{"id":"https://openalex.org/W2124092811","doi":"https://doi.org/10.1038/bjc.2011.382","title":"The role of PARP in DNA repair and its therapeutic exploitation","display_name":"The role of PARP in DNA repair and its therapeutic exploitation","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W2124092811","doi":"https://doi.org/10.1038/bjc.2011.382","mag":"2124092811","pmid":"https://pubmed.ncbi.nlm.nih.gov/21989215","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3208503"},"language":"en","primary_location":{"id":"doi:10.1038/bjc.2011.382","doi":"https://doi.org/10.1038/bjc.2011.382","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.2011.382","pdf_url":"https://www.nature.com/articles/bjc2011382.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2124092811"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/bjc2011382.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054771911","display_name":"Milind M. Javle","orcid":"https://orcid.org/0000-0001-9158-0941","observed_orcids":["https://orcid.org/0000-0001-9158-0941"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Javle","raw_affiliation_strings":["UT-MD Anderson Cancer Centre, Department of Gastrointestinal Medical Oncology, 1515 Holcombe Boulevard, Unit 426, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT-MD Anderson Cancer Centre, Department of Gastrointestinal Medical Oncology, 1515 Holcombe Boulevard, Unit 426, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001447451","display_name":"Nicola J. Curtin","orcid":"https://orcid.org/0000-0003-1369-1843","observed_orcids":["https://orcid.org/0000-0003-1369-1843"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"N J Curtin","raw_affiliation_strings":["Newcastle University, Northern Institute for Cancer Research, Medical School, Newcastle upon Tyne, NE2 4HH, UK","Newcastle University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Newcastle University, Northern Institute for Cancer Research, Medical School, Newcastle upon Tyne, NE2 4HH, UK","institution_ids":["https://openalex.org/I84884186"]},{"raw_affiliation_string":"Newcastle University","institution_ids":["https://openalex.org/I84884186"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001447451"],"corresponding_institution_ids":["https://openalex.org/I84884186"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":2.8102,"has_fulltext":true,"cited_by_count":342,"citation_normalized_percentile":{"value":0.95307135,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"105","issue":"8","first_page":"1114","last_page":"1122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.875},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8560000061988831},{"id":"https://openalex.org/keywords/homologous-recombination-deficiency","display_name":"homologous recombination deficiency","score":0.8679999709129333},{"id":"https://openalex.org/keywords/brca-mutations","display_name":"BRCA mutations","score":0.9919999837875366},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8259999752044678},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.8610000014305115},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9110000133514404},{"id":"https://openalex.org/keywords/poly-adp-ribose-polymerase","display_name":"poly(ADP-ribose) polymerase","score":0.6380000114440918},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.7509838938713074},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.6964244842529297},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.662455141544342},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.6367162466049194},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6163246631622314},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.6097663044929504},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5407429337501526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.518325686454773},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.480106383562088},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4159674346446991},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.41547125577926636},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.35045504570007324},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.321804404258728},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.10545998811721802},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06992518901824951}],"mesh":[{"descriptor_ui":"D000067856","descriptor_name":"Poly(ADP-ribose) Polymerase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/bjc.2011.382","doi":"https://doi.org/10.1038/bjc.2011.382","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.2011.382","pdf_url":"https://www.nature.com/articles/bjc2011382.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2462993","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3208503","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:21989215","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21989215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3208503","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3208503/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"doi:10.25405/ncl.34169232","doi":"https://doi.org/10.25405/ncl.34169232","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34169232","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34169232.v1","doi":"https://doi.org/10.25405/ncl.34169232.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34169232.