{"id":"https://openalex.org/W2124032449","doi":"https://doi.org/10.1111/j.1442-2050.2004.00402.x","title":"p27 and Barrett\u2019s esophagus: a review*","display_name":"p27 and Barrett\u2019s esophagus: a review*","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2124032449","doi":"https://doi.org/10.1111/j.1442-2050.2004.00402.x","mag":"2124032449","pmid":"https://pubmed.ncbi.nlm.nih.gov/15230722"},"language":"en","primary_location":{"id":"doi:10.1111/j.1442-2050.2004.00402.x","doi":"https://doi.org/10.1111/j.1442-2050.2004.00402.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1442-2050.2004.00402.x","pdf_url":null,"source":{"id":"https://openalex.org/S170171939","display_name":"Diseases of the Esophagus","issn_l":"1120-8694","issn":["1120-8694","1442-2050"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases of the Esophagus","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111836898","display_name":"F. Henry Ellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"F. H. Ellis","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Division of Cardiothoracic Surgery, Harvard Medical School, Boston, MA 02215, USA. mjwe@rcn.com","Beth Israel Deaconess Medical Center, Division of Cardiothoracic Surgery, Harvard Medical School, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Division of Cardiothoracic Surgery, Harvard Medical School, Boston, MA 02215, USA. mjwe@rcn.com","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Division of Cardiothoracic Surgery, Harvard Medical School, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071763026","display_name":"Massimo F. Loda","orcid":"https://orcid.org/0000-0001-9674-8379","observed_orcids":["https://orcid.org/0000-0001-9674-8379"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Loda","raw_affiliation_strings":["Department of Adult Oncology, Dana Farber Cancer Institute; Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School Boston, USA","Department of Adult Oncology, Dana Farber Cancer Institute","Department of Pathology, Brigham and Women's Hospital, Harvard Medical School Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Dana Farber Cancer Institute; Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School Boston, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579","https://openalex.org/I4210161994"]},{"raw_affiliation_string":"Department of Adult Oncology, Dana Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Harvard Medical School Boston, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5111836898"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":{"value":4113,"currency":"USD","value_usd":4113},"apc_paid":null,"fwci":0.0655,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.12232416,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"2","first_page":"113","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.9909999966621399},{"id":"https://openalex.org/keywords/barrett-s-esophagus","display_name":"Barrett's esophagus","score":0.9259999990463257},{"id":"https://openalex.org/keywords/barrett-s-adenocarcinoma","display_name":"Barrett's adenocarcinoma","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9259999990463257},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.746999979019165},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9430000185966492},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8767720460891724},{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.7863954305648804},{"id":"https://openalex.org/C2778589982","wikidata":"https://www.wikidata.org/wiki/Q808892","display_name":"Barrett's esophagus","level":4,"score":0.7551252245903015},{"id":"https://openalex.org/C2992824209","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal adenocarcinoma","level":4,"score":0.6152422428131104},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5663094520568848},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.5491849780082703},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5482988953590393},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4846380352973938},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4438636004924774},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4435001611709595},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3811158835887909},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2658676505088806},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05988287925720215},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.050496906042099}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1442-2050.2004.00402.x","doi":"https://doi.org/10.1111/j.1442-2050.2004.00402.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1442-2050.2004.00402.x","pdf_url":null,"source":{"id":"https://openalex.org/S170171939","display_name":"Diseases of the Esophagus","issn_l":"1120-8694","issn":["1120-8694","1442-2050"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases of the Esophagus","raw_type":"journal-article"},{"id":"pmid:15230722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15230722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W141382627","https://openalex.org/W1671132870","https://openalex.org/W1777669545","https://openalex.org/W1898566859","https://openalex.org/W1965049479","https://openalex.org/W1970779989","https://openalex.org/W1973367648","https://openalex.org/W1982330769","https://openalex.org/W1985822229","https://openalex.org/W1987412457","https://openalex.org/W1989071455","https://openalex.org/W1992917167","https://openalex.org/W1992965559","https://openalex.org/W1995086741","https://openalex.org/W1997850959","https://openalex.org/W2005316593","https://openalex.org/W2016728878","https://openalex.org/W2018221017","https://openalex.org/W2020337400","https://openalex.org/W2021457628","https://openalex.org/W2022640628","https://openalex.org/W2028742513","https://openalex.org/W2031899806","https://openalex.org/W2033505235","https://openalex.org/W2036584706","https://openalex.org/W2040143851","https://openalex.org/W2042275657","https://openalex.org/W2069300021","https://openalex.org/W2084472051","https://openalex.org/W2109881839","https://openalex.org/W2112221714","https://openalex.org/W2114609647","https://openalex.org/W2138714350","https://openalex.org/W2150634345","https://openalex.org/W2156030206","https://openalex.org/W2157769701","https://openalex.org/W2162097862","https://openalex.org/W2164277308","https://openalex.org/W2164406463","https://openalex.org/W2166064341","https://openalex.org/W2170659347","https://openalex.org/W2296237183","https://openalex.org/W2332789960","https://openalex.org/W2418594024","https://openalex.org/W2434150621","https://openalex.org/W4255683556"],"related_works":["https://openalex.org/W2918943885","https://openalex.org/W1971955922","https://openalex.org/W2039183314","https://openalex.org/W2495582601","https://openalex.org/W2133443700","https://openalex.org/W2418771459","https://openalex.org/W2164408689","https://openalex.org/W2133099108","https://openalex.org/W2028742513","https://openalex.org/W1536646210"],"abstract_inverted_index":{"The":[0],"rising":[1],"prevalence":[2],"of":[3,27,53],"Barrett's":[4,7,56],"esophagus":[5,57],"and":[6,58,62],"associated":[8],"adenocarcinoma":[9],"in":[10,18,24,55],"the":[11,34,48,51],"Western":[12],"world":[13],"has":[14,22,39],"stimulated":[15],"increasing":[16],"interest":[17],"this":[19,44],"disease.":[20],"This":[21],"resulted":[23],"a":[25],"plethora":[26],"articles":[28],"concerning":[29,50],"its":[30,59,65,83],"molecular":[31],"biology,":[32],"but":[33],"tumor":[35],"suppressor":[36],"gene,":[37],"p27,":[38],"received":[40],"little":[41],"attention.":[42],"In":[43],"article,":[45],"we":[46,63],"review":[47],"literature":[49],"role":[52,67],"p27":[54],"malignant":[60],"transformation,":[61],"evaluate":[64],"possible":[66],"as":[68,73,75],"an":[69],"important":[70],"clinical":[71,78],"biomarker,":[72],"well":[74],"potential":[76],"chemopreventive":[77],"agents":[79],"aimed":[80],"at":[81],"substituting":[82],"antitumoral":[84],"activity.":[85]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}