{"id":"https://openalex.org/W2124005455","doi":null,"title":"Motor control in zebrafish : excitatory drive and developmental changes","display_name":"Motor control in zebrafish : excitatory drive and developmental changes","publication_year":2014,"publication_date":"2014-11-20","ids":{"openalex":"https://openalex.org/W2124005455","mag":"2124005455"},"language":"en","primary_location":{"id":"pmh:oai:openarchive.ki.se:10616/42294","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/42294","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/42294","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011001409","display_name":"Sabine G\u00f6rgens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sabine G\u00f6rgens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5011001409"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.021800000220537186,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.49900001287460327},{"id":"https://openalex.org/keywords/v2a-interneurons","display_name":"V2a interneurons","score":0.9039999842643738},{"id":"https://openalex.org/keywords/excitatory-interneurons","display_name":"excitatory interneurons","score":0.8240000009536743},{"id":"https://openalex.org/keywords/locomotor-rhythm-generation","display_name":"locomotor rhythm generation","score":0.871999979019165},{"id":"https://openalex.org/keywords/swimming","display_name":"swimming","score":0.503000020980835},{"id":"https://openalex.org/keywords/motor-neurons","display_name":"motor neurons","score":0.593999981880188},{"id":"https://openalex.org/keywords/primary-motoneurons","display_name":"primary motoneurons","score":0.703000009059906},{"id":"https://openalex.org/keywords/escape-behavior","display_name":"escape behavior","score":0.753000020980835},{"id":"https://openalex.org/keywords/optogenetic-stimulation","display_name":"optogenetic stimulation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/rhythmic-bursting","display_name":"rhythmic bursting","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.7617775797843933},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7435609698295593},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.681078314781189},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.6413793563842773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6035904884338379},{"id":"https://openalex.org/C169453685","wikidata":"https://www.wikidata.org/wiki/Q1054066","display_name":"Central pattern generator","level":3,"score":0.5862135887145996},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.4554036557674408},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.45475661754608154},{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.43993204832077026},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4142269492149353},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3270341753959656},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07629743218421936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:openarchive.ki.se:10616/42294","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/42294","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2124005455","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/10616/42294/3/Thesis_Sabine_G%c3%b6rgens.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/42294","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/42294","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W1500504256","https://openalex.org/W1502952578","https://openalex.org/W1563421928","https://openalex.org/W1618912177","https://openalex.org/W1706576307","https://openalex.org/W1779245441","https://openalex.org/W1917415069","https://openalex.org/W1941953147","https://openalex.org/W1942201467","https://openalex.org/W1947859348","https://openalex.org/W1969109504","https://openalex.org/W1974300077","https://openalex.org/W1975050865","https://openalex.org/W1978862241","https://openalex.org/W1979606683","https://openalex.org/W1980125007","https://openalex.org/W1982288105","https://openalex.org/W1986436832","https://openalex.org/W1991490329","https://openalex.org/W1992938999","https://openalex.org/W1993875383","https://openalex.org/W1997474041","https://openalex.org/W1999968440","https://openalex.org/W2002015872","https://openalex.org/W2002116211","https://openalex.org/W2006047257","https://openalex.org/W2009005402","https://openalex.org/W2011202168","https://openalex.org/W2016910258","https://openalex.org/W2018172747","https://openalex.org/W2019920550","https://openalex.org/W2023582410","https://openalex.org/W2024634955","https://openalex.org/W2026319364","https://openalex.org/W2026820481","https://openalex.org/W2029517350","https://openalex.org/W2030150624","https://openalex.org/W2032335526","https://openalex.org/W2032725699","https://openalex.org/W2032843299","https://openalex.org/W2033924235","https://openalex.org/W2034951262","https://openalex.org/W2035046572","https://openalex.org/W2039474031","https://openalex.org/W2040335094","https://openalex.org/W2044746434","https://openalex.org/W2045604027","https://openalex.org/W2061191160","https://openalex.org/W2061314910","https://openalex.org/W2064792669","https://openalex.org/W2068467384","https://openalex.org/W2069156135","https://openalex.org/W2073389632","https://openalex.org/W2074412203","https://openalex.org/W2076214837","https://openalex.org/W2076879580","https://openalex.org/W2080004698","https://openalex.org