{"id":"https://openalex.org/W2123976909","doi":null,"title":"New insights into inflammatory bowel disease and colitis-associated neoplasia","display_name":"New insights into inflammatory bowel disease and colitis-associated neoplasia","publication_year":2012,"publication_date":"2012-11-15","ids":{"openalex":"https://openalex.org/W2123976909","mag":"2123976909"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/256453","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/256453","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/256453","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001408070","display_name":"Fiona D M van Schaik","orcid":"https://orcid.org/0009-0003-2451-1809","observed_orcids":["https://orcid.org/0009-0003-2451-1809"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fiona D. M. van Schaik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001408070"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/colitis-associated-neoplasia","display_name":"colitis-associated neoplasia","score":0.9739999771118164},{"id":"https://openalex.org/keywords/serological-markers","display_name":"serological markers","score":0.7879999876022339},{"id":"https://openalex.org/keywords/farnesoid-x-receptor","display_name":"farnesoid X receptor","score":0.8600000143051147},{"id":"https://openalex.org/keywords/chenodeoxycholic-acid","display_name":"chenodeoxycholic acid","score":0.9160000085830688},{"id":"https://openalex.org/keywords/fxr-agonists","display_name":"FXR agonists","score":0.734000027179718},{"id":"https://openalex.org/keywords/low-grade-dysplasia","display_name":"low-grade dysplasia","score":0.8709999918937683},{"id":"https://openalex.org/keywords/histopathological-diagnosis","display_name":"histopathological diagnosis","score":0.6579999923706055},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8980000019073486},{"id":"https://openalex.org/keywords/alpha-methylacyl-coa-racemase","display_name":"AMACR","score":0.9959999918937683},{"id":"https://openalex.org/keywords/immunohistochemical-markers","display_name":"immunohistochemical markers","score":0.8629999756813049},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.8489999771118164},{"id":"https://openalex.org/keywords/colorectal-cancer-risk","display_name":"colorectal cancer risk","score":0.9110000133514404},{"id":"https://openalex.org/keywords/colorectal-cancer-screening","display_name":"colorectal cancer screening","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.8228355646133423},{"id":"https://openalex.org/C203862802","wikidata":"https://www.wikidata.org/wiki/Q14905041","display_name":"Farnesoid X receptor","level":5,"score":0.7557744979858398},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7227118611335754},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7176204323768616},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.6643533706665039},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6502050757408142},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6067781448364258},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.589397668838501},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5316475033760071},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.5073794722557068},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.419455885887146},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.35238590836524963},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.24150392413139343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08032777905464172},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/256453","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/256453","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/256453","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/256453","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/256453","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/256453","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2123976909","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/1874/256453/2/schaik.