{"id":"https://openalex.org/W2124123200","doi":"https://doi.org/10.1242/jeb.085779","title":"Insulin-like peptides (AmILP1 and AmILP2) differentially affect female caste development in the honey bee (Apis mellifera)","display_name":"Insulin-like peptides (AmILP1 and AmILP2) differentially affect female caste development in the honey bee (Apis mellifera)","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2124123200","doi":"https://doi.org/10.1242/jeb.085779","mag":"2124123200","pmid":"https://pubmed.ncbi.nlm.nih.gov/23997199","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3836288"},"language":"en","primary_location":{"id":"doi:10.1242/jeb.085779","doi":"https://doi.org/10.1242/jeb.085779","is_oa":true,"landing_page_url":"https://doi.org/10.1242/jeb.085779","pdf_url":"https://jeb.biologists.org/content/jexbio/216/23/4347.full.pdf","source":{"id":"https://openalex.org/S20257348","display_name":"Journal of Experimental Biology","issn_l":"0022-0949","issn":["0022-0949","1477-9145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jeb.biologists.org/content/jexbio/216/23/4347.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ying Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Arizona State University, USA;","School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University, USA;","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060919219","display_name":"Sergio Vicente de Azevedo","orcid":"https://orcid.org/0000-0002-4774-3923","observed_orcids":["https://orcid.org/0000-0002-4774-3923"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sergio V. Azevedo","raw_affiliation_strings":["Universidade de S\u00e3o Paulo, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo, Brazil;","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041388627","display_name":"Klaus Hartfelder","orcid":"https://orcid.org/0000-0001-7981-8427","observed_orcids":["https://orcid.org/0000-0001-7981-8427"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Klaus Hartfelder","raw_affiliation_strings":["Universidade de S\u00e3o Paulo, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo, Brazil;","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009288169","display_name":"Gro Vang Amdam","orcid":"https://orcid.org/0000-0001-7797-6464","observed_orcids":["https://orcid.org/0000-0001-7797-6464"]},"institutions":[{"id":"https://openalex.org/I54108979","display_name":"Norwegian University of Life Sciences","ror":"https://ror.org/04a1mvv97","country_code":"NO","type":"education","lineage":["https://openalex.org/I54108979"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["NO","US"],"is_corresponding":false,"raw_author_name":"Gro Amdam","raw_affiliation_strings":["Arizona State University, USA; University of Life Sciences, Aas, Norway","Department of Chemistry, Biotechnology and Food Science, University of Life Sciences, 1432 Aas, Norway","School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University, USA; University of Life Sciences, Aas, Norway","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"Department of Chemistry, Biotechnology and Food Science, University of Life Sciences, 1432 Aas, Norway","institution_ids":["https://openalex.org/I54108979"]},{"raw_affiliation_string":"School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA","institution_ids":["https://openalex.org/I55732556"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55732556"],"apc_list":null,"apc_paid":null,"fwci":3.2845,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.92249135,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"216","issue":"Pt 23","first_page":"4347","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10702","display_name":"Insect and Arachnid Ecology and Behavior","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10702","display_name":"Insect and Arachnid Ecology and Behavior","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11641","display_name":"Insect and Pesticide Research","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-peptides","display_name":"insulin-like peptides","score":0.9850000143051147},{"id":"https://openalex.org/keywords/apis-mellifera","display_name":"Apis mellifera","score":0.9010000228881836},{"id":"https://openalex.org/keywords/insulin-igf-1-signaling","display_name":"insulin/IGF-1 signaling","score":0.8880000114440918},{"id":"https://openalex.org/keywords/juvenile-hormone","display_name":"juvenile hormone","score":0.8619999885559082},{"id":"https://openalex.org/keywords/ovarian-development","display_name":"ovarian development","score":0.9279999732971191},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.5720000267028809},{"id":"https://openalex.org/keywords/larval-nutrition","display_name":"larval nutrition","score":0.6539999842643738},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.7680000066757202},{"id":"https://openalex.org/keywords/caste-determination","display_name":"caste