{"id":"https://openalex.org/W2124096797","doi":null,"title":"Characterization of the Alzheimer\u00b4s disease-associated clac protein","display_name":"Characterization of the Alzheimer\u00b4s disease-associated clac protein","publication_year":2005,"publication_date":"2005-03-18","ids":{"openalex":"https://openalex.org/W2124096797","mag":"2124096797"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26897995","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Characterization_of_the_Alzheimer_s_disease-associated_clac_protein/26897995","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/39314","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019058126","display_name":"Linda S\u00f6derberg","orcid":"https://orcid.org/0009-0003-6075-4568","observed_orcids":["https://orcid.org/0009-0003-6075-4568"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Linda S\u00f6derberg","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-6075-4568","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019058126"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9470000267028809},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8790000081062317},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.824999988079071},{"id":"https://openalex.org/keywords/furin-cleavage","display_name":"furin cleavage","score":0.9390000104904175},{"id":"https://openalex.org/keywords/triple-helical-structure","display_name":"triple-helical structure","score":0.7549999952316284},{"id":"https://openalex.org/keywords/heparin-binding","display_name":"heparin binding","score":0.8299999833106995},{"id":"https://openalex.org/keywords/glycosylation","display_name":"glycosylation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.5220000147819519},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37929442524909973}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26897995","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Characterization_of_the_Alzheimer_s_disease-associated_clac_protein/26897995","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/39314","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/39314","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2124096797","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/10616/39314/1/thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/39314","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/39314","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":161,"referenced_works":["https://openalex.org/W70790455","https://openalex.org/W218942033","https://openalex.org/W347088393","https://openalex.org/W1481000570","https://openalex.org/W1492654684","https://openalex.org/W1498798237","https://openalex.org/W1510688843","https://openalex.org/W1516306407","https://openalex.org/W1533120728","https://openalex.org/W1549447146","https://openalex.org/W1555517932","https://openalex.org/W1571248124","https://openalex.org/W1571263856","https://openalex.org/W1575225446","https://openalex.org/W1590499183","https://openalex.org/W1611407165","https://openalex.org/W1626267121","https://openalex.org/W1757428799","https://openalex.org/W1758831574","https://openalex.org/W1782613870","https://openalex.org/W1833346013","https://openalex.org/W1923107093","https://openalex.org/W1928664922","https://openalex.org/W1964741226","https://openalex.org/W1965496447","https://openalex.org/W1966388070","https://openalex.org/W1966451439","https://openalex.org/W1967464880","https://openalex.org/W1967838681","https://openalex.org/W1967864208","https://openalex.org/W1968458015","https://openalex.org/W1968551454","https://openalex.org/W1969070418","https://openalex.org/W1969457796","https://openalex.org/W1970396449","https://openalex.org/W1972139563","https://openalex.org/W1972567838","https://openalex.org/W1976740378","https://openalex.org/W1978314140","https://openalex.org/W1979004999","https://openalex.org/W1979221090","https://openalex.org/W1981554609","https://openalex.org/W1983184188","https://openalex.org/W1985323612","https://openalex.org/W1988757615","https://openalex.org/W1989178832","https://openalex.org/W1989972829","https://openalex.org/W1991435932","https://openalex.org/W1992598058","https://openalex.org/W1992810464","https://openalex.org/W1992849341","https://openalex.org/W1993754322","https://openalex.org/W1995650022","https://openalex.org/W1997274666","https://openalex.org/W2000706612","https://openalex.org/W2000769077","https://openalex.org/W2002100378","https://openalex.org/W2002983419","https://openalex.org/W2003305541","https://openalex.org/W2004402098","https://openalex.org/W2005294501","https://openalex.org/W2006927174","https://openalex.org/W2007966378","https://openalex.org/W2008232759","https://openalex.org/W2008966525","https://openalex.org/W2011874786","https://openalex.org/W2012215271","https://openalex.org/W2014049241","https://openalex.org/W2015675204","https://openalex.org/W2017324222","https://openalex.org/W2019450646","https://openalex.org/W2019586377","https://openalex.org/W2020842716","https://openalex.org/W2021181758","https://openalex.org/W2021333248","https://openalex.org/W2021950004","https://openalex.org/W2026783024","https://openalex.org/W2027402816","https://openalex.org/W2029205666","https://openalex.org/W2029267203","https://openalex.org/W2030163251","https://openalex.org/W2032127240","https://openalex.org/W2032665239","https://openalex.org/W2033797893","https://openalex.org/W2033847972","https://openalex.org/W2037599912","https://openalex.org/W2037914242","https://openalex.org/W2038484123","https://openalex.org/W2043740986","https://openalex.org/W2046997550","https://openalex.org/W2048509804","https://openalex.org/W2049535318","https://openalex.org/W2052742260","https://openalex.org/W2055176898","https://openalex.org/W2055568011","https://openalex.org/W2055615966","https://openalex.org/W2056157930","https://openalex.org/W2058124777","https://openalex.org/W2059077273","https://openalex.org/W2059804089","https://openalex.org/W2061033316","https://openalex.org/W2061163887","https://openalex.org/W2062593465","https://openalex.org/W2064093411","https://openalex.org/W2064722086","https://openalex.org/W2064883694","https://openalex.org/W2066339048","https://openalex.org/W2070488302","https://openalex.org/W2070887142","https://openalex.org/W2071953900","https://openalex.org/W2071993331","https://openalex.org/W2072153468","https://openalex.org/W2072682191","https://openalex.org/W2073516240","https://openalex.org/W2074909707","https://openalex.org/W2076973809","https://openalex.org/W2077464099","https://openalex.org/W2079364698","https://openalex.org/W2085258824","https://openalex.org/W2085899859","https://openalex.org/W2088151512","https://openalex.org/W2088957977","https://openalex.org/W2089040344","https://openalex.org/W2089824266","https://openalex.org/W2094831799","https://openalex.org/W2097707959","https://openalex.org/W2098358795","https://openalex.org/W2099150585","https://openalex.org/W2099570666","https://openalex.org/W2100610042","https://openalex.org/W2101077392","https://openalex.org/W2103440561","https://openalex.org/W2104932745","https://openalex.org/W2108242612","https://openalex.org/W2108676263","https://openalex.org/W2113118331","https://openalex.org/W2114308491","https://openalex.org/W2117513966","https://openalex.org/W2120833123","https://openalex.org/W2121753059","https://openalex.org/W2122242099","https://openalex.org/W2131068139","https://openalex.org/W2132470450","https://openalex.org/W2134365974","https://openalex.org/W2135493625","https://openalex.org/W2139391555","https://openalex.org/W2140992384","https://openalex.org/W2141606521","https://openalex.org/W2142692094","https://openalex.org/W2146610745","https://openalex.org/W2152192643","https://openalex.org/W2163429946","https://openalex.org/W2167754585","https://openalex.org/W2169152986","https://openalex.org/W2170166079","https://openalex.org/W2171405125","https://openalex.org/W2276055318","https://openalex.org/W2343515739","https://openalex.org/W2401341471","https://openalex.org/W2401675758","https://openalex.org/W2419312309"],"related_works":["https://openalex.org/W2093054541","https://openalex.org/W2122242099","https://openalex.org/W3112678516","https://openalex.org/W2141606521","https://openalex.org/W1527718103","https://openalex.org/W3022024