{"id":"https://openalex.org/W2123972371","doi":"https://doi.org/10.1111/j.1600-0404.1999.tb00405.x","title":"Methylation of cortical brain proteins from patients with HIV infection","display_name":"Methylation of cortical brain proteins from patients with HIV infection","publication_year":2009,"publication_date":"2009-01-29","ids":{"openalex":"https://openalex.org/W2123972371","doi":"https://doi.org/10.1111/j.1600-0404.1999.tb00405.x","mag":"2123972371","pmid":"https://pubmed.ncbi.nlm.nih.gov/10536921"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0404.1999.tb00405.x","doi":"https://doi.org/10.1111/j.1600-0404.1999.tb00405.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0404.1999.tb00405.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0404.1999.tb00405.x","source":{"id":"https://openalex.org/S66034498","display_name":"Acta Neurologica Scandinavica","issn_l":"0001-6314","issn":["0001-6314","1600-0404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neurologica Scandinavica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0404.1999.tb00405.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090286753","display_name":"Michael Goggins","orcid":"https://orcid.org/0000-0002-4286-2296","observed_orcids":["https://orcid.org/0000-0002-4286-2296"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"M. Goggins","raw_affiliation_strings":["Department of Clinical Medicine, Trinity College, Dublin, Ireland","Dept. of Clinical Medicine, Trinity College, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Trinity College, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Dept. of Clinical Medicine, Trinity College, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111525276","display_name":"J. M. Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"J. M. Scott","raw_affiliation_strings":["Department of Clinical Medicine, Trinity College, Dublin, Ireland","Dept. of Clinical Medicine, Trinity College, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Trinity College, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Dept. of Clinical Medicine, Trinity College, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040331916","display_name":"D. G. Weir","orcid":"https://orcid.org/0000-0001-6025-2603","observed_orcids":["https://orcid.org/0000-0001-6025-2603"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"D. G. Weir","raw_affiliation_strings":["Department of Clinical Medicine, Trinity College, Dublin, Ireland","Dept. of Clinical Medicine, Trinity College, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Trinity College, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Dept. of Clinical Medicine, Trinity College, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090286753"],"corresponding_institution_ids":["https://openalex.org/I205274468"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":null,"fwci":0.2382,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.58734555,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"100","issue":"5","first_page":"326","last_page":"331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.426800012588501,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.426800012588501,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.31150001287460327,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-encephalitis","display_name":"HIV encephalitis","score":0.949999988079071},{"id":"https://openalex.org/keywords/s-adenosylmethionine","display_name":"S-adenosylmethionine","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cortical-white-matter","display_name":"cortical white matter","score":0.7210000157356262},{"id":"https://openalex.org/keywords/vitamin-b12-deficiency","display_name":"vitamin B12 deficiency","score":0.8169999718666077},{"id":"https://openalex.org/keywords/subacute-combined-degeneration-of-the-spinal-cord","display_name":"subacute combined degeneration","score":0.8130000233650208},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8659999966621399},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6876817941665649},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.6736124157905579},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5743709802627563},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.49291062355041504},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47402623295783997},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.46954354643821716},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.4611392915248871},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.4558289647102356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45283105969429016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3962636888027191},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3026122450828552},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.25496214628219604},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08248284459114075},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.06316623091697693},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05949592590332031},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011496","descriptor_name":"Protein Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012435","descriptor_name":"S-Adenosylhomocysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012436","descriptor_name":"S-Adenosylmethionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018792","descriptor_name":"Encephalitis, Viral","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0404.1999.tb00405.x","doi":"https://doi.org/10.1111/j.1600-0404.1999.tb00405.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0404.1999.tb00405.