differentiation","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.8563456535339355},{"id":"https://openalex.org/C2779509574","wikidata":"https://www.wikidata.org/wiki/Q484416","display_name":"Caste","level":2,"score":0.821347713470459},{"id":"https://openalex.org/C2777907900","wikidata":"https://www.wikidata.org/wiki/Q102857","display_name":"Honey bee","level":2,"score":0.6846411228179932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6837018728256226},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.3770318329334259},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.3331247568130493},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.2783048748970032},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2407257854938507},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.05815526843070984},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001516","descriptor_name":"Bees","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D001516","descriptor_name":"Bees","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001516","descriptor_name":"Bees","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006458","descriptor_name":"Hemolymph","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014199","descriptor_name":"Trehalose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019476","descriptor_name":"Insect Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019476","descriptor_name":"Insect Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019849","descriptor_name":"Sex Determination Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049628","descriptor_name":"Body Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1242/jeb.085779","doi":"https://doi.org/10.1242/jeb.085779","is_oa":true,"landing_page_url":"https://doi.org/10.1242/jeb.085779","pdf_url":"https://jeb.biologists.org/content/jexbio/216/23/4347.full.pdf","source":{"id":"https://openalex.org/S20257348","display_name":"Journal of Experimental Biology","issn_l":"0022-0949","issn":["0022-0949","1477-9145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3836288","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3836288","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Biol","raw_type":"Text"},{"id":"pmid:23997199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23997199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1242/jeb.085779","doi":"https://doi.org/10.1242/jeb.085779","is_oa":true,"landing_page_url":"https://doi.org/10.1242/jeb.085779","pdf_url":"https://jeb.biologists.org/content/jexbio/216/23/4347.full.pdf","source":{"id":"https://openalex.org/S20257348","display_name":"Journal of Experimental Biology","issn_l":"0022-0949","issn":["0022-0949","1477-9145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.5666999816894531,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4300217723","display_name":null,"funder_award_id":"185306","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G546234630","display_name":"The Biodemographic Determinants of Life Span","funder_award_id":"P01AG022500","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6928983868","display_name":null,"funder_award_id":"NIA P01 AG22500","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8461217701","display_name":null,"funder_award_id":"AG22500","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8943164936","display_name":null,"funder_award_id":"180504","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124123200.pdf","grobid_xml":"https://content.openalex.org/works/W2124123200.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W17158802","https://openalex.org/W74010023","https://openalex.org/W105893388","https://openalex.org/W624317177","https://openalex.org/W1501652874","https://openalex.org/W1514943426","https://openalex.org/W1544591346","https://openalex.org/W1572420852","https://openalex.org/W1572491129","https://openalex.org/W1578756142","https://openalex.org/W1585352605","https://openalex.org/W1593865165","https://openalex.org/W1755699214","https://openalex.org/W1863715486","https://openalex.org/W1987942547","https://openalex.org/W1989998925","https://openalex.org/W1993061638","https://openalex.org/W1994113364","https://openalex.org/W1996368877","https://openalex.org/W1996742950","https://openalex.org/W1999631075","https://openalex.org/W2001970248","https://openalex.org/W2009989509","https://openalex.org/W2010492673","https://openalex.org/W2011792389","https://openalex.org/W2012033127","https://openalex.org/W2012209682","https://openalex.org/W2012911113","https://openalex.org/W2014887370","https://openalex.org/W2023584696","https://openalex.org/W2023788395","https://openalex.org/W2024271828","https://openalex.org/W2027661132","https://openalex.org/W2030890733","https://openalex.org/W2033005572","https://openalex.org/W2034235936","https://openalex.org/W2034452543","https://openalex.org/W2035711164","https://openalex.org/W2038436434","https://openalex.org/W2039725919