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/256453","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/256453","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W26561002","https://openalex.org/W119850406","https://openalex.org/W1763504554","https://openalex.org/W1867930941","https://openalex.org/W1910112204","https://openalex.org/W1942180523","https://openalex.org/W1964102710","https://openalex.org/W1966071820","https://openalex.org/W1969109852","https://openalex.org/W1970911427","https://openalex.org/W1973914171","https://openalex.org/W1974120463","https://openalex.org/W1980640495","https://openalex.org/W1983464240","https://openalex.org/W1984831472","https://openalex.org/W1989215734","https://openalex.org/W1990397098","https://openalex.org/W1990508468","https://openalex.org/W1991572280","https://openalex.org/W1993177841","https://openalex.org/W2002596304","https://openalex.org/W2002780176","https://openalex.org/W2005227103","https://openalex.org/W2007954617","https://openalex.org/W2010662708","https://openalex.org/W2021461643","https://openalex.org/W2023412125","https://openalex.org/W2024763754","https://openalex.org/W2026267347","https://openalex.org/W2028025555","https://openalex.org/W2028862816","https://openalex.org/W2035742267","https://openalex.org/W2038176882","https://openalex.org/W2043004569","https://openalex.org/W2045807658","https://openalex.org/W2046582338","https://openalex.org/W2048204343","https://openalex.org/W2050383365","https://openalex.org/W2057964098","https://openalex.org/W2058161157","https://openalex.org/W2058564944","https://openalex.org/W2059596409","https://openalex.org/W2060126383","https://openalex.org/W2063131548","https://openalex.org/W2077105214","https://openalex.org/W2078339059","https://openalex.org/W2079828772","https://openalex.org/W2092533578","https://openalex.org/W2093690138","https://openalex.org/W2097733438","https://openalex.org/W2097786984","https://openalex.org/W2097879197","https://openalex.org/W2097899355","https://openalex.org/W2099467873","https://openalex.org/W2100559261","https://openalex.org/W2104855101","https://openalex.org/W2105058392","https://openalex.org/W2106212265","https://openalex.org/W2106865732","https://openalex.org/W2109302050","https://openalex.org/W2112569623","https://openalex.org/W2114729980","https://openalex.org/W2119543164","https://openalex.org/W2121352821","https://openalex.org/W2124199533","https://openalex.org/W2125524268","https://openalex.org/W2130078150","https://openalex.org/W2130503272","https://openalex.org/W2134247833","https://openalex.org/W2135003409","https://openalex.org/W2138075385","https://openalex.org/W2146427687","https://openalex.org/W2147923982","https://openalex.org/W2152412756","https://openalex.org/W2152872749","https://openalex.org/W2155919167","https://openalex.org/W2157503717","https://openalex.org/W2161733605","https://openalex.org/W2170646682","https://openalex.org/W2275120066","https://openalex.org/W2321811895"],"related_works":["https://openalex.org/W168828028","https://openalex.org/W2119543164","https://openalex.org/W56002123","https://openalex.org/W2891566615","https://openalex.org/W7095095779","https://openalex.org/W131253717","https://openalex.org/W3021856680","https://openalex.org/W181963962","https://openalex.org/W2779044681","https://openalex.org/W2107841708"],"abstract_inverted_index":{"This":[0,123],"thesis":[1,124,166],"describes":[2],"new":[3,167],"insights":[4,168],"into":[5,169],"the":[6,24,27,53,64,70,131,150,161,170,205,232,257,270,280,296,310,399,403,461],"development":[7,54,171],"of":[8,29,34,43,46,55,66,69,107,128,154,164,172,179,204,211,247,282,285,298,302,323,337,348,382,405,416,428,443,458,463,494],"inflammatory":[9],"bowel":[10],"disease":[11,18],"(IBD:":[12],"ulcerative":[13],"colitis":[14],"(UC)":[15],"or":[16,249,333],"Crohn\u2019s":[17,81,121,141],"(CD))":[19],"and":[20,184,194,201,255,304,315,330,354,392,421],"IBD-associated":[21,173],"neoplasia