/W2081235375","https://openalex.org/W2081296105","https://openalex.org/W2084811348","https://openalex.org/W2087862328","https://openalex.org/W2090074774","https://openalex.org/W2093990877","https://openalex.org/W2094933429","https://openalex.org/W2097083972","https://openalex.org/W2114074319","https://openalex.org/W2115682148","https://openalex.org/W2117723173","https://openalex.org/W2122239265","https://openalex.org/W2125295969","https://openalex.org/W2125349610","https://openalex.org/W2127787712","https://openalex.org/W2128427412","https://openalex.org/W2128650008","https://openalex.org/W2141996385","https://openalex.org/W2144797544","https://openalex.org/W2145869625","https://openalex.org/W2148695338","https://openalex.org/W2162975378","https://openalex.org/W2233489363","https://openalex.org/W2314146467","https://openalex.org/W2318950931","https://openalex.org/W2322206633","https://openalex.org/W7073899588"],"related_works":["https://openalex.org/W1516770215","https://openalex.org/W2026820481","https://openalex.org/W4220788753","https://openalex.org/W2000571470","https://openalex.org/W7049051648","https://openalex.org/W1991490329","https://openalex.org/W2892012523","https://openalex.org/W2080004698","https://openalex.org/W2007053324","https://openalex.org/W2915367011"],"abstract_inverted_index":{"An":[0],"essential":[1],"characteristic":[2],"of":[3,30,46,63,99,116,129,136,141,237,249,258,288,377],"human":[4],"and":[5,36,43,81,109,154,160,225,272,317,345,359,370],"animal":[6],"life":[7],"is":[8,66,177,221,252,362],"the":[9,27,47,57,69,93,97,118,133,137,149,169,188,201,235,255,259,263,285,289,313,337,348,367],"ability":[10],"to":[11,16,20,67,91,151,180,186,217,253,283,297,301,352],"move":[12],"from":[13,172,234,294,319],"one":[14,39,113],"place":[15],"\\nanother,":[17],"in":[18,22,73,145,148,157,213,291,341,366],"order":[19],"survive":[21],"a":[23,155,354,363],"complex":[24],"environment.":[25],"All":[26],"different":[28,277],"forms":[29],"locomotion,":[31],"\\nlike":[32],"walking,":[33],"swimming,":[34,182],"crawling":[35],"flying,":[37],"have":[38],"common":[40],"feature:":[41],"rhythmic":[42,197],"alternating":[44],"movements":[45,50],"body.":[48],"These":[49],"are":[51,89,318,343],"generated":[52],"by":[53,223],"neuronal":[54],"networks":[55],"\\nin":[56,310],"spinal":[58],"cord.":[59],"The":[60],"overall":[61],"aim":[62,248],"this":[64,250],"thesis":[65,251],"investigate":[68],"mechanisms":[70],"underlying":[71,239],"\\nlocomotion":[72],"zebrafish,":[74],"with":[75],"particular":[76],"focus":[77],"on":[78],"excitatory":[79,170,338],"drive":[80,105,171,181],"developmental":[82,256,278],"\\nchanges.":[83],"\\n":[84,85,86,163,164,165,243,244,245,329,330,331],"\\nExcitatory":[87],"interneurons":[88,108,143,176,190,195,340],"believed":[90],"represent":[92],"core":[94],"components":[95],"for":[96,132,347],"generation":[98],"\\nthe":[100,210],"locomotor":[101,368],"rhythm,":[102],"since":[103],"they":[104,124],"both":[106],"inhibitory":[107],"motoneurons.":[110],"By":[111,266],"\\nablating":[112],"specific":[114],"group":[115],"interneurons,":[117,120],"V2a":[119,142,175,189,194,240,339],"we":[121,183,280,334],"show":[122,335],"that":[123,168,199,209,230,336,360],"\\nrepresent":[125],"an":[126,146,238],"intrinsic":[127],"source":[128],"excitation":[130],"necessary":[131,344],"normal":[134],"expression":[135],"\\nlocomotor":[138],"rhythm.":[139],"Ablation":[140],"results":[144],"increase":[147],"threshold":[150],"\\ninduce":[152],"swimming":[153,158,218,231,260,292,300,311,356],"decrease":[156],"frequency":[159],"episode":[161],"duration.":[162],"\\nTo":[166],"demonstrate":[167],"ipsilateral":[173],"premotor":[174],"also":[178],"\\nsufficient":[179,346],"used":[184],"optogenetics":[185],"activate":[187],"\\nspecifically.":[191],"Upon":[192],"illumination,":[193],"displayed":[196],"oscillations":[198],"\\nresembled":[200],"typical":[202],"beat-and-glide":[203],"swimming.":[204],"Peripheral":[205],"nerve":[206,270],"recordings":[207],"confirmed":[208],"bursting":[211],"activity":[212,236,271],"single":[214],"neurons":[215],"corresponds":[216],"activity,":[219],"which":[220],"\\ncharacterized":[222],"left-right-alternation":[224],"rostrocaudal":[226],"delay.":[227],"This":[228],"indicates":[229],"\\nactivity":[232],"emerges":[233],"interneuron":[241],"network.":[242],"\\nThe":[246],"third":[247],"reveal":[254],"changes":[257],"pattern":[261,369],"\\nand":[262],"motoneuron":[264,274,372],"properties.":[265],"systematically":[267],"recording":[268],"peripheral":[269],"\\nprimary":[273],"properties":[275],"during":[276],"stages,":[279],"were":[281],"able":[282],"\\ndefine":[284],"time":[286,315],"frame":[287],"switch":[290,365],"behavior":[293],"larval":[295],"episodic":[296],"adult":[298],"\\ncontinuous":[299],"4-5":[302,375],"weeks":[303,322,376],"post":[304],"fertilization.":[305],"Primary":[306],"motoneurons":[307],"stop":[308],"participating":[309],"within":[312],"same":[314],"window":[316],"around":[320,374],"6":[321],"onward":[323],"only":[324],"active":[325],"\\nduring":[326],"escape":[327],"behavior.":[328],"\\nIn":[332],"conclusion,":[333],"zebrafish":[342],"rhythm":[349],"generating":[350],"network":[351],"generate":[353],"coordinated":[355],"motor":[357],"\\npattern":[358],"there":[361],"major":[364],"primary":[371],"\\nrecruitment":[373],"development.":[378]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