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1038/bjc.2011.382","doi":"https://doi.org/10.1038/bjc.2011.382","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.2011.382","pdf_url":"https://www.nature.com/articles/bjc2011382.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124092811.pdf","grobid_xml":"https://content.openalex.org/works/W2124092811.grobid-xml"},"referenced_works_count":239,"referenced_works":["https://openalex.org/W111284505","https://openalex.org/W159690873","https://openalex.org/W569424146","https://openalex.org/W991841292","https://openalex.org/W1498308778","https://openalex.org/W1530211929","https://openalex.org/W1548727679","https://openalex.org/W1552661588","https://openalex.org/W1584549675","https://openalex.org/W1605052148","https://openalex.org/W1606173842","https://openalex.org/W1608617260","https://openalex.org/W1674116136","https://openalex.org/W1780458417","https://openalex.org/W1833181362","https://openalex.org/W1848063234","https://openalex.org/W1877440701","https://openalex.org/W1906314377","https://openalex.org/W1917632054","https://openalex.org/W1943407880","https://openalex.org/W1945295084","https://openalex.org/W1968960110","https://openalex.org/W1969175804","https://openalex.org/W1970572497","https://openalex.org/W1973123264","https://openalex.org/W1973268287","https://openalex.org/W1975927718","https://openalex.org/W1976583784","https://openalex.org/W1976657680","https://openalex.org/W1978000569","https://openalex.org/W1978595257","https://openalex.org/W1980721628","https://openalex.org/W1981735078","https://openalex.org/W1981995938","https://openalex.org/W1985598285","https://openalex.org/W1989302474","https://openalex.org/W1989389011","https://openalex.org/W1990717111","https://openalex.org/W1991182906","https://openalex.org/W1992042096","https://openalex.org/W1992332625","https://openalex.org/W1992413029","https://openalex.org/W1992975619","https://openalex.org/W1993031792","https://openalex.org/W1993582972","https://openalex.org/W1993972255","https://openalex.org/W1994209879","https://openalex.org/W1994432408","https://openalex.org/W1995632307","https://openalex.org/W1997349871","https://openalex.org/W1998452180","https://openalex.org/W1998769612","https://openalex.org/W1999659306","https://openalex.org/W2003100658","https://openalex.org/W2003345927","https://openalex.org/W2003645883","https://openalex.org/W2005458257","https://openalex.org/W2005845638","https://openalex.org/W2006299554","https://openalex.org/W2007091564","https://openalex.org/W2007859567","https://openalex.org/W2009007206","https://openalex.org/W2009754997","https://openalex.org/W2010168200","https://openalex.org/W2010682205","https://openalex.org/W2011028367","https://openalex.org/W2011476357","https://openalex.org/W2012026523","https://openalex.org/W2012656271","https://openalex.org/W2013537373","https://openalex.org/W2013646036","https://openalex.org/W2014035904","https://openalex.org/W2014300705","https://openalex.org/W2014599726","https://openalex.org/W2015720223","https://openalex.org/W2015840105","https://openalex.org/W2017462648","https://openalex.org/W2018329608","https://openalex.org/W2019947412","https://openalex.org/W2021424740","https://openalex.org/W2022353228","https://openalex.org/W2023448397","https://openalex.org/W2024719590","https://openalex.org/W2024954071","https://openalex.org/W2025634029","https://openalex.org/W2026330110","https://openalex.org/W2031694870","https://openalex.org/W2033761616","https://openalex.org/W2034548183","https://openalex.org/W2035386385","https://openalex.org/W2037147607","https://openalex.org/W2039477833","https://openalex.org/W2040026049","https://openalex.org/W2040840466","https://openalex.org/W2040859770","https://openalex.org/W2042251066","https://openalex.org/W2045164971","https://openalex.org/W2045506022","https://openalex.org/W2045620095","https://openalex.org/W2046770300","https://openalex.org/W2049566913","https://openalex.org/W2049727461","https://openalex.org/W2050164541","https://openalex.org/W2050746381","https://openalex.org/W2053827853","https://openalex.org/W2054248299","https://openalex.org/W2057132693","https://openalex.org/W2057689058","https://openalex.org/W2058241739","https://openalex.org/W2059177130","https://openalex.org/W2059650806","https://openalex.org/W2062067118","https://openalex.org/W2064588859","https://openalex.org/W2065849886","https://openalex.org/W2067117419","https://openalex.org/W2068160432","https://openalex.org/W2070758111","https://openalex.org/W2071966564","https://openalex.org/W2072528578","https://openalex.org/W2074565257","https://openalex.org/W2075174658","https://openalex.org/W2076151974","https://openalex.org/W2076176285","https://openalex.org/W2076190319","https://openalex.org/W2077559325","https://openalex.org/W2079203845","https://openalex.org/W2079840996","https://openalex.org/W2081292130","https://openalex.org/W2082771722","https://openalex.org/W2084291773","https://openalex.org/W2086038769","https://openalex.org/W2087521387","https://openalex.org/W2091803091","https://openalex.org/W2093619128","https://openalex.org/W2093675229","https://openalex.org/W2095798342","https://openalex.org/W2096136751","https://openalex.org/W2096843793","https://openalex.org/W2097964346","https://openalex.org/W2098737737","https://openalex.org/W2099268944","https://openalex.org/W2100457669","https://openalex.org/W2103270230