.":[22,446],"In":[23,160,275,398,423,477],"first":[25],"part,":[26],"value":[28,281],"serological":[30,47],"markers":[31,48,287],"as":[32,319,363,365,475],"predictors":[33],"IBD":[35,56,349,359,370,391,393,429,469],"was":[36,49,76,112,306,341,433,473,484],"investigated":[37,77,199,292,343],"in":[38,57,78,118,138,157,224,237,251,288,312,326,344,358,418,468],"a":[39,60,84,90,100,145,209,227,245,283,320,345,424,439],"large":[40,346,425],"European":[41],"cohort":[42,347,427],"individuals.A":[44],"combination":[45],"found":[50,114,307,376,434,486],"to":[51,115,147,188,220,262,264,277,295,308,356,377,387,435,479,487],"predict":[52],"individuals":[58],"from":[59],"low-risk":[61],"population.":[62],"Furthermore,":[63],"role":[65,153],"pharmacological":[67],"activation":[68,127],"nuclear":[71,91],"farnesoid":[72],"X":[73],"receptor":[74,92],"(FXR)":[75],"patients":[79,119,139,225,238,252,290,327,350,367,371,389,394,430,470],"with":[80,120,140,226,239,253,260,293,328,351,368,372,438,454,490],"colitis,":[82,142],"using":[83,471],"synthetic":[85],"FXR":[86,88,101,109,129,132,155],"agonist.":[87,102],"is":[89,136],"that":[93,126,244,357],"exerts":[94],"anti-inflammatory":[95],"effects":[96,404],"when":[97],"stimulated":[98],"by":[99,130,208,231],"Under":[103],"unstimulated":[104],"conditions,":[105],"expression":[106],"ileal":[108],"target":[110],"genes":[111],"previously":[113],"be":[116,309,317,436,488],"lower":[117],"colitis.":[122],"shows":[125],"ligand":[133],"chenodeoxycholic":[134],"acid":[135],"feasible":[137],"which":[143],"provides":[144],"rationale":[146],"further":[148],"explore":[149],"potential":[151,321],"therapeutic":[152],"agonists":[156],"these":[158],"patients.":[159],"second":[162],"part":[163],"this":[165,278,313],"neoplasia":[174,190,222,340,385],"are":[175,410],"addressed.":[176],"Progression":[177],"rates":[178],"flat":[180,331],"low-grade":[181],"dysplasia":[182,186,192],"(LGD)":[183],"indefinite":[185],"(IND)":[187],"advanced":[189,221,265,384,445],"(high-grade":[191],"(HGD)":[193],"colorectal":[195,339],"cancer":[196,466],"(CRC))":[197],"were":[198,291,375,407],"before":[200],"after":[202],"review":[203],"histological":[206],"diagnosis":[207,229,246],"panel":[210],"three":[212],"expert":[213],"gastrointestinal":[214],"pathologists.":[215],"The":[216,241,335],"5-year":[217],"progression":[218,263,325],"rate":[219],"increased":[223,380,456,492],"LGD":[228,248,332],"confirmed":[230],"panel,":[233],"whereas":[234],"it":[235],"decreased":[236,441],"IND.":[240,334],"results":[242],"demonstrate":[243],"IND":[250],"IBD,":[254],"therefore":[256],"associated":[258,437,453,489],"prognosis":[259],"regard":[261,294],"neoplasia,":[266],"largely":[267],"depends":[268],"on":[269],"interpretation":[271],"ofthe":[272],"consulting":[273],"pathologist.":[274],"addition":[276],"study,":[279],"series":[284],"immunohistochemical":[286],"UC":[289,329,420],"prediction":[297],"neoplastic":[299,324],"progression.":[300],"Co-expression":[301],"p53":[303],"AMACR":[305],"best":[311],"respect,":[314],"might":[316],"useful":[318],"marker":[322],"risk":[336,381,442,457,462,493],"subsequent":[338],"also":[342],"an":[352,373,379,396,455,491],"adenoma":[353,374,388],"compared":[355,386],"subjects":[360],"without":[361,390,395],"adenomas":[362],"well":[364],"non-IBD":[366],"adenomas.":[369],"have":[378],"developing":[383,444],"adenoma.":[397],"last":[400],"two":[401],"chapters":[402],"thiopurines":[406,472],"investigated.":[408],"Thiopurines":[409],"immunomodulators":[411],"commonly":[412],"used":[413],"for":[414],"maintenance":[415],"remission":[417],"both":[419],"CD.":[422],"Dutch":[426],"thiopurine":[431,448,482],"use":[432,449,483],"significantly":[440],"Since":[447],"has":[450],"often":[451],"been":[452],"extra-intestinal":[459],"malignancies,":[460],"non-melanoma":[464],"skin":[465],"(NMSC)":[467],"evaluated":[474],"well.":[476],"contrast":[478],"previous":[480],"studies,":[481],"not":[485],"NMSC.":[495]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}