":[82],"who":[83],"provided":[84],"plasma":[85],"samples.":[86],"The":[87,204],"prognostic":[88],"effect":[89,97,208],"the":[95],"surrogate":[96],"were":[102,118,215],"assessed":[103],"by":[104,193,210],"Cox":[105],"models":[106],"after":[107],"9.4":[108],"years.":[109],"RESULTS:":[110],"Among":[111],"controls,":[112],"high":[113,251],"elevated":[121],"[top":[126],"versus":[127],"bottom":[128],"tertile,":[129],"hazard":[131],"(HR)":[133],"=":[134,142,147,153,169,176,184,196,202],"1.94,":[135],"95%":[136,149,198],"confidence":[137],"interval":[138],"(CI),":[139],"0.87-4.31,":[140],"P":[141,152,168,175,183,201],"0.105;":[143],"HR":[146],"0.40,":[148],"CI,":[150,166,173,181,199,218,223],"0.18-0.93,":[151],"0.033].":[154],"Fenretinide":[155,227],"induced":[156,228],"IGF-I:IGFBP-3":[162,213],"8%":[164],"(95%":[165,172,180,217,222],"2-12%;":[167],"0.004),":[170],"3%":[171],"1-5%;":[174],"0.002),":[177],"5%":[179],"0-10%;":[182],"0.050),":[185],"respectively.":[186,225],"Second":[187],"was":[191],"reduced":[192],"39%":[194],"(HR":[195],"0.61;":[197],"0.40-0.94;":[200],"0.026).":[203],"percentage":[205],"treatment":[207],"explained":[209],"4.8%":[216],"0.8-28.9%)":[219],"3.1%":[221],"0.5-20.8%),":[224],"CONCLUSIONS:":[226],"moderate":[230],"reduction":[231],"which":[234],"marginally":[235],"explains":[236],"In":[247],"this":[248],"age":[249],"group":[250],"particularly":[254],"risk.":[262]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}