","https://openalex.org/W2106390123","https://openalex.org/W2109001339","https://openalex.org/W2109306755","https://openalex.org/W2109578285","https://openalex.org/W2110017381","https://openalex.org/W2110264095","https://openalex.org/W2111429259","https://openalex.org/W2113125265","https://openalex.org/W2114124586","https://openalex.org/W2114197677","https://openalex.org/W2114416638","https://openalex.org/W2114860131","https://openalex.org/W2114927201","https://openalex.org/W2116005493","https://openalex.org/W2117006689","https://openalex.org/W2117964602","https://openalex.org/W2118306647","https://openalex.org/W2118682535","https://openalex.org/W2120872266","https://openalex.org/W2123207674","https://openalex.org/W2123825855","https://openalex.org/W2124371549","https://openalex.org/W2125126547","https://openalex.org/W2125732268","https://openalex.org/W2126153567","https://openalex.org/W2126575569","https://openalex.org/W2127104690","https://openalex.org/W2127808743","https://openalex.org/W2128263621","https://openalex.org/W2130083789","https://openalex.org/W2131670056","https://openalex.org/W2131674211","https://openalex.org/W2137755195","https://openalex.org/W2137903987","https://openalex.org/W2138545604","https://openalex.org/W2139580868","https://openalex.org/W2141702105","https://openalex.org/W2141798197","https://openalex.org/W2141868357","https://openalex.org/W2142468673","https://openalex.org/W2142658272","https://openalex.org/W2144085357","https://openalex.org/W2144351239","https://openalex.org/W2144510519","https://openalex.org/W2144768837","https://openalex.org/W2146501567","https://openalex.org/W2147071985","https://openalex.org/W2147111123","https://openalex.org/W2149464818","https://openalex.org/W2150844516","https://openalex.org/W2151797852","https://openalex.org/W2153787932","https://openalex.org/W2153980875","https://openalex.org/W2155244882","https://openalex.org/W2155851270","https://openalex.org/W2156077962","https://openalex.org/W2156442575","https://openalex.org/W2157016693","https://openalex.org/W2157899948","https://openalex.org/W2157962151","https://openalex.org/W2158489637","https://openalex.org/W2158742893","https://openalex.org/W2160073632","https://openalex.org/W2160234594","https://openalex.org/W2160466424","https://openalex.org/W2162157249","https://openalex.org/W2164497259","https://openalex.org/W2164510297","https://openalex.org/W2164607388","https://openalex.org/W2164708087","https://openalex.org/W2165091409","https://openalex.org/W2165770167","https://openalex.org/W2167692560","https://openalex.org/W2168014505","https://openalex.org/W2168169655","https://openalex.org/W2168756897","https://openalex.org/W2168891239","https://openalex.org/W2168953464","https://openalex.org/W2170176648","https://openalex.org/W2170932866","https://openalex.org/W2171624011","https://openalex.org/W2171972386","https://openalex.org/W2176655192","https://openalex.org/W2204987058","https://openalex.org/W2207221522","https://openalex.org/W2208114517","https://openalex.org/W2241745863","https://openalex.org/W2325814368","https://openalex.org/W2330044266","https://openalex.org/W2336058493","https://openalex.org/W2340291575","https://openalex.org/W2343141906","https://openalex.org/W2502963628","https://openalex.org/W2952954173","https://openalex.org/W3093265161","https://openalex.org/W4323966466"],"related_works":["https://openalex.org/W2142658272","https://openalex.org/W3125948939","https://openalex.org/W2476665479","https://openalex.org/W2549651109","https://openalex.org/W2900056609","https://openalex.org/W4220932078","https://openalex.org/W2571868515","https://openalex.org/W2937080225","https://openalex.org/W2987653633","https://openalex.org/W2076746363"],"abstract_inverted_index":{"Historically,":[0],"PARP":[1,104,114],"inhibitors":[2],"(PARPi)":[3],"were":[4],"developed":[5],"to":[6,54,79,87,103,113],"potentiate":[7],"the":[8,70],"cytotoxic":[9],"effect":[10],"of":[11,36,108],"certain":[12],"chemotherapeutic":[13],"agents":[14,29],"and":[15,33,90,100],"are":[16,30,41,76,84],"currently":[17],"being":[18,73],"investigated":[19],"in":[20,24,82],"combination":[21],"with":[22,38,63],"chemotherapy":[23],"diverse":[25],"cancer":[26,92],"types.":[27],"These":[28],"also":[31],"radiosensitisers":[32],"clinical":[34],"trials":[35],"PARPi":[37],"concurrent":[39],"radiation":[40],"required.":[42],"It":[43],"has":[44],"long":[45],"been":[46],"recognised":[47],"that":[48,60],"defective":[49,64],"DNA":[50],"repair":[51,68],"pathways":[52],"lead":[53],"tumour":[55,61],"susceptibility.":[56],"Recent":[57],"studies":[58],"indicate":[59],"cells":[62],"homologous":[65],"recombination":[66],"(HR)":[67],"pathways,":[69],"classic":[71],"example":[72],"BRCA":[74],"mutations,":[75],"exquisitely":[77],"sensitive":[78],"PARPi.":[80],"Defects":[81],"HR":[83,98],"not":[85],"restricted":[86],"BRCA-associated":[88],"tumours":[89],"other":[91],"types":[93],"may":[94],"be":[95],"enriched":[96],"for":[97,111,120],"defects":[99],"hence":[101],"susceptible":[102],"inhibition.":[105],"The":[106],"identification":[107],"predictive":[109],"markers":[110],"sensitivity":[112],"inhibition":[115],"is":[116],"a":[117],"priority":[118],"area":[119],"research.":[121]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":31},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":26},{"year":2012,"cited_by_count":25}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