","https://openalex.org/W2043922111","https://openalex.org/W2046427450","https://openalex.org/W2056886679","https://openalex.org/W2063098376","https://openalex.org/W2064490629","https://openalex.org/W2068873501","https://openalex.org/W2069733880","https://openalex.org/W2073318890","https://openalex.org/W2080351920","https://openalex.org/W2083850113","https://openalex.org/W2083958499","https://openalex.org/W2086904982","https://openalex.org/W2093119239","https://openalex.org/W2095127197","https://openalex.org/W2097233732","https://openalex.org/W2099645775","https://openalex.org/W2100769763","https://openalex.org/W2101831496","https://openalex.org/W2102749897","https://openalex.org/W2107277218","https://openalex.org/W2107900138","https://openalex.org/W2108244474","https://openalex.org/W2110107454","https://openalex.org/W2117275105","https://openalex.org/W2124791602","https://openalex.org/W2124971965","https://openalex.org/W2125322494","https://openalex.org/W2127108219","https://openalex.org/W2127291959","https://openalex.org/W2128648826","https://openalex.org/W2134435405","https://openalex.org/W2135121608","https://openalex.org/W2137090378","https://openalex.org/W2137448711","https://openalex.org/W2141593523","https://openalex.org/W2141720980","https://openalex.org/W2145028184","https://openalex.org/W2147841227","https://openalex.org/W2154166273","https://openalex.org/W2154946742","https://openalex.org/W2157725915","https://openalex.org/W2163749582","https://openalex.org/W2478896280","https://openalex.org/W2785712230","https://openalex.org/W4245941001","https://openalex.org/W6634443797"],"related_works":["https://openalex.org/W2024271828","https://openalex.org/W2101831496","https://openalex.org/W2163749582","https://openalex.org/W7099223570","https://openalex.org/W2127291959","https://openalex.org/W2023816733","https://openalex.org/W2387934437","https://openalex.org/W1673302067","https://openalex.org/W2021365870","https://openalex.org/W249796338"],"abstract_inverted_index":{"The":[0],"food":[1,50],"a":[2,13,19,41,91,126,142,167],"honey":[3,72,137],"bee":[4,73,138],"female":[5],"larva":[6],"receives":[7],"determines":[8],"whether":[9],"she":[10],"develops":[11],"into":[12,55],"large":[14],"long-lived":[15],"fertile":[16],"queen":[17],"or":[18],"short-lived":[20],"sterile":[21],"worker.":[22],"Through":[23],"well-established":[24],"nutrient-sensing":[25],"and":[26,75,107,113,134,200],"growth-promoting":[27,93],"functions":[28],"in":[29,44,49,71,86,97,136,169,228,238],"metazoans,":[30],"the":[31,76,108,163,180,198,229,233],"insulin/insulin-like":[32],"growth":[33],"factor":[34],"1":[35],"signaling":[36],"(IIS)":[37],"pathway":[38],"has":[39],"become":[40],"focal":[42],"topic":[43],"investigations":[45],"on":[46,129],"how":[47],"differences":[48],"environment":[51],"can":[52],"be":[53,222],"translated":[54],"internal":[56],"signals":[57],"responsible":[58],"for":[59],"queen-worker":[60,98],"determination.":[61],"However,":[62],"low":[63],"expression":[64],"levels":[65,155,190],"of":[66,78,95,102,115,207,235],"two":[67,117],"insulin":[68],"receptors":[69],"(AmInRs)":[70],"larvae":[74,139],"failure":[77],"one":[79],"AmInR":[80],"to":[81,232],"influence":[82,192],"caste":[83,208],"differentiation":[84],"are":[85],"potential":[87],"conflict":[88],"with":[89],"such":[90,103,196,210],"classical":[92],"role":[94],"IIS":[96],"development.":[99],"In":[100,217],"view":[101],"an":[104],"apparent":[105],"contradiction,":[106],"fact":[109],"that":[110,151,187],"binding":[111],"partners":[112],"affinities":[114],"these":[116,183],"AmInRs":[118],"have":[119],"not":[120,176],"been":[121],"worked":[122],"out,":[123],"we":[124,185],"performed":[125],"functional":[127],"study":[128],"insulin-like":[130],"peptide":[131],"genes":[132],"(AmILP1":[133],"AmILP2)":[135],"by":[140,158,179,224],"using":[141],"double-stranded":[143],"RNA":[144],"(dsRNA)-mediated":[145],"gene":[146],"knockdown":[147,165],"approach.":[148],"We":[149],"found":[150],"juvenile":[152],"hormone":[153],"(JH)":[154],"were":[156,175],"diminished":[157],"AmILP1":[159,225],"dsRNA":[160],"treatment,":[161],"while":[162,203],"AmILP2":[164,188],"caused":[166],"reduction":[168],"ovary":[170,199],"size.":[171],"Blood":[172],"sugar":[173],"titers":[174],"significantly":[177],"affected":[178],"treatments.":[181],"From":[182],"results":[184],"conclude":[186],"transcript":[189],"may":[191,213,221],"specific":[193],"organ":[194],"development,":[195],"as":[197,211],"body":[201],"mass,":[202],"more":[204],"general":[205],"traits":[206],"differentiation,":[209],"mandibles,":[212],"require":[214],"additional":[215],"regulators.":[216],"addition,":[218],"JH":[219],"production":[220],"regulated":[223],"expressed":[226],"locally":[227],"brain,":[230],"similar":[231],"function":[234],"certain":[236],"ILPs":[237],"Drosophila.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":9}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}