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0404.1999.tb00405.x","source":{"id":"https://openalex.org/S66034498","display_name":"Acta Neurologica Scandinavica","issn_l":"0001-6314","issn":["0001-6314","1600-0404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neurologica Scandinavica","raw_type":"journal-article"},{"id":"pmid:10536921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10536921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta neurologica Scandinavica","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1600-0404.1999.tb00405.x","doi":"https://doi.org/10.1111/j.1600-0404.1999.tb00405.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0404.1999.tb00405.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0404.1999.tb00405.x","source":{"id":"https://openalex.org/S66034498","display_name":"Acta Neurologica Scandinavica","issn_l":"0001-6314","issn":["0001-6314","1600-0404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neurologica Scandinavica","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2123972371.pdf","grobid_xml":"https://content.openalex.org/works/W2123972371.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W40412007","https://openalex.org/W46965905","https://openalex.org/W326708618","https://openalex.org/W1490954319","https://openalex.org/W1492953040","https://openalex.org/W1528442160","https://openalex.org/W1533219519","https://openalex.org/W1558320996","https://openalex.org/W1832129726","https://openalex.org/W1960667696","https://openalex.org/W1980131626","https://openalex.org/W1992689843","https://openalex.org/W1993833985","https://openalex.org/W2005186311","https://openalex.org/W2005807968","https://openalex.org/W2006367124","https://openalex.org/W2011249560","https://openalex.org/W2013281474","https://openalex.org/W2017973363","https://openalex.org/W2024476573","https://openalex.org/W2025392129","https://openalex.org/W2026770293","https://openalex.org/W2045939131","https://openalex.org/W2052713955","https://openalex.org/W2067709032","https://openalex.org/W2070271805","https://openalex.org/W2070469985","https://openalex.org/W2071372933","https://openalex.org/W2074291228","https://openalex.org/W2085577787","https://openalex.org/W2088696081","https://openalex.org/W2092563800","https://openalex.org/W2093530590","https://openalex.org/W2107959354","https://openalex.org/W2132586158","https://openalex.org/W2290439349","https://openalex.org/W2339085593","https://openalex.org/W2339922662","https://openalex.org/W2431433597","https://openalex.org/W2444365178","https://openalex.org/W6611371716"],"related_works":["https://openalex.org/W1993833985","https://openalex.org/W2070469985","https://openalex.org/W2116797320","https://openalex.org/W1980529612","https://openalex.org/W2314549541","https://openalex.org/W2150447827","https://openalex.org/W2005186311","https://openalex.org/W3152755878","https://openalex.org/W2323603430","https://openalex.org/W2416572086"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Experimental":[1],"models":[2],"of":[3,25,50,62,124,162,167,189,194,220,225,239],"vitamin":[4,30],"B12":[5,31],"deficient-neuropathy":[6],"are":[7],"characterized":[8],"by":[9],"central":[10,40],"nervous":[11,41],"system":[12,42],"protein":[13,60,214],"hypomethylation.":[14],"The":[15,122,187,218],"encephalitis/vacuolar":[16],"myelopathy":[17],"complicating":[18],"HIV":[19,51,104,168,200,228,240],"infection":[20,201],"and":[21,36,64,111,131,202],"subacute":[22],"combined":[23],"degeneration":[24],"the":[26,48,148,158,163,179,223,237],"cord":[27],"due":[28,211],"to":[29,184,212],"deficiency":[32],"share":[33],"similar":[34,156],"biochemical":[35],"pathological":[37],"abnormalities.":[38],"Altered":[39],"methylation":[43,61,193],"may":[44],"be":[45],"important":[46],"in":[47,74,141,147,157,178,191,216,222],"pathogenesis":[49],"encephalitis.":[52,169,241],"To":[53],"test":[54],"this":[55],"hypothesis":[56],"we":[57],"compared":[58,183],"brain":[59,77,135,195],"HIV-positive,":[63],"control,":[65],"subjects.":[66],"MATERIALS":[67],"AND":[68],"METHODS:":[69],"Carboxymethyltransferase":[70,153],"activity":[71,154],"was":[72,143,155,175],"assayed":[73],"postmortem":[75],"cortical":[76,138,171],"samples":[78],"obtained":[79],"from":[80,137,197],"16":[81],"control":[82],"patients":[83,95,113,198,226],"(9":[84],"males);":[85],"mean":[86,106],"age":[87,107,118],"(59+/-5.1":[88],"years,":[89],"range":[90,109],"21-87":[91],"years),":[92],"9":[93],"HIV-positive":[94],"(7":[96],"males,":[97],"6":[98],"IVDA,":[99],"3":[100,112],"homosexual,":[101],"4":[102],"with":[103,114,199,227],"encephalitis,":[105],"37,":[108],"23-45),":[110],"Alzheimer's":[115,180,203],"disease":[116,181,204],"(mean":[117],"78":[119],"years).":[120],"RESULTS:":[121],"amount":[123],"radiolabelled":[125],"SAM":[126],"(S-adenosylmethionine)":[127],"incorporated":[128],"into":[129],"carboxymethyl,":[130],"N-methylation":[132],"sites":[133,209],"within":[134],"proteins":[136,196],"white":[139],"matter":[140],"vitro":[142,192],"significantly":[144],"lower":[145,177],"(P<0.05)":[146],"HIV+":[149],"group":[150,173,182],"vs":[151],"controls.":[152,185],"HIV-infected":[159],"brains":[160,224],"irrespective":[161],"presence":[164],"or":[165],"absence":[166,219],"Mean":[170],"methyl":[172],"incorporation":[174],"also":[176],"CONCLUSION:":[186],"observation":[188],"reduced":[190],"suggests":[205,230],"that":[206,231],"fewer":[207],"unmethylated":[208],"exist":[210],"relative":[213],"hypermethylation":[215],"vivo.":[217],"hypomethylation":[221,232],"encephalitis":[229],"is":[233],"not":[234],"necessary":[235],"for":[236],"development":[238]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