106","https://openalex.org/W2417927684","https://openalex.org/W2007966378","https://openalex.org/W1979256982","https://openalex.org/W2746665851"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,672],"(AD)":[2],"is":[3,14,70,75,188,228,258,322,450,463,483,605],"the":[4,18,26,33,40,66,78,91,96,103,157,168,174,192,215,234,251,254,268,290,328,425,430,434,438,476,492,498,520,564,578,633,700],"most":[5],"prevalent":[6],"form":[7],"of":[8,20,32,56,68,102,111,170,179,196,211,233,272,294,303,376,387,411,433,478,500,514,522,532,557,566,583,637,643,668,699,707],"dementia":[9],"in":[10,25,95,125,128,156,199,204,262,275,282,291,335,350,401,404,451,456,481,540,611,615,639],"elderly":[11],"people":[12],"and":[13,50,58,127,182,222,270,321,333,354,418,424,449,473,553,603,626,630,635,705,738,741],"neuropathologically":[15],"characterized":[16],"by":[17,44,48,145,163,172,358,526,587,624],"presence":[19],"extracellular":[21],"senile":[22],"plaques":[23],"(SPs)":[24],"brain.":[27,264,641],"SPs":[28,69,92,261,638],"are":[29,138],"mainly":[30],"composed":[31],"amyloid":[34,41,197,218,709,766],"beta-peptide":[35],"(Abeta),":[36],"proteolytically":[37],"derived":[38],"from":[39,470],"beta-precursor":[42],"protein":[43,236,704],"sequential":[45],"cleavages":[46],"performed":[47,124],"beta-":[49],"gammasecretase,":[51],"to":[52,84,90,107,118,140,288,326,346,415,422,465,528,563,570,600],"generate":[53],"Abeta":[54,81,142,149,186,334,349,402,412,503,515,523,535,592,628,737,739],"species":[55],"40":[57],"42":[59],"amino":[60],"acids,":[61],"respectively.":[62],"The":[63,201,369,408,530],"mechanism":[64],"underlying":[65,194],"formation":[67,195,565],"largely":[71],"unknown":[72],"but":[73],"it":[74,308,604],"possible":[76,606],"that":[77,93,136,166,248,298,443,461,607,619],"less":[79],"dense":[80],"deposits,":[82],"referred":[83],"as":[85,380],"diffuse":[86],"plaques,":[87],"represent":[88],"precursors":[89],"occurs":[94],"brain":[97,158],"at":[98,489],"a":[99,109,239,276,304,310,339,351,363,588,612],"later":[100],"stage":[101],"disease.":[104],"In":[105,243,324,397,495],"addition":[106],"Abeta,":[108],"number":[110],"other":[112,467],"non-Abeta":[113],"components":[114,165],"have":[115],"been":[116],"found":[117,247,345],"co-deposit":[119],"with":[120,225,260,393,429,437,453,491,517,560,595],"SPs.":[121],"Many":[122],"studies":[123],"vitro":[126,292],"vivo":[129],"on":[130,185,209,502,534,546],"these":[131,180,212],"so-called":[132],"plaque-associated":[133,213],"proteins":[134,181],"suggest":[135,618],"they":[137],"able":[139,464],"modulate":[141],"aggregation,":[143],"either":[144],"facilitating":[146],"or":[147,385],"preventing":[148],"fibril":[150,504,524,743],"growth.":[151],"An":[152],"increased":[153],"plaque":[154,171,219],"load":[155],"may":[159,609],"also":[160],"be":[161,416,582],"caused":[162],"Abeta-binding":[164,382,395],"increase":[167],"persistence":[169,636],"affecting":[173],"clearance.":[175],"Thus,":[176],"further":[177,538],"characterization":[178],"their":[183],"impact":[184],"aggregation":[187,431],"imperative":[189],"for":[190,267,319,420,485],"understanding":[191],"events":[193],"deposits":[198],"vivo.":[200,616],"work":[202],"presented":[203,455],"this":[205,388],"thesis":[206],"has":[207,445],"focused":[208],"one":[210],"proteins,":[214],"collagenous":[216],"Alzheimer":[217,671],"component":[220,472],"(CLAC)":[221],"its":[223],"interaction":[224,480],"Abeta.":[226],"CLAC":[227,249,274,299,332,343,377,391,423,444,462,501,518,533,561,596,608,620,703,764],"generated":[229,390],"through":[230],"furin":[231],"cleavage":[232],"precursor":[235],"CLAC-P/collagen":[237],"XXV,":[238],"novel":[240],"transmembrane":[241],"collagen.":[242],"paper":[244,283,398,457,496,541],"I":[245],"we":[246,337,575],"was":[250,280,344,356,378,413,506,537],"antigen":[252],"causing":[253],"AMY":[255],"immunoreactivity,":[256],"which":[257,285,459],"co-localized":[259],"AD":[263,482,622,640],"A":[265],"system":[266],"expression":[269],"purification":[271],"recombinant":[273],"mammalian":[277],"cell":[278],"line":[279],"devised":[281],"II,":[284,458],"enabled":[286],"us":[287],"study":[289,327],"properties":[293],"CLAC.":[295],"We":[296,617],"showed":[297],"displays":[300],"features":[301],"characteristic":[302],"collagen":[305],"protein,":[306],"e.g.":[307],"forms":[309],"partly":[311,364],"protease-resistant":[312],"triple-helical":[313],"structure,":[314],"exhibits":[315],"an":[316,381,670,708],"intermediate":[317],"affinity":[318],"heparin":[320],"glycosylated.":[323],"order":[325],"molecular":[329],"interactions":[330],"between":[331],"vitro,":[336],"developed":[338],"solid-phase":[340],"binding":[341,355,421,426,625],"immunoassay.":[342],"bind":[347,466],"aggregated":[348,736],"concentration-dependent":[352],"manner":[353],"impaired":[357],"increasing":[359],"salt":[360],"concentrations,":[361],"suggesting":[362],"ionic":[365],"dependent":[366],"CLAC/Abeta":[367,479,493],"interaction.":[368],"LIKRRLIK":[370],"sequence":[371,447],"within":[372],"non-collagenous":[373],"domain":[374],"2":[375],"identified":[379],"motif.":[383],"Deletion":[384],"substitution":[386],"motif":[389],"variants":[392],"diminished":[394],"affinity.":[396],"III,":[399],"sequences":[400],"involved":[403],"CLAC-binding":[405],"were":[406,597],"examined.":[407],"central":[409],"region":[410],"shown":[414],"necessary":[417],"sufficient":[419],"correlated":[427],"better":[428],"state":[432],"peptide,":[435],"than":[436],"primary":[439],"sequence.":[440],"This":[441],"suggests":[442],"low":[446],"specificity":[448],"agreement":[452],"observations":[454],"show":[460],"fibrils":[468,516,536,559,580,593,767],"formed":[469],"non-amyloid-beta":[471],"amylin.":[474],"Understanding":[475],"role":[477],"essential":[484],"future":[486],"research":[487],"aiming":[488],"interacting":[490],"binding.":[494],"III":[497],"effect":[499,531],"elongation":[505,525],"examined":[507],"using":[508,543],"surface":[509],"plasmon":[510],"resonance":[511],"spectroscopy.":[512],"Treatment":[513],"reduced":[519],"rate":[521],"20":[527],"30%.":[529],"studied":[539],"IV":[542],"assays":[544],"based":[545],"turbidity,":[547],"Thioflavin":[548],"T":[549],"binding,":[550],"sedimentation":[551],"analysis":[552],"electron":[554],"microscopy.":[555],"Incubation":[556],"preformed":[558],"led":[562],"larger":[567],"aggregates":[568,629],"compared":[569],"non":[571],"CLAC-treated":[572],"samples.":[573],"Finally,":[574],"investigated":[576],"whether":[577],"CLAC-induced":[579],"could":[581],"some":[584],"biological":[585],"relevance":[586],"protease":[589,769],"resistance":[590],"assay.":[591],"incubated":[594],"more":[598],"resistant":[599,770],"proteolytic":[601],"degradation":[602],"act":[610],"similar":[613],"way":[614],"effects":[621],"pathogenesis":[623],"assembling":[627],"thereby":[631],"altering":[632],"turnover":[634],"List":[642],"scientific":[644],"papers":[645],"I.":[646],"Soderberg":[647,683,721,747],"L,":[648,684,722,748],"Zhukareva":[649],"V,":[650],"Bogdanovic":[651],"N,":[652],"Hashimoto":[653],"T,":[654,658],"Winblad":[655,691,727,757],"B,":[656,692,728,758],"Iwatsubo":[657],"Lee":[659],"VM,":[660],"Trojanowski":[661],"JQ,":[662],"Naslund":[663,695,729,759],"J":[664,675,696,712],"(2003).":[665],"Molecular":[666],"identification":[667,706],"AMY,":[669],"amyloid-associated":[673],"protein.":[674],"Neuropathol":[676],"Exp":[677],"Neurol.":[678],"62(11):":[679],"1108-17.":[680],"https://pubmed.ncbi.nlm.nih.gov/14656069":[681],"II.":[682],"Kakuyama":[685,719,751],"H,":[686,720,752],"Moller":[687],"A,":[688,690,756],"Ito":[689,755],"Tjernberg":[693,731,761],"LO,":[694],"(2005).":[697,733,763],"Characterization":[698],"Alzheimers":[701],"disease-associated":[702],"beta-peptide-binding":[710],"site.":[711],"Biol":[713],"Chem.":[714],"280(2):":[715],"1007-15.":[716],"https://doi.org/10.1074/jbc.M403628200":[717],"III.":[718],"Horigome":[723],"K,":[724],"Dahlqvist":[725,749],"C,":[726,750],"J,":[730,754,760],"LO":[732,762],"Clac":[734],"binds":[735],"fragments,":[740],"attenuates":[742],"elongation.":[744],"[Submitted]":[745],"IV.":[746],"Thyberg":[753],"assembles":[765],"into":[768],"aggregates.":[771],"FEBS":[772],"Journal.":[773],"[Accepted]":[774],"https://doi.org/10.1111/j.1742-4658.2005.04647.x":[775]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}